Weight Loss Patterns and Outcomes Over 12 Months on a Commercial Weight Management Program (CSIRO Total Wellbeing Diet Online): Large-Community Cohort Evaluation Study by Gilly A Hendrie, Danielle L Baird, Genevieve James-Martin, Emily Brindal, Paige G Brooker

“…This group had an average weight loss of 10.6 kg at 12 months (11.9% of their starting body weight). In a subgroup of participants who consistently lost weight over the 12-month period (284/6602, 4.3% of the sample), weight loss reached up to 22.3 kg (21.7% of their starting body weight). …”
Get full text

Serum neuritin as a predictive biomarker of early neurological deterioration and poor prognosis after spontaneous intracerebral hemorrhage: a prospective cohort study by Yanwen Xu, Hanyu Zhu, Yuqi Su, Zhizhi Chen, Chuanliu Wang, Ming Yang, Feifei Jiang, Yunping Li, Yongming Xu

“…The levels were independently related to GCS scores and hematoma volume. In subgroup analyses, the levels showed a linear relationship with the likelihood of experiencing END and poor prognosis at the 90-day mark after ICH. …”
Get full text

Meta-analysis on the chronic effects of exercise on depression in older adults by Melanie Mack, Claudia Voelcker-Rehage, Pinelopi S. Stavrinou, Iuliia Pavlova, Yaël Netz, Burcu Kömürcü Akik, Antonia Kaltsatou, Sandra Haider, Christoforos D. Giannaki, Arzu Erden, Andreea Badache, Michel Audiffren

“…The moderating effects of intervention and individual characteristics were investigated by subgroup-analyses and meta-regression. Publication bias was addressed through sensitivity analyses. …”
Get full text

Therapeutic potential of short-chain fatty acids for acute lung injury: a systematic review and meta-analysis of preclinical animal studies by Liying Xie, Linyan Wang, Yongxin Liao, Miaoen Yao, Miaoen Yao, Miaoen Yao, Tong Mai, Rongrong Fan, Rongrong Fan, Rongrong Fan, Yun Han, Yun Han, Yun Han, Gengbiao Zhou, Gengbiao Zhou, Gengbiao Zhou

“…The results indicated that the SCFAs significantly reduced lung wet-to-dry weight (SMD = −2.75, 95% CI = −3.46 to −2.03, p < 0.00001), lung injury scores (SMD = −5.07, 95% CI = −6.25 to −3.89, p < 0.00001), myeloperoxidase (SMD = −3.37, 95% CI = −4.05 to −2.70, p < 0.00001), tumor necrosis factor-alpha (SMD = −3.31, 95% CI = −4.45 to −2.16, p < 0.00001) and malondialdehyde (SMD = −3.91, 95% CI = −5.37 to −2.44, p < 0.00001) levels in animal models of ALI. The results of the subgroup analysis indicated that the efficacy of SCFAs varies significantly with dosage and duration of treatment.ConclusionSCFAs can reduce inflammation and oxidative stress in animal models of ALI. …”
Get full text

Genome-Wide Comprehensive Identification and In Silico Characterization of Lectin Receptor-Like Kinase Gene Family in Barley (Hordeum vulgare L.) by Fee Faysal Ahmed, Farah Sumaiya Dola, Md Shohel Ul Islam, Fatema Tuz Zohra, Nasrin Akter, Shaikh Mizanur Rahman, Md. Abdur Rauf Sarkar

“…Lectin receptor-like kinases (LecRLKs) are a significant subgroup of the receptor-like kinases (RLKs) protein family. …”
Get full text

Exploring the benefits and prescribing informations of combining East Asian herbal medicine with conventional medicine in the treatment of rheumatoid arthritis: A systematic review... by Hee-Geun Jo, Jihye Seo, Eunhye Baek, Donghun Lee

“…These patterns were consistent across eight secondary outcomes measuring pain, inflammation, and disease activity in RA. Subgroup analyses showed that EACM's effects were independent of the control CM type. …”
Get full text

Enhancing soil quality in soybean cultivation: Mycorrhizal technology combined with intercropping under high cadmium stress by Xiaohui Wang, Xiaoxu Fan, Wei Chang, Kun Li, Mengmeng Zhang, Gaozhong Pu, Alexander.V. Kurakov, Yuan Ping, Fuqiang Song

“…The combined treatment also enhanced soil enzyme activity by regulating the relative abundance of dominant or key genera such as Subgroup_6, Rokubacteriales and Pseudarthrobacter. …”
Get full text

A deep learning model for carotid plaques detection based on CTA images: a two stepwise early-stage clinical validation study by Zhongping Guo, Ying Liu, Jingxu Xu, Chencui Huang, Fandong Zhang, Chongchang Miao, Yonggang Zhang, Mengshuang Li, Hangsheng Shan, Yan Gu

