Mutual mediation effects of homocysteine and PCSK9 on coronary lesion severity in patients with acute coronary syndrome: interplay with inflammatory and lipid markers by Ping Jin, Juan Ma, Peng Wu, Yitong Bian, Xueping Ma, Shaobin Jia, Qiangsun Zheng

“…The robustness of the findings was validated by conducting subgroup analyses and sensitivity tests. Results Patients with severe conditions showed higher levels of Hcy, PCSK9, and inflammatory markers compared to non-severe cases. …”
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The association between frailty and falls among individuals aged 60 years and older residing in community settings and experiencing hip fractures in China: a cross-sectional study by Lan Jiang, Shulong Ding, Juxia Wang

“…This association was even more pronounced in the pre-frail (CHARLS, OR: 1.95, 95% CI: 1.65–2.32; A single center, OR: 1.67, 95% CI: 0.46–6.08) and frail (CHARLS, OR: 3.43, 95% CI: 2.51–4.68; A single center, OR: 4.01, 95% CI: 0.61–26.41) groups compared to the control group. Subgroup studies revealed a sex-related interaction between frailty and falls in patients with hip fractures but not in older persons residing in the community. …”
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Genetic Structure of Endangered Species <i>Anagallis foemina</i> Mill. and Abundant Weed <i>Anagalis arvensis</i> L. Occurring in Segetal Habitats in South-Eastern Poland by Ewa Kwiecińska-Poppe, Sylwia Sowa, Joanna Lech, Małgorzata Haliniarz, Edyta Paczos-Grzęda

“…Within the <i>A. foemina</i> group, two subgroups were distinguished: the first subgroup included genotypes from the Lublin Upland (LU) and Volhynian Polesie (VP), while the second subgroup consisted of genotypes from Western Volhynian Upland (VU). …”
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L-shaped association of dietary inflammatory index (DII) and chronic diarrhea: results from NHANES 2005–2010 by Qing Zhao, Yue Xu, Xiangrui Li, Xiaotian Chen

“…Multivariate logistic regression models examined the causal connection between DII and chronic diarrhea. Additionally, subgroup analyses and interaction tests were conducted. …”
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Association of valproate use and hippocampal atrophy in idiopathic generalized epilepsy by Xiang Huang, Yingying Zhang, Qiuxing Lin, Kailing Huang, Yuming Li, Peiwen Liu, Danyang Cao, Wenhao Li, Wei Li, Xiuli Li, Qiyong Gong, Dong Zhou, Dongmei An

“…Results: The volumes of bilateral hippocampi were reduced in IGE compared with HCs. Subgroup analysis showed significant volume reductions in right hippocampus and its subfields in GTCA. …”
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Predictive accuracy of lactate albumin ratio for mortality in intensive care units: a nationwide cohort study by Yohei Okada, Yoshitaka Aoki, Mikio Nakajima, Yasuhito Suzuki, Mikihiro Shimizu, Ryo Imai, Soichiro Mimuro, Yoshiki Nakajima

“…Unrestricted spline curves demonstrated that LAR can predict mortality through a monotonic positive dose–response relationship with 0.4 as the optimal cut-off value. In subgroup analysis, areas under the curve were significantly higher in subgroups defined by younger age, female sex, unplanned ICU admission, non-surgical patients, non-infectious patients, non-heart failure patients and lack of end-stage renal disease.Conclusions The LAR might be a useful predictor for screening mortality in ICU patients. …”
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Association of elevated albumin-corrected anion gap with all-cause mortality risk in atrial fibrillation: a retrospective study by Jia Xu, Zhen Wang, Yun Wang, Xinran Chen, Lan Ma, Xiaochen Wang

“…A positive relationship between rising ACAG levels and mortality risk was showed by restricted cubic spline analysis. Subgroup analyses revealed no significant interactions (all interaction P-values > 0.05). …”
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Machine learning prediction models for mortality risk in sepsis-associated acute kidney injury: evaluating early versus late CRRT initiation by Chuanren Zhuang, Ruomeng Hu, Ke Li, Zhengshuang Liu, Songjie Bai, Sheng Zhang, Xuehuan Wen

“…Propensity score matching was performed to address potential selection bias. Subgroup analyses stratified patients by disease severity using SOFA scores (low ≤10, medium 11–15, high &gt;15) and creatinine levels (low ≤3 mg/dL, medium 3–5 mg/dL, high &gt;5 mg/dL). …”
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The Relationship Between Novel Inflammatory Markers and Serum 25‐Hydroxyvitamin D Among US Adults by Hang Zhao, Yangyang Zhao, Yini Fang, Weibang Zhou, Wenjing Zhang, Jiecheng Peng

“…A multivariable linear regression model assessed the links between serum 25(OH)D and these novel inflammatory markers, with subgroup analyses for hypertension and diabetes. To further explore the relationship between the two, we applied smooth curve fittings and generalized additive models. …”
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Association between non-high-density lipoprotein cholesterol and type 2 diabetes: a systematic review and meta-analysis of cohort studies by Mengqi Han, Yue Shen, Xin Guo, Cheng Hong, Xincan Ji, Haoyang Guo, Yuelong Jin, Hui Yuan

