Lung transplant outcomes for recipients with alpha-1 antitrypsin deficiency, by use of alpha-1 antitrypsin augmentation therapy by Atharv V. Oak, MEng, Jessica M. Ruck, MD, PhD, Alfred J. Casillan, MD, PhD, Armaan F. Akbar, BS, Ramon A. Riojas, MD, PhD, Pali D. Shah, MD, Jinny S. Ha, MD, MHS, Sara Strout, PharmD, Allan B. Massie, PhD, Dorry L. Segev, MD, PhD, Christian A. Merlo, MD, MPH, Errol L. Bush, MD

“…Post-LT augmentation therapy use was associated with a mortality reduction in the top quartile bilirubin subgroup (p = 0.02, log-rank test). Conclusions: In our study, the use of augmentation therapy post-LT was associated with improved survival. …”
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Intravascular Imaging-Guided Percutaneous Coronary Intervention in Patients With End-Stage Renal Disease on Maintenance Dialysis by Chia-Pin Lin, MD, Fu-Chih Hsiao, MD, Ying-Chang Tung, MD, Tzyy-Jer Hsu, MD, Shing-Hsien Chou, MD, Yu-Sheng Lin, MD, Shao-Wei Chen, MD, PhD, Pao-Hsien Chu, MD

“…The results were similar for all components of the primary outcome and in subgroup analyses. Conclusions: The number of PCI- and IVI-guided procedures has progressively increased in the past decade in Taiwan in both the general and ESRD populations. …”
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Neural structural alterations correlates of quadriceps muscle strength deficits in patients after anterior cruciate ligament reconstruction by Le Yu, Shanshan Zheng, Yushi Chen, Xiao'ao Xue, Zikun Wang, JiaYan Cheng, Yang Sun, He Wang, Yinghui Hua

“…Results: Lower limb symmetry index (LSI) of quadriceps muscle strength was associated with a higher ratio of radial diffusivity (RD, r = −0.379, p = 0.042) in corticospinal tracts of the injured hemisphere to those of the non-injured hemisphere in ACLR patients after controlling for age, BMI, Tegner activity score and graft type. In subgroup analyses of ACLR patients with hamstring autografts, we found that higher injured quadriceps muscle strength was associated with higher axial diffusivity (AD, r = 0.616, p = 0.033) of CST structure and lower LSI of quadriceps muscle strength was associated with higher ratio of mean diffusivity (MD, r = −0.682, p = 0.014) and RD (r = −0.759, p = 0.004) in corticospinal tracts of the injured hemisphere to those of the non-injured hemisphere in ACLR patients after controlling for age, BMI, Tegner activity score. …”
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Structure-Function Relationship between Cluster Mean Defect and Sector Peripapillary Retinal Nerve Fiber Layer Thickness in Primary Open Angle Glaucoma by Jing Han, Wenjiu Yang, Dabo Wang, Haiqing Bai

“…Spearman analysis was used to investigate the correlation between cluster MDs provided by Octopus perimeter and corresponding sector pRNFLT for the total sample and each subgroup, respectively. Then, linear (y = a+ bx) and curvilinear (quadratic, y = a+bx + cx2) regression analyses were employed to investigate the model for the cluster MD-sector pRNFLT pair with significant correlation. …”
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Effectiveness of Different Intervention Modes in Lifestyle Intervention for the Prevention of Type 2 Diabetes and the Reversion to Normoglycemia in Adults With Prediabetes: Systema... by Yachen Wang, Xin Chai, Yueqing Wang, Xuejun Yin, Xinying Huang, Qiuhong Gong, Juan Zhang, Ruitai Shao, Guangwei Li

“…The I² statistic was used to assess heterogeneity across the RCTs. We performed a subgroup analysis to explore the effectiveness of digital health, face-to-face, and blended interventions compared with the control group, which received usual care. …”
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Efficacy and safety of PD-1/PD-L1 inhibitors in advanced or recurrent endometrial cancer: a meta-analysis with trial sequential analysis of randomized controlled trials by Ji Ren, Jinghe Wang, Yanan Wang, Dongying Yang, Jianming Sheng, Shili Zhu, Yunli Liu, Xiaoqi Li, Wei Liu, Binbin Zhang

