A novel way to use cross-validation to measure connectivity by machine learning allows epilepsy surgery outcome prediction by Karla Ivankovic, Alessandro Principe, Justo Montoya-Gálvez, Linus Manubens-Gil, Riccardo Zucca, Pablo Villoslada, Mara Dierssen, Rodrigo Rocamora

“…Connectivity change magnitude at seizure transition could potentially serve as an EN biomarker. The tool provided by this study may aid surgical decision-making.…”
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Unraveling pathogenesis and potential biomarkers for autism spectrum disorder associated with HIF1A pathway based on machine learning and experiment validation by Jinru Cui, Heli Li, Cong Hu, Feiyan Zhang, Yunjie Li, Ying Weng, Liping Yang, Yingying Li, Minglan Yao, Hao Li, Xiaoping Luo, Yan Hao

“…Validation of HIF1A pathway and hub genes was confirmed through Western Blot, qPCR, and immunofluorescence in ASD mice and microglia BV-2 cells. Results: Using CEMiTool and GeneCards, 45 genes associated with ASD and HIF1A pathway were identified. …”
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Wear Behavior Analysis and Gated Recurrent Unit Neural Network Prediction of Coefficient of Friction in Al10Cu-B₄C Composites by Mihail Kolev, Ludmil Drenchev, Veselin Petkov, Rositza Dimitrova, Krasimir Kolev, Boris Yanachkov

“…Furthermore, this study highlights the efficacy of neural network models in accurately predicting COF, providing a powerful tool for optimizing the performance of advanced composite materials.…”
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Individualized diagnosis of Parkinson’s disease based on multivariate magnetic resonance imaging radiomics and clinical indexes by Qianqian Ye, Chenhui Lin, Fangyi Xiao, Tao Jiang, Jialong Hou, Yi Zheng, Jiaxue Xu, Jiani Huang, Keke Chen, Jinlai Cai, Jingjing Qian, Weiwei Quan, Yanyan Chen

“…DCA confirmed the substantial clinical usefulness of the clinical-radiomics integrated model.ConclusionThe integrated clinical-radiomics model offered superior diagnostic performance compared to models based relying solely on imaging or clinical data, underscoring its potential as a non-invasive and effective tool in routine clinical practice for the early diagnosis of PD.…”
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Optic nerve sheath diameter/eyeball transverse diameter ratio by ultrasound in prediction of increased intracranial pressure in children with viral encephalitis by Chun Zhao, Peng-Cheng Sun, Ke-Jie Fang, Hui-Hui Fu, Li-Feng Wei, Yin-Yun Miao, Xin-Xin Guo, Xiao-Ling Weng

“…The ROC curve demonstrated an AUC for ONSD/ETD ratio in predicting the occurrence of increased ICP in children with viral encephalitis was 0.974 [95% confidence interval (CI): 0.939–1.000, p < 0.01], with a sensitivity of 95.1% and specificity of 93.3% at a cut-off value of 0.198.ConclusionOur study shows that ONSD/ETD can be used as an easy reference tool for evaluating ICP in children with viral encephalitis which can reflect the therapeutic effect.…”
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Multimodal data-based longitudinal prognostic model for predicting atrial fibrillation recurrence after catheter ablation in patients with patent foramen ovale and paroxysmal atria... by Shoupeng Duan, Xujun Li, Jun Wang, Yuhong Wang, Tianyou Xu, Fuding Guo, Yijun Wang, Lingpeng Song, Zeyan Li, Xiaomeng Yang, Xiaoyu Shi, Hengyang Liu, Liping Zhou, Yueyi Wang, Hong Jiang, Lilei Yu

“…Conclusion The incorporation of multimodal data in a nomogram visualization tool facilitates the concise representation of multimodal data, thereby enhancing the comprehension of the clinical status of patients with PFO and PAF following catheter ablation and providing accurate risk stratification at 1, 2, and 3 years post-treatment. …”
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Development and evaluation of a CRISPR/Cas12a-based diagnostic test for rapid detection and genotyping of HR-HPV in clinical specimens by Lijuan Yin, Ziqian Zhao, Chunhua Wang, Caihong Zhou, Xiuzhen Wu, Baoxue Gao, Liangyuan Wang, Shuli Man, Xinkuan Cheng, Qiankun Wu, Siqi Hu, Hongxia Fan, Long Ma, Hui Xing, Liang Shen

