Outcomes and physiologic responses associated with ketamine administration after traumatic brain injury in the United States and Canada: a retrospective analysis by Austin J. Peters, Saad A. Khan, Seiji Koike, Susan Rowell, Martin Schreiber

“…In the intracranial hemorrhage subgroup, cardiac events were more likely in ketamine-exposed subjects (2.3% vs. 0.2%, P=0.025). …”
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Seroprevalence of Hepatitis C Viral Infection in Ethiopia: A Systematic Review and Meta-Analysis by Teshiwal Deress, Yihenew Million, Teshome Belachew, Mohabaw Jemal, Mekonnen Girma

“…The possible sources of heterogeneity were analyzed through subgroup analysis, sensitivity analysis, and meta-regression. …”
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Steatotic liver disease in people with HIV at Tshepong Hospital: A post-mortem analysis by Aqeela Moosa, Ebrahim Variava, Alistair D. Calver, Gajendra Chita, Nadia Sabet, Sharol Ngwenya, Maria Papathanasopoulos, Tanvier Omar

“…A preserved CD4 count and being female conferred the highest risk for steatosis, underscoring the need for screening in this subgroup and further research to delineate risks in a Southern African population.…”
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Meta-analysis of the association between overexpression of RAD51 family genes and prognosis and clinical features in breast cancer by Yong-Cheng Liu, Jun Shen

“…High expression of RAD51 family genes was associated with poorer overall survival (OS) [HR = 1.305, 95%CI (1.145–1.488), P < 0.01], disease-free survival/distant metastasis-free survival (DFS/DMFS) [HR = 1.588, 95%CI (1.208–2.089), P < 0.01], and disease-specific survival (DSS) [HR = 1.403, 95%CI (1.066–1.846), P = 0.02]. In addition, subgroup analyses further showed that high RAD51 expression was associated with worsened OS [HR = 1.475, 95%CI (1.275–1.706), P < 0.01], DFS [HR = 1.584, 95%CI (1.133–2.215), P < 0.01] and progression-free survival (PFS) [HR = 2.439, 95%CI (1.172–5.075), P = 0.02]. …”
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Trifluridine/tipiracil regimen in combination with bevacizumab for metastatic colorectal cancer in the third line: an expert opinion by Carmine Pinto, Sara Lonardi, Evaristo Maiello, Erika Martinelli, Michele Prisciandaro, Lisa Salvatore, Lisa Salvatore, Andrea Sartore-Bianchi, Andrea Sartore-Bianchi, Mario Scartozzi, Giuseppe Aprile, Chiara Cremolini, Alberto Sobrero

“…Several therapeutic options are now available, although some differences across countries in drug approval and the optimal therapeutic sequencing associated with each peculiar patient subgroup represent a clinical challenge for oncologists. …”
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The relationship between serum vitamin C levels and high-sensitivity C-reactive protein in children by Ci Li, Zhiwei Zhu, Shicai Jiang, Xiang Feng, Liu Yang, Kaijie Gao, Jiajia Ni, Tiewei Li, Junmei Yang

“…The relationship between serum vitamin C and hs-CRP levels was analyzed using logistic regression, trend tests, and smooth curve fitting. Subgroup analyses and interaction tests were performed to assess the stability of the relationship across different populations. …”
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Meta-Analysis of the Effect of Resistance Exercise Prescription on Glucose and Lipid Metabolism in Overweight and Obese Adults by SUN Yuxin, GUO Xiaoyuan, CHEN Shi, PAN Hui, ZHU Huijuan

“…The literature was screened by 2 researchers according to inclusion and exclusion criteria and relevant data were extracted.Meta-analysis of included literature was performed using RevMan 5.3 software, and publication bias was assessed using funnel plots.ResultsA total of 17 papers and 700 study subjects were included, with 351 cases in the test group, and 349 cases in the control group.Meta-analysis results showed that compared with the control group, the glycosylated hemoglobin of the test group with resistance exercise[SMD (95% CI) =-0.30(-0.53--0.07), P=0.010], fasting blood glucose[SMD (95% CI)=-0.58(-0.90--0.26), P < 0.001], insulin resistance index[SMD (95% CI) =-0.90 (-1.42--0.38), P < 0.001], and low-density lipoprotein cholesterol (LDL-C)[SMD (95% CI) =-0.28 (-0.53--0.04), P=0.020] levels were reduced.Subgroup analysis showed that the glucose metabolism levels of the test group with only resistance exercise and a combination of resistance-anaerobic exercise were significantly lower than those of the control group(both P < 0.05).The heterogeneity of the effect of resistance exercise on glucose metabolism in Asian populations(I2=57%) was smaller than that in Caucasion(I2=76%) and other populations(I2=94%), and the level of decrease in glucose metabolism indexes was significant[SMD(95% CI)=-1.15(-1.73--0.57), P < 0.001].ConclusionResistance exercise can significantly reduce the level of glycolipid metabolism indexes in overweight or obese people.…”
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Chemokine Receptor 2 (CXCR2) Gene Variants and Their Association with Periodontal Bacteria in Patients with Chronic Periodontitis by Denisa Kavrikova, Petra Borilova Linhartova, Svetlana Lucanova, Hana Poskerova, Antonin Fassmann, Lydie Izakovicova Holla

