Associations between hypovitaminosis D, adiposity indices and insulin resistance in adolescents: mediation analyses from NHANES 2011–2018 by Yaping Deng, Yingting Luo, Yilei Shen, Yong Zhao, Wei Cao, Jie Cao, Lijuan Xu, Lin Kong

“…Results Our study revealing significant correlations between adiposity indices, hypovitaminosis D, and IR after variable adjustment. Notably, subgroup analysis indicated a pronounced hypovitaminosis D -adiposity association in female adolescents, which was not observed in males. …”
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Markers of Glomerular and Tubular Damage in the Early Stage of Kidney Disease in Type 2 Diabetic Patients by Agnieszka Żyłka, Paulina Dumnicka, Beata Kuśnierz-Cabala, Agnieszka Gala-Błądzińska, Piotr Ceranowicz, Jakub Kucharz, Anna Ząbek-Adamska, Barbara Maziarz, Ryszard Drożdż, Marek Kuźniewski

“…Albuminuria, urine NGAL, transferrin, IgG, and uromodulin correlated with diabetes control. In a subgroup of 29 patients, retrospective data were available on changes in eGFR and uACR over one year. …”
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Prevalence of asymptomatic Leishmania donovani infection and associated factors in Ethiopia: a systematic review and meta-analysis by Habtamu Belay, Adugna Abera, Esayas Aklilu, Tesfahun Bishaw, Ayinalem Alemu, Geremew Tasew, Berhanu Erko

“…Study heterogeneity assessed using Chi-square (χ²)-based Q test (p < 0.1) and I² subgroup analysis and meta-regression conducted with significance set at p < 0.05. …”
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Investigation of the Mechanism of Complement System in Diabetic Nephropathy via Bioinformatics Analysis by Bojun Xu, Lei Wang, Huakui Zhan, Liangbin Zhao, Yuehan Wang, Meng Shen, Keyang Xu, Li Li, Xu Luo, Shasha Zhou, Anqi Tang, Gang Liu, Lu Song, Yan Li

“…The correlation analysis and subgroup analysis of 7 complement cascade-related hub genes and the clinical characteristics of DN showed that C1QA, C1QB, C3, CFB, ITGB2, VSIG4, and CLU may participate in the development of DN. …”
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Cardiovascular Risk Biomarkers in Women with and Without Polycystic Ovary Syndrome by Manjula Nandakumar, Priya Das, Thozhukat Sathyapalan, Alexandra E. Butler, Stephen L. Atkin

“…TF and renin upregulation observed in the BMI- and IR-matched limited sample PCOS subgroup indicates their potential risk of CVD.…”
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Disproportionality analysis of upadacitinib-related adverse events in inflammatory bowel disease using the FDA adverse event reporting system by Shiyi Wang, Xiaojian Wang, Jing Ding, Xudong Zhang, Hongmei Zhu, Yihong Fan, Changbo Sun

“…Notably, significant but unexpected AEs, such as rosacea, proctalgia, polyp, were also reported. Subgroup analysis indicated that the most prevalent AEs among the elderly included pulmonary embolism, cataract, and sepsis, whereas the 18–65 age group most frequently reported acne, abdominal pain, and nasopharyngitis. …”
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BiomiX, a user-friendly bioinformatic tool for democratized analysis and integration of multiomics data by Cristian Iperi, Álvaro Fernández-Ochoa, Guillermo Barturen, Jacques-Olivier Pers, Nathan Foulquier, Eleonore Bettacchioli, Marta Alarcón-Riquelme, PRECISESADS Flow Cytometry Study Group, PRECISESADS Clinical Consortium, Divi Cornec, Anne Bordron, Christophe Jamin

“…BiomiX also generates statistics, report figures and integrates EnrichR and GSEA for biological process exploration and subgroup analysis based on user-defined gene panels enhancing condition subtyping. …”
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Season of conception and risk of hypertensive disorder during pregnancy by Yanxia Xie, Yi Mu, Peiran Chen, Yanping Wang, Xiaohong Li, Li Dai, Zheng Liu, Qi Li, Mingrong Li, Juan Liang, Jun Zhu

