L-shaped association of body mass index with prognosis in individuals with sepsis: a multicenter cohort study by Kunping Cui, Xiangnan Teng, Wei liu, Xiaoxiao Zhao, Shanling Xu, Lang Bai

“…The results remained robust in multiple distinct models and subgroup analyses. Conclusion An L-shaped relationship was observed between BMI and prognosis in septic patients, indicating that lower BMI values are significantly linked to increased mortality. …”
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Association of neutrophil-to-lymphocyte ratio with severe abdominal aortic calcification: new evidence from the United States by Hao Deng, Mengmeng Sun, Zhentong Zhao, Kun Fan, Zizhang Zhao, Yifan Chi, Wei Sheng

“…Compared with the lowest NLR group [quartile 1 (Q1), <1.64], the adjusted odds ratio values for NLR and SAAC in Q3 (>2.34) were 1.42 (95% confidence interval: 1.02–1.96, p = 0.037), respectively. The results of subgroup analyses revealed no significant interaction effects.ConclusionsThe NLR was positively correlated with SAAC prevalence among adults in the US. …”
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Assessment of Tumor Burden Score as a Feasible and Reliable Tool for Prognosis Prediction for Hepatocellular Carcinoma Undergoing Hepatectomy: A Multicenter, Retrospective Study by Guan R, Zheng Z, Deng M, Mei J, Lin Y

“…Overall survival (OS) and recurrence-free survival deteriorated incrementally with increasing TBS (P< 0.0001). Subgroup analysis indicated that there was a significant survival difference among the three TBS groups across the BCLC stage (P< 0.0001). …”
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Risk Stratification and Adjuvant Chemotherapy for High‐Risk Stage IA Lung Adenocarcinoma: The Unmet Needs by Chen Shen, Haoran Liu, Bofei Li, Jiaming Wang, Yiyang Wang, Feichao Bao, Zhitao Gu, Wentao Fang

“…Further exploration of effective adjuvant target therapies is warranted for this patient subgroup.…”
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Efficacy of brief intervention for drug misuse in primary care facilities: systematic review and meta-analysis protocol by Toshi A Furukawa, Yan Luo, Norio Watanabe, Ethan Sahker, Masatsugu Sakata, Rie Toyomoto, Chiyoung Hwang, Kazufumi Yoshida

“…If heterogeneity is present, subgroup analyses will consider patient variables of age, sex/gender, race/ethnicity, per cent insured, baseline severity and primary drug misused.Ethics and dissemination This study will use published aggregate data and will not require ethical approval. …”
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Long-term effects of SARS-CoV-2 infection and vaccination in a population-based pediatric cohort by Jakob Höppner, Christoph Maier, Anne Schlegtendal, Anna Hoffmann, Astrid Petersmann, Thomas Lücke, Nicole Toepfner, Folke Brinkmann

“…Participants from a pediatric population based seroprevalence study (CorKID study) were followed up at least two and for almost four years by survey of health status features and symptoms suggestive of post-COVID syndrome (PCS). In a subgroup (n = 259) SARS-CoV-2 antibody serology was further investigated. 789 participants of the original CorKID study cohort (n = 2.121; 37.2%) were included. 67.9% reported at least one SARS-CoV2 infection. 46.6% had received one or more SARS-CoV-2 vaccinations. …”
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Anti-HEV antibody reactivity rate in voluntary blood donors in China: a Meta-analysis by XU Niuniu, JIAO Zhanying

“…The RD value of anti-HEV IgG reactivity rate in group B was 33.03% [95% CI (28.01%, 38.05%)], and the RD value of anti-HEV IgM reactivity rate was 1.13% [95% CI (1.05%, 1.21%)]. The results of subgroup analysis showed that in both group A and B, the anti-HEV IgG reactivity rate in voluntary blood donors increased with age. …”
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Predictive value of dendritic cell-related genes for prognosis and immunotherapy response in lung adenocarcinoma by Zihao Sun, Mengfei Hu, Xiaoning Huang, Minghan Song, Xiujing Chen, Jiaxin Bei, Yiguang Lin, Size Chen

“…In contrast, patients in the low-DCRGS subgroup were resistant to chemotherapy but sensitive to the CTLA-4 immune checkpoint inhibitor and targeted therapy. …”
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Comparing the Efficacy and Safety of Glucagon-Like Peptide 1 Receptor Agonists with Sodium-Glucose Cotransporter 2 Inhibitors for Obese Type 2 Diabetes Patients Uncontrolled on Met... by Lu Ding, Bang Sun, Xinhua Xiao

“…No significant difference was detected between GLP-1RAs and SGLT-2is in overall adverse events (RR: 1.03; 95% CI: 0.98, 1.09; p=0.76), but gastrointestinal events showed higher occurrence in GLP-1RAs groups compared with SGLT-2is (RR: 1.62; 95% CI: 1.37, 1.93; p<0.00001). Subgroup analyses revealed that follow-up time did not statistically influence glycemic control. …”
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Association of live microbes intake and risk of all-cause, cardiovascular disease, and cancer-related mortality in patients with chronic kidney disease by Debin Chen, Yongju Ye, Yining Li, Erxu Xue, Qijun Zhang, Youlan Chen, Jianhui Zhao

