Analysis of the effectiveness of premedication in preventing early adverse reactions to antivenom serum from 2017 to 2021: A cohort study by Gustavo Abud Priedols, Jonas Alher Meira Alves, Jordana Meirelles de Oliveira, Jéssica Vertuan Rufino, Edmarlon Girotto, Camilo Molino Guidoni

“…This is a cohort study conducted with data from the Londrina Information and Toxicological Assistance Center (CIATox-Londrina) at the University Hospital of the State University of Londrina (HU-UEL), which included patients treated with AVS between January/2017 and December/2021. …”
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Comprehensive toxicity assessment of silver nanoparticles on Bacteria, human vein endothelial cells, and Caenorhabditis Elegans by Bircan Dinç

“…In HUVEC cells, the IC50 was found to be 38 μg/mL, with cellular uptake increasing proportionally to concentration after 48 h.This study highlights the unique toxicological profile of AgNPs at low concentrations across multiple biological systems, emphasizing the importance of careful consideration for their safe use in biomedical and environmental applications.…”
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Arsenic accumulation and reproductive toxicity in freshwater snail (Pomacea canaliculata) by Xiaoyang Bi, Zhifei Shi, Dongqin Li, Wenhui Zhan, Zhixiong Wang, Huashou Li, Benliang Zhao, Guikui Chen

“…This study aimed to investigate the tissue-specific accumulation patterns of arsenic (As) and the potential toxicological effects of As on the oviposition of a globally distributed aquatic invertebrate, the apple snail (Pomacea canaliculata). …”
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ENVIRONMENTAL SYSTEM ENGINEERING (ESE): MODELING AND OPTIMIZATION OF A TEXTILE EFFLUENT DISCOLORATION PROCESS BY SORPTION by CARMEN ZAHARIA

“…In this system, environmental modeling and process optimization acts together for solving problems with environmental systems, especially for minimizing pollution, or eco-toxicological effects. The present paper proposes the study of modeling and optimization of an environmental system (i.e. textile wastewater treatment system based on sorption onto indigene peat) for its discoloration (consequently, decreasing of color, organic and inorganic loads of effluent discharged in aquatic receptor, or inside reused). …”
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Biodistribution of intravenously delivered PEGylated carbon nanotubes to the rat brain cortex by Gisele Eva Bruch, Gisele Eva Bruch, Lidiane Dal Bosco, Lidiane Dal Bosco, Arthur P. Cordeiro, Marcos F. Cordeiro, Sangram K. Sahoo, Carolina Peixoto, Marta C. Klosterhoff, Luis Alberto Romano, Cristiano Fantini, Adelina P. Santos, Daniela M. Barros

“…In this study, we investigated the biodistribution of intravenously delivered SWCNT-PEG using Raman spectroscopy, as well as possible toxicological outcomes using morphological, histological, biochemical, and behavioral analyses. …”
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Safety of mineral salt containing potassium and magnesium as a novel food pursuant to Regulation (EU) 2015/2283 by EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan De Henauw, Ángeles Jos, Helle Katrine Knutsen, Alexandre Maciuk, Inge Mangelsdorf, Breige McNulty, Harry J. McArdle, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Margarita Aguilera‐Gómez, Francesco Cubadda, Thomas Frenzel, Marina Heinonen, Monika Neuhäuser‐Berthold, Morten Poulsen, Miguel Prieto Maradona, Josef Rudolf Schlatter, Alexandros Siskos, Henk vanLoveren, Emanuela Turla, Karen Ildico Hirsch‐Ernst

“…Taking into account the composition and the nature of the NF, the Panel considers that no toxicological studies with the NF are required. The Panel concludes that the NF (i.e. a mineral salt containing potassium and magnesium) is safe under the proposed conditions of use.…”
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Traditional Uses, Bioactive Compounds, and Pharmacological Investigations of Calendula arvensis L.: A Comprehensive Review by Aya Khouchlaa, Aicha El Baaboua, Hamza El Moudden, Fatima Lakhdar, Saad Bakrim, Naoual El Menyiy, Omar Belmehdi, Hicham Harhar, Nasreddine El Omari, Abdelaali Balahbib, Moon Nyeo Park, Gokhan Zengin, Bonglee Kim, Abdelhakim Bouyahya

“…Nevertheless, pharmacokinetic validation and toxicological examinations are required to detect any possible toxicity for future clinical trials.…”
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Effects of polymethylmethacrylate nanoplastics on the swimming behaviour and gut microbiome of the freshwater amphipod Gammarus pulex by Sareh Yaripour, Mandar Bandekar, Jiri Vihavainen, Kuldeep More, Aslak Eronen, Manuela Faria Durão, Mikhail Daneliya, Tuure Houni, Tia Halonen, Jari T.T. Leskinen, Jaakko Haverinen, Hannu Huuskonen, Ulrika Candolin, Jukka Kekäläinen, Raine Kortet

“…Nanoplastic particles (NPs: <1000 nm) have been drawing attention for their potential toxicological implications on organisms. Aquatic animals are increasingly exposed to NPs but their effects on many aquatic invertebrates remain inadequately known. …”
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Increased miRNA-375 causes oxidative damage but promotes apoptosis resistance and cell migration in the clam Ruditapes philippinarum by Ming Cong, Zhaoshun Li, Wenwen Tian, Yixian Yu, Yu Che, Jiasen Lv

