Imaging flow cytometry-based cellular screening elucidates pathophysiology in individuals with Variants of Uncertain Significance by Irena Josephina Johanna Muffels, Hans R. Waterham, Giuseppina D’Alessandro, Guido Zagnoli-Vieira, Michael Sacher, Dirk J. Lefeber, Celine Van der Vinne, Chaim M. Roifman, Koen L. I. Gassen, Holger Rehmann, Desiree Y. Van Haaften-Visser, Edward S. S. Nieuwenhuis, Stephen P. Jackson, Sabine A. Fuchs, Femke Wijk, Peter van Hasselt

“…Conclusions Our high-throughput IFC-based platform simplifies the process of identifying VUS pathogenicity through six assays and allows for the recognition of useful pathophysiological markers that structure follow-up experiments, thereby representing a novel valuable tool for precise functional diagnostics in genomics.…”
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The associations between single nucleotide polymorphisms and diabetic retinopathy risk: an umbrella review by Shaofen Huang, Yonghui Feng, Ying Sun, Jiazi Liu, Pu Wang, Jingrong Yu, Xin Su, Shasha Han, Shiqi Huang, Haokun Huang, Shiyun Chen, Ying Xu, Fangfang Zeng

“…We evaluated the methodological quality using the Measurement Tool to Assess Systematic Reviews (AMSTAR) 2.0, estimated the summary effect size by using the random effects model and calculated the 95% prediction intervals (PIs). …”
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Functional Evaluation of the Visual Pathway in Patients with Multiple Sclerosis Using a Multifunction Stimulator Monitor by M. Satue, L. Jarauta, J. Obis, M. Cipres, M. J. Rodrigo, C. Almarcegui, I. Dolz, J. R. Ara, J. Martin, L. E. Pablo, E. Garcia-Martin

“…This device may be a fast and useful tool to provide a full evaluation of axonal damage in patients with multiple sclerosis.…”
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Impact of #PCOSweightloss: A global X hashtag analysis study of weight loss narratives in the PCOS community by Munaza Afaq, Kumar Vashisht, Areen Al-Dhoon, Divya Abraham, Atanas G. Atanasov, Maima Matin, Zara Arshad, Rahul Kashyap, Faisal A. Nawaz

“…Methods Fedica research analytics tool ( https://fedica.com ) was utilized to automatically evaluate quantitatively the posts on the platform X containing #PCOSweightloss from July 1st, 2017 to July 1st, 2023. …”
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Implementation of a cascade training model to enhance emergency care capacity of healthcare workers during the COVID-19 outbreak in Uganda by Sulaiman Bugosera Wasukira, Carl Trevor Kambugu, Judith Nanyondo S, Emmanuel Candia, Stephen Emmanuel Aporu, Patricia Ikwaru, Racheal Kwagala, Andrew Kwiringira, Peter Mukiibi, Costance Murungi, Marek Ma, Celine Jacobs, Cliff Asher Aliga, Afizi Kibuuka, Dathan M. Byonanebye, Sylvia Natukunda, Kenneth Bagonza, Rose Muhindo, Prisca Kizito, Benard Toliva Opar, Nathan Kenya-Mugisha, Wilson Etolu, Paska Apiyo, Mohammed Larmode, Joseph Oumo, Rony Bahatungire, John Baptist Waniaye, Annet Alenyo-Ngabirano

“…Methods: In June 2021, the World Health Organisation (WHO) Hospital Emergency Unit Assessment Tool (HEAT) was used to assess emergency units and document existing capacity gaps in regional referral hospitals and general hospitals. …”
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Development and validation of the Japanese version of the Public Attitudes Toward Epilepsy (PATE‐J) Scale by Junichi Hatakeda, Hiroumi Shimazaki, Izumi Kuramochi, Takayuki Iwayama, Sayaka Kobayashi, Hideyuki Matsuki, Haruo Yoshimasu, Kheng Seang Lim

