Tear neuropeptides are associated with clinical symptoms and signs of dry eye patients by Yirou Zhang, Hong Zhang, Xingyu Zhu, Han Ye, Kan Yang, Xujiao Zhou, Jiaxu Hong

“…Multiple linear regression analysis showed that Schirmer test values were related to tear CGRP concentration. Subgroup analysis showed lower tear CGRP concentration in DED patients with severe symptoms (OSDI ≥ 46).Conclusions Levels of tear CGRP and SP decreased in DED patients and showed meaningful correlations with clinical symptoms and signs, implying a potential relationship between tear neuropeptides and ocular neurosensory function.…”
Get full text

Therapeutic effect of mesenchymal stem cell-derived exosome therapy for periodontal regeneration: a systematic review and meta-analysis of preclinical trials by Liping Zhou, Wenjia Cai, Yuhan Zhang, Wenjie Zhong, Ping He, Jingsong Ren, Xiang Gao

“…However, no significant differences were observed in Tp.Th (SMD = 0.03; 95% CI = 0.00, 0.07; p = 0.09) between the exosome-treated group and control group. Additionally, subgroup analysis indicated that preconditioned exosomes (p = 0.03) significantly improved BV/TV. …”
Get full text

Biomechanical Analysis of Truncated Cone Implants for Maxillary Sinus Lift: An In Vitro Study on Polyurethane Laminas by Luca Comuzzi, Tea Romasco, Carlos Fernando Mourão, Giulia Marchioli, Adriano Piattelli, Natalia Di Pietro

“…Polyurethane laminas were divided into two groups based on thickness (1 and 3 mm) and two subgroups based on density (20 and 30 pounds per cubic foot, PCF). …”
Get full text

Association of the triglyceride glucose index with obesity indicators and hypertension in American adults based on NHANES 2013 to 2018 by Pingping Huang, Hongwei Zhang, Gaocan Ren, Yifei Wang, Shuangqing Fu, Yicheng Liu, Zhibo Zhang, Lijun Guo, Xiaochang Ma

“…Using Cox regression analysis, we examined the relationship between TyG and obesity-related indices in relation to hypertensive prognosis, employing threshold effect analysis and fitted smoothed curves for consistency. Subgroup analyses and interaction tests were conducted. …”
Get full text

The Effect of Prebiotics, Alone or as Part of Synbiotics, on Cardiometabolic Parameters in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized... by Elham Razmpoosh, Mala S. Sivanandy, Alan M. Ehrlich

“…Results showed high-quality evidence supporting prebiotics’ effects, alone or as part of synbiotics, in reducing body-mass index [<i>n</i> = 853; weighted-mean difference (WMD): −0.510, 95%CI: −0.669, −0.351 kg/m²] and diastolic blood pressure (WMD: −2.218, 95%CI: −4.425, −0.010 mmHg), moderate-quality evidence for weight, waist-to-hip ratio, and triglycerides improvements, and low or very-low-quality evidence for waist circumference (WC), fat mass, fasting plasma glucose, fasting insulin, low-density lipoprotein (LDL), total cholesterol (TC), high sensitive-C reactive protein, total testosterone, follicle-stimulating hormone and free androgen index improvements. Subgroup analyses revealed possible reduction in LDL with prebiotics, as well as possible decreases in WC, TC, and total testosterone with synbiotics. …”
Get full text

Effects of non-pharmacological interventions on depressive and anxiety symptoms in pregnant women: a systematic review and network meta-analysisResearch in context by Guowei Zeng, Jianfeng Niu, Ke Zhu, Fei Li, Liwen Li, Kaiming Gao, Yanlong Zhuang, Boyang Zhang, Xiaoqiang Han, Gang Ye, Zhikun Gao, Haobai Li

“…Subgroup analysis shows that, in addition to mindfulness therapy, mind-body exercises (SUCRA = 67.43%; SMD = −0.97, 95% CrI = −1.61, −0.33; N = 382) and cognitive-behavioral therapy (SUCRA = 52.60%; SMD = −0.74, 95% CrI = −1.38, −0.09; N = 480) may also be effective in alleviating anxiety symptoms among healthy pregnant women. …”
Get full text

