Polysaccharide-rich extract of Potentilla anserina ameliorates nonalcoholic fatty liver disease in free fatty acid-induced HepG2 cells and high-fat/sugar diet-fed mice by Xiujun Lin, Yimei Zheng, Yingying Yan, Hongting Deng, Shunxin Wang, Yuanju He, Yuting Tian, Wenhui Zhang, Hui Teng

“…(PA) belongs to the Rosaceae family, is a common edible plant in the Qinghai-Tibet Plateau areas of China. This study elucidates the mechanism upon which crude polysaccharide of PA (PAP) on fat accumulation in HepG2 cells stimulated by oleic acid (OA) and high fat high sugar induced mice. …”
Get full text

Climats et origines des grands singes et des hommes by Brigitte Senut

“…En ce qui concerne les orangs outans, ils ont évolué en Asie et leur histoire récente semble se combler grâce à la découverte en Thaïlande sur le plateau de Khorat d'une mandibule vieille de 9 à 7 millions d’années. …”
Get full text

Construction and validation of a risk prediction model for high altitude de-acclimatization syndrome by DING Yu, DING Yu, WANG Zejun, WANG Zejun, XIE Jiaxin, XIE Jiaxin

“…Objective‍　‍To construct risk models for predicting the occurrence of high altitude de-acclimatization syndrome （HADAS） in the population returning from the plateau to the plain based on different machine learning algorithms and validate the predicting efficiency of these models. …”
Get full text

Multiple eco-regions contribute to the seasonal cycle of Antarctic aerosol size distributions by J. Brean, D. C. S. Beddows, E. Asmi, A. Virkkula, A. Virkkula, L. L. J. Quéléver, M. Sipilä, F. Van Den Heuvel, T. Lachlan-Cope, A. Jones, M. Frey, A. Lupi, J. Park, Y. J. Yoon, R. Weller, G. L. Marincovich, G. L. Marincovich, G. C. Mulena, G. C. Mulena, R. M. Harrison, R. M. Harrison, M. Dall'Osto

“…“Aitken high”, “Aitken low” and “bimodal” PNSDs occur 37 %–68 % of the time, most commonly at Dome C on the Antarctic Plateau, and likely arise from atmospheric transport and ageing from aerosol originating likely in both the coastal boundary layer and free troposphere. …”
Get full text

Des vestiges d’un possible aqueduc à Lyon, à l’angle des rues Appian et des Fossés-de-Trion by Tony Silvino

“…At the same time, these structures do not appear to be roads, for example connecting the Trion valley in the north-west to Point-du-Jour plateau in the south-east, since there are no signs of hardtop preparation at the bottom of the structures. …”
Get full text

Study on the In Vitro and In Vivo Antioxidant Activity and Potential Mechanism of <i>Polygonum viviparum</i> L. by Zhen Yang, Jingyuan Man, Haoyu Liu, Di Wu, Qiangwen Gu, Hongjuan Zhang, Yu Liu, Dan Shao, Baocheng Hao, Shengyi Wang

“…(PV) is a natural herbal medicine with antioxidant properties and is used as a traditional medicine in the Tibetan Plateau region. However, there are few studies that have focused on its antioxidant activity and mechanism of action in vitro and in vivo. …”
Get full text

Targeting NANOS1 in triple-negative breast cancer: synergistic effects of digoxin and PD-1 inhibitors in modulating the tumor immune microenvironment by Tangyi Wang, Yadian Lei, Jingwei Sun, Li Wang, Yuxin Lin, Zhijing Wu, Shoude Zhang, Chengzhu Cao, Chengzhu Cao, Chengzhu Cao, Haiyan Wang, Haiyan Wang, Haiyan Wang

Get full text

Comprehensive Evaluation of GPM-IMERG, CMORPH, and TMPA Precipitation Products with Gauged Rainfall over Mainland China by Guanghua Wei, Haishen Lü, Wade T. Crow, Yonghua Zhu, Jianqun Wang, Jianbin Su