“…The DL model based on CTA images showed good precision in plaque diagnosis (validation set: precision = 80.49%, sensitivity = 90.70%, recall = 84.62%; test set: precision = 78.37%, sensitivity = 91.86%, recall = 84.58%). In addition, subgroup analysis of the plaque was carried out in the test set. …”
Get full text

Longitudinal exploration of cancer-related cognitive impairment in patients with newly diagnosed aggressive lymphoma: protocol for a feasibility study by Vincent Dore, Christopher C Rowe, Meinir Krishnasamy, Haryana Dhillon, Adam K Walker, Karla Gough, Priscilla Gates, Carlene Wilson, Eliza Hawkes, Yuliya Perchyonok, Janette L Vardy, Michiel de Ruiter

“…For some patients, their cognitive impairment may be transient, but for a subgroup, these symptoms can be long-standing and have a major impact on the quality of life. …”
Get full text

Associations of Retinal Microvascular Density and Fractal Dimension with Glaucoma: A Prospective Study from UK Biobank by Qi Chen, MD, Suyu Miao, MD, Yuzhe Jiang, MD, Danli Shi, MD, PhD, Weiyun You, MD, Lin Liu, MD, PhD, Mayinuer Yusufu, MTI, Yufan Chen, MD, Ruobing Wang, MD, PhD

“…In the Cox proportional hazards regression model post-PSM, we found that incident glaucoma has significant negative associations with arteriolar VSD (hazard ratio [HR] = 0.24, 95% confidence interval [CI] 0.11–0.52, P < 0.001), venular VSD (HR = 0.34, 95% CI 0.15–0.74, P = 0.007), arteriolar FD (HR = 0.24, 95% CI 0.10–0.60, P = 0.002), and venular FD (HR = 0.31, 95% CI 0.12–0.85, P = 0.022). Subgroup analysis using covariates revealed that individuals aged ≥60 years, nonsmokers, moderate alcohol consumers, and those with hypertension and myopia exhibited P values <0.05 consistently prematching and postmatching, differing from other subgroups within this covariate. …”
Get full text

Can exercise as a complementary technique manage inflammatory markers in women with breast cancer who are overweight and obese? A systematic review and meta-analysis by Liang Tan, Jinyu Mei, Ruihong Tang, Duo Huang, Kai Qi, Zbigniew Ossowski, Xiaoning Wang

“…Exercise significantly reduced C-reactive protein (CRP) (MD: −0.52, 95 % CI: −0.94 to −0.11; p = 0.01; heterogeneity p < 0.1), interleukin-6 (IL-6) (MD: −0.87, 95 % CI: −1.62 to −0.11; p = 0.02; heterogeneity p < 0.1), and leptin (MD: −0.92, 95 % CI: −1.71 to −0.13; p = 0.02; heterogeneity p < 0.1) levels and exercise significantly increased adiponectin levels (MD: 0.89, 95 % CI: 0.03–1.75, p = 0.04; heterogeneity p < 0.1) but had no effect on tumor necrosis factor-α (TNF-α) (MD: −0.26, 95 % CI: −0.82–0.29; p = 0.35; heterogeneity p < 0.1) and IL-10 (MD: 0.14, 95 % CI: −0.17–0.45; p = 0.37; heterogeneity p = 0.45) were not significant. In addition, subgroup analyses suggest that combination training (CE) may be the most recommended type of exercise to decrease pro-inflammatory markers, and increase anti-inflammatory markers in women with overweight obesity, and have breast cancer. …”
Get full text

Dual-positive gastric cancer: an extremely malignant subtype of gastric cancer with high serum alpha-fetoprotein and carcinoembryonic antigen concentrations by Weixun Xie, Chengyu Hu, Hongming Liu, Zelai Wu, Bixian Luo, Xiaoying Wu, Xiaoying Wu, Chuanlei Tuo, Ziyin Deng, Han Liang, Yong Liu, Weihua Gong, Weihua Gong

“…Finally, the treatment responses of this group to different treatment modalities were also reviewed.ResultsApproximately 45% of gastric cancer patients with elevated serum AFP also show increased CEA levels, classifying them as the dual-positive gastric cancer (DPGC) subgroup. These patients exhibit significantly shorter overall survival, heightened metastasis risk, and are more susceptible to systemic inflammation, immune response dysregulation, malnutrition, and cancer-related thrombosis. …”
Get full text

The association between stress-induced hyperglycemia ratio and cardiovascular events as well as all-cause mortality in patients with chronic kidney disease and diabetic nephropathy by Boning Cao, Zhendong Guo, Dan-Ting Li, Le-Ying Zhao, Zhen Wang, Ya-Bin Gao, Yao-Xian Wang

