The Importance of Radiological Patterns and Small Airway Disease in Long-Term Follow-Up of Postacute COVID-19: A Preliminary Study by Roberto Mogami, Ronaldo Carvalho Araújo Filho, Carolina Gianella Cobo Chantong, Fernando Carlos Santos de Almeida, Ana Célia Baptista Koifman, Gustavo Federico Jauregui, Thiago Thomaz Mafort, Hanna da Silva Bessa da Costa, Glenda Aparecida Peres dos Santos, Bruna Zangerolame de Carvalho, Gabriel da Silva Passos, Erick de Souza Barbosa, Angelo Thomaz Abalada Ghetti, Laura Braga Monnerat, Mariana Soares da Cal, Desiree Louise Souza Santos Batista, Helen Aksenow Affonso, Gabriel Oliveira Bousquet, Jose Ignacio Marenco Avila, Anna Luiza Bento Dutra, Caio Leal Leidersnaider, Alexandre Malta da Costa Messeder, Alexandra Monteiro, Agnaldo José Lopes

“…Patients with moderate/severe impairment on CXR were associated with a higher frequency of hospitalization (p = 0.033; 77.8%, CI 95%: 58.6%–97.0%) and had significantly more moderate/severe classifications in the acute phase than the subgroup with normal/mild impairment on CXR (p = 0.017; 88.9%, CI 95%: 74.4%–100%). …”
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Determining the effect of frailty on survival in advanced ovarian cancer: study protocol for a prospective multicentre national cohort study (FOLERO) by Daniel Hunde, Niklas Ekerstad, Mihaela Asp, Päivi Kannisto, Madelene Wedin, Charlotte Palmqvist, Pernilla Dahm-Kähler, Yvonne Brandberg, Mirna Abraham-Nordling, Kristina Åhlund, Vilhelm Mörlin, Nina Groes-Kofoed, Sahar Salehi

“…Background and purpose: There is an urgent need to improve patient-selection to surgical treatment in advanced ovarian cancer as our results showed that cytoreductive surgery was without effect or even detrimental in a yet unknown subgroup of women. With an ageing population, 30% of women with advanced ovarian cancer in Sweden are >75 years. …”
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Comparative Lipid-Lowering/Increasing Efficacy of 7 Statins in Patients with Dyslipidemia, Cardiovascular Diseases, or Diabetes Mellitus: Systematic Review and Network Meta-Analyse... by Xiaodan Zhang, Lu Xing, Xiaona Jia, Xiaocong Pang, Qian Xiang, Xia Zhao, Lingyue Ma, Zhiyan Liu, Kun Hu, Zhe Wang, Yimin Cui

“…Firstly, mixed treatment overall comparison analyses, in the form of frequentist NMAs, were conducted using STATA 15.0 software. Then, subgroup analyses were conducted according to different baseline diseases. …”
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Regulatory T Cell Phenotype Related to Cytokine Expression Patterns in Post‐COVID‐19 Pulmonary Fibrosis and Idiopathic Pulmonary Fibrosis by Sara Gangi, Laura Bergantini, Irene Paggi, Marco Spalletti, Paolo Cameli, Elena Bargagli, Miriana d'Alessandro

“…Results Higher CD8 percentages were observed in IPF than in HCs and PCLF (p = 0.020 and p = 0.007, respectively). PCLF subgroup showed higher Th‐naïve, Th‐effector, Tc‐naïve, and Tc‐reg percentages than IPF (p < 0.001; p = 0.018; p = 0.005; p = 0.017, respectively). …”
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Experience in setting up non-robotic minimally invasive direct coronary artery bypass grafting in a non-routine off-pump coronary artery bypass center by Yukiharu Sugimura, Tomoyuki Suzuki, Sebastian Johannes Bauer, Friederike Irmgard Schoettler, Moritz Benjamin Immohr, Michael André Maliwa, Arash Mehdiani, Lachmandath Tewarie, Gereon Schaelte, Ajay Moza, Payam Akhyari

“…We analyzed operation time and incidence of major adverse cardiac and cerebrovascular events (MACCE). Further, subgroup analyses included body mass index (BMI) with a cut-off of 30 kg/m2 [BMI ≧ 30: n = 18 (25.0%)] and body surface area (BSA) with a cut-off of 2.0 m2 [BSA ≧ 2.0: n = 34 (47.2%)]. …”
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Real-world clinical evidence of oral semaglutide on metabolic abnormalities in subjects with type 2 diabetes: a multicenter retrospective observational study (the Sapporo-Oral SEMA... by Sho Furusawa, Hiroshi Nomoto, Chiho Oba-Yamamoto, Jun Takeuchi, Miki Ito, Hiroyoshi Kurihara, Shin Aoki, Aika Miya, Hiraku Kameda, Akinobu Nakamura, Tatsuya Atsumi

