Autologous Blood Transfusion after Local Infiltration Analgesia with Ropivacaine in Total Knee and Hip Arthroplasty by Torben Breindahl, Ole Simonsen, Peter Hindersson, Bjarne Brødsgaard Dencker, Mogens Brouw Jørgensen, Sten Rasmussen

“…However, very limited data are available for toxicological risk assessment. Methods. Autotransfusion was studied in patients after total knee arthroplasty (TKA: n=25) and total hip arthroplasty (THA: n=27) with LIA using 200 mg ropivacaine, supplemented with two postoperative bolus injections (150 mg ropivacaine). …”
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Antiplasmodial, Antitrypanosomal, and Cytotoxic Effects of Anthonotha macrophylla, Annickia polycarpa, Tieghemella heckelii, and Antrocaryon micraster Extracts by Aboagye Kwarteng Dofuor, Emmanuel Kofi Kumatia, Jersley Didewurah Chirawurah, Frederick Ayertey

“…However, the scientific basis of their use and toxicological profiles have not been assessed. We have, therefore, evaluated the antiplasmodial, antitrypanosomal, and cytotoxic activities of four African medicinal plant extracts namely, Anthonotha macrophylla leaf (AML), Annickia polycarpa leaf (APLE), Tieghemella heckelii stem bark (THBE), and Antrocaryon micraster stem bark (AMSBE) extracts in vitro against P. falciparum (W2mef laboratory strain), T. brucei (GUTat 3.1 strain), and mammalian RAW 264.7 macrophage cell line, respectively. …”
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Safety of frozen, dried and powder forms of house crickets (Acheta domesticus) as a novel food pursuant to Regulation (EU) 2015/2283 by EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch‐Ernst, Ángeles Jos, Alexandre Maciuk, Inge Mangelsdorf, Breige McNulty, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Margarita Aguilera‐Gómez, Francesco Cubadda, Thomas Frenzel, Marina Heinonen, Monika Neuhäuser‐Berthold, Helle Katrine Knutsen Morten Poulsen, Miguel Prieto Maradona, Josef Rudolf Schlatter, Alexandros Siskos, Henk vanLoveren, Domenico Azzollini, Harry J. McArdle

“…The Panel notes that no safety concerns arise from the toxicological information on A. domesticus. The Panel considers that the consumption of the NF might trigger primary sensitisation to A. domesticus proteins and may cause allergic reactions in subjects allergic to crustaceans, mites and molluscs. …”
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Sex steroid hormones mediate the association between neonicotinoids and obesity among children and adolescents by Qian Su, Jinzhu Luo, You Zhou, Miao Liu, Shaohua Zeng, Yin Li, Jieying Gao

“…Background: Neonicotinoids are the most widely used insecticide worldwide. Toxicological and epidemiological studies suggest that exposure to neonicotinoid may be linked to the development of childhood obesity. …”
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Insecticidal Activity and Chemical Composition of the Morinda lucida Essential Oil against Pulse Beetle Callosobruchus maculatus by Moses S. Owolabi, Eduardo Padilla-Camberos, Akintayo L. Ogundajo, Isiaka A. Ogunwande, Guido Flamini, Olaniyi K. Yusuff, Kirk Allen, Karen Isabel Flores-Fernandez, Jose Miguel Flores-Fernandez

“…M. lucida essential oil showed a high toxicological effect, producing 100% mortality after 72 hours at a dose of 0.20 μg/mL. …”
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Seasonal fluctuation of total water intake and hydration status among young men and women: a prospective cohort study by Jianfen Zhang, Jianfen Zhang, Na Zhang, Na Zhang, Junbo Lu, Junbo Lu, Shufang Liu, Yongwei Lin, Guansheng Ma, Guansheng Ma

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Selective Serotonin Reuptake Inhibitors: Antimicrobial Activity Against ESKAPEE Bacteria and Mechanisms of Action by Thiago Hideo Endo, Mariana Homem de Mello Santos, Sara Scandorieiro, Bruna Carolina Gonçalves, Eliana Carolina Vespero, Márcia Regina Eches Perugini, Wander Rogério Pavanelli, Gerson Nakazato, Renata Katsuko Takayama Kobayashi

