Savolitinib Induced Pathological Complete Response in Non-small Cell Lung Cancer with MET Amplification: A Case Report by Meng LU, Ran ZHANG, Baiwei LI, Haidi XU, Yongkuan GUO, Jian YOU, Bingsheng SUN

“…Mesenchymal-epithelial transition factor (MET) gene mutation is a large class of mutations commonly seen in non-small cell lung cancer (NSCLC). …”
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Real‐World Study of EGFR‐TKI Rechallenge With Another TKI After First‐Line Osimertinib Discontinuation in Patients With EGFR‐Mutated Non‐Small Cell Lung Cancer: A Subset Analysis o... by Kei Sonehara, Kazunari Tateishi, Kiyotaka Yoh, Kazuhiro Usui, Yukio Hosomi, Kazuma Kishi, Go Naka, Kageaki Watanabe, Shu Tamano, Kohei Uemura, Hideo Kunitoh

“…The primary reason for first‐line osimertinib discontinuation was toxicity in 32 (60.4%, 17 patients with pneumonitis) and disease progression in 20 (37.7%) patients. The most common rechallenge EGFR‐TKI was afatinib (n = 24, 45.3%), followed by gefitinib (n = 16, 30.2%) and erlotinib (n = 8, 15.1%). …”
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The First Ground‐Level Enhancement of Solar Cycle 25 as Seen by the High‐Energy Particle Detector (HEPD‐01) on Board the CSES‐01 Satellite by Matteo Martucci, Monica Laurenza, Simone Benella, Francesco Berrilli, Dario DelMoro, Luca Giovannelli, Alexandra Parmentier, Mirko Piersanti, Gabor Albrecht, Simona Bartocci, Roberto Battiston, William J. Burger, Donatella Campana, Luca Carfora, Giuseppe Consolini, Livio Conti, Andrea Contin, Cinzia De Donato, Cristian De Santis, Francesco Maria Follega, Roberto Iuppa, Alessandro Lega, Nadir Marcelli, Giuseppe Masciantonio, Matteo Mergé, Marco Mese, Alberto Oliva, Giuseppe Osteria, Francesco Palma, Beatrice Panico, Francesco Perfetto, Piergiorgio Picozza, Michele Pozzato, Ester Ricci, Marco Ricci, Sergio Bruno Ricciarini, Zouleikha Sahnoun, Valentina Scotti, Alessandro Sotgiu, Roberta Sparvoli, Vincenzo Vitale, Simona Zoffoli, Paolo Zuccon

“…The good agreement between data and model, also corroborated by a comparison with other spectral shapes commonly used in these studies, suggests that particles could have possibly been accelerated out from the ambient corona through the contribution of stochastic acceleration at the CME‐driven shock, even if the presence of seed populations influencing spectral shape could not be excluded. …”
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Piloting an external quality assurance program (QAP) for COVID-19 antigen rapid diagnostic tests (Ag-RDTs): findings and lessons learned from Cambodia by Vonthanak Saphonn, John Kaldor, Deborah Williamson, Sothavireak Bory, Philip Cunningham, Jessica Markby, Kennarey Seang, Jacqueline Prestedge, Chan Leakhena Phoeung, Marilyn Ninan, Kanika Heng, Andrew Valley

“…We collaborated with laboratory experts in Australia and piloted an EQA programme of the commonly used COVID-19 Ag-RDTs at the University of Health Sciences’ MERIEUX Laboratory (Tier 1 site—responsible for the in-country receipt and distribution of QA material) and four other participating laboratories (Tier 2—healthcare facility based) between November 2021 and November 2022. …”
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Current practice of using the airway pressure release ventilation mode in acute respiratory distress syndrome patients among respiratory therapists in Saudi Arabia by Abdullah A Alqarni, Abdulelah M Aldhahir, Rayan A Siraj, Ahmed H Alasimi, Jaber S Alqahtani, Hassan Alwafi, Mohammed A Almeshari, Nowaf Y Alobaidi, Mansour S Majrshi, Saeed M Alghamdi, Mohammed M Alyami

“…Inadequate training was the most common barrier (678, 84.54%) to airway pressure release ventilation implementation. …”
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Seasonality of host-seeking Ixodes ricinus nymph abundance in relation to climate by Hoch, Thierry, Madouasse, Aurélien, Jacquot, Maude, Wongnak, Phrutsamon, Beugnet, Fréderic, Bournez, Laure, Cosson, Jean-François, Huard, Frédéric, Moutailler, Sara, Plantard, Olivier, Poux, Valérie, René-Martellet, Magalie, Vayssier-Taussat, Muriel, Verheyden, Hélène, Vourc’h, Gwenaël, Chalvet-Monfray, Karine, Agoulon, Albert

