Feasibility, User Acceptance, and Outcomes of Using a Cancer Prehabilitation App for Exercise: Pilot Cohort Study by Fuquan Zhang, Deepali Bang, Christine Alejandro Visperas, Mon Hnin Tun, San San Tay

“…Patients who participated in the prehabilitation program (n=63) were categorized into 2 groups: those prescribed the app (n=41) and those who were not (n=22). There was further subgroup analysis of those who were prescribed: app users (n=25) versus those who were non-app users (n=16). …”
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Efficacy of PD-1/PD-L1 Inhibitors versus Chemotherapy in Lung Cancer with Brain Metastases: A Systematic Review and Meta-Analysis by Xiaojun Yang, Yihong Zeng, Qinquan Tan, Zhihua Huang, Jun Jia, Guanming Jiang

“…Statistical analysis showed that compared with chemotherapy, PD-1/PD-L1 inhibitors could significantly prolong OS (hazard ratio HR=0.75, 95%confidence interval 95%CI=0.51–0.99) and PFS (HR=0.65, 95%CI=0.51–0.80). In the subgroup analysis, ICIs plus chemotherapy improved PFS (HR=0.60, 95%CI=0.40–0.80), but not OS (HR=0.75, 95%CI=0.30–1.19). …”
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Determinants of outcomes in patients with hepatitis B virus-decompensated cirrhosis by Yi-Jie Huang, Jun-Sing Wang, Cheng-Hsu Chen, Shou-Wu Lee, Chung-Hsin Chang, Szu-Chia Liao, Yen-Chun Peng, Teng-Yu Lee, Tsai-Chung Li

“…Risk factors associated with 3-month all-cause mortality were age, presence of ascites and hepatic encephalopathy, baseline hepatitis flares, pre-treatment HBV DNA levels, and MELD scores. In the subgroup analysis, for 3-month all-cause mortality, significant associations of age, baseline hepatitis flares, and MELD scores with pre-treatment HBV DNA levels were observed (p for interaction were 0.005, 0.032, and 0.030, respectively). …”
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Prognostic significance of programmed cell death 1 expression on CD8+T cells in various cancers: a systematic review and meta-analysis by Zhiyong Wan, Meng Cui, Jia Yang, Dan Liao, Junliang Chen, Fanmin Li, Yin Xiang, Zhiwei Cui, Yang Yang

“…The pooled Hazard Ratio (HR) along with 95% confidence intervals (CIs) of each article were combined for the associations of PD-1+CD8+ T cells with overall survival (OS), progression- free survival (PFS) and disease-free survival(DFS). Subgroup analyses were performed for area, specimen type, cancer type, treatment, detected method and cancer stage.ResultsA total of 20 studies (23 cohorts, 3086 cancer patients) were included in our study. …”
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Combined Liver Stiffness and Α-fetoprotein Further beyond the Sustained Virologic Response Visit as Predictors of Long-Term Liver-Related Events in Patients with Chronic Hepatitis... by Sheng-Hung Chen, Hsueh-Chou Lai, Wen-Pang Su, Jung-Ta Kao, Po-Heng Chuang, Wei-Fan Hsu, Hung-Wei Wang, Tsung-Lin Hsieh, Hung-Yao Chen, Cheng-Yuan Peng

“…Kaplan–Meier analysis revealed that among the stratified subgroups, the subgroup with concurrent LS ≥1.45 m/s and AFP ≥3.00 ng/mL at Y3PSVR exhibited the highest risk of LREs after Y3PSVR (log-rank P<0.001). …”
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Higher oxidative balance score is associated with a decreased risk of infertility: an analysis of NHANES 2013–2020 by Mingjun Ma, Huanying Xu, Huanying Xu, Kexin Wang, Yanfen Chen, Ting Pan, Qiaoling Zhu, Qiaoling Zhu

“…Similarly, women in the highest dietary OBS and lifestyle OBS quartiles had a lower infertility risk compared to those in the lowest quartiles, with ORs of 0.60 (95% CI, 0.39–0.94) and 0.54 (95% CI, 0.32–0.93), respectively. Furthermore, subgroup analysis indicated that the association between the fourth quartile of OBS and infertility remained consistent, except among women with other ethnicities—including multi-racial, and college graduate or higher.ConclusionThese findings suggest that high dietary OBS and lifestyle OBS are associated with a lower risk of infertility.…”
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Fosaprepitant as combination therapy to prevent chemotherapy-induced vomiting in children: a meta-analysis by Yanshuo Shi, Yanshuo Shi, Yuanyuan Yue, Yuanyuan Yue, Yue Zhang, Guoxun Pang