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Safety of frozen and dried forms of whole yellow mealworm (Tenebrio molitor larva) as a novel food pursuant to Regulation (EU) 2015/2283 by EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch‐Ernst, Ángeles Jos, Alexandre Maciuk, Inge Mangelsdorf, Breige McNulty, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Margarita Aguilera‐Gómez, Francesco Cubadda, Thomas Frenzel, Marina Heinonen, Monika Neuhäuser‐Berthold, Helle Katrine Knutsen, Morten Poulsen, Miguel Prieto Maradona, Josef Rudolf Schlatter, Alexandros Siskos, Henk vanLoveren, Gabriela Precup, Ermolaos Ververis, Harry J. McArdle

“…The Panel notes that no safety concerns arise from the toxicological information of the NF. The Panel considers that the consumption of the NF might trigger primary sensitisation to yellow mealworm proteins and may cause allergic reactions in subjects allergic to crustaceans, dust mites and molluscs. …”
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APBIO: bioactive profiling of air pollutants through inferred bioactivity signatures and prediction of novel target interactions by Eva Viesi, Ugo Perricone, Patrick Aloy, Rosalba Giugno

“…The bioactive profiling of air pollutants is challenging and crucial, as their biological activity and toxicological effects have not been deeply investigated yet, and further exploration could shed light on the impact of air pollution on complex disorders. …”
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Screening of the Dichloromethane: Methanolic Extract of Centella asiatica for Antibacterial Activities against Salmonella typhi, Escherichia coli, Shigella sonnei, Bacillus subtili... by Berick Moturi Sieberi, George Isanda Omwenga, Rachael Kitondo Wambua, Judith Chemutai Samoei, Mathew Piero Ngugi

“…The present study indicates that the tested plant can be an important source of antibacterial agents and recommends that the active phytoconstituents be isolated, identified, and screened individually for activities and also subjected further for in vivo and toxicological studies.…”
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Concentrations, composition profiles, and in vitro–in silico-based mixture risk assessment of bisphenol A and its analogs in plant-based foods by Chun-Hui Chiu, Shih-Han Sun, Yun-Jia Yao, Yi Chuang, Yu-Tsung Lee, Yi-Jun Lin

“…However, limited exposure and animal toxicological data on BP analogs hinder comprehensive risk assessments. …”
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Postmortem Analysis of Ethyl Alcohol Concentration in Blood, Urine, Muscle and Bile by Agnė Okulevičiūtė, Sigitas Chmieliauskas, Gabija Laubner-Sakalauskienė, Robertas Badaras, Sigitas Laima, Diana Vasiljevaitė, Jurgita Stasiūnienė

“…The study analyzed ethyl alcohol concentrations in blood, urine, muscle and bile. Toxicological data were processed using R commander statistical software. …”
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Design, Molecular Docking, Synthesis, Characterization and Preliminary Evaluation of Novel 1,3,4-Oxadiazole Derivatives as Cyclin-Dependent Kinase 2 Inhibitors by Yousef Sabah Ali, Monther Faisal Mahdi, Basma Monjid Abd Razik, Talal Aburjai

“…Furthermore, these compounds underwent physicochemical, drug-like, and toxicological predictions. The molecular docking investigation shows that 1,3,4-oxadiazole derivatives bind strongly to the CDK-2 protein's active binding site. …”
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The interplay between RNA m6A modification and radiation biology of cancerous and non-cancerous tissues: a narrative review by Yajia Cheng, Yue Shang, Shuqin Zhang, Saijun Fan

“…It begins with an overview of m6A modification and its detection methods, followed by a detailed examination of how m6A dynamically regulates the sensitivity of cancerous tissues to RT, the injury response in non-cancerous tissues, and the toxicological effects of UV exposure. Notably, this review underscores the importance of novel regulatory mechanisms of m6A and their potential clinical applications in identifying epigenetically modulated radiation-associated biomarkers for cancer therapy and estimation of radiation dosages. …”
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Peculiarities of the blood system of animals under the conditions of consumption of drinking water containing chlorates by T.E. Kravchun, L.A. Tomashevskaya, L.A. Tomashevskaya, V.A. Prokopov, T.V. Kulish, V.S. Tsytsyruk

