Comparison of the efficacy and safety of bupropion versus aripiprazole augmentation in adults with treatment-resistant depression: a nationwide cohort study in South Korea by Dong Yun Lee, Rae Woong Park, Soo Min Jeon

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Trajectory of peripheral inflammation during index ECT in association with clinical outcomes in treatment-resistant depression by Christina M. Hough, Jennifer L. Kruse, Randall T. Espinoza, John O. Brooks, III, Eliza J. Congdon, Viviane Norris, Michelle G. Craske, Katherine L. Narr

“…Improved understanding of these processes may provide critical insight into effective intervention for treatment-resistant depression (TRD). Methods: Plasma inflammatory markers were assessed at pre-treatment (T1), after the second ECT session (T2), and after ECT index series completion (post-treatment/T3) in TRD (n = 40). …”
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A Comparative Study on the Effectiveness of Electroconvulsive Therapy and Ketamine in Persons Suffering from Treatment-resistant Depressive Disorder by Vikhram Ramasubramanian, S. Mathumathi, Gautami Thirumalaisamy, Sugaparaneetharan Ayyanar, Gopi Rajendhiran, M. Kannan

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Intranasal racemic ketamine maintenance therapy for patients with treatment-resistant depression: a naturalistic feasibility study by Katelyn Halpape, Raelle Pashovitz, Annabelle Wanson, Monika Hooper, Evyn M. Peters

“…Abstract Background Ketamine is a promising therapy for treatment-resistant depression due to its rapid onset, although benefits are often transitory, with patients needing maintenance therapy to prevent relapse. …”
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Predicting treatment response to ketamine in treatment-resistant depression using auditory mismatch negativity: Study protocol. by Josh Martin, Fatemeh Gholamali Nezhad, Alice Rueda, Gyu Hee Lee, Colleen E Charlton, Milad Soltanzadeh, Karim S Ladha, Sridhar Krishnan, Andreea O Diaconescu, Venkat Bhat

“…<h4>Background</h4>Ketamine has recently attracted considerable attention for its rapid effects on patients with major depressive disorder, including treatment-resistant depression (TRD). Despite ketamine's promising results in treating depression, a significant number of patients do not respond to the treatment, and predicting who will benefit remains a challenge. …”
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The Effect of Accelerated Transcranial Magnetic Stimulation on Insomnia Severity and Sleep Quality in Patients With Treatment-Resistant Depression by Hilal Uygur, Rukiye Tekdemir, Hülya Ertekin

“…This study explored how accelerated transcranial magnetic stimulation (aTMS) affects insomnia severity and sleep quality in patients with treatment-resistant depression (TRD). Methods This retrospective study included files from 28 patients with TRD who met specific inclusion and exclusion criteria. …”
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The Efficacy of Pramipexole, a Dopamine Receptor Agonist, as an Adjunctive Treatment in Treatment-Resistant Depression: An Open-Label Trial by Hiroaki Hori, Hiroshi Kunugi

“…Dopaminergic dysfunction is implicated in the pathophysiology of treatment-resistant depression. Although the efficacy of adjunctive pramipexole treatment has been demonstrated in treatment-resistant bipolar depression, such data are scarce for major depressive disorder (MDD). …”
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Trazodone Addition to Paroxetine and Mirtazapine in a Patient with Treatment-Resistant Depression: The Pros and Cons of Combining Three Antidepressants by Rui Lopes, José Carlos Alves, Raquel Garcia Rego

“…Dual antidepressant combination for treatment-resistant depression is a strategy well supported by literature and accepted in clinical practice. …”
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Therapeutic Approaches to Tackle the Challenge of Depression That Is Resistant to Treatment–A Narrative Review by Md. Rajdoula Rafe, Abdul Waris, Pranoy Saha