“…Meta-analysis results showed that the complete response (CCR, no vomiting/rescue medication) rates were higher in the observation group compared to that in the control group during the acute [the relative risk: RR = 1.64, 95% confidence interval: 95%CI = 1.35–1.99, P &lt; 0.00001], delayed vomiting [RR = 2.05, 95%CI = 1.32–3.17, P = 0.001] and overall phases [RR = 2.08, 95%CI = 1.69–2.57, P &lt; 0.00001], with statistical significance (P &lt; 0.05). The subgroup analysis of salvage treatment proportion revealed that the need for rescue medication was higher for patients in the control than fosaprepitan regimens [RR = 0.20, 95%CI = 0.08–0.54, P = 0.001] There was no difference in the incidence of adverse drug reaction between two groups [RR = 0.95, 95%CI = 0.75–1.19, P = 0.66].ConclusionFosaprepitant in combination with 5-HT3RA (with or without dexamethasone) has the same safety and more effective in preventing chemotherapy-induced vomiting than 5-HT3RA with or without dexamethasone.…”
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Burden of intestinal parasites among diabetic patients in Africa: a systematic review and meta-analysis by Marye Nigatie Debash, Getinet Kumie, Assefa Sisay, Solomon Gedfie, Wagaw Abebe, Agenagnew Ashagre, Tadesse Misganaw, Habtu Debash, Melese Abate Reta

“…Heterogeneity across studies was assessed using Cochran’s Q statistic and I2 statistics. Subgroup analysis was carried out when the I2 value exceeded 50%, indicating substantial heterogeneity. …”
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Association between Life’s Crucial 9 and overactive bladder: the mediating role of weight-adjusted-waist index by Hongyang Gong, Hongyang Gong, Shuqin Duan, Shaoqun Huang

“…This study investigates the relationship between LC9 and OAB and assesses whether WWI moderates this relationship.MethodsData for this study came from the National Health and Nutrition Examination Survey (NHANES). We used subgroup analyses, restricted cubic spline curves (RCS), and multivariate logistic regression to explore the relationship between LC9 and OAB. …”
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Protocol paper: randomized controlled trial of the smart online-to-offline model development for chronic diseases management through digital health in real world setting by Jae Eun Shin, Juho Choi, Heejung Lee, Suk-Won Lee, Juhwan Oh

“…These include intention-to-treat (ITT) analysis to account for all randomized participants, regression models to estimate the treatment effect, and adjustments for baseline covariates to improve precision. Subgroup analyses will explore variations in treatment effects based on factors such as intervention intensity, comorbidity, and healthcare provider. …”
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A comprehensive comparison of PARP inhibitors as maintenance therapy in platinum-sensitive recurrent ovarian cancer: a systematic review and network meta-analysis by Shiya Ji, Lu Chen, Yebo Yu, Xupeng Chen, Liwen Wei, Lili Gou, Cheng Shi, Susu Zhuang

“…Results Six randomized controlled trials were examined and the four PARPis (olaparib, niraparib, rucaparib and fuluzolparib) have been found to significantly increase the PFS in entire population as well as in subgroups of HRD and BRCAm (BRCA mutation). Only olaparib demonstrated a substantial improvement in OS compared to placebo in entire population (hazard ratio [HR] 0.73; 95% confidence interval [CI] 0.60–0.90), as well as in the subgroup of BRCAm. …”
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Effects of Dust Event Days on Influenza: Evidence from Arid Environments in Lanzhou by Ling Zhang, Sheng Li, Bo Wang, Ce Liu, Li He, Xiaobing Shan, Kai Zhang, Bin Luo

“…Compared with the non-dust days, the effects of dust events with duration ≥ 1 day and with duration ≥ 2 days on influenza were the strongest at lag0 day, with the estimated RRs of 1.245 (95% CI: 1.061–1.463) and 1.483 (95% CI: 1.232–1.784), respectively. Subgroup analysis showed that pre-school children and school-aged children were more sensitive to PM and dust events exposure. …”
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Comparing the effectiveness, safety and tolerability of interventions for depressive symptoms in people with multiple sclerosis: a systematic review and network meta-analysis proto... by Amalia Karahalios, Allan G Kermode, Yvonne C Learmonth, Julia Lyons, Stephanie Campese, Alexandra Metse, Claudia H Marck