“…The combination of PD-1/PD-L1 inhibitors with CT significantly improved PFS (HR = 0.617, 95% CI: 0.506-0.752; 95% PI: 0.334-1.140) and OS (HR = 0.774, 95% CI: 0.664-0.902; 95% PI: 0.553-1.083) compared to CT alone (or plus placebo) in the overall population. Subgroup analysis based on mismatch repair (MMR) status revealed pronounced benefits in PFS and OS for patients with deficient MMR (dMMR) (PFS: HR = 0.344, 95% CI: 0.269-0.438; 95% PI: 0.231-0.510; OS: HR = 0.371, 95% CI: 0.245-0.562; 95% PI: 0.025-5.461) compared to those with proficient MMR (pMMR) (PFS: HR = 0.772, 95% CI: 0.627-0.950; 95% PI: 0.394-1.512; OS: HR = 0.996, 95% CI: 0.692-1.435; 95% PI: 0.021-47.662). …”
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Prognostic Impact of Adjuvant Immunotherapy in Patients With Resectable NSCLC After Neoadjuvant Chemoimmunotherapy: A Brief Report by Yichen Dong, MD, Long Xu, MD, Jialiang Wen, MD, Haojie Si, MD, Juemin Yu, MD, Tao Chen, MD, Huikang Xie, MD, Xinjian Li, MD, Minglei Yang, MD, Junqiang Fan, MD, Junqi Wu, MD, Yunlang She, MD, Deping Zhao, MD, Chang Chen, MD, PhD

“…Unstratified Cox proportional hazards models were fitted to the subgroups. Results: In this multi-center cohort, 29.7% of patients (n = 130) achieved a pathologic complete response. …”
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Effectiveness and safety of PD-1/L1 inhibitors as first-line therapy for patients with advanced or metastatic urothelial carcinoma who are ineligible for platinum-based chemotherap... by Weiming Liang, Weiming Liang, Zhijing Wang, Zhilong Huang, Yanping Huang, Chunyan Li, Yiwen Liang, Miaoyan Huang, Duo Zhang, Chenchen Li

“…The median PFS and OS were 4.5 months and 13.7 months, respectively. Subgroup analysis showed that PD-1/L1 inhibitors monotherapy had an ORR rate of 0.25 (95% CI, 0.21 to 0.29) and a DCR rate of 0.50(95% CI, 0.44 to 0.56), while PD-1/L1 dual immunotherapy had a better ORR rate of 0.33 (95% CI, 0.15 to 0.52) and a DCR rate of 0.65 (95% CI, 0.49 to 0.80). …”
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Large language models for pretreatment education in pediatric radiation oncology: A comparative evaluation study by Dominik Wawrzuta, Aleksandra Napieralska, Katarzyna Ludwikowska, Laimonas Jaruševičius, Anastasija Trofimoviča-Krasnorucka, Gints Rausis, Agata Szulc, Katarzyna Pędziwiatr, Kateřina Poláchová, Justyna Klejdysz, Marzanna Chojnacka

“…We aimed to evaluate the responses provided by generative pre-trained transformers (GPT), the most popular subgroup of LLMs, to questions about pediatric radiation oncology. …”
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Clinical Characteristics and Treatment Options of Peripheral Spondyloarthritis by ZENG Lulu, JI Xiaojian, HU Lidong, HU Jiawen, ZHANG Yinan, ZHANG Jiaxin, LIU Xingkang, YANG Shiwei, HUANG Feng

“…Compared to axSpA patients, pSpA1 patients(excluding psoriatic arthritis) did not show significant differences in the prevalence of psoriasis, uveitis, family history of psoriasis, or the use of bDMARDs, but the subgroup analysis of other variables was consistent with the results of pSpA patients.ConclusionspSpA patients tend to have a later onset of disease, a lower proportion of male and HLA-B27 positivity, more associated peripheral arthritis, dactylitis, psoriasis, and a more common family history of psoriasis. …”
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The AEDUCATE Collaboration. Comprehensive antenatal education birth preparation programmes to reduce the rates of caesarean section in nulliparous women. Protocol for an individual... by Soo Downe, Lisa Askie, Sarah J Lord, Hannah G Dahlen, Kenneth William Finlayson, Anna Lene Seidler, Federico Girosi, Kylie Elizabeth Hunter, Kate M Levett, Mary-Ann Davey, Caroline A Smith, Julie Fleet, Mary Steen, Elizabeth Newnham, Anette Werner, Leslie Arnott, Kerry Sutcliffe

