Association between oral microbiome diversity and all-cause mortality: a longitudinal study of NHANES, 2009–2012 by Bo Lin, Liang Zheng, Wanna Chen, Ju Yu, Zhanqiang Zhang, Weiming Lv

“…The dose–response association for all-cause mortality risk was curvilinear; the protective association plateaued when the number of ASVs was larger than 120.Conclusion Despite being linked to greater socioeconomic disadvantages and poorer oral health, higher oral microbiome diversity was significantly associated with a substantial reduction in all-cause mortality.…”
Get full text

Copper Super-Dosing Improves Performance of Heat-Stressed Broiler Chickens through Modulation of Expression of Proinflammatory Cytokine Genes by Sudipto Haldar, Amrita Kumar Dhara, Sayantani Sihi Arora, Arpana Verma Mukherjee, Arup Nayak

“…Interleukin-6 and tumour necrosis factor-α gene expression increased linearly (P=0.0001) as Cu in the diet increased though the response plateaued at 112.5 mg/kg. It was concluded from the present experiment that during conditions of impending HS, dietary supplementation of 112.5 to 150 mg Cu/kg diet as Cu-P may be a novel strategy to alleviate the negative effects of HS without involving any apparent risk of Cu toxicity.…”
Get full text

Trends in initial pharmacological COPD treatment in primary care (2010–2021): a population-based study using the PHARMO Data Network by Guilherme Rodrigues, Joana Antão, Qichen Deng, Brenda N. Baak, Alda Marques, Frits M. E. Franssen, Martijn A. Spruit

“…Moreover, LABA-ICS decreased from 17.6% to 8.5% between 2010 and 2018, after which it plateaued. In contrast, LABA-LAMA sharply increased, from 0.6% in 2010 to 9.6% in 2021. …”
Get full text

Age-stratified analysis of the BMI-kidney stone relationship: findings from a national cross-sectional study by Liuliu Zhou, Wei Gu, Yufeng Jiang, Haimin Zhang

“…In the 40–59-year group, the risk of kidney stones peaked and then plateaued as BMI increased beyond a certain threshold. …”
Get full text

Dietary protein requirement of Chinese hook snout carp (Opsariichthys bidens) and transcriptomic analysis of the liver in response to different protein diets by Yijiang Bei, Linqiang He, Jin Jing, Xiaoming Chen, Fan Yuan, Gaohua Yao, XueYan Ding, Lei Wang, Fan Zhou

“…Growth performance increased with higher dietary protein levels up to 41 % and then plateaued at higher concentrations. On the basis of the second regression analysis, the dietary protein requirement of Chinese hook snout carp was estimated to be 42.97 %. …”
Get full text

Safety and efficacy of filgotinib in patients with rheumatoid arthritis: final results of the DARWIN 3 long-term extension study by Arthur Kavanaugh, Paul Emery, René Westhovens, Mark C Genovese, Kevin L Winthrop, Rieke Alten, Dick de Vries, Lorenzo Dagna, Patrick Verschueren, Maria Greenwald, Regina Cseuz, Robin Besuyen, Vikas Modgill, Ly Huong Le

“…Disease response assessed using non-responder imputation plateaued at LTE week 12 before slowly declining over time, with overall American College of Rheumatology (ACR)20/50/70 response rates of 26.9%/20.2%/14.7% at week 396.Conclusion Filgotinib was well tolerated in patients with RA for up to 8 years. …”
Get full text

Risk factors and prognosis analysis of dysphagia after occipitocervical fusion surgery: a retrospective study of 43 cases by Yufan Chen, Weihong Xu

“…Prognostic analysis indicated rapid recovery was possible by 3 months postoperatively, with full recovery achieved in ~ 30% of patients by 1 year, after which recovery plateaued. Conclusion Postoperative dysphagia after OCF appears to result from multiple factors involving both “static + dynamic” elements. dPIA is a reliable predictor, with patients having a dPIA >-8° being less likely to develop dysphagia. …”
Get full text

Single-cell profiling of SLC family transporters: uncovering the role of SLC7A1 in osteosarcoma by Yan Liao, Junkai Chen, Hao Yao, Ting Zheng, Jian Tu, Weidong Chen, ZeHao Guo, Yutong Zou, Lili Wen, Xianbiao Xie

“…Over the past three decades, therapeutic outcomes have plateaued, underscoring the critical need for innovative therapeutic targets. …”
Get full text