Efficacy and safety of nivolumab plus ipilimumab in gastrointestinal cancers: a systematic review and meta-analysis by Bowen Dai, Jiaping Jiang, Xiaoyu Yu, Haihua Zhan, Zhengchuan Hu

“…The data analysis was conducted using Review Manager version 5.4 and Stata version 12.0.ResultsOverall, the combination of nivolumab and ipilimumab demonstrated superior outcomes, including a higher ORR (OR = 1.69, P = 0.01), prolonged mOS (MD = 1.74, P = 0.04) and extended mDOR (MD = 5.64, P < 0.00001) compared to the control group. Subgroup analysis demonstrated that the ORR (OR = 1.75, P = 0.02) and mOS (MD = 5.02, P = 0.003) were significantly improved in patients with esophageal cancer. …”
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Association of Depression with Age at Natural Menopause: A Cross-Sectional Analysis with NHANES Data by An S, Ren S, Ma J, Zhang Y

“…Additionally, we conducted subgroup analyses and interaction tests.Results: A total of 4732 women were included, and the mean age of natural menopause was 47.9 ± 6.8 years. …”
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Identification of Potential Type II Diabetes in a Chinese Population with a Sensitive Decision Tree Approach by Dongmei Pei, Chengpu Zhang, Yu Quan, Qiyong Guo

“…The decision tree demonstrated that among those participants with age≤49, 5497 participants (97%) of the individuals were identified as nondiabetic, while age>49, 771 participants (50%) of the individuals were identified as nondiabetic. In the subgroup where people were 34<age≤49 and BMI≥25, when with positive family history of diabetes, 89 (92%) out of 97 individuals were identified as diabetic and, when without family history of diabetes, 576 (58%) of the individuals were identified as nondiabetic. …”
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Characterizing the microbiome recruited by the endangered plant Firmiana danxiaensis in phosphorus-deficient acidic soil by Jiayu Li, Jiayu Li, Jiayu Li, Guangda Tang, Guangda Tang, Hongwei Liu, Xiaoying Luo, Juntao Wang, Juntao Wang, Juntao Wang

“…In contrast, P. massoniana rhizosphere harbored more Subgroup2 of Acidobacteria and Gammaproteobacterial N-fixer. …”
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Aldosterone Blockade in Acute Myocardial Infarction: A Systematic Review and Meta-Analysis by Qiao Chen, Die Zhao, Jie Sun, Chengzhi Lu

“…MRA reduced the risk of all-cause mortality by 16% (relative ratio (RR): 0.84; 95% confidence interval (CI) (0.76, 0.94); P=0.002) and the incidence of cardiovascular adverse events by 12% (RR: 0.88, 95% CI (0.83, 0.93), P<0.00001) in post-AMI patients, and further analysis demonstrated that early administration of MRA within 7 days after AMI resulted in a greater reduction in all-cause mortality (RR: 0.72, 95% CI (0.61, 0.85), P<0.0001). Subgroup analyses showed that post-STEMI patients without left ventricular systolic dysfunction (LVSD) treated with MRA had a 36% reduction in all-cause mortality (RR: 0.64, 95% CI (0.46, 0.89), P=0.007) and a 22% reduction in cardiovascular adverse events (RR: 0.78, 95% CI (0.67, 0.91), P=0.002). …”
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Treatment and counselling preferences of postpartum women with and without symptoms of (childbirth-related) PTSD: findings of the cross-sectional study INVITE by Rosa Hannele Horstmann, Lara Seefeld, Julia Schellong, Susan Garthus-Niegel

“…This study aimed to understand how support preferences differ between women with and without postpartum PTSD, considering the two subgroups of postpartum PTSD: childbirth-related PTSD (CB-PTSD) and general PTSD (gPTSD). …”
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Radiofrequency ablation for solitary T1N0M0 papillary thyroid carcinoma in the danger triangle area: a preliminary analysis by Dan-ling Zhang, Sheng Chen, Yuhan Qiu, Jian-chuan Yang, Zhiliang Hong, Jianwei Li, Song-song Wu

“…The incidence of new lesions and LNM was 3.2% (3/94), limited to the T1a subgroup. Further ablation was successfully applied to all new lesions and LMN. …”
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Regular human insulins versus rapid-acting insulin analogues in children and adolescents with type 1 diabetes: a protocol for a systematic review with meta-analysis and Trial Seque... by Johanne Juul Petersen, Sophie Juul, Caroline Barkholt Kamp, Pascal Faltermeier, Christina Dam Bjerregaard Sillassen, Tiago Jeronimo Dos Santos, Janus Christian Jakobsen

