Limitations of the Boston Carpal Tunnel Questionnaire in Assessing Severity in a Homogeneous Occupational Cohort by Venera Cristina Dinescu, Marius Bica, Ramona Constantina Vasile, Andrei Gresita, Bogdan Catalin, Alexandra Daniela Rotaru-Zavaleanu, Florentin Ananu Vreju, Lorena Sas, Marius Bunescu

“…Statistical analyses included comparisons across CTS severity groups and subgroup evaluations based on age and tenure. <b>Results</b>: The BCTQ demonstrated moderate correlations with objective measures, with a strong correlation between SSS and FSS scores (r = 0.86, <i>p</i> < 0.001). …”
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Gonadotropin Releasing Hormone Agonists Combined with Hormone Replacement Therapy Significantly Improves Reproductive Outcomes for Patients with Thin Endometrium and Intramural Fib... by Wei L, Tian B, Wang S, Xu S, Zhang C

“…A logistic regression model indicated that the LBR was significantly higher in the GnRH-a-HRT group compared to both the HRT group (odds ratio, 0.269; 95% confidence interval, 0.114– 0.637; P = 0.003) and the NC group (odds ratio, 0.524; 95% confidence interval, 0.457– 0.956; P = 0.023). Subgroup analyses based on the number and dimension of fibroids demonstrate the positive efficacy of the GnRH-a–HRT regimen.Conclusion: Compared to NC and HRT protocol, improved reproductive outcomes were observed in the GnRH-a–HRT group. …”
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Perioperative infections as a prognostic risk factor in hepatocellular carcinoma and cholangiocellular carcinoma: a comparative analysis by Markus S. Jördens, Hannah C. Oswald, Lisa Heinrichs, Nathalie Gassmann, Linda Wittig, Tom Luedde, Sven H. Loosen, Christoph Roderburg, Wolfram T. Knoefel, Georg Fluegen

“…Results Patients with perioperative infection displayed a significantly impaired OS compared to patients without a documented infection (419 (95% CI: 262–576) days vs. 959 (95% CI: 637–1281) days; log rank X2(1) = 10.28; p < 0.001). Subgroup analysis revealed that this effect was only observed among HCC patients, while the outcome of CCA patients was independent of pre- or postoperative infections. …”
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Meta-analysis of the accuracy for RASSF1A methylation in bronchial aspirates for the diagnosis of lung cancer. by Xu-Ping Chen, Shi-Xu He, Meng-You Chen, Fu-Bin Chen, Peng Wu, Ping Shi, Shi-Cai Zhao, Ling-Yan Zhao, Xiao-Min Xiong, Jia Zeng

“…The sensitivity of the RASSF1A methylation assay was relatively low in a detailed subgroup analysis, fluctuating between 0.39 and 0.90, indicating a limitation in its diagnostic value for lung cancer. …”
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Inosine enhances the efficacy of immune‐checkpoint inhibitors in advanced solid tumors: A randomized, controlled, Phase 2 study by Haiqing Zhao, Wei Zhang, Yuting Lu, Yin Dong, Zhihao He, Hongchao Zhen, Qin Li

“…Compared with the non‐inosine group, the median PFS and ORR of the inosine group were significantly prolonged and improved in the multiple exploratory subgroup analyses. The safety analysis showed that Grades 3 and 4 adverse reactions occurred in 25 (29%) and 31 (36%) patients in the inosine and non‐inosine groups, respectively, and tended to decrease in the inosine group compared with the non‐inosine group. …”
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How do serum cytokine levels change in myocarditis and inflammatory dilated cardiomyopathy relative to healthy individuals? A protocol for a systematic review and meta-analysis by Romuald Wojnicz, Piotr Lewandowski, Maciej Baron, Marcin A Rojek, Marcin Goławski, Karol Krystek, Magdalena Żegleń, Pascal Zytkiewicz, Jakub Kancerek, Klaudia Gabriela Lis, Jakub Warecki, Jakub Kufel, Kamila Kuśpiel

