High-Dose Toremifene as a Promising Candidate Therapy for Hormone Receptor-Positive Metastatic Breast Cancer with Secondary Resistance to Aromatase Inhibitors by Atsushi Fushimi, Isao Tabei, Azusa Fuke, Tomoyoshi Okamoto, Hiroshi Takeyama

“…The median TTF was 6.2 months in the entire AI-resistant group (n=17) and was longer in the secondary resistance subgroup than in the primary resistance subgroup (8.40 vs. 4.87 months; log-rank: p=0.159). …”
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Characterization of preclinical models to investigate spinal cord stimulation for neuropathic pain: a systematic review and meta-analysis by Dave Mugan, Quoc C. Vuong, Birte E. Dietz, Ilona Obara

“…We conducted a post hoc meta-analysis, including subgroup analyses and meta-regression, to assess SCS efficacy on mechanical hypersensitivity in rats subjected to neuropathic pain. …”
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Associations of dietary inflammation index and composite dietary antioxidant index with all-cause mortality in COPD patients by Sue Zhao, Yingjie Su, Hongzhong Yang

“…We employed restricted cubic spline (RCS) analysis to examine the dose–response relationship between two indicators and all-cause mortality, used threshold effect analysis to determine the inflection point, and conducted subgroup analysis and interaction tests to verify the stability of the results.ResultsA total of 1,457 COPD patients aged over 40 were enrolled in the study. …”
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Association Between Resting Heart Rate and the Risk of Incident Hypertension Among Older Chinese Adults: A Prospective Cohort Study by Shiyu Lou, Zihan Yu, Yizhu Song, Dechen Liu

“…Multiplicative interaction effects were analyzed for RHR with age, sex, and regular exercise, and subgroup analyses of the association were also conducted based on these factors. …”
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Craniofacial Morphology of Orthodontic Patients with and without Temporomandibular Disorders: A Cross-Sectional Study by Zhe-Bin Yan, Yi-Dan Wan, Chu-Qiao Xiao, Ya-Qi Li, Yu-Yao Zhang, Yang An, Xin Xiong

“…Craniofacial morphology was compared between TMD and control groups, followed by subgroup analyses based on TMD severity, gender, age, and temporomandibular joint (TMJ) symptoms. …”
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A Nomogram to Predict Benign/Malignant Mediastinal Lymph Nodes Based on EBUS Sonographic Features by Bingchao Ling, Weishun Xie, Yi Zhong, Taowen Feng, Yueli Huang, Lianying Ge, Aiqun Liu

“…Methods. 1082 lymph nodes from 625 patients were randomly enrolled in training (n = 760) and validation (n = 322) sets. The subgroup of EBUS-TBNA postoperative negative lymph nodes (n = 317) was randomly enrolled in a training (n = 224) set and a validation (n = 93) set. …”
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The association between the dietary index for gut microbiota and metabolic dysfunction-associated fatty liver disease: a cross-sectional study by Yangyang Zheng, Jinhui Hou, Shiqi Guo, Jinghai Song

“…RCS analysis further revealed a linear relationship between DI-GM and MAFLD risk. Additionally, subgroup analyses suggested that race may modify the association between DI-GM and MAFLD (P for interaction < 0.05). …”
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Neutrophil-to-lymphocyte ratio as a prognostic factor in patients with castration-resistant prostate cancer treated with docetaxel-based chemotherapy: a meta-analysis by Ying Zhang, Xiao Zhou, Ran Xu, Guangcheng Luo, Xinjun Wang

“…RevMan 5.4.1 was used to summarize the hazard ratio (HR) and its 95% confidence interval (CI) for overall survival (OS) and progression-free survival (PFS) with subgroup analysis. Finally, Stata software was adopted for sensitivity analysis, and Egger’s test was used to calculate the results of stability to determine whether there was publication bias. …”
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Clinical utility of tumour mutational burden on efficacy of immune checkpoint inhibitors in malignant solid tumours: protocol for a systematic review and meta-analysis by Xiaoguang Yang, Yunming Li, Xuemei Xiang, Wang Guo, Pengfei Zhou

“…The HRs of PFS and OS, and the OR of ORR, will be measured by an inverse variance weighted fixed effects model (I2≤50%) or a DerSimonian-Laird random effects model (I2&gt;50%). In addition, subgroup analysis, sensitivity analysis, heterogeneity analysis and publication bias will be conducted. …”
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Diagnostic accuracy of 4D-MRA for the detection and localization of spinal dural arteriovenous fistulas: A retrospective 10-year cohort study by Frederick J.A. Meijer, Vincent Raymaekers, Sjoert A.H. Pegge, Jeroen HD. Boogaarts