“…Results illustrate the following. (1) Except for IMERG V04A’s severe underestimation over the Tibetan Plateau (TP) and Xinjiang (XJ) with high negative relative biases (RBs) and CMORPH-CRT’s overestimation over XJ with high positive RB, the four satellite-based precipitation products generally capture the same spatial patterns of precipitation over China. (2) At the annual scale over China, the IMERG products do not show an advantage over its predecessor (TRMM 3B42) in terms of RMSEs, RRMSEs, and Rs; meanwhile, the performance of IMERG products is worse than TRMM 3B42 in spring and summer according to the RMSE, RRMSE, and R metrics. …”
Get full text

Componentes y Dinámica Natural del Ambiente - Ciudad de Neuquén- by Olga Capua, Elsie Marcela Jurio

“…Abstract The city of Neuquen, capital of the province, is located on the valleys' soils product or Limay and Neuquén rivers and on the surface, slopes and foothills of the plateau, located north of the town center. Up to 70s decade urban region was surrounded by agricultural areas, with intensive irrigation infrastructure and limited by rivers and relief with a marked topographic steep slope dissected by a dense network of rills and gullies. …”
Get full text

Lidar Network for Temperature and Wind Measurements in the Mesosphere and Lower Thermosphere Region by Y. Yang, F. Li, X. Cheng, G. Yang, D. Lyu, X. Lin, L. Liu, X. Fang, J. Zheng, L. Du, W. Wang, L. Ren, J. Wang, J. Liang, K. Ji, L. Xu, Z. Chen, K. Ji, H. Zheng, X. Wang, Y. Wang, J. Jiao, X. Wang, X. Xue, Y. Xia, Y. Li, Z. Lin, L. Chen, Z. Chen, J. Xu, G. Li, L. Hu, S. Gong

“…The preliminary observation results of the lidar near Tibetan plateau is demonstrated in this paper. This lidar network offers horizontal perspectives on large scale that a single‐station lidar system can't provide. …”
Get full text

Le sanctuaire romain du Vigneau à Pussigny (Indre-et-Loire) : un lieu de mémoire, de vie et d’accueil by Arnaud Coutelas, Sébastien Lepetz

“…The archaeological site developed in the upper part of the plateau overlooking the Vienne valley, along a west-facing slope.The centre of the excavation area is characterised by an ancient occupation, divided into two sectors. …”
Get full text

Inter-rater reliability and prognostic value of baseline Radiographic Assessment of Lung Edema (RALE) scores in observational cohort studies of inpatients with COVID-19 by Andrew I Kim, William Bain, Alison Morris, Barbara Methe, Bryan J McVerry, Georgios D Kitsios, Daniel Kotok, Janet S Lee, Nameer Al-Yousif, Christine E Girard, Jana J Jacobs, Konstantin Golubykh, Hafiz Qurashi, Michael Lu, Saketram Komanduri, Anatoliy Korzhuk, Halimat O Lawal, Nicholas Abourizk, Caitlin Schaefer, Kevin J Mitchell, Catherine M Dietz, Ellen K Hughes, Clara S Brandt, Georgia M Fitzgerald, Robin Joyce, Asmaa S Chaudhry, Jose D Rivera, Shruti Shettigar, Allen Lavina, Samantha R Gillenwater, Anas Hadeh, Faraaz A Shah, Matthew Bittner, Niall Prendergast, John Evankovich, Navitha Ramesh, Cathy Kessinger

“…Among invasively ventilated patients, RALE scores were significantly associated with worse respiratory mechanics (plateau and driving pressure) and gas exchange metrics (PaO2/FiO2 and ventilatory ratio), as well as higher plasma levels of IL-6, soluble receptor of advanced glycation end-products and soluble tumour necrosis factor receptor 1 (p&lt;0.05). …”
Get full text

Pierre et carrières dans la Saintonge antique : identification, usages et diffusion by Jacques Gaillard, Egle Conforto

“…The briefly described geomorphological history, underscores the Pyrenean orogeny, a major event which transformed the Aquitaine basin of the secondary era into the current sedimentary plateau. Compressed into vast anticlinal and synclinal undulations, cut into by rivers, notably the Charente, it offered stonemasons a wide range of high-quality limestone, suitable for sculptural and architectural purposes, as well as all other construction needs, whether ashlar or rubble. …”
Get full text

