Evaluation of de novo donor specific antibodies after kidney transplantation in the era of donor-derived cell-free DNA by Yuan Tian, Lukas Frischknecht, Anna Mallone, Fabian Rössler, Thomas Schachtner, Jakob Nilsson

“…While de novo donor-specific antibodies (dnDSA) are crucial in ABMR, the relationship between dd-cfDNA levels and dnDSA features, such as DSA category, MFI and HLA target loci, remains unclear.MethodsWe analyzed dd-cfDNA levels in 75 kidney transplant recipients who developed dnDSA post-transplant. dnDSA were categorized as “true”, “possible”, or “false” based on bead reactivity patterns and HLA typing. dd-cfDNA was assessed alongside dnDSA detection and sequential follow-up samples in a subgroup.Results“True” dnDSA showed significantly higher dd-cfDNA levels compared to “possible” and “false” groups. …”
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The financial toxicity of cancer: unveiling global burden and risk factors – a systematic review and meta-analysis by Addisu Getie, Alemu Birara Zemariam, Befkad Derese Tilahun, Ribka Nigatu Haile, Tegene Atamenta Kitaw, Molla Azmeraw Bizuayehu

“…Heterogeneity was explored to understand variations in study outcomes. Subgroup and sensitivity analyses were conducted to assess individual study impacts, while publication bias was evaluated using Begger and Egger’s tests. …”
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Efficacy and safety of pembrolizumab in patients with advanced endometrial cancer: a systematic review and meta-analysis by Biqiong Pan, Xiaojun Lai, Jiefang Lu, Xiaoyan Bao, Zengke Fan, Jie Sun

“…Outcomes were progression-free survival (PFS), overall survival (OS), objective response rate (ORR), complete remission (CR), and adverse events (AEs); a subgroup analysis was carried out based on combination treatment regimens. …”
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Association between Healthy Eating Index-2020, alternative Mediterranean Diet scores, and gastrointestinal cancer risk in NHANES 2005–2018 by Weijie Wang, Yu Chang, Geng Chen

“…Logistic regression models, restricted cubic splines (RCS), subgroup analysis, and interaction methods were employed to fully evaluate the associations between HEI-2020, aMED scores, and GI cancers. …”
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Efficacy and safety of Xiaoyao San in the treatment of chronic fatigue syndrome: a systematic review and meta-analysis by Qianqian Wang, Jian Zhou, Guanwen Gong

“…The meta-analysis showed that XYS-based interventions significantly improved ER (RR = 1.27, 95% CI: 1.18–1.37, I2 = 0%) and FS-14 (MD = 1.77, 95% CI: 1.49–2.06, I2 = 54%). Subgroup analyses confirmed consistent efficacy for both XYS vs. …”
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Improving the accUracy of Referrals to the emerGency departmEnt of patieNts with chesT pain using the modified HEART score in Emergency Medical Transport (URGENT 2.0): protocol for... by Joan G Meeder, Frits H M Van Osch, Robert T A Willemsen, Braim M Rahel, Lisa D S Frenk, Cees B de Vos, Fabiana G Prestigiacomo, Marcel J W Janssen, Arnoud W van 't Hof

“…The results of this trial will be disseminated in one main paper and in additional papers with subgroup analyses.Trial registration ClinicalTrials.gov, NCT04904107.…”
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Evaluation of the effects of short-term PM2.5 exposure on triglyceride-glucose metrics in a population in eastern China by Zhenpeng Guo, Chenchen Yang, Qiang Zhang, Xinling Shi, Xiaona Li, Qun Zhang, Jianming Wang

“…The association remained significant in the subgroup analyses. Conclusion PM2.5 exposure is related to the TyG index. …”
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The invisible enemy: A systematic review and meta-analysis of maternal smokeless tobacco use as a risk factor for low birth weight. by Akanksha Mahajan, Bhawna Gupta, Michael Tong

“…Pooled estimates of eighteen studies with 733,061 participants showed that there was a statistically significant association (OR = 2.25 [1.63, 3.11] P<0.001); between maternal smokeless tobacco use during pregnancy and low birth weight. Subgroup analysis found a significant association between mishri consumption during pregnancy and low birth weight (n = 646 participants, OR = 10.98 [2.03, 59.34], P = 0.005), but not betel nut (n = 8007 participants, OR = 1.02 [0.84, 1.25]), betel quid (n = 483 participants, OR = 1.51 [0.47, 4.89]) or khat (n = 475 participants, OR = 1.41 [0.64-3.09]).…”
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Association between stress hyperglycemia ratio and all-cause mortality in critically ill patients with sepsis: results from the MIMIC-IV database by Shijie Zhang, Hechen Shen, Yuchao Wang, Meng Ning, Jianghui Zhou, Xiaoyu Liang, Yun Chang, Wenqing Gao, Tong Li

“…The relationship between high SHR and mortality remained consistent across almost all predefined subgroups. Conclusions Our study suggests that high SHR is associated with increased in-hospital and 1-year mortality in critically ill sepsis patients. …”
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Diabetes Mellitus Is Associated with a Lower Risk of Gout: A Meta-Analysis of Observational Studies by Xiaoli Li, Lianju Li, Yuling Xing, Tiantian Cheng, Shaohui Ren, Huijuan Ma