“…Meta-analyses will be used to summarise serum levels of each cytokine if possible. Subgroup analysis will be stratified by age, sex, sample size, New York Heart Association scale, cardiac Troponin T, N-terminal prohormone of brain natriuretic peptide, C reactive protein, number of lymphocytes per mm2 in the endomyocardial biopsy.Ethics approval and dissemination This study does not require ethics approval. …”
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Factors Influencing Informed Consent Preferences in Digital Health Research: Survey Study of Prospective Participants by Brian J McInnis, Ramona Pindus, Daniah Kareem, Daniela G Vital, Eric B Hekler, Camille Nebeker

“…These factors are important to consider as not attending to some details that matter to a specific subgroup of prospective participants may systematically exclude people from research. …”
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Association of TyG index with mortality at 28 days in sepsis patients in intensive care from MIMIC IV database by Heping Xu, Jinyuan Xie, Yan Xia, Huan Niu, Hong Wang, Feng Zhan

“…These findings were consistent across subgroups and various sensitivity analyses. Our study revealed a nonlinear U-shaped relationship between the TyG index and 28-day all-cause mortality, with a critical point at a TyG index of 9.03. …”
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Mortality-related risk factors of carbapenem-resistant Enterobacteriaceae infection with focus on antimicrobial regimens optimization: a real-world retrospective study in China by Sheng Deng, Jinglan Chen, Pengxiang Zhou, Qin Hu

“…Among those 65.4% (51/78) received combination therapy and 34.6% (27/78) received monotherapy. Subgroup analysis of the non-sepsis group showed significantly lower mortality in monotherapy than in combination therapy (0% versus 22.2%, P = 0.034). …”
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Evaluating the Relationship of GDF-15 with Clinical Characteristics, Cardinal Features, and Survival in Multiple Myeloma by Małgorzata Banaszkiewicz, Jolanta Małyszko, Krzysztof Batko, Ewa Koc-Żórawska, Marcin Żórawski, Paulina Dumnicka, Artur Jurczyszyn, Karolina Woziwodzka, Joanna Tisończyk, Marcin Krzanowski, Jacek Małyszko, Anna Waszczuk-Gajda, Ryszard Drożdż, Marek Kuźniewski, Katarzyna Krzanowska

“…We defined five clinically relevant subgroups of patients (symptomatic MM only, patients with and without remission, patients on chemotherapy, and without treatment). …”
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Migraine and subsequent chronic kidney disease risk: a nationwide population-based cohort study by Ming-Ju Wu, Chew-Teng Kor, Chia-Chu Chang, Shuo-Chun Weng, Chia-Lin Wu, Ping-Fang Chiu, Der-Cherng Tarng

“…All the participants were registered in the National Health Insurance Research Database.Participants Finally, data from 7156 subjects with migraine and 7156 propensity-score-matched control subjects were analysed.Primary outcome measure We used Cox proportional hazards regression to estimate adjusted HRs for incident CKD; subgroup analyses were performed to assess the interactive effects of migraine with demographics, comorbidities and long-term medications.Results The incidence of CKD was higher in the migraine group than in the control group. …”
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The association between eight complete blood count-derived inflammatory markers and muscle health by Jingyuan Zhang, Yuqi Wang, Heng Liu, Zhuolin Lei, Shouquan Cheng, Hong Cao

“…Multivariate logistic regression, smooth curve fitting, restricted cubic spline (RCS) analysis, subgroup analysis, and Spearman's correlation were used to comprehensively assess the associations between the eight inflammatory indicators and muscle mass and strength. …”
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Expression and Clinical Significance of DAP3 in Breast Cancer and Effect of Bruceine D on Expression of DAP3:Analysis Based on Data-mining from Bioinformatics by Wenlong WANG, Qingzhi KONG, Hongda LU, Qingdong XIANG, Dianlei LIU

