Associations between Osteocalcin, Calciotropic Hormones, and Energy Metabolism in a Cohort of Chinese Postmenopausal Women: Peking Vertebral Fracture Study by Ruizhi Jiajue, Shuying Liu, Yu Pei, Xuan Qi, Yan Jiang, Qiuping Wang, Wenbo Wang, Xiran Wang, Wei Huang, Xin Zheng, Zhiwei Ning, Ou Wang, Mei Li, Xiaoping Xing, Wei Yu, Ling Xu, Weibo Xia

“…Further classifying the population based on the median value of OC and PTH, low OC and low PTH subgroup had the highest OR, 95% CI for diabetes (1.873, 1.287–2.737) and the lowest OR, 95% CI for hypercholesterolemia (0.472, 0.324–0.688) and for high LDL-C (0.538, 0.376–0.771). …”
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Hypertension Subtypes among Thai Hypertensives: An Analysis of Telehealth-Assisted Instrument in Home Blood Pressure Monitoring Nationwide Pilot Project by Sakolwat Montrivade, Pairoj Chattranukulchai, Sarawut Siwamogsatham, Yongkasem Vorasettakarnkij, Witthawat Naeowong, Patchaya Boonchayaanant, Anut Sakulsupsiri, Aekarach Ariyachaipanich, Vorarit Lertsuwunseri, Voravut Rungpradubvong, Sudarat Satitthummanid, Sarinya Puwanant, Somchai Prechawat, Suphot Srimahachota, Jarkarpun Chaipromprasit, Wacin Buddhari, Smonporn Boonyaratavej, Surapun Sitthisook, Peera Buranakitjaroen, Apichard Sukonthasarn, Somkiat Sangwatanaroj

“…In the medicated older subgroup (n = 487), uncontrolled HBP was more prevalent in male than in female (53.6% vs. 42.4%, p=0.013). …”
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Preoperative and intraoperative neuromonitoring and mapping techniques impact oncological and functional outcomes in supratentorial function-eloquent brain tumours: a systematic re... by Asfand Baig Mirza, Amisha Vastani, Rishabh Suvarna, Sami Rashed, Aws Al-Omari, Engelbert Mthunzi, Feras Fayez, Nicala Rampersad, Josephine Jung, Alba Díaz Baamonde, José Siado Mosquera, Ali Elhag, Francesco Marchi, Richard Gullan, Keyoumars Ashkan, Ranjeev Bhangoo, Francesco Vergani, Ana Mirallave-Pescador, José Pedro Lavrador

“…The main outcomes, assessed through a random-effects model and Cochran's Q-test for subgroup analysis. The study protocol is published on PROSPERO CRD42024512306. …”
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Genome-Wide Analysis, Characterization, and Expression Profile of the Basic Leucine Zipper Transcription Factor Family in Pineapple by Yanhui Liu, Mengnan Chai, Man Zhang, Qing He, Zhenxia Su, S. V. G. N. Priyadarshani, Liping Liu, Guanxi Dong, Yuan Qin

“…According to bioinformatics analysis of a phylogenetic tree, the bZIP gene family was divided into 11 subgroups in pineapple, Arabidopsis, and rice; gene structure and conserved motif analyses showed that bZIP genes within the same subgroup shared similar intron-exon organizations and motif composition. …”
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CD21low B cells reveal a unique glycosylation pattern with hypersialylation and hyperfucosylation by Peter Tobias Felixberger, Peter Tobias Felixberger, Geoffroy Andrieux, Andrea Maul-Pavicic, Andrea Maul-Pavicic, Sigune Goldacker, Sigune Goldacker, Ina Harder, Ina Harder, Sylvia Gutenberger, Sylvia Gutenberger, Jonathan J. M. Landry, Vladimir Benes, Till Fabian Jakob, Melanie Boerries, Melanie Boerries, Lars Nitschke, Reinhard Edmund Voll, Reinhard Edmund Voll, Klaus Warnatz, Klaus Warnatz, Baerbel Keller, Baerbel Keller

“…BackgroundThe posttranslational modification of cellular macromolecules by glycosylation is considered to contribute to disease pathogenesis in autoimmune and inflammatory conditions. In a subgroup of patients with common variable immunodeficiency (CVID), the occurrence of such complications is associated with an expansion of naïve-like CD21low B cells during a chronic type 1 immune activation. …”
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Association of tea consumption with all-cause/cardiovascular disease mortality in the chronic kidney disease population: an assessment of participation in the national cohort by Jin Li, Xing-Ling Chen, Xiao-Lu Ou-Yang, Xiao-Jiao Zhang, Yue Li, Shu-Ning Sun, Ling-Jun Wang, Zhong-Qi Yang, Shi-Hao Ni, Lu Lu

