Generation of Rational Drug-like Molecular Structures Through a Multiple-Objective Reinforcement Learning Framework by Xiangying Zhang, Haotian Gao, Yifei Qi, Yan Li, Renxiao Wang

“…In conclusion, we have demonstrated the potential of METEOR as a practical tool for generating rational drug-like molecules in the early phase of drug discovery.…”
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Design Optimization of a 3-PUU Parallel Machine for Friction Stir Welding Robots by Eka Marliana, Latifah Nurahmi, Arif Wahjudi, I. Made Londen Batan, Guowu Wei

“…To address this issue, a 3-PUU (Prismatic and Universal Joints) parallel machine with 3-DoF (Degrees of Freedom) translational movement is utilized to support the FSW robot’s tool head, allowing the robot to operate over a larger horizontal workspace. …”
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Patient-derived follicular lymphoma spheroids recapitulate lymph node signaling and immune profile uncovering galectin-9 as a novel immunotherapeutic target by Cèlia Dobaño-López, Juan García Valero, Ferran Araujo-Ayala, Ferran Nadeu, Fabien Gava, Carla Faria, Marine Norlund, Renaud Morin, Pascale Bernes-Lasserre, Fabian Arenas, Marta Grau, Cristina López, Irene López-Oreja, Neus Serrat, Ares Martínez-Farran, Lluís Hernández, Heribert Playa-Albinyana, Rubén Giménez, Silvia Beà, Elías Campo, Jean-Michel Lagarde, Armando López-Guillermo, Laura Magnano, Dolors Colomer, Christine Bezombes, Patricia Pérez-Galán

“…In conclusion, FL-PDLS maintains the crosstalk between malignant B cells and the immune LN-TME and constitutes a robust and multiplexed pre-clinical tool to perform drug screening in a patient-derived system, advancing toward personalized therapeutic approaches.…”
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Liver lobes and cirrhosis: Diagnostic insights from lobar ratios by Kriti Pandey, Debabrata Dash, Raj Kumar Koiri

“…A C/RL ratio above 0.65 suggests the presence of cirrhosis, making it a valuable tool in diagnosing the condition. These measurements are non-invasive, safe, and crucial for early diagnosis of cirrhosis.…”
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A Hybrid Model through the Fusion of Type-2 Fuzzy Logic Systems and Sensitivity-Based Linear Learning Method for Modeling PVT Properties of Crude Oil Systems by Ali Selamat, Sunday Olusanya Olatunji, Abdul Azeez Abdul Raheem

“…Sensitivity-based linear learning method (SBLLM) has recently been used as a predictive tool due to its unique characteristics and performance, particularly its high stability and consistency during predictions. …”
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Clinical performance of real-time nanopore metagenomic sequencing for rapid identification of bacterial pathogens in cerebrospinal fluid: a pilot study by Yoon Hyun Sung, Yong Kuk Ju, Hak Jun Lee, Seung Min Park, Jin Woong Suh, Jeong Yeon Kim, Jang Wook Sohn, Young Kyung Yoon

“…Nanopore-based metagenomic sequencing is expected to serve as a complementary tool for pathogen detection in CSF samples by facilitating rapid and accurate diagnosis.…”
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OCF Bridging Techniques for UWB/LoRa IoT Ecosystems by Hyun Seob Oh, Wha Sook Jeon, Dong Geun Jeong

“…Our O2U and O2L bridging implementation is checked for consistency with the OCF standard using the OCF conformance test tool. Three example use-cases are implemented for demonstrating the usability of the developed O2U and O2L bridges, which are proximity-based Zigbee device control combined with UWB, LoRa-based metering, and LoRaWAN as backhaul of UWB system. …”
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Capability of Ophthalmology Residents to Detect Glaucoma Using High-Dynamic-Range Concept versus Color Optic Disc Photography by Mantapond Ittarat, Rath Itthipanichpong, Anita Manassakorn, Visanee Tantisevi, Sunee Chansangpetch, Prin Rojanapongpun

“…HDR-DP may be a screening tool for nonexpert ophthalmologists.…”
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ANALYSIS OF THE INTERACTIONS OF NEURONAL APOPTOSIS GENES IN THE ASSOCIATIVE GENE NETWORK OF PARKINSON’S DISEASE by M. A. Yankina, O. V. Saik, P. S. Demenkov, E. K. Khusnutdinova, E. I. Rogaev, I. N. Lavrik, V. А. Ivanisenko

“…We previously developed the ANDSystem tool, designed to automatically extract knowledge from scientific publications and reconstruct on this basis associative gene networks describing the molecular genetic mechanisms of biological processes. …”
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A new score for predicting intracranial hemorrhage in patients using anticoagulant drugs by Fuxin Ma, Zhiwei Zeng, Jiana Chen, Chengfu Guan, Wenlin Xu, Chunhua Wang, Jinhua Zhang

