An updated systematic review with meta-analysis and meta-regression of the factors associated with human visceral leishmaniasis in the Americas by Anna Gabryela Sousa Duarte, Guilherme Loureiro Werneck, Sarah de Farias Lelis, Thays Santos Mendonça, Daniela Dias Vasconcelos, Tiago Silveira Gontijo, Álisson Oliveira dos Santos, Lucas Edel Donato, Vinícius Silva Belo

“…Associations between VL and risk factors were analyzed using random-effects meta-analysis, subgroup analysis, and meta-regression models. Studies were classified according to level of evidence using the GRADE approach and the evolution in the quality of investigations was assessed. …”
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Analysis of CYP701A1 genes in gossypium species and functional characterization through gene silencing by Zhao Liang, Di Jiachun, Guo Qi, Xu Zhenzhen, Zhao Jun, Xu Peng, Xu Jianwen, Liu Jianguang, Shen Xinlian, Chen Xusheng

“…Specifically, CYP701s, a subgroup of CYP71, encode ent-kaurene oxidase in the gibberellin synthesis pathway. …”
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Effectiveness of educational interventions to promote safe handling of pesticides: protocol for a systematic review and meta-analysis by Anne Cockcroft, Neil Andersson, Sergio Paredes-Solís, José Legorreta-Soberanis, Belén Madeline Sánchez-Gervacio, Víctor Manuel Alvarado-Castro, Miguel Flores-Moreno, Claudia Erika Rios-Rivera, Janet Saldaña-Almazán

“…We will assess heterogeneity using the χ2 test and I2 statistic, conduct a sensitivity analysis by removing each study from the meta-analysis and evaluate publication bias with a funnel plot and Begg and Egger tests. Subgroup analyses will examine the impact of different kinds of educational interventions.Ethics and dissemination Ethics approval is not required as no information from individuals are collected. …”
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Nurses intention to stay in the nursing profession and associated factors in Ethiopia: a systematic review and meta-analysis by Kirubel Eshetu Haile, Yordanos Sisay Asgedom, Atitegeb Alebachew Amsalu, Gizachew Ambaw Kassie, Tsion Zebdiwos Chema, Amanuel Yosef Gebrekidan, Gedion Asnake Azeze

“…The findings of this meta-analysis revealed that the pooled prevalence of nurses' intention to stay in nursing profession among Ethiopian nurses was 45.57% (95% CI; 38.43, 52.72). The subgroup analysis data revealed that the highest pooled prevalence of intention to stay was reported in the Tigray region which is 56.1% (95% CI 52.24, 59.96). …”
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Clinical Utility of the Trajectory of Serum Bilirubin and International Normalized Ratio Values in Hepatitis B Virus-Related Acute-on-Chronic Liver Failure by Song YQ, Fu XY, Yan SY, Qi RB, Zhou YJ, Liang JW, Zhang JQ, Ye LP, Mao XL, Li SW

“…Artificial liver support did not improve short-term prognosis for the stable group; instead, it was a risk factor (OR 2.16, 95% CI [0.23– 3.79], P=0.007). Subgroup analysis showed no interaction between predictive models and trajectory groups. …”
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Association between glyphosate exposure and cardiovascular health using “Life’s Essential 8” metrics in US adults by Yuankang Zhu, Zhenlin Yang, Yuhao Chen, Lingzi Qian, Changning Hao, Liangshi Hao, Boshen Yang, Junli Duan

“…Mediation analysis was used to determine potential mediators correlated with glyphosate and CVH. Further subgroup analysis and sensitive analysis were conducted to confirm the results. …”
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A predictive risk‐scoring model for survival prognosis of multiple myeloma based on gain/amplification of 1q21: Experience in a tertiary hospital in South‐Western China by Yanqiu Xiong, Shanshan Liang, Wenjiao Tang, Li Zhang, Yuhuan Zheng, Ling Pan, Ting Niu

“…Conclusion The UHR model, which integrates the presence of +1q21 with no‐ASCT and TP53 deletion, is designed to identify the early relapse subgroup among patients with +1q21 in NDMM.…”
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Tumor aggression-defense index–a novel indicator to predicts recurrence and survival in stage II-III colorectal cancer by Tong Wu, Lin Fang, Yuli Ruan, Mengde Shi, Dan Su, Yue Ma, Ming Ma, Bojun Wang, Yuanyu Liao, Shuling Han, Xiaolin Lu, Chunhui Zhang, Chao Liu, Yanqiao Zhang

