OpenWFS—a library for conducting and simulating wavefront shaping experiments by Jeroen H Doornbos, Daniël W S Cox, Tom Knop, Harish Sasikumar, Ivo M Vellekoop

Get full text

Relating proton LETd to biological response of parotid and submandibular glands using PSMA-PET in clinical patients by Dirk Wagenaar, Vineet Mohan, Johannes A. Langendijk, Roel J.H.M. Steenbakkers, Wouter V. Vogel, Stefan Both

Get full text

PSMA PET/CT Identifies Intrapatient Variation in Salivary Gland Toxicity From Iodine-131 Therapy by Vineet Mohan MSc, Wouter V. Vogel MD, PhD, Gerlof D. Valk MD, PhD, Jan P. de Boer MD, PhD, Marnix G. E. H. Lam MD, PhD, Bart de Keizer MD, PhD

Get full text

Prevalence and determinants of persistent symptoms after infection with SARS-CoV-2: protocol for an observational cohort study (LongCOVID-study) by Lotte Haverman, Eelco Franz, Ka Yin Leung, Albert Jan Van Hoek, Hans Knoop, Cees C van den Wijngaard, Elizabeth N Mutubuki, Tessa van der Maaden, Albert Wong, Anna D Tulen, Siméon de Bruijn

“…Hence, in this study, we aim to determine the prevalence, severity, risk factors and impact on quality of life of persisting symptoms in the first year following acute SARS-CoV-2 infection.Methods and analysis The LongCOVID-study is both a prospective and retrospective cohort study being conducted in the Netherlands, with a one year follow-up. Participants aged 5 years and above, with self-reported positive or negative tests for SARS-CoV-2 will be included in the study. …”
Get full text

Can electronic monitoring with a digital smart spacer support personalised medication adherence and inhaler technique education in patients with asthma?: Protocol of the randomised... by Job F. M. van Boven, Boudewijn H.J. Dierick, Maria Achterbosch, Sandra Been-Buck, Titia Klemmeier, Susanne J. van de Hei, Paul Hagedoorn, Huib A.M. Kerstjens, Janwillem W.H. Kocks

“…Secondary outcomes are patient and healthcare provider satisfaction and exploratory clinical outcomes are adherence, inhaler technique, TAI score, FeNO, lung function, ACQ and WPAI.Ethics and dissemination Ethical approval was obtained from the RTPO in Leeuwarden, Netherlands (number: NL78361.099.21). Patients will provide written informed consent. …”
Get full text

Expanding the Scope of Microvascular Inflammation: Unveiling Its Presence Beyond Antibody-Mediated Rejection Into T-Cell Mediated Contexts by Hilal Varol, Hilal Varol, Anne Wagenmakers, Konrad Hoeft, Konrad Hoeft, Jasper Callemeyn, Jasper Callemeyn, Roos Bodewes, Wichor Bramer, Andrew Stubbs, Andrew Stubbs, Rafael Kramann, Rafael Kramann, Maarten Naesens, Maarten Naesens, Marian C. Clahsen-Van Groningen, Marian C. Clahsen-Van Groningen, Marian C. Clahsen-Van Groningen

Get full text

Cosmetic Outcome Assessment following Breast-Conserving Therapy: A Comparison between BCCT.core Software and Panel Evaluation by Max Hendrik Haloua, Nicole Marianna Alexandra Krekel, Gerrit Johannes Albertus Jacobs, Barbara Zonderhuis, Mark-Bram Bouman, Marlon Eugène Buncamper, Franciscus Bernardus Niessen, Henri Adolf Hubert Winters, Caroline Terwee, Sybren Meijer, Monique Petrousjka van den Tol

Get full text

Resting-state functional brain connectivity in female adolescents with first-onset anorexia nervosa by Katrien F.M. Bracké, Laura Monteiro Rente Dias, Marisha N. Meijer, Cathelijne P.M. Steegers, Laurinde F. den Heijer, Tess van der Harst, Marjolein H.G. Dremmen, Meike W. Vernooij, Gwen C. Dieleman, Tonya White

Get full text

Trifluridine-tipiracil in previously treated patients with oestrogen receptor-positive, HER2-negative metastatic breast cancer (BOOG 2019-01 TIBET trial): a single-arm, multicentre... by Niels A.D. Guchelaar, Ron H.J. Mathijssen, Maaike de Boer, Marlies L. van Bekkum, Joan B. Heijns, Birgit E.P.J. Vriens, Mandy M. van Rosmalen, Lonneke W. Kessels, Lisanne Hamming, Karin J. Beelen, Peter Nieboer, Susan M. van den Berg, Esther Oomen-de Hoop, Rhodé M. Bijlsma, Monique E.M.M. Bos

“…Methods: Adult patients at least 18 years old diagnosed with hormone receptor positive, HER2− receptor negative MBC with a performance status of 0 or 1 who have been treated with capecitabine in the metastatic setting and up to two other lines of chemotherapy, including a taxane, were enrolled in this single-arm, multicentre, phase 2 study in the Netherlands. The participants received trifluridine-tipiracil 35 mg/m2 orally twice a day on days 1–5 and days 8–12 during a 28-day cycle until disease progression, unacceptable toxicity, or withdrawal of consent. …”
Get full text