“…Efficacy was also confirmed in the subgroup switched from other anti-hyperglycemic agents, including dipeptidyl peptidase-4 inhibitors. …”
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Association between the hemoglobin A1c/High-density lipoprotein cholesterol ratio and stroke incidence: a prospective nationwide cohort study in China by Chaojuan Huang, Hongtao You, Yuyang Zhang, Ligang Fan, Xingliang Feng, Naiyuan Shao

“…Additionally, smoothed curve fitting, subgroup analyses, and interaction tests were conducted to ensure the robustness of the findings. …”
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Tumor-associated lymphatic vessel density is a postoperative prognostic biomarker of hepatobiliary cancers: a systematic review and meta-analysis by Jin Li, Yu-Bo Liang, Qing-Bo Wang, Yu-Kai Li, Xing-Ming Chen, Wan-Ling Luo, Yawhan Lakang, Zi-Sheng Yang, Yan Wang, Zhi-Wei Li, Yang Ke, Yang Ke, Yang Ke

“…The results indicated that a higher level of LVD was associated with worse OS (hazard ratio, HR = 2.87, 95% CI 1.63 to 5.04) and worse RFS (HR = 3.18, 95% CI 1.41 to 7.17) in HBP cancers. Subgroup analysis based on pathological types revealed that a higher level of LVD was significantly related to worse OS in hepatocellular carcinoma (HCC) (HR = 2.35, 95% CI 1.16 to 4.78), cholangiocarcinoma (HR = 4.65, 95% CI 1.70 to 12.70), and gallbladder cancer patients (HR = 4.64, 95% CI 1.37 to 15.71). …”
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Relationship Between Short‐Term Outcomes and PD‐L1 Expression Based on Combined Positive Score and Tumor Proportion Score in Recurrent or Metastatic Head and Neck Cancers Treated W... by Akihiro Ohara, Taisuke Mori, Mai Itoyama, Kazuki Yokoyama, Shun Yamamoto, Ken Kato, Yoshitaka Honma

“…Conversely, nivolumab is utilized for platinum‐pretreated R/M‐HNSCC regardless of the positive tumor proportion score (TPS) following the results of the CheckMate‐141; however, its subgroup analysis indicated that TPS‐positive population tended to have a relatively high overall response rate and progression‐free survival (PFS). …”
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Adherence to integrated care using the ‘Atrial fibrillation Better Care' pathway in asymptomatic patients with atrial fibrillation improves clinical outcomes: A report from the pro... by Yodying Kaolawanich, Arjbordin Winijkul, Ahthit Yindeengam, Poom Sairat, Gregory Y.H. Lip, Rungroj Krittayaphong

“…After adjusting for age, gender, and baseline comorbidities, adherence to the ABC pathway remained significantly associated with a lower rate of composite endpoints (HR 0.69, 95 % CI 0.49–0.98, p = 0.03) and all-cause death (HR 0.58, 95 % CI 0.38–0.90, p = 0.01) compared to non-adherence. Subgroup analyses based on sex, age, AF type, risk scores, and comorbidities consistently demonstrated lower hazard ratios for the composite endpoint among patients who were adherent to the ABC pathway. …”
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Apolipoprotein A-V Is a Novel Diagnostic and Prognostic Predictor in Pediatric Patients with Sepsis: A Prospective Pilot Study in PICU by Chunxia Wang, Yun Cui, Huijie Miao, Xi Xiong, Jiaying Dou, Lujing Shao, Xiaomeng Tang, Yucai Zhang

“…Serum ApoA5 levels on PICU admission were significantly lower in nonsurvivors with sepsis compared with survivors (P=0.009). In subgroup analysis, serum levels of ApoA5 were significantly correlated with sepsis-associated multiple organ dysfunction syndrome (MODS) (P<0.001), shock (P=0.002), acute kidney injury (AKI) (P<0.001), acute liver injury (ALI) (P=0.002), and gastrointestinal (GI) dysfunction (P=0.012), but not respiratory failure, brain injury, and pathogenic species (all P>0.05). …”
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Frequency of Fibromyalgia in Patients with Chronic Hepatitis C Virus Infection and Its Relationship with Vitamin D Levels and Quality of Life by Havva Talay Calis, Fatma Gul Ulku Demir, Ulas Serkan Topaloglu, Hatice Sayan, Deniz Kamalak Guzel, Emel Guler, Fatma Samli, Caglar Karabas, Serap Tomruk Sutbeyaz, Hatice Kayis Topaloglu

“…Based on the presence or absence of fibromyalgia, all scores of FIQ and NHP scales were higher in a subgroup with fibromyalgia. This study documented a prevalence of 56.9% of FMS in patients with HCV (+) in comparison to the control group Conclusion: This study documented a high prevalence of 56.9% of FMS in patients with HCV (+) in comparison to the control group. …”
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The efficacy and safety of qiwei baizhu san in the treatment of type 2 diabetes mellitus: a systematic review and meta-analysis by Quan Zhang, Hongyan Liu, Jiahong Zhang, Yujie Ouyang, Xiaoxu Fu, Xiaoxu Fu, Xiaoxu Fu, Chunguang Xie, Chunguang Xie, Chunguang Xie