“…The substitution analysis explored the effects of replacing a specific type of tea with another type of tea. Subgroup analysis stratified by sex, age, body mass index (BMI), diabetes, cancer, cardiovascular disease (CVD), and urinary albumin. …”
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Evaluation of microRNAs as liquid biopsy markers in adrenocortical tumors by Chrysoula Mytareli, Vassiliki Kalotychou, Alexandros Lafioniatis, Gregory Kaltsas, George N. Zografos, Athina Markou, Labrini Papanastasiou, Athanasios Fountas, Dimitra Argyro Vasilliadi, Evanthia Kassi, Evanthia Kassi, Marina Mantzourani, Anna Angelousi

“…This study aims to validate the diagnostic performance of selected circulating microRNAs, (miR-483-5p, miR-210, miR-335 and miR-22-3p), identified through microRNA profiling studies, as markers of malignancy or cortisol hypersecretion in a cohort of patients with ATs.MethodsWe collected serum samples from 75 patients with ATs, including 50 cases of adrenocortical adenomas (ACA) and 25 cases of adrenocortical carcinomas (ACC), along with 15 controls. In the ACC subgroup, 16 samples were obtained preoperatively or upon detection of recurrence (active ACC group), while the remaining from disease-free patients with long-term follow-up. …”
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DMMR status and synchronous lesions predicts metachronous lesions after curative resection for rectal cancer by Xijie Chen, Xijie Chen, Xijie Chen, Junguo Chen, Junguo Chen, Junguo Chen, Liang Xu, Liang Xu, Dezheng Lin, Dezheng Lin, Dezheng Lin, Xiaoling Hong, Xiaoling Hong, Xiaoling Hong, Junsheng Peng, Junsheng Peng, Junsheng Peng, Xiaowen He, Xiaowen He, Xiaowen He, Jiancong Hu, Jiancong Hu, Jiancong Hu

“…Univariable and multivariable analysis showed dMMR status, synchronous adenomas/polyps, surveillance time > 3, and longer surveillance period patients were significant risk factors for development of metachronous lesions; in subgroup analysis, we also found that among rectal cancer patients with synchronous adenomas, adenomas located in the left colon and rectum, and longer surveillance period were independent risk factors for detecting metachronous adenomas.ConclusionsThis study underscored the importance of extended follow-up protocols and targeted surveillance for identifying and managing metachronous lesions in dMMR rectal cancer patients, especially with synchronous adenomas. …”
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Sepsis-Associated Acute Kidney Disease Incidence, Trajectory, and Outcomes by Hsiu-Yin Chiang, Chih-Chia Liang, Ya-Luan Hsiao, Uyen-Minh Le, Yi-Ching Chang, Pei-Shan Chen, David Ray Chang, I-Wen Ting, Hung-Chieh Yeh, Chin-Chi Kuo

“…Compared with the recovery subgroup, the 1-year mortality risk for the relapse, persistent, and unclassified SA-AKD subgroups were 1.57 (adjusted hazard ratios [aHRs]; 95% CI, 1.22-2.01), 1.36 (1.13-1.63), and 0.65 (0.48-0.89), respectively. …”
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Prevalence and Factors Associated with Drooling in Parkinson’s Disease: Results from a Longitudinal Prospective Cohort and Comparison with a Control Group by Diego Santos-García, Teresa de Deus Fonticoba, Carlos Cores Bartolomé, Maria J. Feal Painceiras, Maria Cristina Íñiguez-Alvarado, Silvia Jesús, Maria Teresa Buongiorno, Lluís Planellas, Marina Cosgaya, Juan García Caldentey, Nuria Caballol, Ines Legarda, Jorge Hernández Vara, Iria Cabo, Lydia López Manzanares, Isabel González Aramburu, Maria A. Ávila Rivera, Víctor Gómez Mayordomo, Víctor Nogueira, Víctor Puente, Julio Dotor García-Soto, Carmen Borrué, Berta Solano Vila, María Álvarez Sauco, Lydia Vela, Sonia Escalante, Esther Cubo, Francisco Carrillo Padilla, Juan C. Martínez Castrillo, Pilar Sánchez Alonso, Maria G. Alonso Losada, Nuria López Ariztegui, Itziar Gastón, Jaime Kulisevsky, Marta Blázquez Estrada, Manuel Seijo, Javier Rúiz Martínez, Caridad Valero, Mónica Kurtis, Oriol de Fábregues, Jessica González Ardura, Ruben Alonso Redondo, Carlos Ordás, Luis M. L. López Díaz, Darrian McAfee, Pablo Martinez-Martin, Pablo Mir, Study Group COPPADIS