“…The associations were slightly stronger in the subgroup of women diagnosed with gestational hypertension and preeclampsia. …”
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Hemoglobin glycation index and mortality risk in metabolic dysfunction-associated steatotic liver disease patients: a novel U-shaped association by Mengjie Zhao, Ning Sun, Yurong Cheng, Wantong Zhang, Jinjin Ji, Qiuyan Li, Fang Lu, Weiliang Weng

“…Above the critical points, HGI was significantly positively correlated with both all-cause mortality (HR 1.36, 95% CI: 1.20–1.53, P < 0.001) and CVD mortality (HR 1.44, 95% CI: 1.11–1.88, P = 0.007). Further subgroup and interaction analyses corroborated the reliability of these findings. …”
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Determinants of Anemia among HIV-Positive Children on Highly Active Antiretroviral Therapy Attending Hospitals of North Wollo Zone, Amhara Region, Ethiopia, 2019: A Case-Control St... by Biruk Beletew, Ayelign Mengesha, Mohammed Ahmed, Awet Fitwi, Mesfin Wudu

“…The rate of progression and mortality in this subgroup of patients is high compared to nonanemic patients. …”
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Association between geriatric nutritional risk index and overactive bladder in the elderly population: a cross-sectional study by Wei Zheng, Wei Zheng, Chuanzan Zhou, Jia Miao, Yunkai Yang, Xuanhan Hu, Heng Wang, Xinyu Zhang, Qi Zhang, Yifan Wang

“…Influencing factors were assessed through subgroup analyses, while the predictive utility of GNRI was assessed with receiver operating characteristic (ROC) curves. …”
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Parastomal hernia repair: A 10-year retrospective study at District General Hospital—Recurrence and complications by Ali Javaid, Karim Muhammad, Nafees Qureshi

“…The recurrence rate in the mesh group was 29.2%, with synthetic mesh subgroup having lower recurrence rate compared with the biological mesh group (25%:38.46%). …”
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Effects of physical activity on depressive and anxiety symptoms of women in the menopausal transition and menopause: a comprehensive systematic review and meta-analysis of randomiz... by Hongyu Yue, Yijiao Yang, Fangfang Xie, Jiahe Cui, Yang Li, Mengran Si, Shanshan Li, Fei Yao

“…The results showed that PA groups demonstrated a statistically significant effect of depressive symptoms versus controls (DS [SMD: -0.66, 95% CI: -0.99 to -0.33; P < 0.001]; AS [SMD: -0.55, 95% CI: -0.82 to -0.27; P < 0.001]). As subgroup analyses demonstrated, physical exercise also reduced depressive symptom of women in menopausal status (SMD =-0.56, 95% CI: −0.96 to − 0.17, p = 0.006, I2 = 69%), postmenopausal status (SMD =-0.94, 95% CI: −1.46 to − 0.42, p = 0.0004, I2 = 94%), and both in menopausal transition and postmenopausal status (SMD =-0.30, 95% CI: −0.49 to − 0.12, p = 0.001, I2 = 0%), while it only reduced anxiety symptom of postmenopausal women (SMD =-0.96, 95% CI: −1.49 to − 0.43, p = 0.0004, I2 = 89%). …”
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Multiple time points for detecting circulating tumor DNA to monitor the response to neoadjuvant therapy in breast cancer: a meta-analysis by Shuyi Niu, Tie Sun, Mozhi Wang, Litong Yao, Tianyi He, Yusong Wang, Hengjun Zhang, Xiang Li, Yingying Xu

“…We also performed a subgroup analysis to more accurately assess the predictive value of ctDNA for triple-negative breast cancer. …”
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Major Adverse Cardiovascular Events in Primary Aldosteronism After Adrenalectomy or Mineralocorticoid Receptor Antagonist Treatment: A Systematic Review and Meta‐Analysis by Chien‐Wei Huang, Tse‐Ying Huang, Ya‐Fei Yang, Li‐Yang Chang, Yu‐Kang Tu, Vin‐Cent Wu, Jui‐Yi Chen

“…We adapted the random‐effects model and performed subgroup and meta‐regression analyses. A total of 20 studies involving 16 927 patients with PA were included. …”
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Behavior of SD-OCT Detectable Hyperreflective Foci in Diabetic Macular Edema Patients after Therapy with Anti-VEGF Agents and Dexamethasone Implants by Anne Rübsam, Laura Wernecke, Saskia Rau, Dominika Pohlmann, Bert Müller, Oliver Zeitz, Antonia M. Joussen