“…Its validated two‐factor structure supports cross‐cultural comparisons and provides a reliable tool for assessing public attitudes, informing interventions, and guiding education campaigns.…”
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Characterization of a New Immunosuppressive and Antimicrobial Peptide, DRS-DA2, Isolated from the Mexican Frog, Pachymedusa dacnicolor by Claire Lacombe, Estefania Aleman-Navaro, Thierry Drujon, Veronica Martinez-Osorio, Emmanuelle Sachon, Erika Melchy-Pérez, Ludovic Carlier, Lorena Elizabeth Fajardo Brigido, Yannick Fleury, Christophe Piesse, Guadalupe Gutiérrez-Escobedo, Alejandro De las Peñas, Irene Castaño, Florie Desriac, Jose Luis Beristain-Hernandez, Christophe Combadiere, Yvonne Rosenstein, Constance Auvynet

“…Collectively, these data suggest that this peptide could be a promising tool in the treatment of inflammatory diseases, such as inflammatory skin diseases, as it could reduce the number of inflammatory cells locally without suppressing the ability to combat infections.…”
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Magnetic resonance imaging -based radiomics of the pituitary gland is highly predictive of precocious puberty in girls: a pilot study by Michele Maddalo, Maddalena Petraroli, Francesca Ormitti, Alice Fulgoni, Margherita Gnocchi, Marco Masetti, Eugenia Borgia, Benedetta Piccolo, Emanuela C. Turco, Viviana D. Patianna, Nicola Sverzellati, Susanna Esposito, Susanna Esposito, Caterina Ghetti, Maria E. Street, Maria E. Street

“…The diagnostic sensitivity was improved compared to pituitary volume only (0.76 versus 0.68, p<0.001) and demonstrated higher inter-reader reliability (ICC>0.57 versus ICC=0.46).DiscussionRadiomics is a promising tool to diagnose CPP as it reflects also functional aspects. …”
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NeuTox 2.0: A hybrid deep learning architecture for screening potential neurotoxicity of chemicals based on multimodal feature fusion by Xudi Pang, Xuejun He, Ying Yang, Ling Wang, Yuzhen Sun, Huiming Cao, Yong Liang

“…In conclusion, NeuTox 2.0 can be used as an efficient tool for early neurotoxicity screening of environmental chemicals.…”
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The association of systemic immune-inflammation index with incident breast cancer and all-cause mortality: evidence from a large population-based study by Yu Li, Yu Li, Meng Yu, Ming Yang, Jingqi Yang

“…These findings highlight the importance of monitoring systemic inflammation and suggest that SII could serve as a valuable prognostic tool.…”
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Development of the cultural tailoring score (CTS): a scoring instrument to assess cultural tailoring of health messaging by Claudia Parvanta, Kayleigh Murray, Samantha Boddupalli, Natalie Erasme, Rheese McNab, Vijay Prajapati, Arabel Severe, Aura Reyes, Richard Harner, Rhonda Holliday

“…Open-ended comments from pretesting respondents support this finding and suggest that cultural components facilitated what the Elaboration Likelihood Model describes as central processing of the main health messages, thereby enhancing health literacy.Discussion The paper discusses recommendations for further development and testing of the CTS to produce a simple tool to guide future multicultural health communication materials production or pretesting.…”
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Plasticizer exposure in Germany from 1988 to 2022: Human biomonitoring data of 20 plasticizers from the German Environmental Specimen Bank by Monika Kasper-Sonnenberg, Claudia Pälmke, Sonja Wrobel, Thomas Brüning, Aline Murawski, Petra Apel, Till Weber, Marike Kolossa-Gehring, Holger M. Koch

“…Human biomonitoring (HBM) is the ideal tool to capture actual mixture exposures per individual, integrating all external exposure sources and pathways, thus we will continue to use HBM in exposure and risk assessment of phthalates and other (anti-androgenic) chemicals.…”
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The Efficacy of Lubiprostone in Patients of Constipation: An Updated Systematic Review and Meta‐Analysis by Umar Akram, Obaid Ur Rehman, Eeshal Fatima, Zain Ali Nadeem, Omer Usman, Waqas Rasheed, Ramsha Ali, Khawaja Abdul Rehman, Abdulqadir J. Nashwan

“…Randomized controlled trials published between July 2019 and June 2024 were selected. Cochrane's RoB 2 tool was used to assess the risk of bias. A meta‐analysis was performed and findings were presented using forest plots. …”
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Comparison of the effectiveness of the helmet interface using flow meters versus the mechanical ventilator for non-invasive ventilation in patients with coronavirus disease 2019. C... by Fernanda dos Reis Ferreira, João Carlos Ferrari Correa, Eduardo Storopoli, Diego Restivo Faria, Karina Cassaro, Natália Feitosa da Hora, Raphael Ritti, Rafael Akira Becker, Simone Dal Corso, Ivan Peres Costa, Luciana Maria Malosá Sampaio