“…The intervention could occur in a hospital-based or community setting.Comparator: standard care alone in hospital-based maternity units.Outcomes Primary: CS.Secondary: epidural analgesia, mode of birth, perineal trauma, postpartum haemorrhage, newborn resuscitation, psychosocial well-being.Subgroup analysis: parity, model of care, maternal risk status, maternal education, maternal socio-economic status, intervention components.Study design An individual participant data (IPD) prospective meta-analysis (PMA) of randomised controlled trials, including cluster design. …”
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Association between Atopic Dermatitis and Dementia: Evidence from Systematic Review, Meta-analysis, and Mendelian Randomization by Yeon-Su Gwak, Seo-Yeon Kim, Chae-Eon Woo, Kihyuk Shin, Eunjeong Son, Jin-Woo Kim, Sung-Jin Kim, Tae-Jin Song, Hae Ryoun Park, Kihun Kim, Dai Sik Ko, Yun Hak Kim

“…In the systematic review and meta-analysis, 5 longitudinal cohort studies (12,576,235 participants) indicated a significant association between atopic dermatitis and all-cause dementia (adjusted hazard ratio: 1.15, 95% CI: 1.07–1.23). Subgroup analyses revealed an adjusted hazard ratio of 1.18 (95% CI: 1.08–1.27) for Alzheimer’s disease in patients with atopic dermatitis, and an adjusted hazard ratio of 1.37 (95% CI: 1.21–1.55) for all-cause dementia in patients with moderate-to-severe atopic dermatitis. …”
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Decreased sirtuin 1 in type 2 diabetes patients with abnormal BMD by Yao Xu, Tianxiao Hu, Peiwu Jiang, Xiujing Wang, Jiaqi Yao, Huiling Shen, Zhenying Zhang, Bojing Zheng, Ting Wang, Yanxia Ren, Jing Wang, Qingying Tan

“…Osteoporosis incidence was higher in T2DM subjects compared to controls (34.8% vs. 18.3%, P = 0.026). Subgroup analysis revealed that SIRT1 levels in T2DM patients with osteoporosis or osteopenia exhibited a significant reduction compared to those with normal BMD (P < 0.05). …”
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Episiotomies and obstetric anal sphincter injuries following a restrictive episiotomy policy in France: An analysis of the 2010, 2016, and 2021 National Perinatal Surveys. by Raphaele Houlbracq, Camille Le Ray, Béatrice Blondel, Nathalie Lelong, Anne Alice Chantry, Thomas Desplanches, ENP2021 Study Group

“…These results should be interpreted with caution given the low prevalence of OASI in some subgroups. Further research is needed to predict the optimal rate of episiotomy for instrumental deliveries. …”
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Trends in incidence and mortality of chronic obstructive pulmonary disease among residents of Xiamen city from 2012 to 2022: analysis of hospital records and death registration dat... by Youlan CHEN, Ahua WU, Moliang CHEN, Yilan LIN, Yanqi LAN, Qun LOU, Zhinan GUO

“…During the study period, the annual crude mortality rates (1/100 000) for COPD were 14.47, 16.19, 19.77, 24.66, 30.42, 33.05, 36.30, 38.39, 34.08, 40.37, and 45. 37 and the annual standardized mortality rates (1/100 000) of COPD were 14.74, 16.46, 19.07, 22.79, 28.23, 31.87, 35.16, 36.33, 30.75, 37.70, and 41.39, respectively; both the crude mortality rate (AAPC = 12.20%, t = 7.6, P < 0. 001) and the standardized mortality rate (AAPC = 10.60%, t = 5.7, P < 0.001) showed a significant increasing trend; further subgroup analysis showed that the increasing trend of the crude COPD mortality rate was significant for male and female residents and for residents aged 60 – 69, 70 – 79, and ≥ 80 years (all P < 0.05), and the increasing trend of standardized COPD mortality rate was significant for both male and female residents (both P < 0.05). …”
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3D synergistic tumor-liver analysis further improves the efficacy prediction in hepatocellular carcinoma: a multi-center study by Yurong Jiang, Jiawei Zhang, Zhaochen Liu, Jinxiong Zhang, Xiangrong Yu, Danyan Lin, Dandan Dong, Mingyue Cai, Chongyang Duan, Shuyi Liu, Wenhui Wang, Yuan Chen, Qiyang Li, Weiguo Xu, Meiyan Huang, Sirui Fu

