Real-world effectiveness of hemodialysis modalities: a retrospective cohort study by Yan Zhang, Anke Winter, Belén Alejos Ferreras, Paola Carioni, Otto Arkossy, Michael Anger, Robert Kossmann, Len A. Usvyat, Stefano Stuard, Franklin W. Maddux

“…The pattern of a beneficial effect of hemodiafiltration was consistently observed among all analyzed subgroups. Among patients receiving high-volume hemodiafiltration (mean convection volume ≥ 23 L), the risk of death was reduced by 30% (HR, 0.70 [95% CI, 0.68–0.72]). …”
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Association Between Nontraditional Lipid Profiles and the Risk of Type 2 Diabetes Mellitus in Chinese Adults With Hypertension: Findings From the China Hypertension Registry Study by Yu Tao, Tao Wang, Wei Zhou, Lingjuan Zhu, Chao Yu, Juxiang Li, Huihui Bao, Xiaoshu Cheng

“…Additionally, the study demonstrated that AIP had a superior ability to identify T2DM. Subgroup analyses indicated that the relationship between AIP and Non‐HDL‐C with T2DM was more significant in the lighter weight population. …”
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Efficacy and safety of dexamethasone or triamcinolone in combination with anti-vascular endothelial growth factor therapy for diabetic macular edema: A systematic review and meta-a... by Bo Zhou, Hua Liu, Feng Xiong

“…However, the combination therapy significantly increased the risk of elevated intraocular pressure (RR 5.783, 95% CI 3.007 to 11.121, 95% PI 0.520 to 56.931) and ocular hypertension (RR 8.885, 95% CI 2.756 to 28.649, 95% PI 1.262 to 39.208). Subgroup analysis suggests that dexamethasone plus anti-VEGF therapy showed a greater reduction in central subfield thickness (SMD -0.440, 95% CI -0.755 to -0.126) compared to anti-VEGF monotherapy among patients with persistent DME.…”
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Continuous high-soy protein soymilk intake affects ordinary walking speed in the Japanese pre-frail and frail elderly: a randomized controlled trial by Nene Sato, Yuji Terashima, Makoto Sugawara, Ryoichi Unno, Hiroaki Asao, Mitsuhiro Iwasaki, Tomoyuki Watanabe, Tomoko Uno, Mitsuo Maruyama

“…Results For the final analysis of the entire cohort (n = 70), there were no significant differences in the endpoints between the two groups. In the subgroup analysis, among participants with a walking speed of at least 1 m/s (n = 35, P = 0.012) and at least 5,000 steps/day before intervention (n = 27, P = 0.0083), the variation in walking speed after the 12-week intervention was significantly higher in the high-soy protein group than in the control group. …”
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Mesalazine for People with Diverticular Disease: A Systematic Review of Randomized Controlled Trials by Andrea Iannone, Marinella Ruospo, Germaine Wong, Michele Barone, Mariabeatrice Principi, Alfredo Di Leo, Giovanni F. M. Strippoli

“…We quantified heterogeneity by Chi2 and I2 tests. We performed subgroup analyses by disease subtype, comparator, follow-up duration, mesalazine dose, and mode of administration. …”
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Intratesticular Testosterone and Its Precursors among Azoospermic Men: A Pilot Study by I-Shen Huang, Li-Hua Li, Wei-Jen Chen, Chi-Chang Juan, William J. Huang

“…Results: Men with NOA who had not undergone hormone treatment exhibited significantly higher intratesticular concentrations of testosterone (median 1,528.1 vs. 207.5 ng/mL), androstenedione (median 10.6 vs. 1.9 ng/mL), and 17-OH progesterone (median 13.0 vs. 1.8 ng/mL) than men diagnosed with OA. Notably, in the subgroup of patients with NOA subjected to medical treatment, men with successful sperm retrieval had significantly reduced levels of androstenedione (median androstenedione 5.7 vs. 18.5 ng/mL, p=0.004). …”

Association of preoperative body mass index with postoperative complications and survival for patients with gastric cancer: A systematic review and meta-analysis. by Zhenzhen Li, Lili Cui, Jing Sun, Wanlu Liu

