Next generation sequencing uncovers multiple miRNAs associated molecular targets in gallbladder cancer patients by Rahul Saxena, Baskar Chakrapani, M. P. Sarath Krishnan, Amit Gupta, Sweety Gupta, Jayanta Das, Subash C. Gupta, Anissa A. Mirza, Shalinee Rao, Bela Goyal

“…Panther analysis revealed the insulin-like growth factor (IGF)-mitogen activated protein kinases (MAPK) cascade, p38 MAPK pathway, p53 pathway, and FAS (a subgroup of the tumor necrosis factor receptor) signaling pathway as highly enriched among dysregulated miRNAs. …”
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MicroRNA as a Potential Diagnostic and Prognostic Biomarker in Diffuse Large B‐Cell Lymphoma: A Systematic Review and Meta‐Analysis by Shaghayegh Khanmohammadi, Mahdi Masrour, Parisa Fallahtafti, Fatemeh Hasani

“…Specificity, sensitivity, and AUC were used to assess diagnostic accuracy, and the prognostic value was assessed using the overall survival (OS) and progression‐free survival (PFS) hazard ratio (HR). A subgroup analysis was performed based on the sample type acquired to investigate the heterogeneity. …”
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Use of Simultaneous Bilateral Cataract Surgery (SBCS) to Optimize Parameters Affecting the Subjective Perception of the Procedure by P. Studený, J. Vránová, L. Nováček

“…Only one statistically significant difference in subjective pain perception was in the subgroup where we used eye intracameral anesthesia (0.34 eyes with intracameral anesthesia, 0.44 eyes with only topical anesthesia). …”
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Modulation of Circulating Cytokine-Chemokine Profile in Patients Affected by Chronic Venous Insufficiency Undergoing Surgical Hemodynamic Correction by Veronica Tisato, Giorgio Zauli, Sergio Gianesini, Erica Menegatti, Laura Brunelli, Roberto Manfredini, Paolo Zamboni, Paola Secchiero

“…In this study, the circulating levels of 31 cytokines/chemokines involved in inflammatory/angiogenic processes were analysed in (i) CVI patients at baseline before surgical hemody namic correction, (ii) healthy subjects, and (iii) CVI patients after surgery. In a subgroup of CVI patients, in whom the baseline levels of cytokines/chemokines were analyzed in paired blood samples obtained from varicose vein and forearm vein, EGF, PDGF, and RANTES were increased at the varicose vein site as compared to the general circulation. …”
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Effects of trigger-day progesterone in c-IVF/ICSI cycles on blastocyst culture outcomes by Yating Sun, Jia Wang, Luyun Zhang, Yanjun Chang, Aizhen Zhu

“…After adjustments, multivariate logistic regression analysis revealed that compared with those in the normal level group, available blastocyst rate (adjusted OR, 0.780; 95% CI, 0.645-0.942; P=0.010) and D5 available blastocyst rate (adjusted OR, 0.736; 95% CI, 0.604-0.898; P=0.003) in the high level group were significantly reduced. Subgroup analysis showed that when female age was less than 35 years old, compared with that (36.30%) in the normal level group, the D5 available blastocyst rate (36.92%, adjusted OR, 0.744; 95% CI, 0.602-0.920; P=0.006) in the high level group was significantly reduced. …”
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Nonlinear association between depressive symptoms and homeostasis model assessment of insulin resistance: a cross-sectional analysis in the American population by Chunqi Jiang, Bo Wang, Yinuo Qu, Jun Wang, Xin Zhang

“…The intricate interplay between these two domains holds promising implications for understanding the multifaceted nature of depressive symptom and its impact on metabolic health.MethodsWe used weighted multivariable logistic regression models with subgroup analysis to explore the relationship between depressive symptom and homeostasis model assessment of insulin resistance. …”
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Clinical Characteristics and Risk Factors for Multidrug-Resistant Enterobacter cloacae Complex Bacteremia in a Chinese Tertiary Hospital: A Decade Review (2013–2022) by Han M, Hua M, Xie H, Li J, Wang Y, Shen H, Cao X