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Personalised transcranial magnetic stimulation for treatment-resistant depression, depression with comorbid anxiety and negative symptoms of schizophrenia: a narrative review by Xiao Wei Tan, Hasvinjit Kaur Gulwant Singh, Jovi Zheng Jie Koh, Rachel Si Yun Tan, Phern Chern Tor

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Cortical hypometabolism as a predictor of intermittent theta burst stimulation response in treatment-resistant depression patients: An open-label study by Nidhisha Bajaj, Nand Kumar, Rakesh Kumar, Vaibhav Patil, Anshul Sharma

“…Methods: A total of 25 treatment-resistant depression patients received 15 sessions of iTBS on the left dorsolateral prefrontal cortex. …”
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A meta-analysis comparing the effectiveness and safety of repetitive transcranial magnetic stimulation versus theta burst stimulation for treatment-resistant depression by Xiao Tao, Zheng Wen Jing, Wang Kui Yuan, Guo Hui Yun, Xie Jian Fang, Liao Ming Sheng

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Stem cell therapy for the treatment of psychiatric disorders: a real hope for the next decades by Rosa Villanueva

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Respiratory disease in people with Major Depressive Disorder: A Systematic Review and Meta-analysis by Ana Jiménez-Peinado, David Laguna-Muñoz, María José Jaén-Moreno, Cristina Camacho-Rodríguez, Gloria Isabel del Pozo, Eduard Vieta, Javier Caballero-Villarraso, Fernando Rico-Villademoros, Fernando Sarramea

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Ketamine Therapy in Complex Cases: A Cautionary Tale of Exacerbated Personality Traits and the Crucial Role of Comprehensive Follow-Up and Psychosocial Interventions by Jai Ahuja, Luba Leontieva

“…This case report examines the unexpected increase in suicidal ideation following ketamine infusion therapy in a 75-year-old female with a history of treatment-resistant depression. Despite ketamine’s established efficacy in treating depression and acute suicidality, this patient’s condition deteriorated posttreatment. …”
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A Case of Hepatotoxicity Induced by Therapeutic Ketamine Use for Sedation by Noah Yoo, Sarun Thomas, Michael Bender, Xian Jie Cindy Cheng

“…Ketamine, initially developed as an anesthetic, has shown versatility in medical applications, including pain management, treatment-resistant depression, and sedation in the intensive care unit (ICU). …”
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Testosterone Replacement Therapy in the Treatment of Depression by Danyon J. Anderson, Parsia Vazirnia, Catherine Loehr, Whitney Sternfels, Jamal Hasoon, Omar Viswanath, Alan D. Kaye, Ivan Urits

“… # Results Within some subpopulations such as men with dysthymic disorder, treatment resistant depression, or low testosterone levels, testosterone administration yielded positive results in the treatment of depression. …”
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Trends in research on novel antidepressant treatments by Agnieszka Zelek-Molik, Ewa Litwa

“…The development of rapid-acting drugs is increasingly focused on achieving high efficacy, particularly for treatment-resistant depression. Such advances offer the potential for rapid therapeutic effects without the prolonged and often tedious administration of older generation antidepressants. …”
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An Unexpected Presentation of Serotonin Syndrome in a Patient Receiving ECT by Shahzaib Khan, Breanna Wennberg, Malgorzata Witkowska, Jacob Rattin, Raunak Khisty

“…ECT is a neuromodulatory procedure approved for treatment-resistant depression and schizophrenia that involves electrically stimulating the brain with electrodes on the scalp to induce a seizure. …”
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Is there a risk of esketamine misuse in clinical practice? by Carlos Roncero, Milton Merizalde-Torres, Néstor Szerman, Marta Torrens, Pablo Vega, Pilar Andres-Olivera, Francisco Javier Álvarez

“…In 2019, intranasal esketamine gained approval as a promising therapy for those individuals grappling with treatment-resistant depression. Both clinical trials and real-world studies have underscored its efficacy in alleviating and remitting depressive symptoms, with sustained benefits observed for nearly 4.5 years. …”
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