Nonlinear association between proteinuria levels and the risk of cardiovascular disease events and all-cause mortality among chronic kidney disease patients by Haiying Song, Yuheng Liao, Haofei Hu, Qijun Wan

“…Cox proportional hazards regression, smooth curve fitting, piecewise linear regression, and subgroup analyses were used.Results The mean age of the included individuals was 67.3 ± 13.6 years old. …”
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Prediction Model of New Onset Atrial Fibrillation in Patients with Acute Coronary Syndrome by Na Wu, Junzheng Li, Xiang Xu, Zhiquan Yuan, Lili Yang, Yanxiu Chen, Tingting Xia, Qin Hu, Zheng Chen, Chengying Li, Ying Xiang, Zhihui Zhang, Li Zhong, Yafei Li

“…The discrimination, calibration, and clinical utility of the model were evaluated, and a nomogram was constructed. A subgroup analysis was performed for unstable angina (UA) patients. …”
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Ensemble machine learning models for lung cancer incidence risk prediction in the elderly: a retrospective longitudinal study by Songjing Chen, Sizhu Wu

“…Methods We stratified the population into six subgroups according to age and gender. For each subgroup, random forest, extreme gradient boosting, deep neural networks, support vector machine, multiple logistic regression and deep Q network (DQN) models were developed and validated. …”
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Safety and efficacy of apixaban versus vitamin K antagonists in patients undergoing dialysis: a systematic review and meta-analysis by Yifang Zhang, Jialiang Wang, Nannan Shen, Jie Jiang, Yanna Xie

“…Meta-analysis showed no difference in the risk of ischemic stroke (RR: 0.40, 95% CI: 0.06, 2.69, I2 = 0%), mortality (RR: 1.26, 95% CI: 0.74, 2.16, I2 = 94%) and recurrent venous thromboembolism (RR: 1.02, 95% CI: 0.87, 1.21, I2 = 0%) between the two groups. Subgroup analysis of RCTs showed no difference in bleeding outcomes.Conclusions Low-quality evidence from a mix of RCTs and retrospective studies shows that apixaban may have better safety and equivalent efficacy as compared to VKA in dialysis patients. …”
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Prognostic value of red cell distribution width in patients undergoing percutaneous coronary intervention: a meta-analysis by Xiaoyan Wang, Donglai Bao, Gaojiang Luo, Fuqiang Kan, Jinwei Luo, Changhao Jiang

“…The predictive effect of elevated RDW for all-cause mortality was stronger in the subgroup of patients without anaemia (RR 4.59; 95% CI 3.07 to 6.86) than with anaemia.Conclusions This meta-analysis indicated that elevated RDW was associated with higher risk of mortality and adverse cardiac events in patients with CAD undergoing PCI. …”
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Impact of Simulation-Based and Flipped Classroom Learning on Self-Perceived Clinical Skills Compared to Traditional Training by Samuel Agostino, Gian Maria Cherasco, Grazia Papotti, Alberto Milan, Federico Abate Daga, Massimiliano Abate Daga, Franco Veglio

“…ANCOVA controlled for baseline scores, and paired Wilcoxon signed-rank tests examined overall and subgroup improvements. Results: After the program, significant improvements were observed in self-perceived clinical skills across all domains. …”
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Elbow Injuries Among MLB Pitchers Increased During Covid-19 Disrupted Season, But Not Other Baseball Injuries by Chelsea Martin, Jozef Palasiewicz, Jesse Grullon, Ellen Shanley, Charles Thigpen, Daniel Kline, Stefan Kluzek, Gary Collins, Garrett Bullock

“…Poisson regressions were performed for all injuries and stratified by position to determine association between season and injury incidence. Subgroup analyses were performed on the elbow, groin/hip/thigh, shoulder…”
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Effect of intramuscular midazolam premedication on patient satisfaction in women undergoing general anaesthesia: a randomised control trial by Kwang Ho Lee, Seung Woo Song, Younghyun Jin, Hyunjae Lim, Jonghoon Lee

“…The secondary outcomes included blood pressure, heart rate, oxygen desaturation, recovery duration and postoperative pain.Results Patients who received midazolam were more satisfied than those who received placebo (percentage difference: 21.0%, OR 3.56, 95% CI 1.46 to 8.70). A subgroup analysis revealed that this difference was greater in patients with anxiety, defined as those whose Amsterdam Preoperative Anxiety and Information Scale anxiety score was ≥11, than that for the whole sample population (percentage difference: 24.0%, OR 4.33, 95% CI 1.25 to 14.96). …”
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Evaluating the Effectiveness of Parent Training Pamphlets: An Intervention Study Among Parents at Child Health Checkups by Kazuko Akutsu, Aya Goto, Fareeda Abo-Rass, Hiroyuki Yokoyama

“…The study also analyzed adherence to each recommended parenting technique within subgroups of parents whose children needed follow-up health checkups and those whose children did not. …”
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Association of whole grain food consumption with lung cancer risk: a prospective cohort study by Kanran Wang, Junhan Zhao, Dingyi Yang, Mao Sun, Yongzhong Wu, Wei Zhou

“…These results were consistently observed after a large range of subgroup and sensitivity analyses. A linear dose-response pattern was shown for lung cancer, NSCLC, and SCLC (P for non-linearity > 0.05). …”
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Effects of antioxidant nutrients on muscle mass, strength and function in COPD patients: A meta-analysis of randomized controlled trials. by Qinman He, Pan Yang, Ye Wang, Wanmei Xu, Yi Feng, Fei Xie, Guixiang Xu