“…A DNA microarray detection kit was used for the investigation of the subgingival bacterial colonization, in a subgroup of CP subjects (N=162). No significant differences in allele, genotype, haplotype, or haplogenotype frequencies of CXCR2 gene variants between patients with CP and healthy controls (P>0.05) were determined. …”
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Dietary carotenoid intakes and biological aging among US adults, NHANES 1999–2018 by Xiang Qi, Xuanyang Wang, Licheng Cheng, Yue Li, Keke Dang, Shuo Yang, Yina Wang, Runyi Zhou, Can Zhang, Ying Li

“…Multiple linear regression showed that most carotenoids were significantly negatively correlated with AL (β = -0.017 - -0.011), HD (β = -0.045 - -0.032), KDM (β = -0.984 - -0.471), and PA (β = -0.975 - -0.539). Subgroup analysis indicated that male, older individuals, smokers, alcohol drinkers, and less physically active individuals are particularly sensitive populations. …”
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Application of deep learning models on single-cell RNA sequencing analysis uncovers novel markers of double negative T cells by Tian Xu, Qin Xu, Ran Lu, David N. Oakland, Song Li, Liwu Li, Christopher M. Reilly, Xin M. Luo

“…In addition, we classified three subgroups in nDNT cells and two subgroups in aDNT cells. …”
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Does the CDC Surgical Wound Classification adequately predict postoperative infection in lower extremity fracture surgery? by Elizabeth Cho, MD, Hanna House, MD, Andrew Marten, BS, Marina Feffer, MPH, Julie Agel, MA, John Scolaro, MD, Meir Marmor, MD, Ashley E. Levack, MD, MAS, OTA Classification & Outcomes Committee, James Kellam, MD, Gillian Soles, MD, Jarrod Dumpe, MD, Kyle Schweser, MD, Geoffrey Maracek, MD

“…When compared with Class I, Classes II through IV had increased odds of infection (odds ratio [OR] II: 3.5, P = 0.012; OR III: 6.8, P < 0.001; OR IV: 11.0, P < 0.001). Subgroup analysis of Classes II and III demonstrated no difference in odds of infection. …”
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Clinical Efficacy and Safety of Stem Cell-Based Therapy in Treating Asherman Syndrome: A System Review and Meta-Analysis by Yiming Zhao, Qifan Luo, Xiao Zhang, Yafei Qin, Jingpeng Hao, Dejun Kong, Hongda Wang, Guangming Li, Xiangying Gu, Hao Wang

“…Stem cell combined hormone therapy achieved a higher likelihood of improving menstruation (risk ratio [RR] 22.43, 95% CI: 8.03 to 62.68, P<0.00001), an enhancement of pregnancy outcome (risk ratio [RR] 11.1, 95% CI: 3.58 to 34.38, P<0.0001), and a mean increase of 3-month endometrial thickness (standardized mean difference [SMD] 2.43, 95% CI: 1.72 to 3.13, P<0.00001). Subgroup analysis also indicated that 6-month and 9-month endometrial thickness increased significantly with the stem cell-based treatment. …”
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Assessment of upper GI motor activity and GI symptoms in patients with amyotrophic lateral sclerosis: an observational study by Emanuela Ribichini, Nadia Pallotta, Danilo Badiali, Maria Carlucci, Marco Ceccanti, Chiara Cambieri, Laura Libonati, Enrico Stefano Corazziari, Giovanni Ruoppolo, Maurizio Inghilleri, Maurizio Inghilleri

“…There was no correlation between esophagogastric motor abnormalities and clinical characteristics of ALS, nor GI symptoms.ConclusionsThe presence of UES spasm and the delayed gastric emptying in a subgroup of ALS patients may suggest the role of ANS dysfunction in ALS.…”
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Inverse relationship of oxidative balance score with hyperuricemia among Chinese adults: a population-based cross-sectional study by Hewei Peng, Ying Han, Jingru Huang, Wenxin Qiu, Huajing Chang, Jiangwang Fang, Xian-E Peng