“…Mei Han,1,2,&ast; Miaomiao Hua,3,&ast; Hui Xie,1 Jia Li,1 Yijun Wang,2,4 Han Shen,1 Xiaoli Cao1 1Department of Laboratory Medicine, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, People’s Republic of China; 2Nanjing Field Epidemiology Training Program, Nanjing Municipal Center for Disease Control and Prevention, Nanjing, Jiangsu, People’s Republic of China; 3Department of Laboratory Medicine, The Affiliated Fuyang Hospital of Anhui Medical University, Fuyang, Anhui, People’s Republic of China; 4Nanjing Jiangning District Center for Disease Control and Prevention, Nanjing, Jiangsu, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xiaoli Cao; Han Shen, Email cao-xiao-li@163.com; shenhan10366@sina.comObjective: This study aimed to analyze the antimicrobial resistance profiles, clinical characteristics and risk factors of bacteremia caused by Enterobacter cloacae complex (ECC) strains.Methods: We retrospectively collected clinical data from patients diagnosed with ECC bacteremia between 2013 and 2022 in a tertiary hospital in Jiangsu. Subgroup analyses were performed based on multidrug resistance (MDR), nosocomial acquisition, polymicrobial bacteremia, and mortality.Results: Among 188 ECC strains, the highest resistance was to ceftriaxone (39.9%), followed by ceftazidime (36.7%) and aztreonam (31.2%), with low resistance to carbapenems (< 8.6%) and amikacin (1.6%). …”
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Factors affecting risk perception of COVID-19: differences by age and gender by Sungwook Kang, Chang Hoon You, Young Dae Kwon, Young Dae Kwon

“…In the male group, economic variables such as income and employment status were related to COVID-19 risk perception, whereas in women, family-related variables such as marital status and housing type were related. In most subgroup analyses, lower income levels or lower life satisfaction were associated with higher COVID-19 risk perception.DiscussionThe findings of this study suggest that health authorities need to tailor their responses to COVID-19 risk perception based on different populations and social groups. …”
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Clinical Oral Health Recommended Care and Oral Health Self-Report, NHANES, 2013-2014 by R. Constance Wiener, Nilanjana Dwibedi, Chan Shen, Patricia A. Findley, Usha Sambamoorthi

“…Concordance with clinically evaluated recommended need for oral healthcare varied from 52.0% (oral pain) to 65.4% (overall oral health self-perception). Many subgroup differences were observed. Conclusions. The overall self-perception of oral health and the clinical evaluation of oral healthcare need were substantially concordant; other self-reported measures were moderately concordant. …”
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Investigation of the connection between triglyceride-glucose (TyG) index and the risk of acute kidney injury in septic patients - a retrospective analysis utilizing the MIMIC-IV da... by Pirun Zhang, Wenli Zhang, Yan Han, Tong Yang, Jiayi Zhong, Yun Han, Fang Lai

“…The relationship between the TyG index and the risk of AKI in septic patients was evaluated using Cox proportional hazards and restricted cubic spline models. Subgroup analyses were conducted to investigate the prognostic value of the TyG index in different subgroups. …”
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Abnormal insulin metabolism and decreased levels of mindfulness in type 2 diabetes mellitus by Xue Zhang, Rui Huang, Jiaxin Li, Mingyue Yang, Daowen Zhang, Cancan Liu, Kuanlu Fan

“…Linear regression models were utilized to investigate the relationships between various T2DM categories and mindfulness levels and dimensions. Furthermore, subgroup analyses of key variables were conducted, and mediation analysis was performed to evaluate the sources of differences. …”
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Frequency of orthostatic hypotension in the Pooled Resource Open-Access ALS Clinical Trials database by C. Quarracino, F. Capani, F. Capani, M. Otero-Losada, G. E. Rodríguez, S. Pérez-Lloret, S. Pérez-Lloret

“…Only 22.5% of the patients with OH at baseline had OH at follow-up.ConclusionIn a large sample of ALS patients, OH occurred in 11–13%, pointing to a subgroup that might require special care to avoid related complications.…”
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Association of dietary inflammatory index with ocular diseases: a population-based cross-sectional study by Xue Wang, Can Zhang, Haitao Jiang