“…Additionally, exploratory sensitivity and subgroup analyses were performed.<h4>Results</h4>Twenty-two studies involving 41,144 patients with gastric cancer were included for quantitative analysis. …”
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Fatigue in living kidney donors compared to a German general population sample: an exploratory study by Dilek Akkus, Adrian Westenberger, Gunilla Einecke, Gunilla Einecke, Wilfried Gwinner, Uwe Tegtbur, Mariel Nöhre, Martina de Zwaan

“…A significant exception was found in women aged 45-54 years, where donors showed significant higher general fatigue scores than the corresponding subgroup of the general population sample. Multiple regression analyses in the general population sample revealed associations between female sex and higher age with higher values in most MFI-20 subscales, whereas subjects with higher education showed mostly lower fatigue scores. …”
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Clinical Features of Optic Disc Drusen in an Ophthalmic Genetics Cohort by Jasmine Y. Serpen, Lev Prasov, Wadih M. Zein, Catherine A. Cukras, Denise Cunningham, Elizabeth C. Murphy, Amy Turriff, Brian P. Brooks, Laryssa A. Huryn

“…ODD prevalence in our cohort of patients with inherited retinal degenerations was 2.5%, and ODD were more prevalent in the rod-cone dystrophy subgroup at 2.95% (OR = 3.3 [2.1–5.3], P<0.001) compared to the ophthalmic genetics cohort. …”
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Association of geriatric nutritional risk index with renal prognosis and all-cause mortality among older patients with chronic kidney disease: a secondary analysis of CKD-ROUTE stu... by Lei Chen, Mengyao Yan, Jie Li, Xue Zhao, Lu Zeng, Zhumei Gao, Hongli Jiang, Limin Wei

“…Moreover, the associations were generally consistent across several subgroup and sensitivity analyses.Conclusions The lower GNRI is significantly associated with higher risks of renal prognosis and all-cause mortality in elderly patients with CKD.…”
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Evaluating the Effectiveness of mRNA-1273.815 Against COVID-19 Hospitalization Among Adults Aged ≥ 18 Years in the United States by Amanda Wilson, Neloufar Rahai, Ekkehard Beck, Elisha Beebe, Brian Conroy, Daina Esposito, Priya Govil, Hagit Kopel, Tianyi Lu, James Mansi, Morgan A. Marks, Katherine E. Mues, Rohan Shah, Michelle Skornicki, Tianyu Sun, Astra Toyip, Mitra Yousefi, David Martin, Andre B. Araujo

“…The VE against COVID-19 hospitalization was 51% (95% confidence interval [CI]: 48–54%). Subgroup analyses showed a VE of 56% (95% CI 51–61%) among adults ≥ 65 years and 46% (95% CI 39–52%) in immunocompromised adults. …”
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Intraocular lens calculation formula selection for short eyes: based on axial length and anterior chamber depth by Ruoxi Gao, Jiaqing Zhang, Xiaotong Han, Yiguo Huang, Ruoxuan Huang, Jinfeng Ye, Ling Wen, Xiaozhang Qiu, Xiaoyun Chen, Xuhua Tan, Lixia Luo

“…Methods New-generation formulas (Barrett Universal II [BUII], Emmetropia Verifying Optical [EVO] 2.0, Hill-Radial Basis Function [Hill-RBF] 3.0, Hoffer QST, K6, Kane, Pearl-DGS) and traditional formulas (Haigis, Hoffer Q, Holladay 1 and SRK/T) were evaluated for predictive accuracy. Subgroup analyses were performed based on AL and anterior chamber depth (ACD). …”
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Impact of COVID-19 and other pandemics and epidemics on people with pre-existing mental disorders: a systematic review protocol and suggestions for clinical care by Nitika Sanger, Stephanie Sanger, Lehana Thabane, Zainab Samaan, Lawrence Mbuagbaw, Tea Rosic, Anjali Sergeant, Emma Alaine van Reekum, Alexander Dufort, Sandra Lubert

“…If possible, study findings will be combined in meta-analyses, and subgroup analyses will be performed. We hope that this review will shed light on the impact of pandemics and epidemics on those with pre-existing mental disorders. …”
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Estimated prevalence of post-intensive care cognitive impairment at short-term and long-term follow-ups: a proportional meta-analysis of observational studies by Mu-Hsing Ho, Yi-Wei Lee, Lizhen Wang

