Functional Characterization of the SHIP1-Domains Regarding Their Contribution to Inositol 5-Phosphatase Activity by Spike Murphy Müller, Nina Nelson, Manfred Jücker

“…The Src homology 2 domain-containing inositol 5-phosphatase 1 (SHIP1) is a multidomain protein consisting of two protein–protein interaction domains, the Src homology 2 (SH2) domain, and the proline-rich region (PRR), as well as three phosphoinositide-binding domains, the pleckstrin homology-like (PHL) domain, the 5-phosphatase (5PPase) domain, and the C2 domain. SHIP1 is commonly known for its involvement in the regulation of the PI3K/AKT signaling pathway by dephosphorylation of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P₃) at the D5 position of the inositol ring. …”
Get full text

Serum Inflammatory Cytokines and Growth Factors in Patients with Sjögren’s Syndrome and Diabetes Mellitus by Yalçın Karaküçük, Sema Yilmaz, Ali Unlu, Banu Bozkurt, Şule Nur Acar Duyan

“…Abstract Background/ Aims: Sjögren’s syndrome (SS) and diabetes mellitus (DM) are common causes of dry eye disease (DED) and autologous serum is used when artificial tears are not sufficient. …”
Get full text

Association between retinal markers and cognition in older adults: a systematic review by Gerald Liew, Bamini Gopinath, Joyce Chan, Joyce Siette, Varshanie Jeevakumar, Rebekah Sefton, Tejal M Shah

“…Optical coherence tomography (OCT) was the most commonly used retinal scanning methodology to measure the thickness of retinal nerve fibre layer, the ganglion cell complex, choroid and macula. 51.1% of cross-sectional studies using OCT reported an association between the thinning of at least one retinal parameter and poor cognition. …”
Get full text

Chronic Atrophic Gastritis Presenting as Hemolytic Anemia due to Severe Vitamin B12 Deficiency by Amanda M. Woodford, Rabhea Chaudhry, Gabriella A. Conte, Varsha Gupta, Madhurima Anne

“…Low levels usually stem from either poor intake or a malabsorptive process. Presently, the most common cause of vitamin B12 deficiency is food-bound cobalamin malabsorption, which occurs when there is impaired release of vitamin B12 from ingested food due to an outstanding factor preventing the release of the nutrient from its transport protein. …”
Get full text

Risk prediction models for falls in hospitalized older patients: a systematic review and meta-analysis by Anli Mao, Jie Su, Mingzhu Ren, Shuying Chen, Huafang Zhang

“…Eight models reported discrimination metrics and two models reported calibration metrics. The most common predictors of falls were mobility, fall history, medications, and psychiatric disorders. …”
Get full text

Semi-field experiments reveal contrasted predation and movement patterns of aquatic macroinvertebrate predators of Anopheles gambiae larvae by Hudson Onen, Emmanuel W. Kaindoa, Joel Nkya, Alex Limwagu, Martha A. Kaddumukasa, Fredros O. Okumu, Jonathan K. Kayondo, Anne M. Akol, Frédéric Tripet

“…This study experimentally evaluated the predation efficacy and foraging strategy of three common aquatic macroinvertebrate predators of An. gambiae, diving beetles (Coleoptera), backswimmers (Hemiptera), and dragonfly nymphs (Odonata) in a semi-field system in South-Eastern Tanzania. …”
Get full text

Effect of Different Doses of Sugammadex on Recovery and Hemodynamic Parameters in Reversing Neuromuscular Blockade in Patients Undergoing Electroconvulsive Therapy by Kadir ARSLAN, Gozde UCUKSARAC, Hale CETIN ARSLAN, Erkan AYDIN, Ayca Sultan SAHIN

“…While the average number of ECTs applied to the patients was 6.8+-2.8, the average seizure duration was 28.2+-12.7 seconds. The most common diagnosis (32.7%) in patients who underwent ECT was bipolar disorder. …”
Get full text

Effect of Intestinal Levodopa-Carbidopa Infusion on Pharyngeal Dysphagia: Results from a Retrospective Pilot Study in Patients with Parkinson’s Disease by Bendix Labeit, Inga Claus, Paul Muhle, Sonja Suntrup-Krueger, Rainer Dziewas, Tobias Warnecke

“…Pharyngeal dysphagia is a common symptom of Parkinson’s disease (PD) leading to severe complications. …”
Get full text

Comparison of the lower genital tract microbiome composition in patients with benign gynecological disease by Yonghui Shi, Jun Li, Jinjing Xie, Tianye Yang, Qiongyan Ma, Hua Chen, Wenwei Guo

“…The sequencing libraries were generated and sequenced on an Illumina NovaSeq 6000 platform.ResultsFirmicutes, Actinobacteria and Bacteroidota were the most common phyla in all four groups, whereas OC presented the highest abundance of Firmicutes and the lowest abundance of Bacteroidota. …”
Get full text