Insight into the current practice of ototoxicity monitoring during cisplatin therapy by N. M. Santucci, B. Garber, R. Ivory, M. A. Kuhn, M. Stephen, D. Aizenberg

“…Patients with Head and Neck Cancer (HNC) represented the largest subgroup that received cisplatin (n = 122, 32.2%) and demonstrated higher rates of ototoxicity counseling (n = 103, 84.4%) and pretreatment audiograms (n = 70, 57.4%) compared to the non HNC group (n = 36, 36.2%, P < 0.0001 and n = 22, 8.5%, P < 0.0001). …”
Get full text

Adherence to First-Line Intravesical Bacillus Calmette-Guérin Therapy in the Context of Guideline Recommendations for US Patients With High-Risk Non-muscle Invasive Bladder Cancer by Franklin D. Gaylis, Bruno Emond, Ameur M. Manceur, Anabelle Tardif-Samson, Laura Morrison, Dominic Pilon, Patrick Lefebvre, Lorie A. Ellis, Hiremagalur Balaji, Andrea Ireland

“…**Objectives:** This study evaluated the adequacy of first-line intravesical BCG treatment among high-risk NMIBC patients in the United States, including the subgroup with carcinoma in situ (CIS) of the bladder. …”
Get full text

Association of C-Reactive Protein with Short-Term Outcomes in Spontaneous Intracerebral Hemorrhage Patients with or without Infection: From a Large-Scale Nationwide Longitudinal Re... by Du Y, Liu L, Kang K, Lin Y, Gu H, Bian L, Li Z, Zhao X

“…Logistic regression was used to analyze the relationship between different CRP levels and functional disability (mRS score of 3– 5) at discharge, intracerebral hematoma evacuation, and in-hospital mortality. Subgroup analysis was conducted on patients with or without infection during hospitalization.Results: A total of 14,529 patients with ICH were enrolled in this study. …”
Get full text

Temporary spinal cord stimulation combined with lidocaine patch for postherpetic neuralgia in the elderly: a controlled study by Yun Li, Chunhui Hao, Shengtao Wang, Feng Qiu, Xuli Zhao, Tao Sun

“…Pain intensity (VAS) and sleep quality (PSQI) were assessed at baseline and on days 1, 3, 7, 30, and 90 post-interventions. Subgroup analyses by age and PHN duration were conducted.ResultsAt day 90, the experimental group had greater reductions in VAS scores (1.6 ± 1.1) than the control group (2.7 ± 1.3, p &lt; 0.01). …”
Get full text

Androgen deprivation therapy use and the risk of heart failure in patients with prostate cancer: a systematic review and meta-analysis by Amir Alinejad Khorram, Reyhaneh Pourasgharian, Ali Samadi Shams, Shahin Toufani, Mehrsa Mostafaei, Reza Khademi, Reza Daghayeghi, Maryam Valifard, Mehregan shahrokhi, Sina Seyedipour, Niloofar Deravi, Mahdyieh Naziri, Mahta Malek, Faizan Bashir

“…The overall pooled hazard ratio (HR) was 1.299 (95% CI: 1.003–1.595), indicating a significantly increased risk of heart failure with ADT. Subgroup analyses revealed that the risk was stronger in Asian populations (pooled HR = 1.545, 95% CI: 1.180–1.910) compared to North American populations (pooled HR = 0.779, 95% CI: 0.421–1.138). …”
Get full text

Catastrophic health expenditure associated with non-inpatient costs among middle-aged and older individuals in China by Xiaojuan Zhang, Kun Zhu

“…The study reveals a distinct subgroup of participants (8.91 and 6.82% for UEMIS and URRMS enrollee, respectively) who incurs substantial out-of-pocket non-inpatient expenditure, surpassing 1,000 RMB per month. …”
Get full text

Negative association between 15 obesity- and lipid-related indices and testosterone in adult males: a population based cross-sectional study by Wei Guo, Shuo Zhao, Qinzheng Chang, Jiajia Sun, Yidong Fan, Jikai Liu