“…Specifically, we identified factors associated with drooling and conducted subanalyses in a subgroup of very early PD patients. Patients and Methods. …”
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Perinatal mortality and other severe adverse outcomes following planned birth at 39 weeks versus expectant management in low-risk women: a population based cohort studyResearch in... by Kylie Crawford, Waldemar A. Carlo, Anthony Odibo, Aris Papageorghiou, William Tarnow-Mordi, Sailesh Kumar

“…Multivariable models were built to determine risks of adverse outcomes for planned birth compared to expectant management. Subgroup analyses according to parity and birthweight were also performed. …”
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Treatment-related Hypertension as a Prognostic Factor for De Novo Metastatic Hormone-sensitive Prostate Cancer: A Retrospective Real-world Evidence Study by Giuseppe Salfi, Martino Pedrani, Selin Candan, Vasile Urechie, Sara Merler, Lorenzo Ruinelli, Amos Colombo, Luis Castelo-Branco, Irene Testi, Fabio Turco, Luigi Tortola, Ursula Vogl, Luca Gabutti, Silke Gillessen, Ricardo Pereira Mestre

“…Key findings and limitations: In the overall population, grade (G) 2–3 HTN development within 7 mo from hormonal treatment initiation was associated with improved TTCR and OS at both univariate (TTCR: 19.8 vs 7.9 mo, hazard ratio [HR]: 0.35, 95% confidence interval [CI]: 0.20–0.63, p < 0.001; OS: 42 vs 18.4 mo, HR: 0.48, 95% CI: 0.26–0.87, p = 0.017) and multivariate (TTCR: HR: 0.41, 95% CI: 0.18–0.91, p = 0.029; OS: HR: 0.42, 95% CI: 0.18–0.97, p = 0.042) analyses. A subgroup analysis of the ADT + ARPI–treated population revealed 7-mo treatment-related G2–3 HTN to be an independent positive prognostic factor in terms of both TTCR and OS multivariate survival analyses (HR: 0.30, 95% CI: 0.09–0.95, p = 0.040, and HR: 0.12, 95% CI: 0.02–0.57, p = 0.008, respectively). …”
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A meta-analysis of program for the reduction of physical restraint use in intensive care units in China (国内ICU患者缩减身体约束行动实施效果的Meta分析) by CHEN Zetao (陈泽涛), LI Xiaobing (李晓彬), SHI Yu (石宇), ZHANG Yanfei (张雁飞), YANG Wencai (杨文才), SHAN Miaohang (单妙航)

“…Meta-analysis results indicated that the implementation of reduced physical restraint actions effectively reduced the rate of physical restraint use ［OR=2. 17, 95% CI(1. 86, 2. 53), P＜0. 01］, shortened the average duration of physical restraint ［MD=18. 81, 95% CI(10. 32, 27. 29), P＜0. 01］, decreased the incidence of unplanned extubation ［OR=2. 42, 95% CI(1. 65, 3. 56), P＜0. 01］, and reduced the incidence of restraint-related complications ［OR=3. 76, 95% CI(2. 78, 5. 09), P＜0. 01］. Subgroup analysis results showed that collaboration between medical and nursing staff could further reduce the rate of physical restraint use (χ²=13. 989, P＜0. 01). …”
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25 años de cirugía de Ross: seguimiento y resultados en pacientes reoperados en nuestro centro by Consuelo M. Sisinni-Ganly, Julio C. Lugo-Adán, Francisco Estévez-Cid, Rocío Casais-Pampín, Juan J. Legarra-Calderón

“…We retrospectively reviewed data from a subgroup of patients who underwent reintervention after Ross surgery due to dysfunction of the autograft or homograft. …”
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Interventional Effect and Mechanism of Acupuncture at Baihui （GV 20） and Qubin （GB 7） Acupoints on Rats with Acute Cerebral Hemorrhage by CHEN Qiuxin, TANG Yihe, LIU Xiaoying, XU Ning, XU Siyu