“…We plan to provide summary measures including forest plots, a geometry of the network, surface under the cumulative ranking curve, and a league table, and perform subgroup analyses. Otherwise, a narrative review will be provided.Ethics and dissemination Ethics is not required for a systematic review and network meta-analysis. …”
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Prevalence of prolonged transitional neonatal hypoglycemia and associated factors in Ethiopia: A systematic review and meta-analysis. by Solomon Demis Kebede, Amare Kassaw, Tigabu Munye Aytenew, Kindu Agmas, Demewoz Kefale

“…<h4>Results</h4>The pooled prevalence of PTNHG was 19.71% (95% CI: 16.85-22.56) with substantial heterogeneity (I2 = 79.20%, P < 0.001). Subgroup analysis revealed that PTNHG prevalence was similar for studies with sample sizes >400 and ≤400, at 18% (95% CI: 15-22) and 21% (95% CI: 17-26), respectively. …”
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Associations between Vascular Endothelial Growth Factor Gene Polymorphisms and Different Types of Diabetic Retinopathy Susceptibility: A Systematic Review and Meta-Analysis by Liming Hu, Chunmei Gong, Xiaoping Chen, Honghao Zhou, Junxia Yan, Wenxu Hong

“…Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated, and subgroup analyses were conducted by ethnicity. Sensitivity analysis was conducted to assess the stability of the results. …”
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Evaluation of Safety and Efficacy of a Single Lorecivivint Injection in Patients with Knee Osteoarthritis: A Multicenter, Observational Extension Trial by Christopher J. Swearingen, Jeyanesh R. S. Tambiah, Ismail Simsek, Heli Ghandehari, Sarah Kennedy, Yusuf Yazici

“…The incidence of AEs was similar between groups. In the post hoc subgroup efficacy analyses, LOR 0.07 mg demonstrated greater mean improvements from baseline compared with PBO in WOMAC pain and function scores out to 12 months post-injection. …”
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A New Age of SAR: How Can Commercial Smallsat Constellations Contribute to NASA's Surface Deformation and Change Mission? by Stacey A. Huang, Batuhan Osmanoğlu, Bernd Scheuchl, Shadi Oveisgharan, Jeanne M. Sauber, MinJeong Jo, Ala Khazendar, Ekaterina Tymofyeyeva, Betsy Wusk, Arif Albayrak

“…As part of the SDC mission study, the Commercial Synthetic Aperture Radar (ComSAR) subgroup was tasked with evaluating the current landscape of the SAR and interferometric SAR (InSAR) industry to assess whether NASA could leverage commercial smallsat products to meet the needs of the SDC science mission. …”
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Tramadol use and incident dementia in older adults with musculoskeletal pain: a population-based retrospective cohort study by Si Nae Oh, Hye Jun Kim, Jae Yong Shim, Kyuwoong Kim, Seogsong Jeong, Sun Jae Park, Sang Hyun Lee, Joong Won Ha, Sang Min Park

“…The results showed a similar pattern for Alzheimer’s disease and were robust across subgroup and sensitivity analyses, but not for vascular dementia. …”
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Determination of Electrolytes in Critical Illness Patients at Different pH Ranges: Whom Shall We Believe, the Blood Gas Analysis or the Laboratory Autoanalyzer? by Christopher Hohmann, Roman Pfister, Kathrin Kuhr, Julia Merkle, Julian Hinzmann, Guido Michels

“…Contrarily, the Bland–Altman comparison for sodium displayed that the 95% limits of agreement were very wide (−5.99 to 6.59 mmol/L) for total measurements as well as in every pH subgroup. Total ICC only reached a value of 0.830. …”
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Use of Multimodal Artificial Intelligence in Surgical Instrument Recognition by Syed Ali Haider, Olivia A. Ho, Sahar Borna, Cesar A. Gomez-Cabello, Sophia M. Pressman, Dave Cole, Ajai Sehgal, Bradley C. Leibovich, Antonio Jorge Forte

“…For precise subtype identification of instrument names (like “Mayo scissors” or “Kelly forceps”), all models had low accuracy, with SID 2.0 having an accuracy of 39.1%, followed by ChatGPT-4o (33.69%). Subgroup analysis revealed ChatGPT-4 and 4o recognized trocars in all instances. …”
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