“…The Tumor Aggression-Defense Index (TADI) was derived through a multi-factor COX regression model. Subgroup analysis demonstrated potential of TADI in guiding personalized adjuvant therapy for stage II and III CRC. …”
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Systematic Review and Network Meta-Analysis on Treating Hormone Receptor-Positive Metastatic Breast Cancer After CDK4/6 Inhibitors by Neha Pathak, Abhenil Mittal, Sudhir Kumar, Chitrakshi Nagpal, Eitan Amir, Partha Haldar, Bharath B. Gangadharaiah, Akash Kumar, Ashutosh Mishra, Atul Batra

“…NMA was executed using WINBUGS (Microsoft Excel). Three molecular subgroups were analyzed: HER2-low, PI3K/AKT/mTOR, and the ESR1 mutation subgroup for selective estrogen receptor degrader (SERD). …”
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The effects of Garcinia cambogia on glycaemic control and liver enzymes in adults: a systematic review and meta-analysis of randomised controlled trials by Sogand Tavakoli, Mohammad Reza Amini, Reyhaneh Rabiee, Marieh Salavatizadeh, Mostafa Afsharianfar, Moein Askarpour, Azita Hekmatdoost

“…The results showed that Garcinia cambogia has no significant effect on FBS (weighted mean difference (WMD): 1.02 mg/dl, 95% CI: −1.29, 3.33), insulin (WMD: −0.12 mU/L, 95% CI: −1.50, 1.25), AST (Hedges’ g: −0.08, 95% CI: −0.43, 0.26), and ALT (Hedges’ g: 0.27, 95% CI: −0.20, 0.73). Subgroup analysis showed that Garcinia cambogia significantly increased insulin levels in females and also increased insulin and FBS levels in those with a BMI ≥30 kg/m2. …”
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Predictors of chronic pain and level of physical function in total knee arthroplasty: a protocol for a systematic review and meta-analysis by Jens Ivar Brox, Christopher James Rose, Anners Lerdal, Øystein Skare, Unni Olsen, Maren Falch Lindberg, Eva Marie-Louise Denison, Caryl Lynn Gay, Arild Aamodt, Ove Furnes, Kathryn A Lee

“…Estimates of association from the primary evidence will be synthesised narratively, and quantitatively using multivariate meta-analysis to provide ‘pooled’ estimates of association. Subgroup and sensitivity analyses will be performed. …”
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Impact of interpregnancy weight change on the risk of gestational diabetes mellitus during a second pregnancy in Chinese population: a retrospective cohort study by Ying Wang, Juan Yang, Chang Xu, Yuzhen Liu, Ao Yang, Shilin Zhong

“…The significant association between IPWC value and s-GDM was also shown only in these subgroups (p<0.05). In f-DN subgroup, even an IPWC category of 1 kg/m² to <3 kg/m² was significantly associated with s-GDM (aOR 1.486, 95% CI 1.044 to 2.117). …”
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Adverse Effects of Intraparenchymal and Peritumoral Application of Isosulfan Blue Dye in Sentinel Lymph Node Mapping in Breast Cancer: A Systematic Review and Meta-Analysis by Joshua Agilinko, Aditya Borakati, Andrel Yoong, Ponnuthurai Pratheepan, Suzette Samlalsingh

“…Heterogeneity was expressed with I-squared and tau statistics. Subgroup analysis was conducted for administrative route. …”
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Efficacy of MCU-based and 3D-FEA for Improving Cervical Spondylosis by Meigui KE, Ruixu XU, Ningying HUANG, Hai GUO, Xinghui YAN, Nanxi WU, Sidong DOU

“…After 12 weeks of treatment, VAS scores were lower in the experimental group and in all subgroups than in the control group(<italic>P</italic>&lt;0.05 and <italic>P</italic>&lt;0.017, respectively);and there was a statistical difference in the degree of pain relief in each age subgroup(<italic>P</italic>&lt;0.05), suggesting that young patients had better pain relief than middle-aged and elderly patients. …”
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Impact of thoracic radiotherapy on first‐line treatment outcomes in ES‐SCLC patients by Xiaoli Mu, Yixin Zhou, Qing Liu, Jiantao Wang, Feng Xu, Feng Luo, Ke Wang, Lu Li, Panwen Tian, Yalun Li, Jiewei Liu, Yan Zhang, Jiyan Liu, Yan Li