“…The pooled post-intensive care cognitive impairment prevalence rates at the follow-up timepoints < 1 month, 1–3 month(s), 4–6 months, 7–12 months, > 12 months were 49.8% [95% Prediction Interval (PI), 39.9%–59.7%, n = 19], 45.1% (95% PI, 34.8%–55.5%, n = 23), 47.9% (95% PI, 35.9%–60.0%, n = 16), 28.3% (95% PI, 19.9%–37.6%, n = 19), and 30.4% (95% PI, 18.4%–43.9%, n = 7), respectively. Subgroup analysis showed that significant differences of the prevalence rates between continents and study designs were observed. …”
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Problem of pain in the USA: evaluating the generalisability of high-impact chronic pain models over time using National Health Interview Survey (NHIS) data by Sean Mackey, Titilola Falasinnu, Md Belal Hossain, Mohammad Ehsanul Karim, Kenneth Arnold Weber

“…We assessed model discrimination, calibration and overall performance using metrics such as area under the curve (AUC), calibration slope and Brier score.Results Scenario 1, validating the NHIS 2016 model against 2017 data, demonstrated excellent discrimination with an AUC of 0.89 (95% CI 0.88 to 0.90) for both LASSO and random forest models. Subgroup-specific performance varied, with the lowest AUC among adults aged ≥65 years (0.81, 95% CI 0.78 to 0.82) and the highest among Hispanic respondents (0.91, 95% CI 0.88 to 0.94). …”
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Delirium at the intensive care unit and long-term survival: a retrospective study by Ignazio De Trizio, Maria Angeliki Komninou, Jutta Ernst, Reto Schüpbach, Jan Bartussek, Giovanna Brandi

“…A multivariable logistic regression model was fitted with long-term survival at four years after ICU-discharge as outcome of interest, including several clinical conditions and interventions associated with long-term survival for ICU patients. For subgroup analysis, ICU-survivors were grouped based on age at the time of admission (45–54, 55–64, ≥ 65 years), and on relevant clinical conditions. …”
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Efficacy and Safety of Cataract Surgery Combined with Ab Interno Canaloplasty and Micro-Trabecular Bypass Stent Surgery in Open-Angle Glaucoma by Porter MS, Flowers A, Wood BP, Gallardo MJ

“…Eyes were categorized according to IOP and disease severity. A subgroup of patients on 3+ medications at baseline was included. …”
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Incidence of cancer-related lymphoedema: a protocol for a living systematic review with meta-analysis by Nele Devoogdt, Hildegard Reul-Hirche, Kira Bloomquist, Michael Bernas, Ben Singh, Sandi Hayes, Melanie Plinsinga, Debbie Geyer, Louise Koelmeyer, Neil Piller, Stanley Rockson

“…Random effect models will be used to produce pooled overall lymphoedema incidence estimates. Subgroup analyses that explore relationships between lymphoedema incidence and lymphoedema measurement method, time since cancer diagnosis and treatment and diagnosis, treatment and behavioural characteristics will be conducted dependent on available data.Ethics and dissemination This living systematic review enables clinicians and researchers to consult a contemporary, comprehensive overview of the incidence of cancer-related lymphoedema and the association between lymphoedema and treatment and non-treatment-related risk factors.PROSPERO registration number CRD42022333291.…”
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The Association of moisture intake and constipation among us adults: evidence from NHANES 2005–2010 by Deng-Chao Wang, Xue-Feng Peng, Wen-Xing Chen, Miao Yu

“…Additionally, restricted cubic splines (RCS) were applied to further explore potential non-linear patterns in the relationship between moisture intake and constipation, along with subgroup analysis. Results The study included 14,492 participants, of whom 1,514 reported constipation issues. …”
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Development and internal validation of a nomogram for predicting cognitive impairment after mild ischemic stroke and transient ischemic attack based on cognitive trajectories: a pr... by Panpan Zhao, Panpan Zhao, Lin Shi, Guimei Zhang, Chunxiao Wei, Weijie Zhai, Yanxin Shen, Yongchun Wang, Zicheng Wang, Li Sun

“…The results were presented as nomograms, and receiver operating characteristic curve analysis, calibration, decision curve analysis, and cross-validation were performed to assess model performance.ResultsThe LCGA eventually included 255 patients, and the “22” group was selected for further subgroup analysis. Among them, 29.8% were included in the cognitive impairment trajectory. …”
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