Linking Endotoxins, African Dust PM10 and Asthma in an Urban and Rural Environment of Puerto Rico by Mario G. Ortiz-Martínez, Rosa I. Rodríguez-Cotto, Mónica A. Ortiz-Rivera, Cedric W. Pluguez-Turull, Braulio D. Jiménez-Vélez

“…The objective of the study was to evaluate the toxicological and proinflammatory responses stimulated by ADE PM10 ENX reaching PR using human bronchial epithelial cells. …”
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Selective ATP-Binding Cassette Subfamily C Gene Expression and Proinflammatory Mediators Released by BEAS-2B after PM2.5, Budesonide, and Cotreated Exposures by Jarline Encarnación-Medina, Rosa I. Rodríguez-Cotto, Joseph Bloom-Oquendo, Mario G. Ortiz-Martínez, Jorge Duconge, Braulio Jiménez-Vélez

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Modulation of Stat-1 in Human Macrophages Infected with Different Species of Intracellular Pathogenic Bacteria by Giuditta Fiorella Schiavano, Sabrina Dominici, Laura Rinaldi, Alfonsina Mariarosaria Cangiano, Giorgio Brandi, Mauro Magnani

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Long-term storage of C-141 reference strain of melioidosis agent (<i>Burkholderia pseudomallei</i>) by E. A. Artemeva, L. A. Melnikova, A. P. Rodionov

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Involvement of Stat1 in the Phagocytosis of M. avium by Sabrina Dominici, Giuditta Fiorella Schiavano, Mauro Magnani, Costantina Buondelmonte, Angela Gabriela Celeste, Giorgio Brandi

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One Health: potential synergy between infectious and toxic agents. The case of COVID-19 by Jorge Herkovits

“…For example, some conditions that influence the progression of COVID-19 could have toxicological causes such as cancer, endocrine, neurological, and inflammatory disorders, kidney failure, etc. …”
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A New In Vivo Model System to Assess the Toxicity of Semiconductor Nanocrystals by Angela Tino, Alfredo Ambrosone, Lucia Mattera, Valentina Marchesano, Andrei Susha, Andrey Rogach, Claudia Tortiglione

“…Specifically designed to combine on a single structure multipurpose tags and properties, smart nanomaterials need a comprehensive characterization of both chemicophysical properties and adequate toxicological evaluation, which is a challenging endeavour; the in vitro toxicity assays that are often employed for nanotoxicity assessments do not accurately predict in vivo response. …”
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Bioactive extracts from the industrial byproduct of passion fruit promote better glycemic control in an adjuvant treatment with insulin and prevent kidney and heart damage in rats... by Bárbara Cabral, Ony Araújo Galdino, Iago de Souza Gomes, Jovelina Samara Ferreira Alves, José Ivan Marques, Karla Simone Costa de Souza, Rodrigo Moreira da Silva, Bento João Abreu, Norberto Peporine Lopes, Silvana Maria Zucolotto, Adriana Augusto de Rezende

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Strategies to Enhance Nanocrystal Formulations for Overcoming Physiological Barriers Across Diverse Routes of Administration by Yanamadala Y, Muthumula CMR, Khare S, Gokulan K

“…Yaswanthi Yanamadala,&ast; Chandra Mohan Reddy Muthumula,&ast; Sangeeta Khare, Kuppan Gokulan Division of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, 72079, USA&ast;These authors contributed equally to this workCorrespondence: Kuppan Gokulan, Division of Microbiology, National Center for Toxicological Research, US Food and Drug Administration, 3900 NCTR Road, Jefferson, AR, 72079, USA, Email Kuppan.gokulan@fda.hhs.govAbstract: Poor aqueous solubility and bioavailability limit the translation of new drug candidates into clinical applications. …”
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Effect of Trehalose and Trehalose Transport on the Tolerance of Clostridium perfringens to Environmental Stress in a Wild Type Strain and Its Fluoroquinolone-Resistant Mutant by Miseon Park, Wilfrid J. Mitchell, Fatemeh Rafii

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Leveraging AI to improve disease screening among American Indians: insights from the Strong Heart Study by Paul Rogers, Thomas McCall, Ying Zhang, Jessica Reese, Dong Wang, Weida Tong

