Alpha synuclein and inflammaging by Geneviève L. Putnam, Robert W. Maitta

Subjects: “…α-synuclein…”
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Novel Poly-Arginine Peptide R18D Reduces α-Synuclein Aggregation and Uptake of α-Synuclein Seeds in Cortical Neurons by Emma C. Robinson, Anastazja M. Gorecki, Samuel R. Pesce, Vaishali Bagda, Ryan S. Anderton, Bruno P. Meloni

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The effect of AKT inhibition in α-synuclein-dependent neurodegeneration by Bedri Ranxhi, Zoya R. Bangash, Zachary M. Chbihi, Sokol V. Todi, Sokol V. Todi, Peter A. LeWitt, Peter A. LeWitt, Peter A. LeWitt, Wei-Ling Tsou

Subjects: “…α-synuclein…”
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Spinal Cord Pathology in Alpha-Synuclein Transgenic Mice by Sonja Mendritzki, Saskia Schmidt, Teresa Sczepan, Xin-Ran Zhu, Daniel Segelcke, Hermann Lübbert

“…Accumulation of α-synuclein is observed in neurodegenerative diseases like Parkinson's disease and Multiple System Atrophy. …”
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The Contribution of α-Synuclein Spreading to Parkinson’s Disease Synaptopathy by Francesca Longhena, Gaia Faustini, Cristina Missale, Marina Pizzi, PierFranco Spano, Arianna Bellucci

“…In sporadic PD, the most common age-related neurodegenerative movement disorder, nigrostriatal dopaminergic deficits are responsible for the onset of motor symptoms that have been related to α-synuclein deposition at synaptic sites. Indeed, α-synuclein accumulation can impair synaptic dopamine release and induces the death of nigrostriatal neurons. …”
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Effects of Various Flavonoids on the α-Synuclein Fibrillation Process by Xiaoyun Meng, Larissa A. Munishkina, Anthony L. Fink, Vladimir N. Uversky

“…α-Synuclein aggregation and fibrillation are closely associated with the formation of Lewy bodies in neurons and are implicated in the causative pathogenesis of Parkinson's disease and other synucleinopathies. …”
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Motor cortical neuronal hyperexcitability associated with α-synuclein aggregation by Liqiang Chen, Hiba Douja Chehade, Hong-Yuan Chu

“…To begin to address this question, we injected α-synuclein (αSyn) preformed fibrils (PFFs) into the dorsolateral striatum of mice to seed αSyn pathology in the cortical cortex and induce degeneration of midbrain dopaminergic neurons. …”
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Interaction between 𝛼-Synuclein and Other Proteins in Neurodegenerative Disorders by Kurt A. Jellinger

“…The synergistic effects of α-synuclein, hyperphosphorylated tau, amyloid-β, and other pathologic proteins, and the underlying molecular pathogenic mechanisms, including induction and spread of protein aggregates, are critically reviewed, suggesting a dualism or triad of neurodegeneration in protein-misfolding disorders, although the etiology of most of these processes is still mysterious.…”
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Alpha synuclein overexpression can drive microbiome dysbiosis in mice by Timothy R. Sampson, Zachary D Wallen, Woong-Jai Won, David G. Standaert, Haydeh Payami, Ashley S. Harms

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Therapeutic Potential of α-Synuclein Evolvability for Autosomal Recessive Parkinson’s Disease by Jianshe Wei, Gilbert Ho, Yoshiki Takamatsu, Eliezer Masliah, Makoto Hashimoto

“…The majority of Parkinson’s disease (PD) is sporadic in elderly and is characterized by α-synuclein (αS) aggregation and other alterations involving mitochondria, ubiquitin-proteasome, and autophagy. …”
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Radiological markers of CSF α-synuclein aggregation in Parkinson’s disease patients by Amgad Droby, Avital Yoffe-Vasiliev, Daniel Atias, Kyle B. Fraser, Omar S. Mabrouk, Nurit Omer, Anat Bar-Shira, Mali Gana-Weisz, Orly Goldstein, Moran Artzi, Dafna Ben Bashat, Roy N. Alcalay, Avi Orr-Urtreger, Julia C. Shirvan, Jesse M. Cedarbaum, Nir Giladi, Anat Mirelman, Avner Thaler