“…Metaregression analysis revealed that the types of DM were the source of heterogeneity. Subgroup analysis by types of DM showed that the risk of gout was significantly lower in type 1 DM (T1DM) (aRR: 0.42; 95% CI: 0.28 to 0.63) than in type 2 DM (T2DM) (aRR: 0.72; 95% CI: 0.70 to 0.74). …”
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Large Language Models in Dental Licensing Examinations: Systematic Review and Meta-Analysis by Mingxin Liu, Tsuyoshi Okuhara, Wenbo Huang, Atsushi Ogihara, Hikari Sophia Nagao, Hiroko Okada, Takahiro Kiuchi

“…GPT-4 outperformed GPT-3.5 and Bard, passing more than half of the dental licensing examinations. Subgroup analyses and meta-regression showed that GPT-3.5 performed significantly better in English-speaking countries. …”
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Effect of visit-to-visit blood pressure variability on cardiovascular events in populations with different body mass indexes: a prospective cohort study by Shouling Wu, Haojia Chen, Youren Chen, Weiqiang Wu, Jianhuan Huang, Zekai Chen, Zhichao Chen, Xiuzhu Yan

“…We further divided these groups into four subgroups based on the ARVSBP. A Cox regression model was used to calculate the HRs of the ARVSBP on CVEs in the same and different BMI groups. …”
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Morphological and bone defect mapping analysis of true acetabulum in Crowe type IV hip dysplasia by Yuhui Yang, Duanyong Chen, Bichun Zhang, Qingtian Li, Linyong Hu, Yuanchen Ma, Qiujian Zheng

“…Abstract Background The primary aim of this study was to quantitatively analysis the acetabular morphological feature and 2D/3D coverage of the Crowe IV DDH hip, dividing into subgroups by the false acetabulum. The secondary aim was to propose a 3D bone mapping to determine acetabular bone defect analysis from the perspective of the implanted simulation. …”
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Impact of triglyceride-glucose index on risk of cardiovascular disease among non-diabetic hypertension patients: a 10-year prospective cohort study by Xin Chen, Jinyou Yang, Dan Wang, Jiali Liu, Hang Jin, Yongqing Zhang, Quanyong Xiang

“…Similar results were obtained by subgroup analysis and sensitivity analysis. Conclusion Elevated TyG index may be used as a surrogate for IR and help optimize risk stratification of CVD as well as prevention and management.…”
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The effect of acute sleep deprivation on cortisol level: a systematic review and meta-analysis by Yifei Chen, Wenhui Xu, Yiru Chen, Jiayu Gong, Yanyan Wu, Shutong Chen, Yuan He, Haitao Yu, Lin Xie

“…There was no significant difference in cortisol levels between participants with acute sleep deprivation and normal sleep in 21 crossover-designed studies (SMD = 0.18; 95% CI: –0.11, 0.45; p = 0.208) or 3 RCTs (SMD = 0.26; 95% CI: –0.22, 0.73; p = 0.286). Subgroup analysis revealed that the pooled effects were significant for studies using serum as the sample (SMD = 0.46; 95%CI: 0.11, 0.81; p = 0.011). …”
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Effect of an Electronic Pill Bottle on Hydroxychloroquine Adherence in Pediatric Lupus: Results of a Novel Direct‐to‐Family Pilot Trial by Rachel L. Randell, Laura E. Schanberg, Claire Beard, Thomas Phillips, Christoph P. Hornik, Michael Cohen‐Wolkowiez, Stephen J. Balevic, with the CARRA Registry investigators

“…Post hoc analyses identified different adherence patterns and a subgroup of patients with low HCQ concentrations who could be targeted for future adherence interventions.…”
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Assessment of depression in patients admitted with acute coronary syndrome: a double-blind study by Ela Giladi, Sapir Tzadok, Tamar Shitrit, Ilya Losin, Ziad Arow, Ranin Hilu, Sharon Reisfeld, Yoav Arnson, Abid Assali, David Pereg

“…Similar findings were observed in subgroup analyses according to gender, age, type of ACS, and history of cardiovascular disease. …”
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Association between elevated cystatin C levels and obstructive sleep apnea hypopnea syndrome: a systematic review and updated meta-analysis by Nianying Fu, Xiaotao Tan, Jie He

“…The serum/plasma cystatin C levels in the OSAHS group were significantly increased relative to the controls (SMD = 0.65, 95%CI: 0.50–0.79, P < 0.001). Subgroup analysis considering mean body mass index (BMI), mean age, ethnicity, and study design type consistently showed significantly elevated serum/plasma cystatin C levels in the OSAHS category relative to the controls. …”
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Emergence of Enteric Viruses in Production Chickens Is a Concern for Avian Health by Elena Mettifogo, Luis F. N. Nuñez, Jorge L. Chacón, Silvana H. Santander Parra, Claudete S. Astolfi-Ferreira, José A. Jerez, Richard C. Jones, Antonio J. Piantino Ferreira

“…Chicken astrovirus (CAstV), rotavirus, reovirus, chicken parvovirus (ChPV), fowl adenovirus of subgroup I (FAdV-1), and avian nephritis virus (ANV) were investigated using the conventional polymerase chain reaction (PCR) and the reverse transcription polymerase chain reaction (RT-PCR). …”
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Impact of fetal sex on neonatal outcomes in women with gestational diabetes mellitus: a systematic review and meta-analysis by Mahsa Maghalian, Zohreh Alizadeh-Dibazari, Mojgan Mirghafourvand

“…The quality of the included studies was assessed using the Newcastle-Ottawa Quality Assessment Scale. Subgroup analyses differentiated between retrospective and prospective cohorts for the primary outcomes. …”
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