“…For example, the range of Ixodes ricinus, the most common and widespread tick species in Europe, is currently expanding northward and at higher altitudes. …”
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Epidemiology and Resistance Profiles of Bacteria Isolated From Blood Samples in Septic Patients at Emergency Department Admission: A 6-Year Single Centre Retrospective Analysis Fro... by Valeria Cento, Sara Carloni, Riccardo Sarti, Linda Bussini, Zian Asif, Paola Morelli, Francesco De Fazio, Federica Maria Tordato, Maddalena Casana, Debora Mondatore, Antonio Desai, Elena Generali, Nicola Pugliese, Elena Costantini, Massimo Vanoni, Maurizio Cecconi, Stefano Aliberti, Giorgio Da Rin, Erminia Casari, Michele Bartoletti, Antonio Voza

“…Results: Antibiotic-susceptible Escherichia coli (29.5%) was the most common isolate, including extended-spectrum beta-lactamase (ESBL)-producing strains (11.3%), followed by methicillin-susceptible Staphylococcus aureus (MSSA, 8.4%). …”
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CircCCT2/miR-146a-5p/IRAK1 axis promotes the development of head and neck squamous cell carcinoma by Long He, Lanruo Li, Liting Zhao, Xiaoya Guan, Yujia Guo, Qi Han, Huina Guo, Hongliang Liu, Chunming Zhang

“…Abstract Background Head and neck squamous cell carcinoma (HNSCC), a highly invasive malignancy with a poor prognosis, is one of the most common cancers globally. Circular RNAs (circRNAs) have become key regulators of human malignancies, but further studies are necessary to fully understand their functions and possible causes in HNSCC. …”
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Combination of Hotspot Mutations With Methylation and Fragmentomic Profiles to Enhance Multi‐Cancer Early Detection by Thi Hue Hanh Nguyen, Giang Hoang Vu, Tu Thi Nguyen, Tuan Anh Nguyen, Vu Uyen Tran, Luyen Thi Vu, Giang Thi Huong Nguyen, Nhat Duy Nguyen, Trung Hieu Tran, Van Thien Chi Nguyen, Thanh Dat Nguyen, Trong Hieu Nguyen, Dac Ho Vo, Thi Tuong Vi Van, Thanh Thi Do, Minh Phong Le, Le Anh Khoa Huynh, Duy Sinh Nguyen, Hung Sang Tang, Hoai‐Nghia Nguyen, Minh‐Duy Phan, Hoa Giang, Lan N. Tu, Le Son Tran

“…We previously developed SPOT‐MAS, a multimodal ctDNA‐based assay analyzing methylation and fragmentomic profiles to detect five common cancers. Despite its potential, SPOT‐MAS exhibited moderate sensitivities for early‐stage cancers. …”
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Systemic Diseases in Patients with Congenital Aniridia: A Report from the Homburg Registry for Congenital Aniridia by Jessica Obst, Fabian N. Fries, Maryam Amini, Annamária Náray, Cristian Munteanu, Tanja Stachon, Shweta Suiwal, Neil Lagali, Berthold Seitz, Barbara Käsmann-Kellner, Nóra Szentmáry

“…Systemic diseases were detected in 155 of 337 (46%) patients, with the most common being obesity (29 [8.6%]), thyroid disease (28 [8.3%]), hypertension (26 [7.7%]), intellectual disability (22 [6.5%]), diabetes mellitus (19 [5.6%]), auditory perception disorder/speech development delay (16 [4.7%]), and epilepsy (12 [3.6%]). …”
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Chromosome synapsis, recombination and epigenetic modification in rams heterozygous for metacentric chromosome 3 of the domestic sheep Ovis aries and acrocentric homologs of the ar... by T. I. Bikchurina, E. K. Tomgorova, A. A. Torgasheva, V. A. Bagirov, N. A. Volkova, P. M. Borodin

“…The karyotypes of argali and domestic sheep differ for a Robertsonian translocation, which occurred in the common ancestor of mouflon and domestic sheep (Ovis aries) due to the centric fusion of chromosomes 5 and 11 of the argali (O. ammon) into chromosome 3 of sheep. …”
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Geographic disparities in physical and mental health comorbidities and socioeconomic status of residence among Medicaid beneficiaries in Utah by Roberta Z. Horth, Roberta Z. Horth, Roberta Z. Horth, Srimoyee Bose, Srimoyee Bose, Carl Grafe, Carl Grafe, Navina Forsythe, Angela Dunn

“…Prevalence of complex needs was 18.9% (n = 29,742); beneficiaries with >3 emergency department visits had 12.8 odds of having complex needs; 39.7% of beneficiaries with >$5,000 in annual costs had complex needs. Common comorbid conditions among beneficiaries with complex needs were hypertension (56.0%), hyperlipidemia (35.5%), depression (68.8%), anxiety (56.2%), drug use (16.0%), and alcohol use disorders (15.2%). …”
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Incorporating insulin into alginate-chitosan 3D-printed scaffolds: A comprehensive study on structure, mechanics, and biocompatibility for cartilage tissue engineering by Afsaneh Jahani, Mohammad Sadegh Nourbakhsh, Ali Moradi, Marzieh Mohammadi, Lobat Tayebi

