A pharmacological view on accounting for pharmacokinetic factors in the estimation of pharmaceutical emissions based on drug usage data by Frank Klont, J. Stein Bellinga, Valentina Giunchi, Spyros Balafas, Eelko Hak

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Uterine Rupture at 21 Weeks in Twin Pregnancy with TTTS and Previous C-Section by Gieta Bhikha-kori, Marieke Sueters, Johanna M. Middeldorp

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Incidence, long-term predictors and progression of chronic kidney disease among African migrants and non-migrants: the transcontinental population-based prospective RODAM cohort st... by Charles Agyemang, Ellis Owusu-Dabo, Erik Beune, Karlijn Meeks, Bert-Jan H van den Born, Liffert Vogt, Felix P Chilunga, Charles F Hayfron-Benjamin, Sampson Twumasi-Ankrah, Muhulo Muhau Mungamba, Eva L van der Linden, Engwa A Godwill, Samuel N Darko, Benedicta N Chungag

“…We investigated incidence, long-term predictors and progression of CKD among Ghanaians residing in Ghana and Ghanaian migrants in the Netherlands (Amsterdam).Methods and findings We analysed data from 2183 participants in the transcontinental population-based prospective Research on Obesity and Diabetes among African Migrants cohort, followed for approximately 7 years. …”
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Are dizziness/lightheadedness helpful symptoms for telephone triage of females and males calling the out-of-hours service for acute chest discomfort? A cross-sectional study by Frans H Rutten, Hester M den Ruijter, Sander van Doorn, Dorien L Zwart, Loes T C M Wouters, Anna S M Dobbe, Laurens van der Hem, D Carmen Erkelens

“…Therefore, we investigated if these symptoms are helpful for triage and diagnosis of ACS in females and males with acute chest discomfort.Design Cross-sectional study.Setting Nine out-of-hours service in primary care (OHS-PC) in the Netherlands participated, covering both rural and urban areas, serving a total population of 1.5 million people.Participants 2195 patients were selected calling the OHS-PC with acute chest discomfort, 55.4% were females. …”
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Prediction model study focusing on eHealth in the management of urinary incontinence: the Personalised Advantage Index as a decision-making aid by Huibert Burger, Henk van der Worp, Marco H Blanker, Marjolein Y Berger, Anne Martina Maria Loohuis, Nienke Wessels, Janny Dekker, Alec GGA Malmberg

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Sex-specific differences in children attending the emergency department: prospective observational study by Joany M Zachariasse, Henriette A Moll, Ian K Maconochie, Ewout W Steyerberg, Daan Nieboer, Dorine M Borensztajn, Claudio F Alves, Frank J Smit, Susanne Greber-Platzer, Claudia M G Keyzer-Dekker

“…Objective To assess the role of sex in the presentation and management of children attending the emergency department (ED).Design The TrIAGE project (TRiage Improvements Across General Emergency departments), a prospective observational study based on curated electronic health record data.Setting Five diverse European hospitals in four countries (Austria, The Netherlands, Portugal, UK).Participants All consecutive paediatric ED visits of children under the age of 16 during the study period (8–36 months between 2012 and 2015).Main outcome measures The association between sex (male of female) and diagnostic tests and disease management in general paediatric ED visits and in subgroups presenting with trauma or musculoskeletal, gastrointestinal and respiratory problems and fever. …”
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Added Value of Liver MRI in Patients Eligible for Surgical Resection or Ablation of Colorectal Liver Metastases Based on CT: A Systematic Review and Meta-Analysis by Burak Görgec, MD, Inez M. Verpalen, MD, PhD, Jasper P. Sijberden, MD, Mohammad Abu Hilal, MD, PhD, Shandra Bipat, PhD, Cornelis Verhoef, MD, PhD, Rutger-Jan Swijnenburg, MD, PhD, Marc G. Besselink, MD, MSc, PhD, Jaap Stoker, MD, PhD

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Mouse strain-specific responses along the gut-brain axis upon fecal microbiota transplantation from children with autism by Naika Prince, Lucia N. Peralta Marzal, Léa Roussin, Magali Monnoye, Catherine Philippe, Elise Maximin, Sabbir Ahmed, Karoliina Salenius, Jake Lin, Reija Autio, Youri Adolfs, R. Jeroen Pasterkamp, Johan Garssen, Laurent Naudon, Sylvie Rabot, Aletta D. Kraneveld, Paula Perez-Pardo

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Diagnostic accuracy in coronary CT angiography analysis: artificial intelligence versus human assessment by James K Min, Paul Knaapen, Nick S Nurmohamed, Erik S G Stroes, Andrew D Choi, Ibrahim Danad, James Earls, Michiel J Bom, Ruben W de Winter, Rachel Bernardo, Ruurt Jukema, Ralf Sprengers

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Aberrant B cell receptor signaling responses in circulating double-negative 2 B cells from radiographic axial spondyloarthritis patients by Rick Wilbrink, Stefan F.H. Neys, Rudi W. Hendriks, Anneke Spoorenberg, Frans G.M. Kroese, Odilia B.J. Corneth, Gwenny M.P.J. Verstappen