“…Abstract Alpha-synuclein (αS) aggregation is a widely regarded hallmark of Parkinson’s disease (PD) and can be detected through synuclein amplification assays (SAA). …”
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Dementia in Parkinson's Disease Correlates with α-Synuclein Pathology but Not with Cortical Astrogliosis by Simone A. van den Berge, Josta T. Kevenaar, Jacqueline A. Sluijs, Elly M. Hol

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αSynuclein and Mitochondrial Dysfunction: A Pathogenic Partnership in Parkinson’s Disease? by David Protter, Charmaine Lang, Antony A. Cooper

“…Multiple potential mechanisms exist in which mitochondrial dysfunction and αSynuclein could interact to exacerbate their neurodegenerative properties. …”
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Lipidic folding pathway of α-Synuclein via a toxic oligomer by Vrinda Sant, Dirk Matthes, Hisham Mazal, Leif Antonschmidt, Franz Wieser, Kumar T. Movellan, Kai Xue, Evgeny Nimerovsky, Marianna Stampolaki, Magdeline Nathan, Dietmar Riedel, Stefan Becker, Vahid Sandoghdar, Bert L. de Groot, Christian Griesinger, Loren B. Andreas

“…By contrast, smaller pre-fibrillar α-Synuclein (αS) oligomers, crucial for initiating amyloidogenesis, remain largely uncharacterized. …”
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Postmortem Interval Influences α-Synuclein Expression in Parkinson Disease Brain by Alexandra Dumitriu, Carlee Moser, Tiffany C. Hadzi, Sally L. Williamson, Christopher D. Pacheco, Audrey E. Hendricks, Jeanne C. Latourelle, Jemma B. Wilk, Anita L. DeStefano, Richard H. Myers

“…Duplications and triplications of the α-synuclein (SNCA) gene increase risk for PD, suggesting increased expression levels of the gene to be associated with increased PD risk. …”
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Distinct subcellular localization of tau and alpha-synuclein in lewy body disease by D. Luke Fischer, Marissa Menard, Omar Z. Abdelaziz, Nicholas M. Kanaan, Virginia G. Cobbs, Richard E. Kennedy, Geidy E. Serrano, Thomas G. Beach, Laura A. Volpicelli-Daley

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Mitochondrial Dysfunction and α-Synuclein Synaptic Pathology in Parkinson’s Disease: Who’s on First? by Michela Zaltieri, Francesca Longhena, Marina Pizzi, Cristina Missale, PierFranco Spano, Arianna Bellucci

“…These are intraneuronal and intraneuritic proteinaceous insoluble aggregates whose main constituent is the synaptic protein α-synuclein. Compelling lines of evidence indicate that mitochondrial dysfunction and α-synuclein synaptic deposition may play a primary role in the onset of this disorder. …”
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Age-dependent alpha-synuclein aggregation and Lewy body formation in Parkinson’s disease by Chun Chau Sung, Kenny K. K. Chung

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Blood Plasma of Patients with Parkinson’s Disease Increases Alpha-Synuclein Aggregation and Neurotoxicity by Peng Wang, Xin Li, Xuran Li, Weiwei Yang, Shun Yu

“…This has been attributed to the spread of α-synuclein (α-syn) aggregates, which involves release of α-syn from a neuron and its reuptake by a neighboring neuron. …”
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Essential Oils May Lead α-Synuclein towards Toxic Fibrils Formation by Dina Morshedi, Mahour Nasouti

“…α-Synuclein (α-Syn) fibrillation links with Parkinson’s disease (PD) and several related syndromes. …”
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