“…Thus, the nature and features of changes in hematological indicators in the body of experimental animals during a chronic sanitary-toxicological experiment under the influence of chlorates in drinking water may indicate that chlorates affect the indicators of the blood system, being the indirect signs of disorders of other functional systems in the body, namely – slowing of redox reactions, hypoxic manifestations, reduction and weakening of the immune response and reactivity, etc.…”
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Biogenic synthesis of titanium nanoparticles by Streptomyces rubrolavendulae for sustainable management of Icerya aegyptiaca (Douglas) by Enayat M. Elqady, Eman El-said, Asmaa A. Tharwat, Lina A. Abou El-Khashab, Inas M. Y. Mostafa, Fatma Z. Hamed, Wesam M. Morsi, Mohamed M. Rezk, Inas M. Abou El-Enain

“…The produced TiO2-NPs were verified by UV examination and characterized by FT-IR, XRD, TEM, EDX, and DLS analyses. Toxicological results revealed that TiO2-NPs have insecticidal effects and high mortality rates reaching 55, 62.5, 80 and 95% at TiO2-NPs dose 120,250,500 and 1000 ppm respectively. …”
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Risks to human and animal health from the presence of bromide in food and feed by EFSA Scientific Committee, Susanne Hougaard Bennekou, Ana Allende, Angela Bearth, Josep Casacuberta, Laurence Castle, Tamara Coja, Amélie Crépet, Thorhallur Halldorsson, Laurentius (Ron) Hoogenboom, Helle Knutsen, Konstantinos Koutsoumanis, Claude Lambré, Søren Nielsen, Dominique Turck, Antonio Vicent Civera, Roberto Villa, Holger Zorn, Vasileios Bampidis, Jacqueline Castenmiller, Marie‐Christine Chagnon, Bruce Cottrill, Keyvin Darney, Jürgen Gropp, Secundino Lopez Puente, Martin Rose, Marco Vinceti, Maria Bastaki, Petra Gergelová, Luna Greco, Matteo Lorenzo Innocenti, Judit Janossy, Anna Lanzoni, Andrea Terron, Diane Benford

“…Insufficient evidence related to the toxicological effects of bromide was available for animals, with the exception of dogs. …”
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Underlying Anticancer Mechanisms and Synergistic Combinations of Phytochemicals with Cancer Chemotherapeutics: Potential Benefits and Risks by Muhammad Ayaz, Asif Nawaz, Sajjad Ahmad, Osama F. Mosa, Alashary Adam Eisa Hamdoon, Modawy Alnour Khalifa, Abdul Sadiq, Farhat Ullah, Abdul Wadood, Atul Kabra, H. C. Ananda Murthy

“…Cancer therapies are associated with various challenges including the emergence of multidrug resistant tumors, toxicological issues, severe side effects, and economic burden. …”
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Antiasthmatic Medicinal Plants of Tanzania: An Ethnomedicinal and Ethnopharmacological Review by David Sylvester Kacholi

“…However, the need to identify the molecular targets of action and toxicological aspects of the TMPs should be considered.…”
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Revealing the diversity of Fusarium micromycetes in agroecosystems of the North Caucasus plains for replenishing the State Collection of Phytopathogenic Microorganisms of the All-R... by N. S. Zhemchuzhina, M. I. Kiseleva, T. M. Kolomiets, I. B. Ablova, A. P. Glinushkin, S. A. Elizarova

“…This requires centralized collections of fungal cultures characterized by a set of stable strains to provide for phytopathological, immunological, breeding, genetic, toxicological, parasitological and other studies. The State Collection of Phytopathogenic Microorganisms of the ARSRIP is the State Depository of Phytopathogenic microorganisms that are non-pathogenic to humans or farmed animals. …”
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