“…The number of foci decreased in 62.5% of patients after anti-VEGF (130.6 vs. 111.1, p=0.07) and in 68% of patients after dexamethasone injection ((123.4 vs. 94.9, p=0.02) 5.1). A subgroup of 15% of eyes, all treated with anti-VEGF, showed accumulation of larger HF in outer retinal layers to visible HE during DME resolution, whereas smaller HF, found in all retinal layers, remained unchanged. …”
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Diagnostic performance of digital breast tomosynthesis (DBT) versus digital mammography (DM) in a population clinically referred for breast imaging – a retrospective cohort study by Naomi Noguchi, Farzaneh Boroumand, Katy Bell, Margaret Pooley, Aileen Zeng, Lauren Arnold, Armando Teixeira-Pinto, Nehmat Houssami

“…Abnormal interpretation rate for DBT was 2.83 % (CI 2.38–3.36 %) and for DM it was 2.17 % (CI 1.82–2.58 %), and the biopsy rate for DBT was 8.2 % (CI 7.4–9.0 %) and for DM it was 9.9 % (CI 9.1–10.6 %)).In patients with dense breasts (vs overall cohort) AUC-ROC and sensitivity were lower for both DM and DBT. Within this subgroup, AUC-ROC for DBT was 0.90 (CI 0.84–0.95) and for DM it was 0.85 (CI 0.79–0.92), sensitivity was 78.2 % (CI 65.0–88.2 %) for DBT and 64.8 % (CI 50.6–77.3 %) for DM, and ultrasound was accurate whether it was used with DBT (AUC-ROC 0.95 (CI 0.91 – 0.99)) or DM (AUC-ROC 0.95 (CI 0.90 – 0.99)) Conclusion: In clinically referred patients, diagnostic accuracy and diagnostic yield were similar between DBT and DM. …”
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Albumin Binding Function: The Potential Earliest Indicator for Liver Function Damage by Penglei Ge, Huayu Yang, Jingfen Lu, Wenjun Liao, Shunda Du, Yingli Xu, Haifeng Xu, Haitao Zhao, Xin Lu, Xinting Sang, Shouxian Zhong, Jiefu Huang, Yilei Mao

“…Cirrhosis patients were separated according to Child-Pugh score into A, B, and C subgroup. Albumin metal ion binding capacity (Ischemia-modified albumin transformed, IMAT) and fatty acid binding capacity (total binding sites, TBS) were detected. …”
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Human rights violations are associated with forcibly displaced population’s mental health—a systematic review and meta-analysis by Felix Sisenop, Pallavi Chatarajupalli, Paul A. Bain, Hanna Kaade, Jutta Lindert

“…Pooled associations were calculated using a random-effects meta-analysis model. Subgroup analyses were performed for the Global Peace Index, sampling methodology, also we assessed risk of bias.ResultsOf the 8,555 records screened, 55 with n = 31,573 participants met the inclusion criteria (n = 15,714 males, females, n = 15,859 females). …”
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Effects of music training on executive functions in preschool children aged 3–6 years: systematic review and meta-analysis by Yanan Lu, Lin Shi, Lin Shi, Ahmad Faudzi Musib

“…A random-effects meta-analysis was used to compute standardized mean differences (SMD) and 95% confidence intervals (CI).ResultsIn all, 10 studies were included in the meta-analysis, in which children’s music training groups showed significantly improved inhibitory control (SMD = 0.38, 95% CI: 0.16–0.6), working memory (SMD = 0.35, 95% CI: 0.16–0.54), and cognitive flexibility (SMD = 0.23, 95% CI: 0.04–0.42) in comparison with control groups. Subgroup analyses indicated significant improvements relative to the control groups for inhibitory control following music training having a duration of ≥12 weeks (SMD = 0.51, 95% CI: 0.22–0.8), occurring ≥3 times per week (SMD = 0.48, 95% CI: 0.2–0.75), and lasting 20–30 min per session (SMD = 0.42, 95% CI: 0.2–0.63). …”
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