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Effect of Laminaria japonica Powder on Physicochemical Properties, Rheological Properties and Protein Structure of Silver Carp Surimi Gel by Fengchao ZHOU, Wenting JIANG, Han TIAN, Wei LUO, Xiaolan ZHANG, Jiazhen WANG, Jie LIANG, Leiwen XIANG, Shaoyun WANG, Xixi CAI, Qiming WU, Honglai LIN

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Ecological modelling: A computational analysis of air pollution discourses in English print media of India and Pakistan. by Sana Rabbani, Fasih Ahmed

“…The LDA-generated topics reveal that both countries face the toxicological effects of air pollution on health. The primary topics extracted through LDA revolve around discourses related to vehicular emissions, industrial emissions, and urbanization. …”
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Modern Genetic Education: How Does It Meet Students’ Requests? by T. A. Sedykh, L. A. Amirova, L. A. Gaysina, G. F. Galikeeva, A. I. Fazlutdinova, N. V. Sukhanova

“…It was found that despite the satisfaction of the majority of the surveyed students with the quality of genetic education, there are problems in understanding modern sections of genetics, such as molecular genetics, toxicological genetics, genomics. The students are not sufficiently involved in scientific research, most of them prefer the traditional forms of teaching and learning, only few of them are aware of modern online resources and MOOCs. …”
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Proposing a new anti-Covid-19 agent by using molecular docking and dynamics simulations by Izabella Rodrigues Fonseca da Silva, Luís Felipe Guerreiro Martins, Julliane Yoneda

“…Structural modifications were proposed on the oxoquinoline derivative which formed a more stable complex with Mpro and this proposal formed an even more stable complex besides exhibiting improvements in the toxicological profile. Molecular dynamics simulations indicated that derivatives proposed promote greater stabilization by complexing with Mpro than anisotine.…”
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Urinary concentrations of arsenic species in older Dutch adults and risk of chronic kidney disease by Hannah P. McKeon, Weiluan Chen, Jan Dirk te Biesebeek, Nanette G. Vrijenhoek, Jacqueline J.M. Castenmiller, Marcel J.B. Mengelers

“…It occurs in different chemical forms which vary in toxicological potential. Human biomonitoring (HBM) is used to measure internal (all-route) exposure to different As species. …”
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Natural Products for Cancer Therapy: A Review of Their Mechanism of Actions and Toxicity in the Past Decade by Yasir Osman Ali Abdalla, Bavani Subramaniam, Shaik Nyamathulla, Noorasyikin Shamsuddin, Norhafiza M. Arshad, Kein Seong Mun, Khalijah Awang, Noor Hasima Nagoor

“…Besides, critical analysis of their molecular targets and underlying mechanisms on multiple cancer cell lines, an in-depth probe of their toxicological screening on rodent models is outlined as well to observe the prevalence of their toxicity towards host. …”
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Diosgenin: Recent Highlights on Pharmacology and Analytical Methodology by Mafalda Jesus, Ana P. J. Martins, Eugenia Gallardo, Samuel Silvestre

“…Due to its pharmacological and industrial importance, several extraction and analytical procedures have been developed and applied over the years to isolate, detect, and quantify diosgenin, not only in its natural sources and pharmaceutical compositions, but also in animal matrices for pharmacodynamic, pharmacokinetic, and toxicological studies. Within these, HPLC technique coupled to different detectors is the most commonly analytical procedure described for this compound. …”
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Biostatistical Assessment of Mutagenicity Studies: A Stepwise Confidence Procedure by Michael J. Adjabui, Nathaniel K. Howard, Mathias Akamba

“…The paper addresses the issue of identifying the maximum safe dose in the context of noninferiority trials where several doses of toxicological compounds exist. Statistical methodology for identifying the maximum safe dose is available for three-arm noninferiority designs with only one experimental drug treatment. …”
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Review on per- and polyfluoroalkyl substances exposure, thyroid function, and mechanisms of action in mothers and infants by Lemin GONG, Zhongwu LU, Yuhan ZHOU

“…Epidemiological and toxicological evidence suggest that PFAS have endocrine-disrupting properties and may cause thyroid dysfunction by altering the hormonal homeostasis of the thyroid. …”
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