“…Remarkably, patients who received tRTdemonstrated superior OS and PFS in comparison to those who did not (P < 0.05). Subgroup analysis further confirmed these findings. …”
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Effect of exercise intervention on health-related quality of life in middle-aged and older people with osteoporosis: a systematic review and meta-analysis by Di Geng, Xiaogang Li, Yan Shi

“…Regarding mental HRQOL, significant improvements were found in vitality (SMD = 0.58, 95% CI [0.15–1.01], p = 0.008), social function (SMD = 0.37, 95% CI [0.17–0.58], p = 0.0004), and mental health (SMD = 0.50, 95% CI [0.25–0.74], p < 0.0001). Subgroup analysis results indicated that resistance training (SMD = 1.01, 95% CI [0.50–1.52], p = 0.0001), intervention frequency of at least three times per week (SMD = 0.80, 95% CI [0.22–1.38], p = 0.007), and intervention duration of 13–24 weeks (SMD = 0.85, 95% CI [0.37–1.33], p = 0.0005) had large and significant effects on general HRQOL improvements. …”
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Mechanistic investigation and the optimal dose based on baicalin in the treatment of ulcerative colitis–A preclinical systematic review and meta-analysis by Jinchen Chong, Zepeng Chen, Jiaze Ma, Linhai He, Yijia Zhu, Zhihua Lu, Zhengxi Qiu, Chen Chen, Yugen Chen, Feng Jiang

“…Seventeen studies were selected through manual screening. Meta-analyses and subgroup analyses utilized Rev Man 5.3 and Stata 15.0 software to assess symptom improvement. …”
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The C825T Polymorphism of the G-Protein β3 Gene as a Risk Factor for Functional Dyspepsia: A Meta-Analysis by Yi-Zuo Song, He-Yi You, Zhe-Hui Zhu, Zheng-De Wen, Hui-Ying Xu, Bi-Cheng Chen, Zong-Jing Chen, Qing-Ke Huang

“…We found no associations of GNB3 C825T polymorphism with FD in the overall population (T versus C, OR = 1.06, 95% CI: 0.96–1.18, P=0.26; TT versus CC + CT, OR = 1.16, 95% CI: 0.97–1.39, P=0.11; TT + CT versus CC, OR = 1.01, 95% CI: 0.77–1.31, P=0.96; TT versus CC, OR = 1.15, 95% CI: 0.93–1.44, P=0.20). Subgroup analyses by genotyping method indicated that the magnitude of association was strengthened for additive model (OR = 1.15, 95% CI: 1.07–2.24, P=0.02). …”
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Association between neutrophil-to-eosinophil ratio and efficacy outcomes with avelumab plus axitinib or sunitinib in patients with advanced renal cell carcinoma: post hoc analyses... by Brian Rini, Mariangela Mariani, Alessandra di Pietro, Paul Nathan, Christian Kollmannsberger, Marc-Oliver Grimm, Martin H Voss, Bradley A McGregor, Mehmet A Bilen, Yoshihiko Tomita, Bo Huang, Robert Amezquita, Matthew Tucker, Yu-Wei Chen

“…The HR for PFS in the PD-L1+ subgroup was 0.72 (95% CI 0.520 to 0.986). Comparing NER-defined subgroups in the sunitinib arm, HRs for PFS and OS were 0.93 (95% CI 0.728 to 1.181) and 0.57 (95% CI 0.424 to 0.779), and ORRs were 32.8% versus 30.8%, respectively. …”
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The effectiveness of exercise-based interventions on muscle mass, muscle strength, functional performance, aerobic capacity, and health-related quality of life in adults with malig... by Charlotte Groenset, Magnus N. Bech, Mary Jarden, Nina Høgdal, Martin Hutchings, Charlotte Suetta, Jan Christensen

“…All study authors were contacted to obtain unpublished subgroup data. Two reviewers independently screened and extracted data and assessed the quality of evidence using the revised Cochrane risk-of-bias tool for randomized trials. …”
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