“…Yet, administering differentiation biomolecules through conventional scaffolds poses a persistent challenge. Alginate (Alg) is commonly employed in CTE for its biocompatibility, though it lacks sufficient mechanical properties. …”
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Delirium Management Quality Improvement Project to Improve Awareness and Screening in a Medical ICU by Hirsh Makhija, Kyle Digrande, Omar Awan, Russell G. Buhr, Rajan Saggar, Victoria Ramirez, Rainbow Tarumoto, Janelle M. Fine, Atul Malhotra, Dale M. Needham, Jennifer L. Martin, Biren B. Kamdar

“…<b>Background/Objectives:</b> Although delirium is common during critical illness, standard-of-care detection and prevention practices in real-world intensive care unit (ICU) settings remain inconsistent, often due to a lack of provider education. …”
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Reliability of the OMERACT Giant cell arteritis Ultrasonography Score (OGUS): results of a patient-based exercise involving experts and non-experts in vascular ultrasonography by Christian Dejaco, Stavros Chrysidis, Sara Monti, Cristina Ponte, Peter Mandl, Lene Terslev, Bhaskar Dasgupta, Alojzija Hočevar, Christina Duftner, Wolfgang Schmidt, Carlos Pineda, Eugenio De Miguel, Andreas P Diamantopoulos, Helen Keen, Kati Mykkänen, George A Bruyn, Wolfgang Hartung, Maria Antonietta D’Agostino, Nikitas Gkikopoulos, Luca Seitz, Adela-Cristina Sarbu, Eva Manger, Berit Dalsgaard Nielsen, Norbert Redlinger, Veerendra Chadachan, Maria Correyero, Giovanni Fulvio, Vesselina Kurteva, Paolo Mercatelli, Irina Midtgard, Raili Muller, Duriad Reffat

“…Ultrasonography was conducted on temporal arteries (common superficial, frontal and parietal branches) and axillary arteries bilaterally to calculate the OGUS, the Southend score and the Halo count. …”
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Identification of therapeutic target genes for age-related hearing loss through systematic genome-wide mendelian randomization of druggable genes by Kun Zhang, Bo Hou, Tao Yan, Ruru Qiao, Peng Qu, Xinbo Xu, Hanbing Zhang

“…Background: Age-related hearing loss (ARHL) is a common sensory disorder with significant public health implications. …”
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Heterogeneity of Treatment Effects of Laser Epilation on Pilonidal Disease Recurrence: A Randomized Clinical Trial by Katherine C. Bergus, MD, MPH, Carley Lutz, BS, Jennifer Cooper, PhD, Lindsey Asti, PhD, MPH, Lindsay Gil, MD, MPH, Cory Criss, MD, Katherine J. Deans, MD, MHSc, Peter C. Minneci, MD, MHSc

“…Pilonidal disease is a common, painful disease affecting 1% of the population aged 15 to 30 years with postoperative recurrence rates as high as 30% to 40%. …”
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Adverse outcome pathway-based assessment of pulmonary toxicity from the in vivo mixture of biocides dinotefuran and cetylpyridinium chloride by Yoon Cho, Mi-Kyung Song, Dong Im Kim, Min-Seok Kim, Kyuhong Lee

“…Moreover, increased levels of markers associated with epithelial–mesenchymal transition (EMT) and fibrosis (TNF-α, Acta2, IL-1β, and MMP9), as well as elevated levels of TGF-β, a common downstream signaling factor of TLR4 and PPAR-γ, were identified. …”
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Survival of Generic Escherichia coli on In-Field Mature and Immature Gala and Golden Delicious Apples With or Without Overhead Evaporative Cooling Treatment by Claire M Murphy, Kyu Ho Jeong, Lauren Walter, Manoella Mendoza, Tonia Green, Andy Liao, Karen Killinger, Ines Hanrahan, Mei-Jun Zhu

“…The application of overhead evaporative cooling (EC) with untreated surface water is common in Washington State to decrease sunburn on apples. …”
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Effectiveness and Safety of Hair Growth Formulation Containing L.f (Teak) Leaf Extract: A Randomized, Double-Blind, Placebo-Controlled Study on Males with Androgenic Alopecia by Nutchaninad Tanuphol B.ATM, Neti Waranuch PhD, Vanuchawan Wisuitiprot PhD, Wudtichai Wisuitiprot PhD, Kamonlak Insumrong PhD, Prapapan Temkitthawon PhD, Nungruthai Suphrom PhD, Katechan Jampachaisri PhD, Corine Girard PhD, Kornkanok Ingkaninan PhD

“…Background Androgenic alopecia (AGA) is commonly known as male patterned baldness. A high level of dihydrotestosterone (DHT) plays a significant role in AGA development. …”
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