ERG mediates the differentiation of hepatic progenitor cells towards immunosuppressive PDGFRα+ cancer-associated fibroblasts during hepatocarcinogenesis by Haoran Bai, Xinyu Zhu, Lu Gao, Shiyao Feng, Hegen Li, Xiaoqiang Gu, Jiahua Xu, Chen Zong, Xiaojuan Hou, Xue Yang, Jinghua Jiang, Qiudong Zhao, Lixin Wei, Li Zhang, Zhipeng Han, Wenting Liu, Jianxin Qian

“…This differentiation is mediated by the activation of the MAPK signaling pathway and the downstream transcription factor ERG via the TLR4 receptor. Downregulating the expression of ERG in HPCs significantly reduces the number of PDGFRα+ CAFs and the infiltration of tumour-associated macrophages in HCC, thereby suppressing hepatocarcinogenesis. …”
Get full text

High Glucose Induces Endothelial COX2 and iNOS Expression via Inhibition of Monomethyltransferase SETD8 Expression by Jie Qi, Qichao Wu, Qian Cheng, Xiangyuan Chen, Minmin Zhu, Changhong Miao

“…E26 transformation-specific sequence transcription factor-1 (ESE-1), which belongs to the E26 transformation-specific family of transcription factors, has been demonstrated to be involved in COX2 and iNOS gene transcription. …”
Get full text

The mechanisms of melanogenesis inhibition by glabridin: molecular docking, PKA/MITF and MAPK/MITF pathways by Chunxing Pan, Xiaoying Liu, Yating Zheng, Zejun Zhang, Yongliang Li, Biao Che, Guangrong Liu, Lanyue Zhang, Changzhi Dong, Haji Akber Aisa, Zhiyun Du, Zhengqiang Yuan

“…The treatment by glabridin significantly downregulated both transcriptional and/or protein expression of melanogenesis-related factors including melanocyte stimulating hormone receptor (MC1R), microphthalmia-associated transcription factor (MITF), tyrosinase (TYR), TYR-related protein-1 (TRP-1) and TRP-2 in B16 cells. …”
Get full text

Comparative Analysis of Tenogenic Gene Expression in Tenocyte-Derived Induced Pluripotent Stem Cells and Bone Marrow-Derived Mesenchymal Stem Cells in Response to Biochemical and B... by Feikun Yang, Dean W. Richardson

“…Western blotting revealed that TGF-β3 and BMP12 increased the expression of transcription factors SCX and MKX in both cells, but the tenocyte marker tenomodulin (TNMD) was detected only in BMSCs and upregulated by either inducer. …”
Get full text

Here and there: the double-side transgene localization by P. A. Salnikov, A. A. Khabarova, G. S. Koksharova, R. V. Mungalov, P. S. Belokopytova, I. E. Pristyazhnuk, A. R. Nurislamov, P. Somatich, M. M. Gridina, V. S. Fishman

“…These techniques have already been used for functional gene annotation by transposon-insertion sequencing, for identification of transcription factor binding sites and regulatory sequences, and for dissecting chromatin position effects. …”
Get full text

Functional Genetic Variant in ATG5 Gene Promoter in Acute Myocardial Infarction by Yexin Zhang, Xiaohui He, Jiarui Li, Wentao Yang, Yinghua Cui, Shuchao Pang, Haihua Wang, Bo Yan

“…Furthermore, an electrophoretic mobility shift assay showed that the deletion variant evidently affected the binding of a transcription factor. Therefore, the genetic variant identified in AMI may affect the activity of the ATG5 gene promoter and change the ATG5 level, contributing to AMI as a rare risk factor.…”
Get full text

Heterologous Expression of a Potential ‘<i>Paulownia fortunei</i>’ MYB Factor Gene, <i>PfMYB90</i>, Improves Salt and Cold Tolerance in <i>Arabidopsis</i> by Hongling Wang, Shizheng Shi, Guijie Luo, Ruifang Huang, Dezong Sui, Yunpeng Gao, Lei Wang

“…In the research field of MYB transcription factors of the paulownia tree, it is rare to discuss the resistance to abiotic stress. …”
Get full text

The Relevance of the Virchow Node and Virchow Triad in Renal Cancer Diagnosis by Luiza-Roxana Dorobantu-Lungu, Viviana Dinca, Andrei Gegiu, Dan Spataru, Andreea Toma, Luminita Welt, Mihaela Florentina Badea, Constantin Caruntu, Cristian Scheau, Ilinca Savulescu-Fiedler

“…Renal cell carcinoma (RCC) associated with Xp11.2 translocation/gene fusion TFE3 is a rare subtype of kidney cancer that was classified in 2016 as belonging to the family of renal carcinomas with MiT gene translocation (microphthalmia-associated transcription factor). The prognosis for these kidney cancers is poorer compared to other types. …”
Get full text

Integrated analysis of chromatin and transcriptomic profiling of the striatum after cerebral hypoperfusion in mice by Shijia Le, Fengyiyang Xu, Zhi Luo, Weihao Shi, Shuangshuang Lu, Zengyu Zhang, Zimin Guo, Wenshi Xu, Mingqi Yang, Tianyi Li, Xu Li, Kun Liang, Lei Zhu

“…The integration of these datasets allowed us to correlate chromatin accessibility with transcriptional activity and to identify key transcription factors driving the observed gene expression changes. …”
Get full text

CPSF6-RARγ interacts with histone deacetylase 3 to promote myeloid transformation in RARG-fusion acute myeloid leukemia by Tianhui Liu, Tanzhen Wang, Lijuan Qi, Yujie Liu, Meng Shan, Fuqiang Wang, Yanglan Fang, Sining Liu, Lijun Wen, Suning Chen, Depei Wu, Yang Xu