“…Their discrimination and calibration were compared to determine the optimal model. Subgroup analysis was conducted to test the robustness, and survival analysis was conducted to identify high- and low-risk populations. …”
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Effects of exercise interventions on fatigue of hematopoietic stem cell transplantation patients: A Meta-analysis (运动干预对造血干细胞移植患者疲乏影响的Meta分析)... by ZHOU Min (周敏), ZHANG Qing (张清), HU Shaoyan (胡绍燕), ZHOU Xuemei (周雪梅)

“…Results A total of six studies were included, and the results of meta-analysis showed a statistically significant difference in fatigue scores between the experimental and control groups ［SMD= -0. 24, 95% CI (-0. 44, -0. 03), P<0. 001］; subgroup analysis showed that exercise intervention improved fatigue in HSCT patients ［SMD= -0. 58, 95% CI (-0. 80, -0. 35), P<0. 001］; exercise interventions throughout the transplant period ［SMD= -0. 58, 95% CI (-0. 80, -0. 35), P<0. 001］, and duration longer than 12 weeks ［SMD= -0. 53, 95% CI (-0. 78, -0. 29), P<0. 001］ can reduce fatigue. …”
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Association of handgrip strength asymmetry and weakness with intrinsic capacity impairment among older adults in China by Decheng Li, Yunhe Wang, Shuai Guo, Ziyang Ren, Binbin Su, Lichuan Zhang, Zuliyaer Talifu, Xiaoying Zheng

“…Notably, participants experiencing both HGS asymmetry and weakness were at even higher risk of IC impairment (OR = 2.47, 95 % CI: 1.99–3.08), suggesting compounded effects on IC. Further subgroup analysis showed significant associations between HGS status and impairments in specific IC domains, particularly in locomotion. …”
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Impact of Obesity on Short-Term Outcomes in Patients Undergoing Retroperitoneal Laparoscopic/Retroperitoneoscopic Adrenalectomy for Benign or Malignant Adrenal Diseases: A Meta-Ana... by Maurizio Zizzo, Andrea Morini, Magda Zanelli, Chiara Grasselli, Francesca Sanguedolce, Sze Ling Wong, Munyaradzi G. Nyandoro, Andrea Palicelli, Giuseppe Broggi, Nektarios I. Koufopoulos, Lucia Mangone, Angelo Cormio, Rosario Caltabiano, Antonino Neri, Massimiliano Fabozzi

“…By comparing the Ob and NOb groups, shorter operative time and lower overall postoperative complication rates in the NOb population were recorded through the meta-analysis. Considering the subgroup analysis (BMI ≥ 30 kg/m²), just the operative time maintained statistical significance. …”
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Sox6 and ALDH1A1 Truncation by Asparagine Endopeptidase Defines Selective Neuronal Vulnerability in Parkinson's Disease by Shuke Nie, Bowei Li, Mengmeng Wang, Zijun Chen, Jiayan Ren, Zixuan Li, Xinli Xu, Zhengjiang Qian, Zhongyun Xie, Jianxin Han, Zhentao Zhang, Zhaohui Zhang, Yingjie Zhu, Zuxin Chen, Xifei Yang, Keqiang Ye

“…Here, it is shown that Legumain, also known as asparagine endopeptidase (AEP), is activated in a subgroup of SRY‐box transcription factor 6 /Aldehyde dehydrogenase 1 family member A1, (Sox6+/ALDH1A1+) neurons in the ventral tier of the SNpc and cleaves Sox6 and ALDH1A1, leading to repression of Special AT‐rich sequence binding protein 1 (Satb1) that is a dimeric/tetrameric transcription factor specifically binding to AT‐rich DNA sequences, and toxic dopamine metabolite accumulation. …”
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