Relationship between stress hyperglycemia ratio and progression of non target coronary lesions: a retrospective cohort study by Shiqi Liu, Ziyang Wu, Gaoliang Yan, Yong Qiao, Yuhan Qin, Dong Wang, Chengchun Tang

“…A hybrid model combining logistic regression and XGBoost yielded the best predictive performance, with an AUC of 0.78 (95% CI: 0.72–0.85), incorporating SHR, number and stenosis severity of non target lesions (NTLs), hypertension and high-density lipoprotein cholesterol (HDL-c). Subgroup analysis showed that elevated SHR was a stronger predictor of NTL progression in non-diabetic patients (OR = 3.76, p = 0.007) compared with diabetic patients (OR = 1.69, p = 0.083). …”
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The breast cancer genetic testing experience: probing the potential utility of an online decision aid in risk perception and decision making by Anna Vaynrub, Brian Salazar, Yilin Eileen Feng, Harry West, Alissa Michel, Subiksha Umakanth, Katherine D. Crew, Rita Kukafka

“…Descriptive statistics were generated to compare the interviewed subgroup to the original study cohort of 187 women. …”
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Enhanced renoprotective effects of combined glucagon‐like peptide‐1 receptor agonists and sodium‐glucose cotransporter 2 inhibitors in type 2 diabetes mellitus: Real‐world evidence... by Jian‐Yu Jhu, Yu‐Wei Fang, Chung‐Yen Huang, Hung‐Hsiang Liou, Mon‐Ting Chen, Ming‐Hsien Tsai

“…The GLP‐1 RA plus SGLT2i group had significantly lower risk of MAKE (hazard ratio [HR]: 0.73, 95% confidence interval [CI]: 0.69–0.77), AKI (HR: 0.82, 95% C0I: 0.77–0.87), ESKD (HR: 0.61, 95% CI: 0.47–0.78), and all‐cause mortality (HR: 0.54, 95% CI: 0.50–0.58) compared to the SGLT2i‐only group. Moreover, subgroup analyses showed consistent benefits across different subgroups. …”
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The associations between sedentary behavior and neck pain: a systematic review and meta-analysis by Yunchen Meng, Yaqi Xue, Sanjun Yang, Fang Wu, Yanyu Dong

“…Overall, the meta-analysis revealed a significant relationship between SB and NP (OR = 1.46, 95%CI: 1.33, 1.60). Subgroup analyses revealed that the risk of NP was greater in female (OR = 1.43, 95%CI: 1.22, 1.67) than in male (OR = 1.13, 95%CI: 1.01, 1.27) and was greater in employees (OR = 1.97, 95%CI: 1.70, 2.28) than in students (OR = 1.26, 95%CI: 1.15, 1.39). …”
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Protective role of ginsenoside Rg1 in the dynamic progression of liver injury to fibrosis: a preclinical meta-analysis by Lijuan Dan, Xiuyan Li, Shuanglan Chen, Xiaojie You, Dong Wang, Tianyuan Wang, Jia Li, Wenping Liu, Jie Mu, Quansheng Feng, Quansheng Feng

“…The methodological quality was assessed using SYRCLE’s risk of bias tool. Meta-analysis and subgroup analysis were performed using Revman 5.4 software, while publication bias was evaluated through funnel plots and Egger’s test in STATA 15.0 software. …”
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Gene mutation in diabetic patients with lung adenocarcinoma: a real-world retrospective cohort study by Lei Yang, Yang Hong, TingTing Zeng, HongMei Yue, DePeng Jiang

“…Univariate and multivariate linear regression analyses revealed that being female, having no smoking history, and being in phase II or IV of tumor stage were associated with gene mutation. Subgroup analysis indicated that the rate of gene mutation in male smoking lung adenocarcinoma patients with diabetes was significantly lower than in those without diabetes.ConclusionThis retrospective study of real-world data suggests that patients with lung adenocarcinoma and diabetes may have a reduced likelihood of developing genetic mutations, particularly among male smokers. …”
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Trends in the prevalence of antenatal and postnatal depression in Bangladesh: A systematic review and meta-analysis by Mohammad Injamul Hoq, Md Mohotasin Hossain, Mohammad Aktar Sayeed, Md Jakaria

“…A random-effects model was used for this analysis. We also performed subgroup analyses considering “PND” at different stages, study quality, and prevalence based on the decade of publication. …”
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Effects of exercise intensity and diet on cardiac tissue structure and FGF21/β-Klotho signaling in type 2 diabetic mice: a comparative study of HFD and HFD + STZ induced type 2 dia... by Sevda Moharamzadeh, Majid Kashef, Mojtaba Salehpour, Meysam Torabi, Samira Vesali, Zakieh Samsonchi, Ensiyeh Hajizadeh-Saffar