“…Overall, this study revealed for the first time the regulatory effects of miRNA-375 in the clams and gave valuable clues to understand the toxicological mechanisms of ammonia nitrogen on the marine bivalve.…”
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Sideroxylon inerme L. (Sapotaceae): A narrative of its uses as ethnoveterinary medicine and other medicinal applications by Alfred Maroyi

“…It is therefore recommended that further studies emphasizing toxicological assessments, in vivo, and clinical evaluations aimed at corroborating the EVM and ethnomedicinal applications of S. inerme should be conducted. …”
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Electrostatic properties of human germlines and biodistribution of small biologics by Leticia Maria De Souza Cordeiro, Kelley Christine Atkinson, Argin Aivazian, Patrick Frank Joyce, Fang Jia, Alessandro Mascioni

“…Off-target biodistribution of biologics bears important toxicological consequences. Antibody fragments intended for use as vectors of cytotoxic payloads (e.g. antibody-drug conjugates, radiotherapy) can accumulate at clearance organs like kidneys and liver, where they can cause dose-limiting toxicities. …”
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Toxicity of antimony in housefly after whole-life-cycle exposure: Changes in growth, development, redox homeostasis, mitochondrial function, and fecundity by Yuming Zhang, Jinghua Lv, Xiaoli Sun, Yiwen Zhang, Menghua Shao, Bingbing Shi, Yajie Zhang, Jihai Gu, Chenchen Zhao, Fengsong Liu

“…These comprehensive toxicological data provide insight into the prediction of toxicity and the assessment of the ecological risk of Sb.…”
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A Review of Perfluoroalkyl Acids (PFAAs) in terms of Sources, Applications, Human Exposure, Dietary Intake, Toxicity, Legal Regulation, and Methods of Determination by Katarzyna Sznajder-Katarzyńska, Magdalena Surma, Iwona Cieślik

“…A variety of possible toxicological effects to human health are also discussed. …”
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Revised safety evaluation of the food enzyme endo‐1,4‐β‐xylanase from the genetically modified Bacillus subtilis strain LMG S‐24584 produced by a modified process by EFSA Panel on Food Enzymes (FEZ), Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L. M. Solano, Monika Sramkova, Henk Van Loveren, Laurence Vernis, Silvia Peluso, Magdalena Andryszkiewicz, Daniele Cavanna, Ana Gomes, Natalia Kovalkovicova, Yi Liu

“…As no concerns arising from the microbial source and its genetic modifications or from the manufacturing process have been identified, the Panel considered that toxicological tests were not needed for the assessment of this food enzyme. …”
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Impact of polyvinyl chloride nano-plastics on the biochemical status of Oreochromis niloticus under a predicted global warming scenario by Ahmed Mohamed Soliman, Ayman S. Mohamed, Amr A. Abdel-Khalek, Shereen R. Badran

“…So, this study aims to clarify the potential impact of temperature increases on the toxicological properties of polyvinyl chloride nano-plastics (PVC-NPs) in Nile tilapia (Oreochromis niloticus) by measuring biochemical and oxidative biomarkers. …”
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Concerns arise: wheat allergy risk in pre-packaged food products from China by Wenfeng Liu, Jian Wang, Zhongliang Wang, Fangfang Min, Yong Wu, Juanli Yuan, Jinyan Gao, Hongbing Chen

“…Food allergen risk assessment, derived from classical toxicological principles, can identify and quantify the risk of allergies. …”
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Environmental Applications of Mass Spectrometry for Emerging Contaminants by Anil Kumar Meher, Akli Zarouri

“…Emerging contaminants (ECs), encompassing pharmaceuticals, personal care products, pesticides, and industrial chemicals, represent a growing threat to ecosystems and human health due to their persistence, bioaccumulation potential, and often-unknown toxicological profiles. Addressing these challenges necessitates advanced analytical tools capable of detecting and quantifying trace levels of ECs in complex environmental matrices. …”
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Polycyclic Aromatic Hydrocarbons Burden of Meats Singed with Different Fuel Sources from Abattoirs in Ghana and Associated Cancer Risk Assessment by Prosper Manu Abdulai, Chika Ossai, Anthoneth Ndidi Ezejiofor, Chiara Frazzoli, Joaquim Rovira, Osazuwa Clinton Ekhator, Caleb Kesse Firempong, Orish Ebere Orisakwe

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Dimethomorph induces heart and vascular developmental defects by disrupting thyroid hormone in zebrafish embryos by You Wei, Yunlong Meng, Kun Jia, Weijian Lu, Yushan Huang, Huiqiang Lu

“…However, there is limited understanding of the toxicological properties of DMT on these organisms. In this study, we utilized zebrafish as an animal model to assess the toxicity of DMT induced by exposure 5.5–72 hours post-fertilization (hpf). …”
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Large variability in the alkaloid content of Corydalis yanhusuo dietary supplements by Paula B. Luis, Claus Schneider

“…One of the products was highly enriched in tetrahydropalmatine (≈5 mg/g), suggesting adulteration from the natural product, and raising concerns about possible toxicologic liability.DiscussionConsidering alkaloid content as a key quality criterium for CY supplements, the large variability among the products seems unacceptable and makes it difficult for consumers to select products with an appropriate content of alkaloids.…”
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