“…Weighted mean differences (WMDs) and 95% confidence intervals (CIs) were used as the effect size for measurement data. Further, subgroup analysis was conducted based on whether patients participated in lung rehabilitation plans while receiving nutritional interventions. …”
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The independent and joint relationships between dietary antioxidant intake with risk of chronic obstructive pulmonary disease and all-cause mortality: insights from NHANES by Yifeng Xu, Zhaoqi Yan, Keke Li, Liangji Liu, Lei Xu

“…Furthermore, dietary antioxidant zinc in the second quartile (Hazard Ratio [HR]: 0.25; 95% CI: 0.10–0.62) was negatively associated with the risk of all-cause mortality compared to the lowest quartile. Subgroup analysis results remained stable, and sensitivity analysis did not support the association between selenium and the risk of COPD, with no substantial changes in the remaining associations.ConclusionHigher CDAI is inversely associated with the risk of COPD, and appropriate intake of the dietary antioxidant zinc may reduce all-cause mortality in COPD patients.…”
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Serum Albumin Is Independently Associated with Persistent Organ Failure in Acute Pancreatitis by Wandong Hong, Suhan Lin, Maddalena Zippi, Wujun Geng, Simon Stock, Zarrin Basharat, Bicheng Cheng, Jingye Pan, Mengtao Zhou

“…Multivariate logistic regression and subgroup analysis determined whether decreased albumin was independently associated with persistent organ failure and mortality. …”
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Evaluation of IL-29 in Euthyroid Patients with Graves’ Orbitopathy: A Preliminary Study by Bogusz Falkowski, Ewelina Szczepanek-Parulska, Nadia Sawicka-Gutaj, Aleksandra Krygier, Marek Ruchala

“…Furthermore, participants in the subgroup with GD with GO as compared with GD without GO had higher concentration of IL-29 [165 (133-747) vs. 62 (62-558) pg/mL, p=0.031]. …”
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Surgical Treatment of Epiblepharon Effectively Alleviates Keratopathy but Not Astigmatism: A Case-Control Study Utilizing Vector Analysis in East Asian Children by Shang-Te Ma, Yao-Lin Liu, Ching-Ju Hsieh, Yo-Shen Chen, Tzu-Hsun Tsai

“…This trend was especially observed in the subgroup of baseline astigmatism >2.0 D. However, the difference in the astigmatism magnitude between surgical and nonsurgical groups, even in highly astigmatic children, was not significant at 6 months. …”
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Prognostic Value of Combination of Pretreatment Red Cell Distribution Width and Neutrophil-to-Lymphocyte Ratio in Patients with Gastric Cancer by Danyang Zhou, Ying Wu, Zhenyu Lin, Liangliang Shi, Lei Zhao, Tao Liu, Dandan Yu, Tao Zhang

“…Moreover, high RDW + NLR was strongly related to age, tumor location, TNM stage, CA125, and CA199. In a subgroup analysis for patients with advanced gastric cancer (AGC), we observed that the level of RDW + NLR was markedly associated with OS and PFS. …”
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Prior Appendectomy and the Onset and Course of Crohn’s Disease in Chinese Patients by Dafan Chen, Jing Ma, Qiwen Ben, Lungen Lu, Xinjian Wan

“…No significant differences in disease location, behavior, medication, and intestinal resection between appendectomy and nonappendectomy CD patients were found, even in the subgroup analysis by age of appendectomy. Conclusion. …”
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Effects of bioactive peptides combined with probiotics on serum uric acid in patients with hyperuricemia by HAN Dan，ZHAO Ya，HUANG Enshan，YE Shuhua，WANG Wanjin，WU Fangmin，WANG Dingliang，ZHANG Ronghua

“…However, there was no statistically significant interaction between the intervention time and group (both P>0.05). Subgroup analysis showed that after 28 days of interventions, the decrease in SUA levels in the patients aged 55 years and older and without hypertension in the intervention group was greater than those in the control group (both P<0.05). …”
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Association between Red Blood Cell Distribution Width and In-Hospital Mortality among Congestive Heart Failure Patients with Diabetes among Patients in the Intensive Care Unit: A R... by Kai Zhang, Yu Han, Yu Xuan Gao, Fang Ming Gu, Tianyi Cai, Rui Hu, Zhao Xuan Gu, Jia Ying Liang, Jia Yu Zhao, Min Gao, Bo Li, Dan Cui

“…We examined the association between RDW on ICU admission and in-hospital mortality using multivariable logistic regression models, restricted cubic spline analysis, and subgroup analysis. Results. The cohort consisted of 7,063 patients with both DM and CHF (3,135 females and 3,928 males). …”
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Prevalence of Autoimmune Diseases in Patients Treated With Immune Checkpoint Inhibitors: An Epidemiological Study Using A Global Network of Health Care Organizations by Pushti Khandwala, Devashish Desai, Arthur Lau

“…Multivariate Cox proportional hazard models and Kaplan Meier method were used to assess risk of developing ACs among the groups. Subgroup analysis was done to evaluate risk of ACs in patients receiving cytotoxic T‐lymphocyte‐associated protein 4 inhibitor (CTLA4i) versus program cell death protein 1 inhibitor (PD1i) and program death ligand 1 inhibitor (PDL1i) inhibitors and combination treatment (CT) (CTLA4 + PD1i/PDL1i) versus PD1i/PDL1i. …”
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