“…Then, the mice in the ND, HFD and HFD + STZ groups were divided into three subgroups of control (C), HIIT and MICT, and mice were placed in one of nine groups ND-C, ND-HIIT, ND-MICT, HFD-C, HFD-HIIT, HFD-MICT, HFD + STZ-C, HFD + STZ-HIIT, and HFD + STZ-MICT. …”
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Simultaneous Changes in Astigmatism with Noncycloplegia Refraction and Ocular Biometry in Chinese Primary Schoolchildren by Yaoyao Lin, Dandan Jiang, Chunchun Li, Xiao Chang, Balamurali Vasudevan, Xiaoqiong Huang, Wenzhe Zhou, Lei Qin, Yanyan Chen

“…Children with increased astigmatism had longer baseline ALs (23.33 mm, P<0.001), higher AL/CRC ratios (2.99 mm, P<0.001), and more negative spherical equivalent refraction (SER) (−0.63 D, P<0.001) compared with the decreased and no astigmatism change subgroups. Also, children in the increased astigmatism subgroup had more AL growth (0.68 mm, P<0.001), higher increases in AL/CRC ratio (0.08, P<0.001), and more negative SER change (−0.86 D, P<0.001) compared with the decreased and no astigmatism change subgroups. …”
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Nr5a2 promotes cancer stem cell properties and tumorigenesis in nonsmall cell lung cancer by regulating Nanog by Ting Ye, Jingyuan Li, Zhiwei Sun, Yongli Liu, Liangsheng Kong, Shixia Zhou, Junlin Tang, Jianyu Wang, H. Rosie Xing

“…Cancer stem cells (CSCs) are a subgroup of cancer cells with self‐renewal capability similar to that of normal stem cells (NSCs). …”
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Effect of Laryngeal Mask Airway Insertion on Intraocular Pressure Response: Systematic Review and Meta-Analysis by Mohammed Suleiman Obsa, Zewde Zema kanche, Robera Olana Fite, Tilahun Saol Tura, Bulcha Guye Adema, Aseb Arba Kinfe, Melkamu Worku kercho, Kebreab Paulos chanko, Getahun Molla Shanka, Atkuregn Alemayehu Lencha, Gedion Asnake Azeze, Lolemo Kelbiso Hanfore, Nefsu Awoke Adulo, Blen Kassahun Dessu, Getahun Dendir Wolde, Shimelash Bitew Workie

“…Heterogeneity between studies was assessed by the I2 statistics test. A subgroup analysis was done to assess the source of variation between the studies. …”
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PD(L)1 Inhibitors Plus Lenvatinib Vs Atezolizumab Plus Bevacizumab Combined With HAIC for Unresectable HCC: A Propensity Score Matching Study by He Z, Chen H, Liang C, Tang X, Jiang L, Xie F, Liu Q, Zheng Y

“…Median OS was significantly better in the PLEN-HAIC group (p = 0.045, both not reached). Subgroup analysis revealed that Lenvatinib showed a better OS compared to Bevacizumab when combined with HAIC and PDL1 inhibitors (p = 0.023).Conclusion: PLEN-HAIC offers significant survival benefits over AT-HAIC in advanced HCC. …”
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Effects of aerobic exercise on cognitive function and quality of life in patients with Alzheimer’s disease: a systematic review and meta-analysis by Linlin Yang, Zhichao Yuan, Chenggen Peng

“…For the Minimum Mental State Examination (MMSE) (SMD=0.95, 95% CI 0.58 to 1.32, Z=5.06, p&lt;0.00001), Alzheimer’s Disease Assessment Scale-Cognitive Section (ADAS-cog) (SMD=−0.67, 95% CI −1.15 to –0.2, Z=2.77, p=0.006) and quality of life (SMD=0.36, 95% CI 0.08 to 0.64, Z=2.51, p=0.01), but not statistically significant for depressive symptoms (SMD=−0.25, 95% CI −0.63 to 0.13, Z=1.27, p=0.21). Subgroup analysis showed that duration greater than 16 weeks and less than 50 min per intervention improved MMSE Scores. …”
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The prognostic utility of the ratio of lymphocyte to monocyte in patients with metastatic colorectal cancer: a systematic review and meta-analysis by Pingping Mei, Li Huang, Lu Lin, Yan Chen, Xiutian Guo