Duckweed: a starch-hyperaccumulating plant under cultivation with a combination of nutrient limitation and elevated CO2 by Ling Guo, Ling Guo, Yang Fang, Songhu Wang, Yao Xiao, Yanqiang Ding, Yanling Jin, Xueping Tian, Anping Du, Zhihua Liao, Kaize He, Shuang Chen, Yonggui Zhao, Li Tan, Zhuolin Yi, Yuqing Che, Lanchai Chen, Jinmeng Li, Leyi Zhao, Peng Zhang, Zhengbiao Gu, Fangyuan Zhang, Yan Hong, Qing Zhang, Hai Zhao

Get full text

Le réseau hydraulique à Pompéi (Italie) de l’époque des Samnites à Auguste (fin ive-fin ier s. av. J.-C.) by Federico Giletti

“…While the latter type appears equally in both private and public contexts, the burrow cistern by contrast differs in that it is excavated entirely into the lava stratum and has been demonstrated, as far as we currently know, only on the main outcrops of the lava plateau, such as on the rocky crest of the southern drop in height below insula 2 of Regio VIII.While the type of cistern with a burrow or bainhole seems to have been inspired by models already widespread in Punic-Carthaginian sites in Africa and on the islands and in the Magna-Greek area, cases of cisterns with a burrow collected to several arms primarily bear strong similarities to Etruscan-Latian examples, as does the technique of drainage tunnels entirely excavated in the geological bank and the custom of digging deep artesian wells. …”
Get full text

Villa d’époque romaine et habitat médiéval à Mont-Saint-Jean (Sarthe) : bilan des recherches 2008-2020 by Florian Sarreste, Paul-André Besombes, Phaedra Bouvet, Chloé Genies, Étienne Jaffrot, Florian Jedrusiak, Thomas Jubeau, Anthony Ledauphin, Annaïg Le Martret, Christophe Loiseau, Hugo Meunier, Aurore Noël, Sandrine Paradis-Grenouillet, Boris Robin

“…The thalweg provides access to this massif, the highest points of which loom above the surrounding plateau by more than 120 m. Thus, this zone would have allowed for easy access to the Roman iron ore workshops located in the forest, the closest of which, the Saut du Cerf, is situated less than 1.2 km south of the villa.The ancient rural settlement was founded around AD 30-40, on a plot of land ostensibly untouched by any prior activity. …”
Get full text

The maturation of infant and toddler visual cortex neural activity and associations with fine motor performance by Katharina Otten, J. Christopher Edgar, Heather L. Green, Kylie Mol, Marybeth McNamee, Emily S. Kuschner, Mina Kim, Song Liu, Hao Huang, Marisa Nordt, Kerstin Konrad, Yuhan Chen

“…Results showed a nonlinear decrease in N1m and P1m latency as a function of age, characterized by rapid changes followed by slower progression, with the N1m latency plateauing at 6–7 months and the P1m latency plateauing at 8–9 months. …”
Get full text

An Examination of the Enforcement of Ireland’s Public Health (Alcohol) Act 2018: A Paper Tiger by Frank Houghton, John Lombard

“…Although compliance rates have improved over time, they remain below 86% and appear to be plateauing. It is notable that in four full years of operation, no convic- tions for summary or indictable offences related to the Act were recorded, despite over 1900 inspections reporting non-compliance. …”
Get full text

Early Hepatic Dysfunction in a Large Animal Model of Nonhypotensive Sepsis by Stephen Sullivan, Michael Troster, Adam Linton

“…By 48 h the alkaline phosphatase had returned to presepsis levels, the bilirubin continued to rise, the AST and lactate dehydrogenase had plateaued while the alhumin remained low. These biochemical alterations were confirmed by examining data from 25 sheer used in similar sepsis experiments. …”
Get full text

Distinct Expression Patterns of Apoptosis and Autophagy-Associated Proteins and Genes during Postnatal Development of Spiral Ganglion Neurons in Rat by Shule Hou, Penghui Chen, Jiarui Chen, Junmin Chen, Lianhua Sun, Jianyong Chen, Baihui He, Yue Li, Huan Qin, Yuren Hong, Shuna Li, Jingchun He, Dekun Gao, Fabio Mammano, Jun Yang

“…The number of SGNs was decreased from P1 to P7 and plateaued from P10 to P14. Immunohistochemistry results revealed positive expression of cleaved-caspase3, bcl-2, microtubule-associated protein light chain 3-II (LC3-II), Beclin1, and sequestosome 1 (SQSTM1/P62) in SGNs. …”
Get full text