“…Data will be analyzed using fixed-effect meta-analyses, random-effects meta-analyses, and Trial Sequential Analysis. Several subgroup analyses are planned. Risk of bias will be assessed with the Cochrane Risk of Bias tool—version 2, an eight-step procedure will be used to assess if the thresholds for clinical significance are crossed, and the certainty of the evidence will be assessed by Grading of Recommendations, Assessment, Development and Evaluations (GRADE). …”
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Effectiveness of Traditional Chinese Medicine in Psychological Rehabilitation After Lung Cancer Surgery: Systematic Review and Meta-Analysis protocol by Luchang Cao PhD, Zilin Wang MM, Xinmiao Wang PhD, Guanghui Zhu PhD, Ying Zhang PhD, Jie Li PhD

“…The study will assess the quality of the reports and conduct a subgroup analysis based on various postoperative stages, intervention measures, intervention duration, and sex to gather more evidence to fill the gap in psychological function rehabilitation after lung cancer surgery. …”
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Sunlight exposure practice and its associated factors among infants in Ethiopia, systematic review and meta-analysis. by Fanos Yeshanew Ayele, Natnael Kebede, Asnakew Molla Mekonen, Mengistu Mera Mihiretu, Yawkal Tsega, Elsabeth Addisu, Niguss Cherie, Tesfaye Birhane, Chala Daba, Ahmed Hussien Asfaw, Zinet Abegaz, Abel Endawekie, Anissa Mohammed, Dagnachew Melak, Fekade Demeke Bayou, Husniya Yasin, Aregash Abebayehu Zerga, Fikre Bayu Gebeyehu, Birhanu Wagaye

“…A random effect model was used to compute the pooled prevalence, while subgroup analysis was performed to identify the possible source of heterogeneity. …”
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Clinical Characteristics and Outcomes in Patients with Ruptured Middle Cerebral Artery Aneurysms: A Multicenter Study in Northern China by Xiuhu An, Jingliang Su, Bingxin Duan, Long Zhao, Bangyue Wang, Yan Zhao, Tianxing Li, Shuai Zhou, Xinyu Yang, Zhenbo Liu

“…The Cox proportional hazards model was used to analyze risk factors and mortality risk, whereas logistic regression was used to identify factors influencing 2-year survival. Subgroup analyses were performed to verify the robustness of the results. …”
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Transcanalicular laser-assisted and external dacryocystorhinostomy anatomical and functional success in primary acquired nasolacrimal duct obstruction: systematic review and meta-a... by Khalid W. Helmi, Ahmed S. Abdulhamid, Mohammed S. Alomari, Ali S. Alsudais, Badran S. Alqurashi, Abdullah Alsharif, Abdulrahman H. Alzahrani, Abdulrahman M. Bahalaq, Mohammed F. Qutub, Hashem S. Almarzouki

“…Results There was a statistically significant difference in anatomical success (RR = 0.84, 95% CI 0.72–0.97; P = 0.02), favoring EX-DCR; functional success (RR = 0.87, 95% CI 0.78–0.97; P = 0.01), favoring EX-DCR; operative (OR) time (SMD = -2.42, 95% CI -2.92 – -1.91; P < 0.00001) favoring TC-DCR; and intraoperative complications (RR = 0.16, 95% CI 0.06–0.43; P = 0.0003), favoring TC-DCR. Moreover, the subgroup analysis comparing single-diode TC-DCR to EX-DCR revealed a statistically significant difference in terms of anatomical success and functional success; however, the comparison of multidiode TC-DCR to EX-DCR revealed no statistically significant difference. …”
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Association Between Four Non-Insulin-Based Insulin Resistance Indices and the Risk of Post-Stroke Depression by Wang P, Wang M, Xie Z, Zhi Z, Wang Y, Liu F, Liu Y, Zhao L

“…Restricted cubic spline analysis revealed a linear dose-response relationship between the four IR indices and PSD. In the subgroup analysis, only the TyG index showed a significant interaction with diabetes (P for interaction = 0.014). …”
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Occurrence of Fatal and Nonfatal Adverse Outcomes after Heart Transplantation in Patients with Pretransplant Noncytotoxic HLA Antibodies by Luciano Potena, Andrea Bontadini, Sandra Iannelli, Fiorenza Fruet, Ornella Leone, Francesco Barberini, Laura Borgese, Valentina Manfredini, Marco Masetti, Gaia Magnani, Francesco Fallani, Francesco Grigioni, Angelo Branzi