“…In patients with diabetic kidney disease (DKD) and chronic kidney disease (CKD), SHR demonstrated a J-shaped relationship with all-cause mortality and a U-shaped relationship with cardiovascular mortality. Subgroup analyses indicated that the effect of spontaneous hypertension on mortality was consistent across all subgroups. …”
Get full text

Short-Term Effect of Air Pollution on Daily Hospital Visits for Anxiety Disorders in Southern China with Low Pollution Concentrations by Xinyuan Zhong, Tingting Guo, Jianghui Zhang, Qiong Wang, Rong Yin, Kunpeng Wu, Qing Zou, Meng Zheng, Brian J. Hall, Andre M. N. Renzaho, Kangning Huang, Wen Chen

“…The effects of NO₂ and CO remained robust across subgroup analyses and sensitivity analyses. Females and middle-aged individuals showed stronger associations than other subgroups. …”
Get full text

Identification of <i>Bacillus anthracis</i> Strains from Animal Cases in Ethiopia and Genetic Characterization by Whole-Genome Sequencing by Abebe Olani, Domenico Galante, Matios Lakew, Bayeta Senbeta Wakjira, Getnet Abie Mekonnen, Tesfaye Rufael, Tsegaye Teklemariam, Wondwosen Kumilachew, Shimalis Dejene, Ayele Woldemeskel, Adanech Wakjira, Getachew Abichu, Baye Ashenafi, Nigatu Kebede, Aklilu Feleke Haile, Fufa Dawo Bari, Laura Del Sambro, Tadesse Eguale

“…Three strains (BA2, BA5, and BA6) belonged to the A.Br.034 subgroup (A.Br.005/006), and two strains (BA1 and BA4) belonged to the A.Br.161 (Heroin) clade of the Trans-Eurasian (TEA) group. …”
Get full text

Comparative efficacy and safety of GLP-1 receptor agonists for weight reduction: A model-based meta-analysis of placebo-controlled trials by Haoyang Guo, Juan Yang, Jihan Huang, Ling Xu, Yinghua Lv, Yexuan Wang, Jiyuan Ren, Yulin Feng, Qingshan Zheng, Lujin Li

“…Time-course, dose-response, and covariate models were used to describe the efficacy characteristics and influencing factors of different GLP-1RAs. Subgroup analyses were performed to explore efficacy differences in receptor specificity. …”
Get full text

The association of visceral and subcutaneous fat areas with phenotypic age in non-elderly adults, mediated by HOMA-IR and HDL-C by Yuanhong Liu, Min Xu, Liqing Wang, Linyun Meng, Mengran Li, Shumin Mu

“…To examine the association between body fat area and PhenoAgeAccel, logistic regression was applied. Additionally, subgroup analysis was used to identify variations in population characteristics. …”
Get full text

Association between lymphocyte to high-density lipoprotein cholesterol ratio and insulin resistance and metabolic syndrome in US adults: results from NHANES 2007–2018 by Junwei Guo, Kelibinuer Mutailipu, Xin Wen, Jiajing Yin, Hui You, Shen Qu, Haibing Chen, Le Bu

“…Results Compared to the lowest LHR quartile, individuals in the highest quartile indicated significantly increased prevalence of IR (odds ratio = 3.72, 95% confidence intervals: 3.01–4.59) and MetS (odds ratio = 11.38, 95% confidence intervals: 8.85–14.63) in fully adjusted models. Subgroup analyses demonstrated that the association between the LHR and IR remained consistent across all subgroups, with no significant interaction effect observed. …”
Get full text

Association Between Urinary Metal Levels and Chronic Kidney Dysfunction in Rural China: A Study on Sex-Specific Differences by Kaisheng Teng, Qinyi Guan, Qiumei Liu, Xiaoting Mo, Lei Luo, Jiahui Rong, Tiantian Zhang, Wenjia Jin, Linhai Zhao, Songju Wu, Zhiyong Zhang, Jian Qin

“…Interactions may exist between V and Cu, as well as Cu and Sr and Pb. The female subgroup in the BKMR model demonstrated consistency with the overall association. …”
Get full text

Adrenal aldosterone synthase (CYP11B2) histopathology and its association with disease-induced sudden death: a cross-sectional studyResearch in context by Antero Ylänen, Juhani Isojärvi, Antti Virtanen, Helena Leijon, Tiina Vesterinen, Aapo L. Aro, Heini Huhtala, Eeva Kokko, Ilkka Pörsti, Marianna Viukari, Pasi I. Nevalainen, Niina Matikainen

“…Individuals in the DSD group and the subgroup with sudden cardiac death (SCD) were more likely to have APA or APN than individuals in the nDSD group [23 (8.9%) vs. 2 (1.4%), p = 0.002; 16 (8.8%) vs. 2 (1.4%), p = 0.003, respectively]. …”
Get full text