“…Heterogeneity sources were examined via subgroup analyses, the robustness of the results was determined by sensitivity analyses, publication bias was evaluated using funnel plots and Egger’s test, evidence quality was appraised with GRADEpro, and possible mechanisms of QWBZS for T2DM were categorized and summarized.ResultsThis analysis encompassed 14 qualifying trials with a total of 1,169 subjects. …”
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Nonlinear Association Between the Liver Fat Content and the Risk of Hyperuricemia in Prediabetic Individuals: Evidence from Cross-Sectional Health Screening Data in China by Liu A, Li X, Zhang X, Chen K, Zou Z, Sun Y, Zhou J, Li Z, Wu X, Lv X, Li H, Guo Z, Li Y

“…Statistical analyses included multivariate logistic regression, limited cubic spline regression models, and subgroup analyses to explore the association between LFC and hyperuricemia among individuals with pre-diabetes.Results: The prevalence of hyperuricemia among the 2,950 prediabetic individuals was observed to be 22.20%. …”
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Machine Learning Approaches in High Myopia: Systematic Review and Meta-Analysis by Huiyi Zuo, Baoyu Huang, Jian He, Liying Fang, Minli Huang

“…In the validation set, subgroup analyses were conducted based on the ML target events (diagnosis and prediction of high myopia and diagnosis of pathological myopia and high myopia-associated glaucoma) and modeling methods. …”
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Impaired pulmonary function increases the risk of gout: evidence from a large cohort study in the UK Biobank by Zijian Kang, Jianzheng Zhang, Chen Zhu, Ying Zhu, Hanlei Jiang, Qiang Tong, Sheng-Ming Dai

“…MR further revealed a potential causal effect of decreased pulmonary function on an increased risk of gout. Subgroup analysis revealed significant interactions between impaired pulmonary function and several factors, including body mass index (BMI), levels of physical activity, and diabetes status, in their associations with the risk of gout. …”
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Treatable traits in idiopathic pulmonary fibrosis: focus on respiratory tract infections—a systematic review and a meta-analysisResearch in context by Zsombor Matics, Anna Bardóczi, Csongor Galkó, Bence Szabó, Noémi Gede, Zsolt Molnár, Gábor Duray, Caner Turan, Péter Hegyi, Gábor Horváth, Veronika Müller

“…Pooled risk ratio with 95% confidence interval (CI), risk of bias, GRADE and CINEMA assessments were conducted along with subgroup analyses for upper and lower RTI and for different antifibrotic doses. …”
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Clinical outcomes of chimeric antigen receptor T-cell therapy following autologous hematopoietic stem cell transplantation in 38 patients with refractory/relapsed primary or second... by Jiaying Wu, Wanying Liu, Yang Cao, Yang Yang, Zhen Shang, Mi Zhou, Yicheng Zhang, Fankai Meng, Xiaojian Zhu, Yi Xiao

“…After therapy, the best overall response rate (ORR) of all patients was 78.9%. Subgroup analysis found that a lower ORR was observed in patients with lactate dehydrogenase levels above the upper limit of normal (60.0% vs. 91.3%, P = 0.039). …”
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Aspartate aminotransferase to alanine aminotransferase ratio and short-term prognosis of patients with type 2 diabetes hospitalized for heart failure by Dan Liu, Li Liu, Nan Li, Yiling Zhou, Hongmei Huang, Jidong He, Heling Yao, Xiangyang Chen, Xiaochi Tang, Miye Wang, Ying Qi, Si Wang, Ye Zhu, Haoming Tian, Zhenmei An, Sheyu Li

“…Compared to patients in the lowest quartile for the AST/ALT ratio, those in the highest quartile have elevated risk of death within 30 days after discharge and major systemic infection (HRs [95% CIs]: 1.61 [1.18 to 2.19] and 1.28 [1.06 to 1.56], respectively). Subgroup analyses and sensitivity analyses confirmed the robustness of the findings. …”
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Efficacy of intermittent fasting on improving liver function in individuals with metabolic disorders: a systematic review and meta-analysis by Mousa Khalafi, Sara K Rosenkranz, Faeghe Ghasemi, Shokoufeh Kheradmand, Aref Habibi Maleki, Mallikarjuna Korivi, Jung-Piao Tsao

“…Overall, IF effectively decreased liver fat with a large effect size [SMD: -1.22 (95% CI: -1.63 to -0.80), p = 0.001], liver steatosis with a medium effect size [SMD: -0.73 (95% CI: -1.12 to -0.35), p = 0.001], ALT with a small effect size [SMD: -0.44 (95% CI: -0.58 to -0.30), p = 0.001], and AST with a small effect size [SMD: -0.30 (95% CI: -0.49 to -0.11), p = 0.001], but not liver fibrosis [SMD: -0.28 (95% CI: -0.59 to 0.02), p = 0.07]. Subgroup analyses showed that IF decreased liver fat and ALT significantly, independent of IF mode, participant age, health status, weight status, and intervention duration. …”
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