“…In addition, HLA-ab detection was associated with increased prevalence of early graft failure (35 versus 15%; P=0.05) and late cellular rejection (29 versus 11%; P=0.03). Of the subgroup of 37 patients suspected for antibody mediated rejection (AMR), the 9 with pretransplant HLA ab were more likely to display pathological AMR grade 2 (P=0.04). …”
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Inferior vena cava diameter in patients with chronic heart failure and chronic kidney disease: a retrospective study by Jianan Li, Chi Wang, Hui wu Dong, Jing Qi, Chongyou Rao, Qiuyang Li, Kunlun He

“…This association were mediated by log NT-proBNP (mediated effect: 37.8% (95%CI 22.0–73.0%), P < 0.001) and serum albumin (mediated effect: 14.1% (95%CI 6.2–28.0%), P < 0.001). In subgroup analyses, there was no significant interaction in different subgroups of cardiac and renal function for the association between IVC and all-cause mortality. …”
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Association between the C-reactive protein-triglyceride–glucose index and endometriosis: a cross-sectional study using data from the national health and nutrition examination surve... by Yanan Ren, Ren Xu, Junqin Zhang, Ying Jin, Di Zhang, Yazhuo Wang, Luyang Su

“…Multivariate logistic regression, restricted cubic splines, and subgroup analyses were performed to examine the association between the CTI and EM. …”
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Artificial Liver Support Systems in Acute Liver Failure and Acute-on-Chronic Liver Failure: Systematic Review and Meta-Analysis by Robert S. Brown, Jr, MD, MPH, Robert A. Fisher, MD, FACS, TACC, Ram M. Subramanian, MD, MBA, Adam Griesemer, MD, Milene Fernandes, PharmD, MSc, William H. Thatcher, MS, Kathryn Stiede, BS, Michael Curtis, PhD

“…Overall, NBAL/BAL was not statistically associated with mortality at 28–30 days (RR, 0.85; 95% CI, 0.67–1.07; p = 0.169) or frequency of at least one SAE (RR, 1.15; 95% CI, 0.99–1.33; p = 0.059), compared with standard medical treatment. Subgroup results on ALF patients suggest possible benefit for mortality (RR, 0.67; 95% CI, 0.44–1.03; p = 0.069). …”
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Auricular Acupuncture for Perioperative Pain Management: A Systematic Review and Meta-Analysis of Randomized Controlled Trials by Zhou Y, Bao Q, Yang C, Li S, Yin Z, Xiong J, Sun M, Yang J, Liu F, Liang F

“…Perioperative anxiety improvement did not differ significantly between the AA and control groups (MD= − 5.45, 95% CI: − 32.99 to 22.09). Subgroup analysis showed that AA exerted a significant analgesic effect as a preoperative intervention and in orthopedic surgery. …”
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Effectiveness and safety of percutaneous endoscopic debridement and drainage for spinal infections: a systematic review and meta-analysis by Guozhong Zhou, Xiaorong Liu, Zhi Liang, Xuesong Chen, Chao Song

“…The rates of complication, reoperation, and mortality were 4.1% (95% CI 1.5–8.0%), 8.6% (95% CI 4.3–14.3%), and 1.7% (95% CI 0.4–4.1%), respectively. Subgroup analyses demonstrated a significantly lower reoperation rate in the group that discontinued antibiotics based on a normal CRP than in the fixed-duration group (2.7% [95% CI 0.3–7.7%] vs 20.1% [95% CI 14.5–26.3%], p = 0.0002). …”
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Identification of a postoperative survival scoring index for adult liver transplantation by Shuai Wang, Xiaohong Lin, Yefu Li, Zhonghao Xie, Ming Zhang, Yicheng Liang, Chuchen Zhu, Yuqi Dong, Ping Zeng, Xiaoshun He, Weiqiang Ju, Maogen Chen

“…Finally, the interpretation of the long-term mortality and subgroup analyses extended the application of the POSS index.Results Finally, a total of five factors (donor sex, recipient body mass index (BMI), total bilirubin (Tbil), international normalized ratio (INR) and total operative time) were identified as independent risk parameters and included in our POSS index. …”
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