A smartphone-guided secondary prevention digital health application reduces systolic blood pressure in patients with chronic coronary syndrome and insufficient blood pressure contr... by Philip Düsing, Stephan H. Schirmer, Sebastian Schäfer, Alexander Krogmann, Jan-Malte Sinning, Nikos Werner, Florian Bönner, Alexander Sedaghat, Cornelius Müller, Irina Eckardt, Georg Nickenig, Andreas Zietzer

“…From the original cohort, subgroups of patients with systolic BP ≥140 mmHg (n = 44), ≥130 mmHg (n = 89) and diastolic BP ≥90 mmHg (n = 28) were analyzed for BP reduction after 12 weeks.ResultsIn patients with systolic BP ≥140 mmHg, the intervention group showed a reduction in systolic BP by 15.5 mmHg (± 16.7 mmHg, p = 0.0001), which was greater compared to the control group (6.0 ± 13.0 mmHg, p = 0.058). …”
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Unveiling the Role of <i>GhP5CS1</i> in Cotton Salt Stress Tolerance: A Comprehensive Genomic and Functional Analysis of <i>P5CS</i> Genes by Hui Fang, Xin Gao, Yunhao Wu, Ke Zhang, Ying Wu, Junyi Li, Dongmei Qian, Ruochen Li, Haijing Gu, Teame Gereziher Mehari, Xinlian Shen, Baohua Wang

“…Phylogenetic analysis of 100 <i>P5CS</i> genes from nine species revealed three subgroups, with <i>Gossypium hirsutum</i> closely related to <i>Gossypium barbadense</i>. …”
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Efficacy and Safety of Rivaroxaban versus Warfarin for the Treatment of Acute Pulmonary Embolism: A Real-World Study by Yan Huang, Linli Duan, Wenjun He, Cheng Hong, Yehui Guo, Xinni Wang, Nuofu Zhang, Yanghang Chen, Tao Wang, Jian Wang, Chunli Liu

“…There was no significant difference in rivaroxaban monotherapy subgroups (including frail patients, tumor patients, and thrombolysis or nonthrombolysis at intermediate-high-risk patients). …”
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Associations of lamplight exposure during sleep and sleep duration with attention-deficit/hyperactivity disorder among preschool children in China by Hui Jiang, Bin Yu, Yuanyang Liu, Hui Gao, Ruijuan Song, Siyue Tan, Shufen Han, Hui Zuo, Hui Zuo, Hui Zuo

“…The risk associations of lamplight exposure during sleep with ADHD were similar in subgroups stratified by sex, picky eating, gestational hyperglycemia, and gestational anemia. …”
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Real-World Efficacy and Safety of Avelumab Plus Axitinib in Metastatic Renal Cell Carcinoma: Results from the Ambispective RAVE-Renal Study by Ilya Tsimafeyeu, Vyacheslav Chubenko, Olga Baklanova, Alexey Kalpinskiy, Sufia Safina, Andrei Lebedinets, Vladislav Petkau, Elvira Parsadanova, Maria Turganova, Aleksei Shkurat, Natalia Tovbik, Elena Tkacheva, Yulia Anzhiganova, Olga Novikova, Varvara Bragina, Ruslan Zukov, Rashida Orlova

“…The regimen was effective and well tolerated across various patient subgroups.…”
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Safety and recommendation of voriconazole for invasive pulmonary aspergillosis in severe liver disease patients: a retrospective cohort study by Xin Zhang, Caopei Zheng, Ling Zhang, Yuqing Sun, Ying Liang, Xue Chen, Lijun Pang, Yulin Zhang

“…Voriconazole monotherapy was associated with lower short-term mortality (OR 0.223, 95%CI 0.070–0.650, p = 0.008) and did not seem to exacerbate hepatic function deterioration in SLD patients with IPA (OR 0.259, 95%CI 0.094–0.674, p = 0.007) when compared to echinocandins monotherapy. Among the three subgroups of voriconazole monotherapy, no-loading dose regime demonstrated a superior response to IPA therapy compared to the standard-dose regimen (OR 0.264, 95%CI 0.068–0.845, p = 0.035). …”
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Association between population viral load surrogate indicator and HIV transmission potential: a prospective cohort study in Xinjiang, China by Qian He, Yongkang Ni, Yuefei Li, Xiaoyuan Hu, Xiaomin Hu, Zhen Ni, Changyu Zeng, Aizimaiti Aikebaier, Bixin Xu, Mingjian Ni

