HDAC and MEK inhibition synergistically suppresses HOXC6 and enhances PD-1 blockade efficacy in BRAFV600E-mutant microsatellite stable colorectal cancer by Xin Li, Peng Yang, Jin Gu, Nan Chen, Dengbo Ji, Jinhong Xia, Jinying Jia, Zhuang Sun, Mengyuan Shi, Hanyang Wang, Zhaoya Gao

“…Background B-Raf proto-oncogene, serine/threonine kinase (BRAF)V600E-mutant microsatellite stable (MSS) colorectal cancer (CRC) constitutes a distinct CRC subgroup, traditionally perceived as minimally responsive to standard therapies. …”
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Influence of Zinc Supplementation in Acute Diarrhea Differs by the Isolated Organism by Archana B. Patel, Michael J. Dibley, Manju Mamtani, Neetu Badhoniya, Hemant Kulkarni

“…We used data on 801 children with acute diarrhea recruited in a randomized, double blind controlled trial (ISRCTN85071383) of zinc and copper supplementation. Using prespecified subgroup analyses, multidimensionality reduction analyses, tests of heterogeneity, and stepwise logistic regression for tests of interactions, we found that the influence of zinc on the risk of diarrhea for more than 3 days depended on the isolated organism—beneficial in Klebsiella, neutral in Esherichia coli and parasitic infections, and detrimental in rotavirus coinfections. …”
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Diamond Blackfan Anemia at the Crossroad between Ribosome Biogenesis and Heme Metabolism by Deborah Chiabrando, Emanuela Tolosano

“…Recently, the analysis of mice from which the gene coding for the heme exporter Feline Leukemia Virus subgroup C Receptor (FLVCR1) is deleted suggested that this gene may be involved in the pathogenesis of DBA. …”
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Experimental Investigation of the Permeability Measurement of Radial Flow through a Single Rough Fracture under Shearing Action by Ran Tan, Junrui Chai, Cheng Cao

“…Eight types of test case were designed, and subgroup tests with varied normal stress, shear velocity, and roughness of fracture surface were conducted. …”
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A Reappraisal of Women’s Health Initiative Estrogen-Alone Trial: Long-Term Outcomes in Women 50–59 Years of Age by Eric Roehm

“…Younger women (50–59 years), compared to older women, had more favorable cumulative long-term outcomes for MI and global index. Though a subgroup analysis is not an adequate basis for making primary prevention guideline recommendations, the WHI Estrogen-Alone Trial outcomes strongly suggest that a similar course of estrogen initiated at 50–59 years in postmenopausal women with prior hysterectomy results in significant long-term health benefit.…”
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Associations of CTLA4 Gene Polymorphisms with Graves’ Ophthalmopathy: A Meta-Analysis by Pengfei Du, Xiaojie Ma, Changjiang Wang

“…Results showed that the G allele was related to the increased risk of GO compared with the A allele under allelic genetic model (OR = 1.14, 95% CI: 1.14–1.72, P=0.001) in European subgroup. No publication bias was detected. Our results showed that the SNP49 polymorphism of CTLA4 gene was related to increased risk of GO.…”
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Evaluating the Shear Bond Strength of Repaired Composites Using Different Surface Treatments and Repair Materials: An In-Vitro Comparative Study by Prinaxy Byxyx, Ajay Kumar Nagpal, Prashasti Pandey, Darshan Das, Mihir Anand, Anupama Pradhan

“…Each group was further subdivided into two subgroups, treated with either Ivoclar Tetric N-bond or 3M ESPE Single Bond Universal adhesive. …”
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Prognostic value of procalcitonin in acute exacerbation of chronic obstructive pulmonary disease: A systematic review and meta-analysis. by Pang Qiyuan, Lin Changyang, Li Gaigai, Qiu Ju, Zhou Xun

“…We found PCT levels in patients hospitalized for AECOPD are not associated with increased risk of mortality (RR 1.03, 95%CI 0.99-1.08). However, subgroup analysis showed PCT levels are indeed associated with an increased risk of mortality in mild to moderate AECOPD(RR 1.74, 95%CI 1.11-2.73). …”
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Correspondence: Can Menstrual Cycle Length Predict Cardiovascular Risk in Healthy Indian Females? by Avnesh Kumar Singh, Shikha Singh

“…Ensuring that each subgroup is fairly represented in the sample allows for more precise conclusions…”
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Clinicopathological importance of immunohistochemical expression of OCT4, c-MYC and Ki-67 in colorectal cancer by Rabia Hursitoglu, Abdulkadir Yasir Bahar, Sezen Koçarslan, Gökmen Aktaş, Neslihan Kurtul, Emine Kılınç