"LETTER TO THE KING" BY JULES DESTRY: FROM SEPARATISM TO UNITARISM IN BELGIUM by E. V. Ermakova

“…The ideas embodied in his "Letter to the King", formed the basis of the principles of peaceful co-existence of further autonomous regions as part of the union, which was manifested in the future during the First World War, when the Walloons and Flemings alongside confronted a common enemy.…”
Get full text

A patient choice‐driven lifestyle intervention lowers HbA1c in type 2 diabetes: A feasibility study by Nathan R. Weeldreyer, Mindy L. McEntee, Matthew P. Martin, Chong D. Lee, Farshad Fani Marvasti, Glenn A. Gaesser, Rodger Kessler, Siddhartha S. Angadi

“…Abstract Type 2 diabetes (T2D) is a common metabolic disorder in which only 25% of patients meet management targets. …”
Get full text

The status of serum 25(OH)D levels is related to breast cancer by Mohammad Momivand, Mahta Razaghi, Farshid Mohammadi, Edris Hoseinzadeh, Roya Najafi-Vosough

“…Aim: Breast cancer is the second most common cancer among women and the leading cause of cancer-related mortality in this population. …”
Get full text

Effect of taking a dietary supplement containing Lactobacillus delbrueckii subsp. bulgaricus on clinical manifestations of functional dyspepsia and patients’ quality of life by I.G. Paliy, S.V. Zaika, O.O. Ksenchyn, I.V. Chernova

“…Functional dyspepsia is a common disorder that is difficult to treat and has a significant negative impact on the quality of life of patients. …”
Get full text

Blocks identical by descent in the genomes of the indigenous population of Siberia demonstrate genetic links between populations by N. A. Kolesnikov, V. N. Kharkov, K. V. Vagaitseva, A. A. Zarubin, V. A. Stepanov

“…For this, DNA fragments were analyzed, which had been inherited without recombination by each pair of individuals from their recent common ancestor, that is, segments (blocks) identical by descent (IBD). …”
Get full text

Root Canal Configuration of Burmese (Myanmar) Maxillary First Molar: A Micro-Computed Tomography Study by M. M. Kyaw Moe, H. J. Jo, J. H. Ha, S. K. Kim

“…In 101 specimens, 83 (82.18%) mesiobuccal roots had multiple canals. The most common canal type is type IV (45.5%), followed by type II (17.8%) and I (17.8%) canals. …”
Get full text

Analysis of the behaviour of the Tukad Buluk Poh flood water at the Gilimanuk - Denpasar National Road Crossing by Hidayat Acep, Suprapti, Isradi Muhammad, Dwi Praptoyo Riska

“…In most of Indonesia, floods are a common natural disaster that spreads into several watersheds during the rainy season. …”
Get full text

Non-Alcoholic Fatty Liver Disease in Cardiac Patients with Overweight and Obesity by I. V. Logacheva, T. A. Ryazanova, V. R. Makarova, O. V. Surnina

“…A relationship is established between the most significant structural and functional indicators of the heart (myocardial mass index, volume of the left atrium), blood vessels (endotheliumdependent vasodilation, the size of the intima-media complex of the common carotid artery) and NAFLD. It is demonstrated that the correlation coefficients grow with the progression of fatty infiltration and liver fibrosis signs.Conclusions. …”
Get full text

Is Topical Tranexamic Acid Effective in Reducing Hematoma and Seroma in Breast Surgery? A Systematic Review and Meta-analysis by Ammar S.A. Hashemi, MD, Sara M. Hussein, MD, Zainab H. Alshehab, Abdullah A. Al Qurashi, MD, Lucas Kreutz-Rodrigues, MD, Basel A. Sharaf, MD, DDS, FACS

“…Postoperative fluid-related complications, such as hematoma and seroma formation, are common concerns in breast surgery, adversely affecting surgical outcomes and patient recovery. …”
Get full text

Antioxidant Stability of Moringa Leaves Extract Powders Obtained by Cocrystallization, Vacuum Drying, and Plating by Bambang Nurhadi, Fatsyarien Citra Angiputri, Robi Andoyo, Riksfardini Annisa Ermawar, Rudy Adi Saputra

“…Cocrystallization and vacuum drying are two relatively novel, less common techniques offering a simpler and more cost-effective method, but their effect on the antioxidant stability of moringa leaves extract has not yet been studied. …”
Get full text

Challenges and Technology Trends in Implementing a Human Resource Management System: A Systematic Literature Review by Rahma Destriani, Raihansyah Yoga Adhitama, Dana Indra Sensuse, Deden Sumirat Hidayat, Erisva Hakiki Purwaningsih

“…Results: The result was in the form of a table mapping of the challenges faced by each stakeholder in HRMS, including resistance to change, lack of management support, and limited technology infrastructure. Meanwhile, the most common technology challenges found were system integration issues, data security, and lack of technical capabilities or skills. …”
Get full text