“…The analysis used weighted linear and logistic regression methods to announce the association between 15 obesity- and lipid-related factors and serum testosterone levels as well as TD. Subgroup analyses were further carried out to confirm and validate the findings. …”
Get full text

Lipid metabolism indicators provide tools for the diagnosis of non-alcoholic fatty liver disease: results of a nationwide survey by Yongxin Wang, Chang Fu, Hengwei Jin, Yibo Yang, Xiaocong Li, Xiaocong Li, Kai Liu

“…To further elucidate this connection, we utilized restricted cubic splines and conducted subgroup analysis. Additionally, the receiver operating characteristics (ROC) curve was employed to evaluate the predictive effectiveness of CMI, VAI, and LAP for NAFLD.ResultsThe study included 2,878 adults as the study population, of whom 1,263 participants were diagnosed with NAFLD. …”
Get full text

Associations between biomarkers of inflammation and depressive symptoms—potential differences between diabetes types and symptom clusters of depression by Christian Herder, Anna Zhu, Andreas Schmitt, Maria C. Spagnuolo, Bernhard Kulzer, Michael Roden, Norbert Hermanns, Dominic Ehrmann

“…For the remaining four biomarkers (CD6, CD244, FGF-5, IFNγ) associations were not significant in either subgroup. Biomarker associations were more pronounced with somatic and anhedonia than with cognitive-affective symptoms. …”
Get full text

Changes in Vitamin D Status in Overweight Middle-Aged Adults with or without Impaired Glucose Metabolism in Two Consecutive Nordic Summers by Petra Lundström, Kenneth Caidahl, Maria J. Eriksson, Tomas Fritz, Anna Krook, Juleen R. Zierath, Anette Rickenlund

“…These findings were verified in a subgroup of the study population during the subsequent summer. …”
Get full text

Causal analysis of dietary preferences and the risk of endometriosis using large-scale population data by Xin Cheng, Dan Ma, Xiuhong Wang, Meiling Li, Jinpeng Jiang

“…Conversely, preferences for different types of coffee and orange juice were associated with an increased likelihood of EM across these stages. Subgroup analysis indicated that asparagus preference had a protective effect against deep EM, ovarian EM, pelvic peritoneal EM, and rectovaginal septum and vaginal EM. …”
Get full text

Preoperative hemoglobin and perioperative blood transfusion in major head and neck surgery: a systematic review and meta-analysis by Munib Ali, Joseph C. Dort, Khara M. Sauro

“…The primary outcome was the proportion of patients who had a PBT. Subgroup analysis examined sources of heterogeneity for perioperative predictors of PBT (age, sex, flap type, flap site and preoperative Hgb). …”
Get full text

Contamination and washing of cloth masks and risk of infection among hospital health workers in Vietnam: a post hoc analysis of a randomised controlled trial by Abrar Ahmad Chughtai, Chandini Raina MacIntyre, Bayzidur Rahman, Holly Seale, Tham Chi Dung

“…This was the only published RCT of cloth masks at the time of the COVID-19 pandemic.Objective To do a post hoc analysis of unpublished data on mask washing and mask contamination from the original RCT to further understand poor performance of the two-layered cotton cloth mask used by HCWs in that RCT.Setting 14 secondary-level/tertiary-level hospitals in Hanoi, Vietnam.Participants A subgroup of 607 HCWs aged ≥18 years working full time in selected high-risk wards, who used a two-layered cloth mask and were part of a randomised controlled clinical trial comparing medical masks and cloth masks.Intervention Washing method for cloth masks (self-washing or hospital laundry). …”
Get full text

Influences of age and sex on the diagnostic accuracy of human epididymis secretory protein 4 for malignant pleural effusion by Qian Yang, Yan Niu, Qianghua Zhou, Dan-Ni Yang, Hong-Zhe Zhu, Cheng Yan, Su-Na Cha, Ting-Wang Jiang, Li Yan, Wen-Qi Zheng, Jian-Xun Wen, Zhi-De Hu

“…Additionally, we conducted subgroup analyses and used a resampling method with different upper age limits to investigate the impacts of age and sex on the diagnostic accuracy of HE4 for MPE. …”
Get full text