“…The pooled analysis found that high LMR was correlated with better OS (HR: 0.55, 95% CI: 0.49-0.62, p&lt;0.00001), PFS (HR: 0.68, 95% CI: 0.57-0.81, p&lt;0.0001) and CSS(HR: 0.55, 95% CI: 0.32-0.95, p=0.03),The prognostic value of high LMR values for DFS(HR: 0.93, 95% CI: 0.78-1.12, p=0.46) in patients with metastatic rectal cancer was not found to be significant. We performed subgroup analyses based on study characteristics to confirm the robustness of our findings. …”
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Role of the Bronchoalveolar Lavage in Noncritically Ill Patients during the SARS-CoV-2 Epidemic by Olivier Taton, Emmanuelle Papleux, Benjamin Bondue, Christiane Knoop, Sébastien Van Laethem, Alain Bauler, Delphine Martiny, Isabel Montesinos, Marie-Luce Delforge, Kahina Elmaouhab, Dimitri Leduc

“…Results of BAL in case of negative NPS testing are underreported, especially in the subgroup of immunocompromised patients. Objectives. …”
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Impact of Initial Heart Rate, Diastolic Pressure, and Pulse Pressure on Prognostic Outcomes in Heart Failure Patients with Mildly Reduced Ejection Fraction by Hu H, Liu Z, Zeng J, Jiang M

“…While heart failure with mildly reduced ejection fraction (HFmrEF) is a distinct subgroup of heart failure, the prognostic impact of these hemodynamic parameters in this population remains unclear, necessitating focused investigation. …”
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A network comparison on efficacy and safety profiling of PD-1/PD-L1 inhibitors in first-line treatment of advanced non-small cell lung cancer by Jie Fu, Jie Fu, Yi-Dan Yan, Xu Wan, Xiao-Fan Sun, Xiao-Fan Sun, Xiu-Mei Ma, Ying-Jie Su

“…Findings included overall survival (OS), objective response rate (ORR), progression-free survival (PFS), and grade ≥3 treatment-related adverse events (TRAEs). Furthermore, subgroup analyses were conducted based on PD-L1 expression levels and histological type.ResultsWe analyzed 29 studies including 18,885 patients. …”
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Dual inhibition of BET and EP300 has antitumor activity in undifferentiated pleomorphic sarcomas and synergizes with ferroptosis induction by Stéphanie Verbeke, Aurélien Bourdon, Mathilde Lafon, Vanessa Chaire, Bertolo Frederic, Amina Naït Eldjoudi, Marie-Alix Derieppe, Francis Giles, Antoine Italiano

“…Moreover, we identified GPX4 as a gene involved in resistance and showed synergy between BET inhibition and ferroptosis induction.The present study demonstrated that dual BET/EP300 inhibitors have a relevant antitumor activity in a subgroup of UPS characterized by expression of MYC-targets pathway and identified a potent combination therapeutic strategy that deserves further investigation in the clinical setting.…”
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Exploring the association between caffeine intake and benign prostatic hyperplasia: results from the NHANES 2005–2008 by Fei Zhang, Fei Zhang, Fei Zhang, Andong Zhang, Andong Zhang, Andong Zhang, Junyue Tao, Junyue Tao, Junyue Tao, Meng Zhang, Meng Zhang, Meng Zhang, Chaozhao Liang, Chaozhao Liang, Chaozhao Liang

“…Multivariate logistic regression was used to analyze the independent relationship between caffeine intake and BPH, and the results are presented as odds ratio (OR) and 95% confidence interval (CI), subgroup analysis was also performed.ResultsA total of 2,374 participants were analyzed. …”
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Effectiveness of eHealth literacy interventions: a systematic review and meta-analysis of experimental studies by Chiara Barbati, Elvira Maranesi, Cinzia Giammarchi, Matteo Lenge, Manila Bonciani, Elisa Barbi, Giacomo Pietro Vigezzi, Mauro Dragoni, Tania Bailoni, Anna Odone, Roberta Bevilacqua

“…In the analysis between the intervention and control groups, we found a statistically significant difference in eHL improvement in favour of the intervention group, with mean eHEALS scores 3.62 points (95% CI = 1.63–5.60, N = 1258) higher in the intervention group than in the control groups. Subgroup analyses by intervention type, stratified by Collaborative Learning (CL) or Individualistic Learning (IL) showed significant increases in eHealth Literacy in the pre-post intervention analysis (CL: UMD = 5.19, CI = 0.01–10.38, N = 402; IL: UMD = 6.05; CI = 3.14–8.97, N = 623) and in the intervention vs. control analysis in the IL group (DMD = 4.98; CI = 1.77–8.12, N = 540). …”
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