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Nissen-Sleeve procedure versus laparoscopic Roux-en-Y gastric bypass in patients with morbid obesity and gastro-oesophageal reflux disease: protocol for a non-inferiority randomise... by Jan A Apers, Martin Dunkelgrun, Ivonne Leeuwenburgh, Judith W H 't Hart, Bo J Noordman, Laser U Biter

“…The study results will be disseminated through peer-reviewed publications and conference presentations.Trial registration number NL9789; The Netherlands Trial Registry.…”
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Dose-volume parameter evaluation of a sub-fractionation workflow for adaptive radiotherapy of prostate cancer patients on a 1.5 T magnetic resonance imaging radiotherapy system by Georgios Tsekas, Cornel Zachiu, Gijsbert H. Bol, Jochem R.N. van der Voort van Zyp, Sandrine M.G. van de Pol, Johannes C.J. de Boer, Bas W. Raaymakers

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Productivity loss due to menstruation-related symptoms: a nationwide cross-sectional survey among 32 748 women by Mark E Schoep, Eddy M M Adang, Jacques W M Maas, Bianca De Bie, Johanna W M Aarts, Theodoor E Nieboer

“…Objective To evaluate age-dependent productivity loss caused by menstruation-related symptoms, measured in absenteeism (time away from work or school) and presenteeism (productivity loss while present at work or school).Methods Design/setting: internet-based, cross-sectional survey conducted in the Netherlands from July to October 2017.Participants: 32 748 women aged 15–45 years, recruited through social media.Outcome measures: self-reported lost productivity in days, divided into absenteeism and presenteeism; impact of menstrual symptoms; reasons women give when calling in sick; and women’s preferences regarding the implications of menstruation-related symptoms for schools and workplaces.Results A total of 13.8% (n=4514) of all women reported absenteeism during their menstrual periods with 3.4% (n=1108) reporting absenteeism every or almost every menstrual cycle. …”
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Association between incident falls and subsequent fractures in patients attending the fracture liaison service after an index fracture: a 3-year prospective observational cohort st... by Piet Geusens, Jacqueline R Center, Tuan V Nguyen, Thach Tran, Johanna Driessen, Joop P van den Bergh, John Eisman, Caroline E Wyers, Lisanne Vranken, Robert Y Van der Velde, Heinrich M J Janzing, Sjoerd Kaarsemakers, Dana Bliuc

“…Objectives To evaluate the risk of subsequent fractures in patients who attended the Fracture Liaison Service (FLS), with and without incident falls after the index fracture.Design A 3-year prospective observational cohort study.Setting An outpatient FLS in the Netherlands.Participants Patients aged 50+ years with a recent clinical fracture.Outcome measures Incident falls and subsequent fractures.Results The study included 488 patients (71.9% women, mean age: 64.6±8.6 years). …”
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Physical activity behaviour up to 1 year post-rehabilitation among adults with physical disabilities and/or chronic diseases: results of the prospective cohort study ReSpAct by Lucas H V van der Woude, Rienk Dekker, Trynke Hoekstra, Leonie A Krops, Femke Hoekstra, Florentina J Hettinga, Pim Brandenbarg, Bregje L Seves

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How patients and informal caregivers can be trained to effectively contribute to improved quality of healthcare services: action research on the development of the Dutch Patient As... by Carolin Sehlbach, Sjim Romme, Max Hermans, Matthijs Hugo Bosveld, Angela Plak, Marloes Amantia van Bokhoven

“…Patients and informal caregivers who participated as patient and partner educators in health professions education in the Netherlands could participate.Intervention Participants followed the Patient As a Person Academy, a 15-week training programme that aims to prepare patients and informal caregivers to become patient partners.Results Participants reported that the Patient As a Person Academy’s focus on self-management skills, understanding healthcare professionals’ perspectives and communication skills helped them to engage in meaningful dialogue with healthcare professionals as patient partners and made them more confident in their roles. …”
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Identification and characterization of Faecalibacterium prophages rich in diversity-generating retroelements by Anastasia Gulyaeva, Lei Liu, Sanzhima Garmaeva, Marloes Kruk, Rinse K. Weersma, Hermie J. M. Harmsen, Alexandra Zhernakova

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VIBE: an R-package for VIsualization of Bulk RNA Expression data for therapeutic targeting and disease stratification by Indu Khatri, Saskia D. van Asten, Leandro F. Moreno, Brandon W. Higgs, Christiaan Klijn, Christiaan Klijn, Francis Blokzijl, Iris C. R. M. Kolder

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Policy relevance of IPCC reports for the Sustainable Development Goals and beyond by Prajal Pradhan, Sushobhan Joshi, Kshitij Dahal, Yaunchao Hu, Daya Raj Subedi, Muhammad Panji Islam Fajar Putra, Shrijana Vaidya, Laxmi Prasad Pant, Shobhakar Dhakal, Klaus Hubacek, Maheswar Rupakheti, Debra C. Roberts, Bart van den Hurk

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The Carcinoma–Stromal Ratio of Colon Carcinoma Is an Independent Factor for Survival Compared to Lymph Node Status and Tumor Stage by Wilma E. Mesker, Jan M. C. Junggeburt, Karoly Szuhai, Pieter de Heer, Hans Morreau, Hans J. Tanke, Rob A. E. M. Tollenaar

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