“…Mechanistically, CR fusion interacts with histone deacetylase 3 (HDAC3) to suppress expression of genes associated with myeloid differentiation including the myeloid transcription factor PU.1. Disrupting CR-HDAC3 interaction, restores PU.1 expression and myeloid differentiation. …”
Get full text

Under simulated microgravity and gravity, anthocyanin is regulated by DcaWRKY2 in Dendrobium catenatum leaves by Tianze Hou, Baoqiang Zheng, Fucheng Peng, Zehui Jiang, Wenbo Zhang, Yan Wang

“…A more in-depth analysis evaluating the function of DcaWRKY2, transcription factor gene DcaWRKY2, was silenced by virus-induced gene silencing under gravity conditions, which resulted in the increase of anthocyanin accumulation in leaves, and the expression levels of anthocyanin biosynthesis pathway (ABP) structural genes, including DcaCHS, DcaCHI, DcaF3H, DcaDFR, and DcaANS were increased significantly. …”
Get full text

Palmitic acid-induced cell death: impact of endoplasmic reticulum and oxidative stress, mitigated by L-citrulline by Md. Rezwanul Habib, Yukako Tokutake, Shinichi Yonekura

“…Results 4-PBA significantly reduced PA-induced mRNA expressions of activating transcription factor 4 (ATF4), C/EBP homologous protein (CHOP), nuclear factor (erythroid-derived 2)-like 2 (NRF2), and intracellular ROS levels. …”
Get full text

CircBAZ1B stimulates myocardial ischemia/reperfusion injury (MI/RI) by modulating miR-1252-5p/ATF3-mediated ferroptosis by Ruili Wei, Tianxiao Yang, Weihong Li, Xiqian Wang

“…We also found that activating transcription factor 3 (ATF3) knockdown promoted myocardial cell viability and inhibited ferroptosis. …”
Get full text

Exercise-induced methylation of the Serhl2 promoter and implication for lipid metabolism in rat skeletal muscle by Mutsumi Katayama, Kazuhiro Nomura, Jonathan M. Mudry, Alexander V. Chibalin, Anna Krook, Juleen R. Zierath

“…Hypomethylation of the Serhl2 promoter influences Nr4a transcription factor binding, promoter activity, and gene expression, linking exercise-induced epigenomic regulation of Serhl2 to lipid oxidation and triacylglycerol synthesis.…”
Get full text

Diet with high content of advanced glycation end products induces oxidative stress damage and systemic inflammation in experimental mice: protective effect of peanut skin procyanid... by Li Zhao, Xingxing Zhang, Langzhi He, Yubing Li, Yue Yu, Qun Lu, Rui Liu

“…Molecular docking technique was used to confirm that the parent compound of procyanidins and its main metabolites, such as 3-hydroxyphenylacetic acid, could interact with RAGE, which might inhibit the activation of nuclear transcription factor (NF-κB), and ultimately reduce oxidative stress and inflammation in mice.…”
Get full text

The O-glycosyltransferase C1GALT1 promotes EWSR1::FLI1 expression and is a therapeutic target for Ewing sarcoma by Shahid Banday, Alok K. Mishra, Romana Rashid, Tianyi Ye, Amjad Ali, Junhui Li, Jason T. Yustein, Michelle A. Kelliher, Lihua Julie Zhu, Sara K. Deibler, Sunil K. Malonia, Michael R. Green

“…However, as a transcription factor, EWSR1::FLI1 is considered undruggable. …”
Get full text

Decoding oral cancer: insights from miRNA expression profiles and their regulatory targets by Xin Wang, Xin Wang, Shuang Zhang, Shuang Zhang, Shuyi Wang, Tao Cao, Tao Cao, Hong Fan, Hong Fan

“…Functional annotation and pathway enrichment analyses highlighted significant involvement of DEmiRs and their target genes in cell cycle-related processes, including enrichment in the nucleus, transcription factor activity, regulation of nucleosides, nucleotide and nucleic acids, cell growth and/or maintenance, mitotic cell cycle, mitotic M-M/G1 phases an DNA replication. …”
Get full text

Lung adenocarcinoma metastasis within a pituitary neuroendocrine tumor: a case report with review of literature by Koji Suzuki, Shigeyuki Tahara, Yujiro Hattori, Shinichiro Teramoto, Eitaro Ishisaka, Chie Inomoto, Robert Yoshiyuki Osamura, Akio Morita, Yasuo Murai

“…Histopathological examination revealed a group of thyroid transcription factor-1- and napsin A-positive papillary proliferating cells intermingled with α-subunit- and steroidogenic factor-1-positive PitNET cells. …”
Get full text

Overexpression of IL-6 and STAT3 may provide new insights into ovine pulmonary adenocarcinoma development by Corina Toma, Roxana Popa, Lidia Ciobanu, Ioana Baldea, Irina Amorim, Diana Bochynska, Alan Wolfe, Andrada Negoescu, Claudiu Gal, Marian Taulescu

“…The precise mechanisms of OPA oncogenesis are still uncertain. The transcription factor signal transducer and activator of transcription 3 (STAT3) is activated by interleukin-6 (IL-6) in many cancers, but this aspect is unknown in OPA. …”
Get full text

Identification and functional analysis of energy metabolism and pyroptosis-related genes in diabetic nephropathy by Shan He, Jian Ye, Yu Wang, Lu yang Xie, Si Yi Liu, Qin kai Chen

“…Additionally, mRNA-miRNA, mRNA-drug, and mRNA-transcription factor (TF) interaction networks were constructed. …”
Get full text