Association of blood inflammatory phenotypes and asthma burden in children with moderate-to-severe asthma by Amir Hossein Alizadeh Bahmani, Susanne J.H. Vijverberg, Simone Hashimoto, Christine Wolff, Catarina Almqvist, Lizan D. Bloemsma, Susanne Brandstetter, Paula Corcuera-Elosegui, Mario Gorenjak, Susanne Harner, Anna M. Hedman, Michael Kabesch, Leyre López-Fernández, Aletta D. Kraneveld, Anne H. Neerincx, Maria Pino-Yanes, Uroš Potočnik, Olaia Sardón-Prado, Barbara S. Dierdorp, Tamara Dekker, Nariman K.A. Metwally, Jan Willem Duitman, René Lutter, Paul Brinkman, Mahmoud I. Abdel-Aziz, Anke H. Maitland-van der Zee

Get full text

The HFA‐PEFF score identifies ‘early‐HFpEF’ phenogroups associated with distinct biomarker profiles by Michiel T.H.M. Henkens, Anne‐Mar vanOmmen, Sharon Remmelzwaal, Gideon B. Valstar, Ping Wang, Job A.J. Verdonschot, Mark R. Hazebroek, Leonard Hofstra, Vanessa P.M. vanEmpel, Joline W.J. Beulens, Hester M. denRuijter, Stephane R.B. Heymans

“…Methods and results Subjects referred to the Cardiology Centers of the Netherlands, location Utrecht, with non‐acute possibly cardiac‐related symptoms (such as dyspnoea or fatigue) were prospectively enrolled in the HELPFul cohort (N = 507) and were included in the current analysis. …”
Get full text

Bryostatin-1 enhances the proliferation and functionality of exhausted CD8+ T cells by upregulating MAP Kinase 11 by Ling Li, Manzhi Zhao, Marjan van Meurs, Inge Brouwers-Haspels, Renske J. H. den Dekker, Merel E. P. Wilmsen, Dwin G. B. Grashof, Harmen J. G. van de Werken, Shringar Rao, Casper Rokx, Yvonne M. Mueller, Peter D. Katsikis

Get full text

Prolonged Helium Postconditioning Protocols during Early Reperfusion Do Not Induce Cardioprotection in the Rat Heart In Vivo: Role of Inflammatory Cytokines by Gezina Tanya Mei Ling Oei, Hamid Aslami, Raphaela Priscilla Kerindongo, Renske Johanna Steenstra, Charlotte Jacqueline Peter Beurskens, Anita Maria Tuip-de Boer, Nicole Petra Juffermans, Markus Werner Hollmann, Benedikt Preckel, Nina Claudia Weber

Get full text

Addition of PARP1-inhibition enhances chemoradiotherapy and thermoradiotherapy when treating cervical cancer in an in vivo mouse model by Marloes IJff, Xionge Mei, Enzo M. Scutigliani, Hans M. Rodermond, Gregor G. W. van Bochove, Przemek M. Krawczyk, Nicolaas A. P. Franken, Lukas J. A. Stalpers, Johannes Crezee, Arlene L. Oei

Get full text

Potential Target Antigens for a Universal Vaccine in Epithelial Ovarian Cancer by Renee Vermeij, Toos Daemen, Geertruida H. de Bock, Pauline de Graeff, Ninke Leffers, Annechien Lambeck, Klaske A. ten Hoor, Harry Hollema, Ate G. J. van der Zee, Hans W. Nijman

Get full text

Effectiveness of ‘Tackle Your Tics’, a brief, intensive group-based exposure therapy programme for children with tic disorders: study protocol of a randomised controlled trial by Danielle Cath, Annet Heijerman-Holtgrefe, Chaim Huyser, Cara Verdellen, Jolande van de Griendt, Laura Beljaars, Kees-Jan Kan, Ramón Lindauer, Pieter Hoekstra, Lisbeth Utens

Get full text

Investigating the ROS Formation and Particle Behavior of Food-Grade Titanium Dioxide (E171) in the TIM-1 Dynamic Gastrointestinal Digestion Model by Nicolaj S. Bischoff, Anna K. Undas, Greet van Bemmel, Jacco J. Briedé, Simone G. van Breda, Jessica Verhoeven, Sanne Verbruggen, Koen Venema, Dick T. H. M. Sijm, Theo M. de Kok

Get full text

Land use intensity differently influences soil communities across a range of arable fields and grasslands by Chenguang Gao, Johanna E.M. Schild, Gabriel Y.K. Moinet, T. Martijn Bezemer, Franciska T. de Vries, Jan Hassink, Nick van Eekeren, Kevin Beentjes, Peter M. van Bodegom

Get full text

Turning green: the impact of changing to more eco-friendly respiratory healthcare – a carbon and cost analysis of Dutch prescription data by Evelyn A Brakema, johan Kooistra, Niels Chavannes, Paul Hagedoorn, Pieter ten Have, Peter van Hal, Iris Wichers, Pauline de Heer, Hans C Ossebaard

“…We estimated that this could be reduced by 70% which would lead to an annual reduction in greenhouse gas emission of 63 million kg.CO2 equivalents saving at best EUR 49.1 million per year.Conclusions In the Netherlands, substitution of pMDIs to NPIs for eligible patients is theoretically safe and in accordance with medical guidelines, while reducing greenhouse gas emission by 63 million kg.CO2 equivalents on average and saving at best EUR 49.1 million per year. …”
Get full text

Muscle contractile properties and perceived fatigue in the general and diseased population by Isa H. Mast, Neeltje A. E. Allard, Dominique tenHaaf, Anouk A. F. Stoffels, Lando Janssen, Hieronymus W. H. vanHees, Silvie Timmers, Bregina T. P. Hijmans‐Kersten, Maria T. E. Hopman, Laurien M. Buffart

Get full text