“…Our aim was to identify factors associated with cerebral hemorrhage in patients using anticoagulants and to develop a predictive model that would provide an effective tool for the clinical assessment of cerebral hemorrhage.MethodsIn our study, indications for patients receiving anticoagulation included AF, VTE, stroke/TIA, arteriosclerosis, peripheral vascular diseases (PVD), prosthetic mechanical valve replacement, etc. …”
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How are new collective models transforming support for smallholder farmers? Empirical evidence from thematic and sentiment content analysis by Rajiv B. Kale, Pooja A. Dangi, Vinayak Nikam, Kiran Khandagale, Shailendra S. Gadge, Vijay Mahajan

“…Utilizing a descriptive quantitative approach, this research employs content analysis to gather primary data from 4,382 research articles. The NVivo 15 tool is used to analyze the data, identifying key themes, functions, and support agencies as units of analysis. …”
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Factors Influencing Seasonal and Daily Dynamics of the Genus Stomoxys Geoffroy, 1762 (Diptera: Muscidae), in the Adamawa Plateau, Cameroon by Sevidzem S. Lendzele, Mavoungou J. François, Zinga-Koumba C. Roland, Koumba A. Armel, Gérard Duvallet

“…The Vavoua trap was an ideal tool for Stomoxyinae collection. Stomoxyines abundantly occurred at the end of the dry season (March 2017) and beginning of the rainy season (May 2017). …”
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Assessing Ground Displacement in Oran City, Algeria: A Comparative Analysis of PSInSAR, SBAS, and Combined Method by Kamel Hasni, Bachir Gourine, Boudhane Boubaker, Slimani Mohammed El Amine

“…Overall, the combination technique estimated displacements with better precision than the other methods, highlighting its potential as an effective tool for monitoring ground deformation.…”
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Analysis of partial discharges in supporting insulators by D. A. Polyakov, K. I. Nikitin, N. A. Tereshchenko, A. S. Novoselov, Ya. P. Bilevich

“…Therefore, the article investigates the diagnosis of insulators by the method of partial discharges as a tool for personnel protection. The electric field of normal and defective insulators is simulated. …”
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SILAC-based quantification reveals modulation of the immunopeptidome in BRAF and MEK inhibitor sensitive and resistant melanoma cells by Melissa Bernhardt, Anne Rech, Marion Berthold, Melina Lappe, Jan-Niklas Herbel, Florian Erhard, Annette Paschen, Bastian Schilling, Bastian Schilling, Andreas Schlosser

“…We established a data analysis workflow that integrates the de novo sequencing-based tool Peptide-PRISM for comprehensive HLA peptide identification with MaxQuant for accurate quantification.ResultsWe employed this strategy to explore the modulation of the immunopeptidome upon MAPK pathway inhibition (MAPKi) and to investigate alterations associated with early cellular responses to inhibitor treatment and acquired resistance to MAPKi. …”
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Data-driven Dynamics with Orbital Torus Imaging: A Flexible Model of the Vertical Phase Space of the Galaxy by Adrian M. Price-Whelan, Jason A. S. Hunt, Danny Horta, Micah Oeur, David W. Hogg, Kathryn Johnston, Lawrence Widrow

“…We release an open-source tool, torusimaging , to accompany this article.…”
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CFD modelling and simulation of anaerobic digestion reactors for energy generation from organic wastes: A comprehensive review by Muhammad Usman Farid, Indiana A. Olbert, Andreas Bück, Abdul Ghafoor, Guangxue Wu

“…Computational fluid dynamics (CFD) is an applied mathematical tool which helps to understand and predict the fluid dynamics, heat flow as well as species transport in different domains. …”
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Comparison of Resampling Methods and Radiomic Machine Learning Classifiers for Predicting Bone Quality Using Dual-Energy X-Ray Absorptiometry by Mailen Gonzalez, José Manuel Fuertes García, María Belén Zanchetta, Rubén Abdala, José María Massa

“…The primary aim is to provide clinicians with an accessible tool for quality bone assessment, which is currently limited. …”
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Deep Learning Applications in Ionospheric Modeling: Progress, Challenges, and Opportunities by Renzhong Zhang, Haorui Li, Yunxiao Shen, Jiayi Yang, Wang Li, Dongsheng Zhao, Andong Hu

“…Overall, deep learning provides a powerful tool for ionospheric modeling and indicates promising prospects for its application in early warning systems and future research.…”
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Harmonizing multisite neonatal diffusion-weighted brain MRI data for developmental neuroscience by Alexandra F. Bonthrone, Manuel Blesa Cábez, A. David Edwards, Jo V. Hajnal, Serena J. Counsell, James P. Boardman

“…Our aim was to investigate the utility of ComBat, an empirical Bayes tool for multisite harmonization, in removing site effects from white matter (WM) dMRI measures in healthy infants born at 37 gestational weeks+ 0 days-42 weeks+ 6 days from the Theirworld Edinburgh Birth Cohort (n = 86) and Developing Human Connectome Project (n = 287). …”
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