“…Based on these findings, our CRISPR/Cas-based HR-HPV detection platform holds promise as a novel clinical detection tool, offering a visually intuitive and expedited alternative to existing HPV infection diagnostics and providing fresh perspectives for clinical cervical cancer screening.IMPORTANCEThis study developed a novel high-risk human papillomavirus (HR-HPV) detection platform based on CRISPR/Cas12a technology. …”
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Development and validation of the age-associated dementia policy (AgeD-Pol) computer simulation model in the USA and Europe by Anand Viswanathan, Lee H Schwamm, Krishna P Reddy, Emily P Hyle, Fatma M Shebl, Kenneth A Freedberg, Julia H A Foote, Yiqi Qian, Shibani S Mukerji, Nattanicha Wattananimitgul, Ankur Pandya

“…Similarly, model-projected survival provided good fit to the Rotterdam (RMSE, 1.9–3.6 among those with and without AAD) and KPNC cohorts (RMSE, 7.6–18.0 among those with AAD).Conclusions The AgeD-Pol model performed well when validated to published data for AAD cumulative incidence and mortality and provides a useful tool to project the AAD disease burden for health systems planning in the USA.…”
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Comparing efficacy and safety of low-dose versus standard-dose antiplatelet therapy in stroke patients: a meta-analysis by Zhao Ren, Chunxing Li, Xin Zhang, Lichaoyue Sun, Hui Zhu, Dongxiao Wang, Yumin Wang, Shuo Liang, Guanchun Wang

“…The Cochrane Risk of Bias Tool (RoB 2) was used for quality. Performed meta-analysis using Stata 15.0, with relative risk (RR) and 95% confidence interval (CI) as effect estimates.ResultsTen studies involving 7,703 Asia participants, mainly from China and Japan, were analyzed. …”
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The association between monocyte to high-density lipoprotein cholesterol ratio and chronic kidney disease in a Chinese adult population: a cross-sectional study by Lingling Xu, Dongling Li, Zongwei Song, Jin Liu, Yang Zhou, Junwei Yang, Ping Wen

“…Similar conclusions were confirmed in subgroup analysis stratified by gender, age, BMI, central obesity, hypertension, and diabetes mellitus, after justification for confounding factors.Conclusion Elevated MHR level was independently associated with the presence of CKD, suggesting that it might serve as a useful clinical tool for risk stratification, offering valuable insights to inform preventive and therapeutic approaches for clinicians in their routine medical practice.…”
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Ultrasound super-resolution imaging for non-invasive assessment of microvessel in prostate lesion by Xin Huang, Huarong Ye, Yugang Hu, Yumeng Lei, Yi Tian, Xingyue Huang, Jun Zhang, Yao Zhang, Bin Gui, Qianhui Liu, Ge Zhang, Qing Deng

“…And, US SRI may be a valuable tool in clinical practice with its ability to display and quantify microvessel with high precision.…”
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A Wideband Chemical Survey of Massive Star-forming Regions at Subarcsecond Resolution with the Submillimeter Array by Charles J. Law, Qizhou Zhang, Arielle C. Frommer, Karin I. Öberg, Roberto Galván-Madrid, Eric Keto, Hauyu Baobab Liu, Paul T. P. Ho, Andrés F. Izquierdo, L. Ilsedore Cleeves

“…Overall, these results demonstrate that the SMA's wide bandwidth is a powerful tool to untangle the complex molecular gas structures associated with massive star formation.…”
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Virulence profile of carbapenem-resistant Klebsiella pneumoniae strains by an in vivo model of Galleria mellonella by María Guembe, Rama Hafian, Marta Díaz-Navarro, Andrés Visedo, Flavio De Maio, Fulvia Pimpinelli, Ilaria Cavallo, Mauro Truglio, Francesca Sivori, Enea Gino Di Domenico