“…On-line analysis of nine DAP3 gene datasets collected from Oncomine database showed that the expression of DAP3 gene in breast cancer tissues was distinctly higher than that of breast adjacent normal tissues(<italic>P</italic>&lt;0.05).Moreover, <italic>Kaplan-Meier plotter</italic> of overall survival indicated that the breast cancer patients with high expression of DAP3 have a worse survival, and the breast cancer patients with low expression of DAP3 have a better survival(<italic>P</italic>&lt;0.05).Further subgroup analysis revealed that the expression of DAP3 had a significant effect(<italic>P</italic>&lt;0.05)on the prognosis of breast cancer patients except for basal-like subtype, estrogen receptor-negative subtype and human epidermal growth factor receptor-2 overexpression subtype breast cancer patients. …”
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Comparison of microvascular density in cervical carcinoma in relation to predictive pathohistological parameters by Mandić Aljoša, Ivković-Kapicl Tatjana, Gutić Bojana, Maričić Slobodan, Stevanović Nemanja, Šolajić Nenad, Nikin Zoran, Maksimović Tamara, Stevanović Tijana

“…A statistically significant difference was confirmed by comparing HMVD and LMVD in cervical cancer patients with lymph nodes metastasis (p<0.029). In the subgroup of patients with other worse pathohistological prognostic factors, a tumor size greater than 2 cm, depth of stromal invasion >10 mm, infiltration of "isthmus" of the uterus, a difference with no statistical significance was confirmed. …”
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Relationship between Tai Chi and clinical outcomes in elderly patients with COVID-19: a protocol for systematic review and dose–response meta-analysis by Yang Wang, Na Li, Xiao Peng, Chun Wang, Sheng He, Jinfeng Yang, Yuanpeng Liao

“…The heterogeneity and variability will be analysed by I2 and τ2 statistics. Risk of bias, subgroup analysis and sensitivity analysis will also be performed. …”
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Effect of acute kidney injury care bundle on kidney outcomes in cardiac patients receiving critical care: a systematic review and meta-analysis by Fatma Refaat Ahmed, Nabeel Al-Yateem, Seyed Aria Nejadghaderi, Rawia Gamil, Mohannad Eid AbuRuz

“…Future large-scale RCTs focusing specifically on cardiac surgery patients are recommended to clarify the impact of care bundles within this subgroup. Registration ID in PROSPERO CRD42024498972.…”
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Vitamin D Deficiency as a Risk Factor for Diabetic Retinopathy: A Systematic Review and Meta-Analysis by Claudia Elena Petrea, Laura Andreea Ghenciu, Roxana Iacob, Emil Robert Stoicescu, Dorel Săndesc

“…Mean serum vitamin D levels were lower in individuals with DR (18.11 ± 5.35 ng/mL) compared to those without DR (19.71 ± 7.44 ng/mL), with a progressive decline observed across DR severity stages. Subgroup analyses showed significantly lower levels of vitamin D in proliferative DR compared to non-proliferative stages. …”
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Rechallenge therapy versus tyrosine kinase inhibitor (TKI) for advanced metastatic colorectal cancer: a retrospective study by Chenming Liu, Jintao Chen, Yuxing Liu

“…The median PFS for the rechallenge group was 5.0 months (95% CI: 4.3–6.7), compared with 3.4 months (95% CI: 2.7–4.8) in the TKI group, with a statistically significant difference too (HR = 0.54, 95% CI: 0.32–0.91; P = 0.019). Furthermore, subgroup analysis showed that in Group A, the rechallenge group also had superior median OS and PFS compared with the TKI group. …”
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Worse survival of hepatocellular cancer patients with membranous insulin receptor overexpression by Steffen Markus Heckl, Carolin Schneider, Lukas Kercher, Hans-Michael Behrens, Jan-Paul Gundlach, Alexander Bernsmeier, Stephan Schmidt, Sandra Krüger, Felix Braun, Rainer Günther, Thomas Becker, Stefan Schreiber, Christoph Röcken

“…Intriguingly, membranous IR expression was associated with worse tumor specific survival (p = 0.017) in the subgroup of patients undergoing sorafenib therapy. …”
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The relationship between dietary inflammatory index (DII) and early renal injury in population with/without hypertension: analysis of the National health and nutrition examination... by Jingda Huang, Huimin Li, Xu Yang, Chuyue Qian, Yihui Wei, Mindan Sun

“…A significant association was observed between hypertension and abnormality of early kidney damage markers. Subgroup analysis reveals that the positive correlation between DII and the occurrence of abnormal markers of early kidney damage is only observed in individuals with hypertension. …”
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