“…The correlation between DII and risk of ocular diseases was examined using weighted multivariable logistic regression analysis, restricted cubic spline (RCS) plots, and subgroup analysis. Results In total, 2885 participants from the NHANES database were included. …”
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The regular effects of concurrent aerobic and resistance exercise on global cognition in healthy elderly populations: A systematic review with meta-analysis of randomized trials by Liang Ding, Lijie Lou, Mingyang Zhang, Xing Zhang

“…The meta-analysis revealed non-significant effects of concurrent exercise on global cognition (SMD = 0.12, 95 % CI: −0.08 to 0.33, p = 0.200). The subgroup analysis indicated that concurrent exercise cannot enhance global cognition compared to active controls (SMD = −0.03, 95 % CI: −0.23 to 0.18, p = 0.80), but it does show significant improvement compared to passive controls (SMD = 0.35, 95 % CI: 0.14 to 0.56, p < 0.001). …”
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Evaluation of Intraocular Lens Tilt and Decentration in Congenital Ectopia Lentis by the Pentacam Scheimpflug System by Huiwen Ye, Zhenzhen Liu, Qianzhong Cao, Zhangkai Lian, Xinyu Zhang, Danying Zheng, Guangming Jin

“…The decentration of CEL patients in the AL ≥ 26 subgroup was greater than those with AL < 24 mm and AL 24 to 26 mm subgroups (for superior: 0.72 ± 0.28 mm vs. 0.46 ± 0.25 mm and 0.48 ± 0.22 mm, all P<0.05; for inferior: -0.94 ± 0.56 mm vs. −0.44 ± 0.26 mm and -0.44 ± 0.46 mm, all P<0.05). …”
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Efficacy and safety of antifibrotic drugs for interstitial lung diseases other than IPF: A systematic review, meta-analysis and trial sequential analysis. by Mei Yang, Yuying Tan, Ting Yang, Dan Xu, Mei Chen, Lei Chen

“…However, based on two studies with 324 patients, benefit of antifibrotic drugs in FVC was not shown in the subgroup taking mycophenolate (mean difference 17.08; 95% CI -56.22 to 90.37), which also had higher risk of SAEs (RR 1.71; 95% CI 1.09 to 2.70), although both were contested by TSA.…”
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Relationship between Maternal Central Obesity and the Risk of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Cohort Studies by Da Yao, Qing Chang, Qi-Jun Wu, Shan-Yan Gao, Huan Zhao, Ya-Shu Liu, Yu-Ting Jiang, Yu-Hong Zhao

“…The degree of heterogeneity among the studies was low (I2=14.4, P=0.307). The subgroup analyses showed that heterogeneity was affected by selected study characteristics (methods of exposure and trimesters). …”
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Development of a Prognostic Nomogram Incorporating the Naples Prognostic Score for Postoperative Oral Squamous Cell Carcinoma Patients by Xu XL, Cheng H

“…The nomogram developed in this study holds significant clinical application potential. The low-risk subgroup of patients was not required to undergo postoperative radiotherapy.Keywords: oral squamous cell carcinoma, naples prognostic score, nomogram, risk stratification, radiotherapy…”
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Safety of Rimegepant in Adults with Migraine and Anxiety, Depression, or Using Antidepressants: Analysis of a Multicenter, Long-Term, Open-Label Study by David Kudrow, Susan Hutchinson, Glenn C. Pixton, Terence Fullerton

“…Participants with a history of 2–14 migraine attacks per month of moderate or severe pain intensity self-administered rimegepant 75 mg as needed up to once daily for up to 52 weeks. These post hoc subgroup analyses assessed safety according to self-reported history of anxiety (yes or no) or depression (yes or no), and current use of SSRIs (yes or no) or other antidepressants (yes or no). …”
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Alpha-glucosidase inhibitor decreases the risk of colorectal adenoma in the aged with Type 2 diabetes by Dingchao Xia, Lanling Jin, Binfeng Wang, Yi Jin, Qun Zheng, Jie Xu, Senzhong Chen

“…A similar trend was also observed in the PSM analysis (OR = 0.362, 95% CI = 0.176–0.744, p = 0.004). Subgroup analysis reveals hypertension as a potential modulator of the inverse relationship between AGI and colorectal adenoma occurrence post-PSM (p = 0.049). …”
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