“…Implications for clinical practice: using the helmet interface with the flow meter and positive end-expiratory pressure valve can simplify device installation, potentially reducing the need for intubation, making it a valuable tool for nurses and physiotherapists in daily clinical practice.…”
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Diversity and seasonal variation of zooplankton community in a large deep-water reservoir of Eastern China using eDNA and morphological methods by Lei Hao, Lei Hao, Xinting Xu, Xinting Xu, Yan Zhou, Yan Zhou, Dan Liu, Dan Liu, Jianqiang Shao, Jiayong Pan, Guangxi He, Zhongjun Hu, Zhongjun Hu, Qigen Liu, Qigen Liu

“…Although eDNA cannot yet replace morphological methods, its efficiency and sensitivity make it a valuable complementary tool for zooplankton monitoring, with considerable potential for future applications.…”
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Rehabilitation and release of orphaned Eurasian lynx (Lynx lynx) in Europe: Implications for management and conservation. by Anja Molinari-Jobin, Fridolin Zimmermann, Stéphanie Borel, Luc Le Grand, Elena Iannino, Ole Anders, Elisa Belotti, Ludek Bufka, Duško Ćirović, Nolwenn Drouet-Hoguet, Thomas Engleder, Michał Figura, Christian Fuxjäger, Eva Gregorova, Marco Heurich, Sylvia Idelberger, Jakub Kubala, Josip Kusak, Dime Melovski, Tomma Lilli Middelhoff, Tereza Mináriková, Paolo Molinari, Lorane Mouzon-Moyne, Gilles Moyne, Robert W Mysłajek, Sabina Nowak, Janis Ozolins, Andreas Ryser, Bardh Sanaja, Maryna Shkvyria, Teodora Sin, Magda Sindičić, Vedran Slijepčević, Christian Stauffer, Branislav Tám, Aleksander Trajce, Josefa Volfová, Sybille Wölfl, Diana Zlatanova, Kristina Vogt

“…Rehabilitation of injured or immature individuals has become an increasingly used conservation and management tool. However, scientific evaluation of rehabilitations is rare, raising concern about post-release welfare as well as the cost-effectiveness of spending scarce financial resources. …”
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Fabrication and characterization of rGO-SnO2 nanocomposite for electrochemical sensor of ciprofloxacin by Prastika Krisma Jiwanti, Dewi Kartika Azizah Sukardi, Anis Puspita Sari, Mai Tomisaki, Siti Wafiroh, Sri Hartati, Arramel, Yew Hoong Wong, Pei Meng Woi, Joon Ching Juan

“…Consequently, the SPE modified with rGO-SnO2 nanocomposite emerges as a highly promising and effective tool for precise and sensitive CIP measurement, offering unparalleled performance metrics and opening avenues for enhanced environmental and health monitoring.…”
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Acupuncture for patients with type 2 diabetes mellitus with dry eye: protocol for a systematic review and meta-analysis by Ting Li, Xin Xu, Juan Wei, Qingbo Wei, Zhouyu Xie, Xiangyu Bian, Yunchuan Wu

“…The risk of bias will be independently assessed using Cochrane’s ‘risk of bias’ tool.Ethics and dissemination Ethical approval will not be required since raw data will not be collected or generated. …”
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Sex-specific anatomical variation of circle of Willis arteries by Phebe J. Groenheide, Iris N. Vos, Robin Bülow, Irene C. van der Schaaf, Birgitta K. Velthuis, Ynte M. Ruigrok

“…Diameters and bifurcation angles of large CoW arteries (>1.2 mm) were measured with a semi-automatic tool. Diameters of smaller anterior communicating artery (Acom) and posterior communicating arteries (Pcoms) and the anatomical variants of the CoW were determined manually. …”
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Mineralogy as a potential driver of irregular radiocarbon patterns among Icelandic fluvial carbon pools by Nora Gallarotti, Lisa Bröder, Julie Lattaud, Stephan Wartenweiler, Negar Haghipour, Timothy I Eglinton

“…Radiocarbon dating serves as a valuable tool, providing crucial insights into turnover and residence times within these pools. …”
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