“…The association between OBS and hyperuricemia was investigated using logistic regression analysis. Subgroup analyses identified sensitive populations. …”
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How to Reliably Measure Stroke Volume Index in Pulmonary Arterial Hypertension: A Comparison of Thermodilution, Direct and Indirect Fick, and Cardiac MRI by Andrea Baccelli, Deepa Gopalan, Rachel J. Davies, Gulammehdi Haji, Wendy Gin-Sing, Luke S. Howard, Francesco Lo Giudice

“…We aimed to compare these different invasive methods, and in a subgroup of patients, to a non-invasive method using MRI. …”
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The correlation and predictive value of Hb, RDW and their association for short-term and long-term mortality in patients with acute aortic dissection by Peng Hou, Peng Hou, Lin Xia, Fangran Xin, Boxuan Sun, Guoxin Zhang, Liming Yu, Huishan Wang

“…Using adjusted Cox regression and Kaplan-Meier survival curve analyses, we assessed the relationship between Hb, RDW and their association at admission and mortality at multiple post-discharge intervals (30 days, 90 days, 1 year, and 5 years) among patients with AAD. Additionally, subgroup analyses and receiver operating characteristic (ROC) curve analyses were conducted to evaluate the predictive accuracy of Hb, RDW and their association for mortality in this patient population.ResultsHigh RDW combined with low Hb (RDW ≥ 13.60 and Hb &lt; 7.9) significantly predicted increased mortality at 30 days, 90 days, 1 year, and 5 years post-diagnosis, with hazard ratios (HRs) as follows: 4.33 (95% CI: 1.82–10.33, P &lt; 0.001), 4.48 (95% CI: 2.06–9.77, P &lt; 0.001), 3.38 (95% CI: 1.70–6.70, P &lt; 0.001), and 3.07 (95% CI: 1.66–5.66, P &lt; 0.001), respectively.ConclusionHb and RDW are both abnormal (Hb with low level, RDW with high level) is positively correlated with 30 days, 90 days, 1 year, and 5 years mortality risk in patients with AAD. …”
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The prediction value of serum anion gap for short-term mortality in pulmonary hypertension patients with sepsis: a retrospective cohort study by Jinhua Zhu, Zeying Zhang, Yefei Lei, Zhenrong Ouyang, Shelby Kutty, Qiming Liu, Yunbin Xiao, Yunbin Xiao

“…The relationship between elevated AG and in-hospital mortality remains stable after subgroup analyses.ConclusionElevated serum AG is associated with increased risk-adjusted short-term mortality in PH patients with sepsis, and it may aid clinicians in identifying patients with poor prognosis as early as possible.…”
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Systematic review and meta-analysis on the prevalence and risk factors of oral frailty among older adults by Pingping Huang, Linjing Wu, Rongxiang Zhang, Rongxiang Zhang, Shiqi Chen, Shiqi Chen, Yu Zhang, Yuan Chen, Yuan Chen

“…The overall prevalence of oral frailty among older adults was 34.0% (95% CI: 27.9–40.1%, I2 = 99.7%, p &lt; 0.001). Subgroup analyses revealed statistically significant differences in the prevalence of oral frailty among different assessment tools and age groups (p &lt; 0.05). …”
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The association between working hours and working type with non-alcoholic fatty liver disease: results from the NHANES 1999-2014 by Ruli Wang, Ningxi Wu, Huan Qu, Xiaowei Zheng, Haoyang Zhang, Lihong Zhu, Xiaolei Wang, Xiaodie Yao, Le Zhang

“…In addition, further subgroup analysis was performed based on sex, age, ratio of family income to poverty (PIR), education, and diabetes.ResultsLong working hours were significantly linked to an elevated risk of NAFLD (OR: 1.57, 95%CI: 1.21-2.05), even after controlling for confounding factors. …”
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Temporal Trends in the Utilization and Survival Outcomes of Lobar, Segmental, and Wedge Resection for Early-Stage NSCLC, 2004 to 2020 by Eden Z. Deng, BS, Xiaofei Wang, PhD, Jianrong Zhang, MD, MPH, Thomas E. Stinchcombe, MD, Chi-Fu (Jeffrey) Yang, MD, Nasser Altorki, MD

“…To compare the OS of the three treatments, we used inverse probability of treatment weighting to analyze a subgroup of cases with nodal examination and minimal comorbidity burden. …”
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