“…Patients were included who had undergone spinal 4D-MRA in the period January 2010–February 2021. A subgroup was identified, who had subsequent digital subtraction angiography (DSA), or clinical/radiological follow-up. …”
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Potential of albumin dialysis at terminal liver failure in patients with chronic liver diseases by O. E. Nikiforova, Ye. N. Bessonova, O. M. Lesnyak, O. A. Stroganova

“…Among patients, receiving treatment with albumin dialysis the stage of hepatic encephalopathy at patients in the subgroup with cirrhosis of toxic (alcohol-induced) etiology significantly decreased (р&lt;0,01). …”
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Ultrasound evaluation of gallbladder wall thickness for predicting severe dengue: a systematic review and meta-analysis by Amirhossein Shahsavand Davoudi, Hamid Harandi, Reza Samiee, Shayan Forghani, Keyhan Mohammadi, Maryam Shafaati

“…Then, we performed a meta-analysis using a random effects model and subgroup analyses based on severity criteria to determine the relationship between GBWT and severe dengue. …”
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Does Scoliosis-Specific Exercise Treatment in Adolescence Alter Adult Quality of Life? by Maciej Płaszewski, Igor Cieśliński, Paweł Kowalski, Aleksandra Truszczyńska, Roman Nowobilski

“…The transformed WHOQOL-BREF scores ranged from 54.6 ± 11.19 in the physical domain in the mild scoliotic subgroup to 77.1 ± 16.05 in the social domain in the able-bodied subgroup. …”
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Association of Fibrinogen Aα Thr312Ala (rs6050) Polymorphism with Venous Thrombosis and Chronic Thromboembolic Pulmonary Hypertension: A Meta-Analysis by Han Cheng MM, Haozhe Yang BM, Yantong Zhang BM, Zhanxu Wei MM, Lei Xia BM, Jing Yang PhD

“…To assess the strength of associations, we calculated pooled odds ratios (ORs) and 95% confidence intervals (CIs) in different genetic models. Additionally, subgroup analyses, sensitivity analysis, and assessment of publication bias were also carried out. …”
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Association of the Effect of Alcohol Consumption on Luteinizing Hormone (LH), Follicle-Stimulating Hormone (FSH), and Testosterone Hormones in Men: A Systematic Review and Meta-Ana... by Mahmood Moosazadeh, Keyvan Heydari, Kimia Rasouli, Soroush Azari, Mahdi Afshari, Saeed Barzegari, Roja Nikaeen, Maryam Kardan-Souraki, Soghra Khani, Farzaneh Motafeghi, Aref Hoseini

“…We included observational studies (cohorts, case-controls, and cross-sectional studies) comparing FSH, LH, or testosterone levels in alcohol consumers versus non-consumers. Subgroup analysis based on alcohol intake levels was conducted to explore potential heterogeneity sources. …”
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Association of oxidative balance score with all-cause and cardiovascular mortality in overweight and obese by Shuxin Ying, Hongyan Ding, Yanjin Chen, Su Zheng

“…These results were validated through subgroup analyses. The analysis of RCS revealed a notable inverse association between OBS and mortality outcomes. …”
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Associations between ultra-processed foods intake and preserved ratio impaired spirometry in U.S. adults by Weiliang Kong

“…RCS analysis demonstrated linear relationships for both PRISm and lung function. Subgroup analysis revealed increased susceptibility primarily among individuals with occupational exposure. …”
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The association of visceral fat metabolism score with hyperuricemia—evidence from NHANES 1999–2018 by Lin Xie, Huali Qu, Dandan Lai, Juan Li, Xushan Chen, Jiajia Xie

“…In RCS analysis, a non-linear positive correlation was observed between METS-VF and the incidence of HUA (before PSM: p-non-linear &lt;0.001; after PSM: p-non-linear = 0.0065). Subgroup analysis and interaction tests revealed that the impact of METS-VF on HUA was modified by sex and ethnicity.ConclusionThere is a significant positive correlation between METS-VF and HUA in adults in the United States. …”
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Bilateral oophorectomy amplifies depression risk following hysterectomy NHANES 2006–2017 by Chenghui Xu, Guangchun Zhao, Wenlei Yao, Yanhua Zhang

“…Further analysis revealed that hysterectomy was significantly associated with higher depressive scores, particularly in the PHQ-9 ≥ 20 group. Subgroup analysis indicated significant interaction effects between surgical types and factors such as BMI, Income-to-Poverty Ratio (IPR), smoking, and alcohol consumption. …”
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Associations between asthma and Life’s Essential 8: a cross-sectional study by Jiao Xu, Jianlei Tang

“…However, a linear dose–response correlation was noted between health behavior scores and asthma (p non-linear = 0.30). Subgroup analysis showed no significant interaction effects (p &gt; 0.05), except in the sex and drinking status subgroups (p for interaction = 0.02).ConclusionAsthma is associated with components of LE8, which warrants further attention and may contribute to reducing asthma prevalence.…”
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