“…CVL was higher in the male, ≤ 25 years of age, primary school or below, other household registration, other medical insurance types, other source of sample, nonmarital and noncommercial heterosexual contact, and nonmarital and commercial heterosexual contact subgroups. Community-based cross-sectional analyses showed that CVL in community 10 was positively correlated with viral unsuppression rate and viremia prevalence but negatively correlated with ART coverage rate, suggesting that the community was a hotspot for HIV epidemics. …”
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Antimicrobial susceptibility and epidemiological types of Legionella pneumophila human isolates from Italy (1987–2020) by Maria Scaturro, Alessio Lanni, Fabiola Mancini, Antonietta Girolamo, Silvia Fillo, Andrea Ciammaruconi, Florigio Lista, Clementina Elvezia Cocuzza, Rosario Musumeci, Christophe Ginevra, Ghislaine Descours, Sophie Jarraud, Jessica Iera, Paolo Visca, Maria Luisa Ricci

“…All isolates were typed by sequence-based typing, and Legionella pneumophila serogroup 1 (Lp1) isolates by monoclonal antibody subgrouping. Minimum inhibitory concentration (MIC) data were correlated with the possible source of infection and geographical distribution. …”
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Mechanism of mTOR/RILP-regulated autophagic flux in increased susceptibility to myocardial ischemia-reperfusion in diabetic mice by Jiyao Zhao, Wei Shi, Yan Zheng, Junjie Wang, Muzhao Yuan, Yultuz Anwar, Yuxuan He, Haiping Ma, Jianjiang Wu

“…This was followed by the validation of potential mechanisms of action between impaired autophagic flux and increased susceptibility at the cellular and animal levels, respectively.ResultsAfter I/RI in diabetic myocardium, there was a significant increase in the number of CM1 subgroups and a specific downregulation of 239 autophagy-related genes led by RILP. …”
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Biomarker microRNA-371a-3p - expression in malignancies other than germ-cell tumours by Gazanfer Belge, Markus Klemke, Bendix Hansen, Cansu Dumlupinar, Aylin Igde, Dirk Arnold, Hans Salwender, Christian Wülfing, Armin Soave, Klaus-Peter Dieckmann

“…Median M371 serum levels and percentages of M371 level elevations were calculated for the entire NTM group and for entity-specific subgroups. The results were compared with GCT patients (n = 20) and with tumour-free male controls (n = 20) using descriptive statistical methods. …”
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Plasma Asprosin Levels Are Associated with Glucose Metabolism, Lipid, and Sex Hormone Profiles in Females with Metabolic-Related Diseases by Xing Li, Mingyu Liao, Rufei Shen, Linlin Zhang, Hua Hu, Jun Wu, Xiuli Wang, Hua Qu, Shaodong Guo, Min Long, Hongting Zheng

“…The BMI-categorized subgroups of PCOS subjects also showed correlations of asprosin with metabolic profiles and sex-related hormones. …”
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Vascularized fibular grafting following tumor resection demonstrates acceptable long-term outcomes in Denmark: a national retrospective cohort study by Christian Lind Nielsen, Daniel Thor Halberg Dybdal, Peter Vester-Glowinski, Lisa Lyngsie Hjalgrim, Pernille Edslev Wendtland, Birgitte Jul Kiil, Michael Melchior Bendtsen, Michael Mørk Petersen, Thomas Baad-Hansen

“…Patients were analyzed overall, as well as in subgroups based on tumor location (upper versus lower extremity) and pathology (osteosarcoma versus Ewing sarcoma). …”
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Predictive marker for response to trifluridine/tipiracil plus bevacizumab in metastatic colorectal cancer patients by Toshiaki Takahashi, Kunitoshi Shigeyasu, Yoshitaka Kondo, Sho Takeda, Hibiki Umeda, Kazuya Moriwake, Masashi Kayano, Yuya Sakurai, Shunsuke Nakamura, Masafumi Takahashi, Kaori Nitta, Kazuhiro Yoshida, Yuki Matsumi, Hiroyuki Michiue, Hideki Yamamoto, Hiroyuki Kishimoto, Fuminori Teraishi, Ryohei Shoji, Nobuhiko Kanaya, Hajime Kashima, Yoshihiko Kakiuchi, Shinji Kuroda, Shunsuke Kagawa, Toshiyoshi Fujiwara