“…The G. mellonella model may serve as an effective in vivo system for evaluating the virulence of emerging K. pneumoniae lineages.IMPORTANCEWe demonstrate that the Galleria mellonella model is a useful tool to analyze the virulence of carbapenem-resistant Klebsiella pneumoniae strains. …”
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Topologically constrained DNA-mediated one-pot CRISPR assay for rapid detection of viral RNA with single nucleotide resolutionResearch in context by Yanan Li, Ru Xu, Fenglei Quan, Yonghua Wu, Yige Wu, Yongyuan Zhang, Yan Liang, Zhenzhong Zhang, Hua Gao, Ruijie Deng, Kaixiang Zhang, Jinghong Li

“…Interpretation: Our study provides a rapid and accurate molecular diagnostic tool for point-of-care testing, epidemiological screening, and the detection of diseases associated with other RNA biomarkers with excellent single nucleotide differentiation, high sensitivity, and simplicity. …”
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Is the topical application of sesame oil (Sesamum indicum L.) combined with standard care valuable and safe for managing infusion-related phlebitis: Evidence from a systematic revi... by Morteza Nasiri, Leila Amirmohseni, Mohammad Farzollah Abbasi, Fatemeh Yarahmadi, Sahar Zonoori, Mahya Torkaman, Elham Sadeghi Moghimi, Mehrnaz Ardaneh, Masoomeh Asadi

“…The Cochrane risk-of-bias tool and GRADE framework were employed to appraise the quality of the evidence. …”
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Unambiguous identification of fungi: where do we stand and how accurate and precise is fungal DNA barcoding? by Robert Lücking, M. Catherine Aime, Barbara Robbertse, Andrew N. Miller, Hiran A. Ariyawansa, Takayuki Aoki, Gianluigi Cardinali, Pedro W. Crous, Irina S. Druzhinina, David M. Geiser, David L. Hawksworth, Kevin D. Hyde, Laszlo Irinyi, Rajesh Jeewon, Peter R. Johnston, Paul M. Kirk, Elaine Malosso, Tom W. May, Wieland Meyer, Maarja Öpik, Vincent Robert, Marc Stadler, Marco Thines, Duong Vu, Andrey M. Yurkov, Ning Zhang, Conrad L. Schoch

“…Because of clade-specific evolutionary histories, there is currently no single tool for the identification of fungi, although DNA barcoding using the internal transcribed spacer (ITS) remains a first diagnosis, particularly in metabarcoding studies. …”
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Murine model of cross-IgE sensitization and cross-anaphylactic reactions among multiple group food allergens by Ibrahim Musa, Fariba Ardalani, Nan Yang, Soheila J. Maleki, Xiu-Min Li, Xiu-Min Li, Xiu-Min Li

“…This will provide an essential tool for developing novel therapies for cross-reactivity multiple food allergies.…”
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Identification of standing dead trees in Robinia pseudoacacia plantations across China’s Loess Plateau using multiple deep learning models by Li Zhang, Xiaodong Gao, Shuyi Zhou, Zhibo Zhang, Tianjie Zhao, Yaohui Cai, Xining Zhao

“…This study highlights the potential of YOLOv9-ECA as a powerful tool for the efficient detection of SDTs, offering insights for the sustainable management of Robinia pseudoacacia plantations on the CLP and holding potential applicability to similar environments globally.…”
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Exploring using HBsAg to predict interferon treatment course to achieve clinical cure in chronic hepatitis B patients: a clinical study by Fei Yan, Fei Tang, Jing Chen, YiCheng Lin, XinYu Chen, Qin Du, WeiLi Yin, Jing Liang, Lei Liu, Fang Wang, BaiGuo Xu, Qing Ye, HuiLing Xiang

“…External validation also suggests that the model can be used as a tool for initial assessment.ConclusionBaseline HBsAg in chronic hepatitis B patients were a risk factor for prolonged IFN treatment course with a positive correlation. …”
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Toward autism spectrum disorders and Williams-Beuren syndrome co-occurrence condition in Tunisian patients: Genetic insights by Rim Khelifi, Afef Jelloul, Houda Ajmi, Wafa Slimani, Sarra Dimassi, Khouloud Rjiba, Manel Dardour, Moez Gribaa, Ali Saad, Soumaya Mougou-Zerelli

“…We underline the utility of array-CGH as a valuable genetic diagnostic tool for characterizing WBS cases, and we shed light on the complex interplay of behavioral disorders in the 7q11.2 region rearrangements.…”
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