“…Consistent results were observed in subgroup and sensitivity analyses. A significant negative association was observed between live microbe intake and the risk of all-cause mortality as well as CVD mortality in the CKD population, with a p-value for trend < 0.05.Conclusion Our study indicated that high dietary live microbe intake could mitigate the risk of all-cause and CVD mortality in CKD patients. …”
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Vitamin D supplementation during intensive care unit stay is associated with improved outcomes in critically Ill patients with sepsis: a cohort study by Caifeng Li, Ke Zhao, Qian Ren, Lin Chen, Ying Zhang, Guolin Wang, Keliang Xie

“…Vitamin D supplementation was associated with decreased 28-day all-cause mortality (HR, 0.56; 95% CI, 0.49-0.64; p &lt; 0.001). Subgroup analyses showed consistent benefits regardless of the baseline vitamin D status (deficiency: HR, 0.70; 95% CI, 0.33-1.50; p = 0.36; insufficiency: HR, 0.10; 95% CI, 0.03-0.34; p &lt; 0.001; sufficiency: HR, 0.33; 95% CI, 0.12-0.88; p = 0.03). …”
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ZINQ-L: a zero-inflated quantile approach for differential abundance analysis of longitudinal microbiome data by Shuai Li, Runzhe Li, John R. Lee, John R. Lee, Ni Zhao, Wodan Ling

“…In addition, the existing methods are mostly mean-based, unable to identify heterogeneous associations such as tail events or subgroup effects, which could be important biomedical signals.MethodsWe propose a zero-inflated quantile approach for longitudinal (ZINQ-L) microbiome differential abundance test. …”
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Association between ambient air pollution and outpatient visits of cardiovascular diseases in Zibo, China: a time series analysis by Yamei Wang, Shaoning Qu, Ting Li, Liang Chen, Liping Yang

“…Distributed lag non-linear models (DLNM) including single-pollutant model in single-day (lag0-lag7) and cumulative-days (lag01-lag07), concentration-response curve, subgroup analysis, and double-pollutant model were utilized to examine the relationships of daily air pollutants on CHD, stroke, and arrhythmia. …”
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Serum metalloproteinase-7 as a biomarker of progressive pulmonary fibrosis by Márcia Araújo, Marília Beltrão, Oksana Sokhatska, Natália Melo, Patrícia Caetano Mota, Helder Novais Bastos, André Terras, David Coelho, Luís Delgado, António Morais

“…Conclusions In patients with fibrotic non-IPF ILDs, serum MMP-7 levels were significantly greater in the subgroup of patients meeting the PPF criteria at follow-up. …”
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Fermented Ophiocordyceps sinensis mycelium products for preventing contrast-associated acute kidney injury: a systematic review of randomized controlled trials by Fenglan Pu, Tianli Li, Chen Shen, Yingqiao Wang, Chunmei Tang, Xiaowen Zhang, Lijiao Yan, Qihe Xu, Jianping Liu

“…Compared with routine preventive procedure (RPP) (saline hydration and alprostadil), FOSM products plus RPP showed beneficial effects in reducing the incidence of CA-AKI (14.62% and 5.35%, respectively; RD −0.06, 95% CI −0.09 to −0.03). Subgroup analysis showed that Bailing/Jinshuibao plus RPP demonstrated lower incidence of CA-AKI compared to RPP. …”
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Nursing professionalism and associated factors in Ethiopia: a systematic review and meta-analysis by Moges Tadesse Abebe, Agerie Mengistie Zeleke, Yeshiwas Ayale Ferede, Yosef Aragaw Gonete, Worku Chekol Tassew

“…We also computed a sensitivity analysis and subgroup analysis by sample size and study period. …”
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The clinical impact of glenoid concavity and version on anterior shoulder stability by Sebastian Oenning, MD, Clara de Castillo, Elena Jacob, MD, Arne Riegel, MD, Philipp A. Michel, MD, Jens Wermers, MSc, Michael J. Raschke, MD, J. Christoph Katthagen, MD

“…A higher retroversion was seen in the instability cohort (−13.1° vs. −11.4°; P = .041). Subgroup analyses showed higher BSSR (SI) in ≥60-year-old patients compared to ≤30-year-old patients. …”
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Perennial disaster patterns in Central Europe since 2000 and implications for hospital preparedness planning – a cross-sectional analysis by Maik von der Forst, Maximilian Dietrich, Felix C. F. Schmitt, Erik Popp, Markus Ries

“…More than 50% of the technological disasters were categorized in the transport accident subgroup. Technological disasters were spread equally over the whole year. …”
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The association between blood selenium and metabolic syndrome in adults: a systematic review and dose–response meta-analysis of epidemiologic studies by Zahra Hajhashemy, Zahra Hajhashemy, Sahar Foshati, Mohammad Bagherniya, Gholamreza Askari

“…Due to a significant between-study heterogeneity (I2 = 90.4%, p &lt; 0.001), subgroup analysis was conducted based on potential confounders. …”
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Cellular heterogeneity and communication networks in gastric cancer: Single-cell analysis reveals β-hydroxybutyrylation-associated genes and immune infiltration characteristics by You Hu, Jun Xu, Jian Lv, Yan Qin, Yongda Lu, Fan Cen, Hongbao Yang, Kai Chen, Suhua Xia

“…Hierarchical clustering based on these genes classified gastric cancer patients into two subgroups with distinct prognostic outcomes. Patients in the high-risk subgroup exhibited increased expression of pro-tumor genes and reduced immune infiltration, correlating with poorer survival. …”
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