“…Our results show that the Ki67 L /c-MYC H /OCT4 H subgroup was associated with lower survival and resistance to treatment compared to the other subgroups. …”
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Improved Results Over Time With Bridge-to-Lung Transplantation: A 10-Year Experience of a Single High-Volume Center by Gyungah Kim, Jee Hwan Ahn, Tae Sun Shim, Pil-Je Kang, Geun Dong Lee, Sehoon Choi, Won Kim, Sung-Ho Jung, Dong Kwan Kim, Seung-Il Park, Sang-Bum Hong

“…Improved survival was observed in the subgroup with BTT duration of 14 days or more. Taken together, more experiences in BTT and improved competence may contribute to better survival after LTx, especially in patients receiving ECMO for 14 days or more.…”
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Disseminated Exfoliative Dermatitis Associated with All-Transretinoic Acid in the Treatment of Acute Promyelocytic Leukemia by Yonal Ipek, Dogru Hulya, Aktan Melih

“…All-trans retinoic acid (ATRA) is a subgroup of the retinoid family, which induces complete remission (CR) in APL by causing differentiation and apoptosis in immature malignant promyelocytes rather than inducing cell death by cytotoxicity (Warrell et al. (1993), Liu et al. (2000), and Cassinat et al. (2001)). …”
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A Large-Scale Group Decision-Making Consensus Model considering the Experts’ Adjustment Willingness Based on the Interactive Weights’ Determination by Shizhen Bai, Hao He, Dan Luo, Mengke Ge, Ruobing Yang, Xinrui Bi

“…First, the determination method of the interactive weight, which obtains the DMs’ attitude towards the decision-making results, is presented. The subgroups’ weights are calculated, and the unit adjustment cost for each DM is defined. …”
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Integrated Community-Based Nutrition Interventions Improve Diet Quality, Food, and Credit Access among Rural Women in Northern Ghana by Clement Kubreziga Kubuga, Gifty Sienso

“…Globally, micronutrient deficiencies are widespread in women due to poor diet quality and elevated needs of the subgroup. Undernutrition, specifically micronutrient deficiencies, is a major problem in Ghana, especially in northern Ghana during the prolonged dry/lean season. …”
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Functional dyspepsia and gastroparesis: are they distinct disorders, a spectrum of diseases or one disease? by Simon Keely, Nicholas J Talley, Michael Potter, Kerith Duncanson, Stella-Maris Egboh

“…A comprehensive literature search was performed and the full texts of eligible articles were retrieved for the extraction of information reported in this review.This summary of evidence supports the hypothesis that GP and FD represent two ends of the same disease spectrum in a major subgroup. Improved understanding of the similarities, differences and overlap is likely to help guide the development of objective biomarkers and better-targeted therapies.…”
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Wreathing, discrete gauging, and non-invertible symmetries by Julius F. Grimminger, William Harding, Noppadol Mekareeya

“…We present a prescription for refining the index with respect to the fugacities associated with the Abelian discrete symmetries that are subgroups of G. This allows us to study sequential gauging of various subgroups of G and construct symmetry webs. …”
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FK228 Analogues Induce Fetal Hemoglobin in Human Erythroid Progenitors by Levi Makala, Salvatore Di Maro, Tzu-Fang Lou, Sharanya Sivanand, Jung-Mo Ahn, Betty S. Pace

“…Using the dual-luciferase system, a subgroup of FK228 analogues was shown to be inducers of HbF at nanomolar concentrations. …”
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Meta analysis of resting frontal alpha asymmetry as a biomarker of depression by Yiwen Luo, Mingcong Tang, Xiwang Fan

“…Despite the presence of high heterogeneity across studies, subgroup analyses did not identify significant differences based on calculation formula, reference montage, age, or depression severity. …”
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Diagnosing Celiac Disease: Towards Wide-Scale Screening and Serology-Based Criteria? by Alina Popp, Laura Kivelä, Valma Fuchs, Kalle Kurppa

“…The increasing prevalence of celiac disease and the development of autoantibody assays have also led to a gradual shift in the diagnostics towards less invasive serology-based criteria in a subgroup of symptomatic children. The main open questions concern whether these criteria are applicable to all countries and clinical settings, as well as to adult patients. …”
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Patent Foramen Ovale Closure for Treating Migraine: A Meta-Analysis by Yu Zhang, Haijiao Wang, Ling Liu

“…Compared with control intervention in migraine, PFO closure could significantly reduce headache frequency (OR = 1.5698, 95% CI: 1.0465–2.3548, p=0.0293) and monthly migraine attacks and monthly migraine days (OR = 0.2594, 95% CI: 0.0790–0.4398, p=0.0048). Subgroup analysis of patients who all completed PFO surgery showed resolution of migraine headache for migraines with aura (OR = 1.5856, 95% CI: 1.0665–2.3575, p=0.0227). …”
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