“…ObjectiveTo investigate the interventional effect of acupuncture at Baihui (GV 20) and Qubin (GB 7) acupoints on the expression of recombinant cluster of differentiation 36 (CD36) and Toll-like receptor 4 (TLR4) in rats with acute cerebral hemorrhage (ICH), and to explore the mechanism of acupuncture treatment for ICH.MethodsA total of 144 male Wistar rats were randomly divided into sham operation group, model group, acupuncture group and inhibitor group, with 36 cases in each group, and then each group was divided into three subgroups at the 1st, 3rd and 7th day, with 12 cases in each subgroup. …”
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Diagnostic Accuracy of Detective Flow Imaging Endoscopic Ultrasonography for Evaluating Blood Flow Within Mural Nodules of Intraductal Papillary Mucinous Neoplasms by Kazuki Endo, Haruo Miwa, Kazuya Sugimori, Kozue Shibasaki, Shoichiro Yonei, Yugo Ishino, Shotaro Tsunoda, Hayato Yoshimura, Akihiro Funaoka, Hiromi Tsuchiya, Ritsuko Oishi, Yuichi Suzuki, Satoshi Komiyama, Takashi Kaneko, Manabu Morimoto, Kazushi Numata, Shin Maeda

“…Inter-reader agreement was substantial (kappa values, 0.6–0.8). The subgroup analysis revealed that all MNs ≥ 10 mm had detectable blood flow on DFI-EUS, whereas MNs < 10 mm had reduced detection rates (75%; 12/16 cases). …”
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Evaluation of the diagnostic efficiency of fluorescence in situ hybridization for pulmonary tuberculosis: a systematic review and meta-analysis by Yu-Qi Hu, Yu-Qi Hu, Kang Liu, Kang Liu, Le-Qing Lai, Le-Qing Lai, Yi-Ru He, Yi-Ru He, Li-Ping Hong, Li-Ping Hong, Chu-Qian Jiang, Chu-Qian Jiang, Si-Min Liu, Si-Min Liu, Ming-Zhu Cao

“…The combined FISH sensitivity and specificity were 0.89 (95% CI 0.86–0.92) and 0.98 (95% CI 0.97–0.99), respectively. Furthermore, subgroup analysis was performed based on probes and PTB incidence.ConclusionFISH may be useful in the diagnosis of pulmonary tuberculosis. …”
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Decreased risk of cardiovascular disease mortality associated with occasional positive screens following cancer screenings by Yuting Ji, Yu Zhang, Hongyuan Duan, Xiaomin Liu, Yunmeng Zhang, Zhuowei Feng, Jingjing Li, Zeyu Fan, Ya Liu, Yacong Zhang, Lei Yang, Zhangyan Lyu, Fangfang Song, Fengju Song, Hua Li, Yubei Huang

“…Sensitivity analyses excluding screening-detected cancers showed similar association in the overall population [0.933 (0.897–0.970)], as well as in both subgroups with [0.945 (0.898–0.995)] and without previous CVD [0.919 (0.865–0.976)]. …”
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Beyond Dermatological Findings: Multisystem Involvement in Prolidase Deficiency by Ezgi Yalcin Gungoren, Zeynep Meric, Asena Pinar Sefer, Asuman Deveci Ozkan, Salim Can, Royala Babayeva, Nurhan Kasap, Ercan Nain, Esra Ozek Yucel, Ayca Kiykim, Sevgi Bilgic-Eltan, Ayse Deniz Yucelten, Elif Karakoc-Aydiner, Ahmet Ozen, Safa Baris

“…Two patients had elevated IgE levels. Lymphocyte subgroup analysis showed an inverted CD4/CD8 ratio in all patients. …”
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Assessment of platelet-to-white blood cell ratio on short-term mortality events in patients hospitalized with acute decompensated heart failure: evidence from a cohort study from J... by Xin Huang, Xin Huang, Xin Huang, Xin Huang, Maobin Kuang, Maobin Kuang, Maobin Kuang, Maobin Kuang, Jiajun Qiu, Jiajun Qiu, Jiajun Qiu, Jiajun Qiu, Chao Wang, Chao Wang, Chao Wang, Chao Wang, Guotai Sheng, Guotai Sheng, Yang Zou, Guobo Xie

“…Additionally, the results of receiver operating characteristic curve analysis indicated that PWR had high predictive accuracy for mortality events within 30 days of hospitalization in ADHF patients and is significantly better than the traditional HF marker N-Terminal Pro-Brain Natriuretic Peptide (AUC: NT-proBNP 0.69, PWR 0.76; Delong test P &lt; 0.05). Subgroup analysis showed that compared to subjects with reduced or moderately reduced ejection fraction, ADHF patients with preserved ejection fraction had a lower risk of short-term mortality associated with PWR (HR:0.99 vs. 0.98 vs. 0.87, P for interaction = 0.0067).ConclusionThis study reveals, for the first time, a negative correlation between the inflammatory marker PWR and all-cause mortality within 30 days of hospitalization in ADHF patients. …”
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