“…The FTD/TPI plus bevacizumab regimen should be proactively implemented in the low NLR and high ADAR1 subgroups.…”
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Renal Damage Frequency in Patients with Solitary Kidney and Factors That Affect Progression by T. Basturk, Y. Koc, Z. Ucar, T. Sakaci, E. Ahbap, E. Kara, F. Bayraktar, M. Sevinc, T. Sahutoglu, A. Kayalar, A. Sinangil, C. Akgol, A. Unsal

“…According to the presence of kidney damage, each group was divided into two subgroups: group 1a/b and group 2a/b. Results. Patients in group 1 were older than those in group 2 (p=0.001). 34 patients who comprise group 1a had smaller kidney size (p=0.002) and higher uric acid levels (p=0.028) than those in group 1b at presentation. …”
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Recovery trajectories of mental health symptoms among Chinese adolescents following the end of COVID-19 by Jun Peng, Meihui He, Yongxing Guo, Yongxing Guo, Yongxing Guo, Jiangdong Diao, Jiangdong Diao, Kun Chen, Ziyi Deng, Lei Mo, Ruixiang Gao

“…A novel index was developed to account for both the number and severity of mental health risk factors, allowing for the classification of psychological symptoms into three subgroups: no, moderate, and severe. Polynomial regression models were applied to determine the acceleration inflection point, and multivariate logistic regressions identified predictors of trajectory membership.ResultsSignificant declines in psychological symptoms were observed. …”
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Association between triglyceride-glucose (TyG) index and risk of depression in middle-aged and elderly Chinese adults: Evidence from a large national cohort study by Zhang-Yang Xu, Hong Zheng, Zi-Jun Pan, Shou-Yi Hu, Yun-Xia Wang, Wen-Jun Su

“…Stratified analyses across various subgroups were also conducted to confirm the robustness of the conclusions.Over the follow-up period, 1,782 participants (58.9%) developed depression, with incidence rates of 30.2%, 34.0%, and 35.8% in tertiles 1, 2, and 3, respectively. …”
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Impact of thyrotropin levels on outcomes in T1N0M0 papillary thyroid cancer after microwave ablation by Ying Wei, Zhen-Long Zhao, Jie Wu, Shi-Liang Cao, Na Yu, Li-Li Peng, Yan Li, Ming-An Yu

“…Patients were stratified into uni-focal (U-PTC) and multifocal (M-PTC) groups and further categorized based on post-ablation TSH levels into low (≤1 mU/L), medium (1–2 mU/L), and high (>2 mU/L) subgroups. The tumor progression rates and progression-free survival were assessed.Results In U-PTC patients, lower TSH levels were significantly associated with higher tumor progression rates (10.1%) compared to those in the medium (2.9%) and high (2.1%) TSH groups (p = .009). …”
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Genomic characterization and molecular predictive biomarkers for chemotherapy in patients with metastatic triple-negative breast cancer treated in a real-world setting by Erik Olsson, Henrik Lindman, Evangelos Digkas, Viktoria Thurfjell, Haidar Mir Ali, Ute Krüger, Anna-Karin Wennstig, Marie Sundqvist, Antonios Valachis

“…Conclusions: Patients with tumor alterations in HRD-related genes seem to define subgroups that respond favorably to platinum-based chemotherapy. …”
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Perception of antibiotic use and antibiotic resistance among faculty and staff in a medical school: insights from a mixed mode survey in Bahrain by Ronni Mol Joji, Archana Prabu Kumar, Amer Almarabheh, Ali Al-Mahmeed, Mohd Shadab, Khalid Bindayna, Mohammad Shahid

“…After the questionnaire administration, in-depth interviews were conducted with subgroups of faculty, technicians, and administrative staff. …”
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Development of the pulmonary fibrosis, pulmonary vascular resistance, six minute walk distance, B-type natriuretic peptide, age (PVD-B65) risk score for patients with chronic lung... by Shameek Gayen, Jay Pescatore, Matthew Bittner, Mario Naranjo, Gerard J. Criner, Sheila Weaver, Temple Lung Center Pulmonary Vascular Disease Working Group

“…Once patients were stratified into the three risk groups, Kaplan–Meier survival analysis demonstrated significant differences in one-year survival between the subgroups (logrank p = 0.002). The risk assessment model demonstrated internal validation via bootstrapping (p < 0.05). …”
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