“…A random-effects model was used to calculate the effect estimates and 95% confidence intervals. Subgroup analyses and univariate Meta-regression were performed to explore sources of heterogeneity. …”
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Prevalence and clinical correlates of chronic obstructive pulmonary disease in heart failure patients: a cross-sectional study in China by Ailing Zhu, Manman Hu, Dehai Ge, Xiujian Zhang, Jinfeng Zhang, Yangchun Wang, Xin Yao, Junjun Liu

“…Divided into 233 COPD cases and 1775 non-COPD controls, a multivariable logistic regression identified factors linked to COPD onset in HF, with thorough examination of intergroup clinical differences.ResultsThe incidence of COPD in HF individuals was 11.60% (233/2008). The COPD subgroup featured a higher ratio of individuals over 60 and males, alongside lower systolic blood pressure (SBP), body mass index (BMI), higher Charlson Comorbidity Index (CCI) scores, and increased PaCO₂ levels (p &lt; 0.05). …”
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Association between life's essential 8 and Parkinson's disease: a case–control study by Jiaxin Fan, Yanfeng Wang, Xingzhi Guo, Shuai Cao, Shuqin Zhan, Rui Li

“…The stability of this effect was validated by subgroup analysis and interaction test. Results A total of 26,975 eligible participants (including 271 PD cases and 26,704 non-PD cases) were included in this study. …”
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The Clinicopathological Features and Prognostic Significance of HER2-Low in Early Breast Tumors Patients Prognostic Comparison of HER-Low and HER2-Negative Breast Cancer Stratified... by Sanaa Gamrani, Laila Akhouayri, Sara Boukansa, Mehdi Karkouri, Hinde El Fatemi

“…It is important to note that this particular subgroup is different from the HER2-negative one and should not be treated in the same way. …”
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Association of workforce participation with depression among US older adults: results from NHANES 2005–2018 by Zhenyu Sun, Yi Wang, Xi Chen, Dongfu Qian

“…These effects were consistent across the analyses of subgroup and sensitivity. Conclusions Regular daytime working was positively related to decreased depression risk among US older adults, and the suggested optimal working hours were 25 to 35 per week. …”
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Prognostic Value of the Red Blood Cell Distribution Width-to-Albumin Ratio in Critically Ill Older Patients with Acute Kidney Injury: A Retrospective Database Study by Lei Guo, Dezhun Chen, Bihuan Cheng, Yuqiang Gong, Benji Wang

“…We generated Cox proportional hazards and logistic regression models to determine RA’s prognostic values and subgroup analyses to determine the subgroups’ mortality. …”
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Association of systemic immune-inflammation index (SII) with risk of psoriasis: a cross-sectional analysis of National Health and Nutrition Examination Survey 2011–2014 by Xuan Yang, Yuxin Pan, Yang Zhang, Yang Meng, Tang Tong, Mingyi Zhao

“…Multiple logistic regression analyses with appropriate covariates adjustment were the major methods in this study. Subgroup analyses were conducted by age, gender, race, smoking status, alcohol consumption, history of heart attack, stroke, coronary heart disease and diabetes. …”
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Lipid Levels and Lung Cancer Risk: Findings from the Taiwan National Data Systems from 2012 to 2018 by Jung-Yueh Chen, Nai-Hui Chi, Ho-Shen Lee, Chia-Ni Hsiung, Chang-Wei Wu, Kang-Chi Fan, Meng-Rui Lee, Jann-Yuan Wang, Chao-Chi Ho, Jin-Yuan Shih

“…Hypercholesterolemia was associated with a lower risk of squamous cell carcinoma (0.84 [0.76–0.94]). In the subgroup analysis, lower HDL cholesterol levels were associated with greater risk across most subgroups. …”
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Postdiagnostic use of antihypertensive medications and survival in colorectal, lung, corpus uteri, melanoma and kidney cancer patients with hypertension by Rūta Everatt, Irena Kuzmickienė, Birutė Brasiūnienė, Ieva Vincerževskienė, Birutė Intaitė, Saulius Cicėnas, Ingrida Lisauskienė

“…Increased cancer-specific mortality was observed among corpus uteri cancer patients using ARBs and among melanoma patients using beta blockers (BBs); however, there was no evidence of consistent statistically significant associations in subgroup analyses. Conclusion This study supports a link between ARB and ACEI use and increased survival among colorectal cancer patients. …”
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Usefulness of computed tomography-guided puncture biopsy coupled with rapid on-site evaluation for diagnosis of pulmonary lesions: a systematic review and meta‑analysis by Zhongbao Zhang, Rui Liu, JunLin Li, Kai Zhang, Yuan Li, Xiaoqin Zhang, Sanjay Rastogi

“…The threshold effect and subgroup analysis were used to determine the source or heterogeneity. …”
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Brief Report: Not Created Equal: Survival Differences by KRAS Mutation Subtype in NSCLC Treated With Immunotherapy by Lova Sun, MD, MSCE, Yunyun Zhou, PhD, Elizabeth A. Handorf, PhD, Hossein Borghaei, DO, Jessica Bauman, MD, Charu Aggarwal, MD

“…In the 50% or higher PD-L1 subgroup, patients with KRAS G12V had worse survival (median overall survival [mOS] = 8.2 mo) compared with KRASwt (mOS = 13.3 mo) and other KRAS subgroups (mOS ranging from 13.4 to 19.9 mo). …”
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