Quantification of Myocardial Biomarkers in Sudden Cardiac Deaths Using a Rapid Immunofluorescence Method for Simultaneous Biomarker Analysis by Matteo Antonio Sacco, Valerio Riccardo Aquila, Saverio Gualtieri, Roberto Raffaele, Maria Cristina Verrina, Lucia Tarda, Santo Gratteri, Isabella Aquila

“…Results: The study identified statistically significant differences in myoglobin and TnI levels between the SCD group and the control group, though myoglobin’s diagnostic reliability remains limited due to its lack of specificity for myocardial injury. …”
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Surface water and flood-based agricultural systems: Mapping and modelling long-term variability in the Senegal river floodplain by Andrew Ogilvie, Cheickh Sadibou Fall, Ansoumana Bodian, Didier Martin, Laurent Bruckmann, Djiby Dia, Issa Leye, Papa Malick Ndiaye, Donissongou Dimitri Soro, Jean Homian Danumah, Jean-Claude Bader, Jean-Christophe Poussin

“…Validated against ground truth data, the approach is upscaled using cloud computing across this 2250 km2 floodplain over 1999–2022. Statistical regression models are then developed to estimate flooded and cultivated areas based on upstream flow values since 1950 and analyse trends and exceedance probabilities over time. …”
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Deep immunophenotyping of circulating immune cells in major depressive disorder patients reveals immune correlates of clinical course and treatment response by Fabiola Stolfi, Claudio Brasso, Davide Raineri, Virginia Landra, Camilla Barbero Mazzucca, Ali Ghazanfar, Lorenza Scotti, Riccardo Sinella, Vincenzo Villari, Giuseppe Cappellano, Paola Rocca, Annalisa Chiocchetti

“…The diagnosis of MDD remains clinical, based on the Diagnostic and Statistical Manual of Mental Disorders (DSM)-5 criteria, as biomarkers have not yet been validated for diagnostic purposes or as predictors of treatment response. …”
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Effects of ambient air pollutants on cardiovascular disease hospitalization admission by L. Salvaraji, R. Avoi, M.S. Jeffree, S. Saupin, H.R. Toha, S.B. Shamsudin

“…Collected data were analysed spatially and statistically. Autoregressive integrated moving average modelling was implemented to forecast the cardiovascular disease hospital admission.FINDING: Kota Kinabalu recorded the highest hospital admissions for cardiovascular disease, followed by Sandakan, Tawau and Keningau. …”
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Long-term outcome of photodynamic therapy with hexyl aminolevulinate, 5-aminolevulinic acid nanoemulsion and methyl aminolevulinate for low-risk Basal Cell Carcinomas by M. Salmivuori, M. Grönroos, T. Tani, J. Räsänen, E. Snellman, N. Neittaanmäki

“…Results: According to intention-to-treat (ITT) analyses, the cumulative response rate at one year was 90.6 % for MAL, 81.3 % for BF-200 ALA, and 75.8 % for HAL, and correspondingly at five years 71.9 %, 54.6 % and 60.6 %. There were no statistically significant differences between interventions and comparator. …”
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Epicardial Fat Tissue: A Potential Marker for Coronary Microvascular Dysfunction by Waiel Abusnina, Ilan Merdler, Matteo Cellamare, Kalyan R. Chitturi, Abhishek Chaturvedi, Irwin M. Feuerstein, Cheng Zhang, Sevket Tolga Ozturk, Teshome Deksissa, Vaishnavi Sawant, Kassandra Lopez, Lior Lupu, Dan Haberman, Itsik Ben‐Dor, Lowell F. Satler, Ron Waksman, Hayder D. Hashim, Brian C. Case

“…Univariate regression analysis demonstrated a statistically significant association between EFV index and CMD diagnosis (odds ratio, 1.037 [95% CI, 1.014–1.063]; P=0.003), while no significance was observed for EFV (odds ratio, 1.006 [95% CI, 0.995–1.017]; P=0.292). …”
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Endothelial Activation and Stress Index (EASIX) to predict mortality after allogeneic stem cell transplantation: a prospective study by Axel Benner, Peter Dreger, Grzegorz W Basak, Christian Koenecke, Olaf Penack, Christophe Peczynski, Lucia López Corral, Ivan Moiseev, Hélène Schoemans, Zinaida Peric, Thomas Luft, Simona Sica, Mutlu Arat, Maija Itäla-Remes, Nicolaas P M Schaap, Michal Karas, Ludek Raida, Thomas Schroeder, Elisabetta Metafuni, Tulay Ozcelik, Brenda M Sandmaier, Lambros Kordelas

“…We were able to validate the cut-off and found that EASIX ≥3 was associated with more than twofold increased risk for NRM in multivariate analysis (HR=2.18, 95% CI 1.2 to 3.94; p=0.01). No statistically significant difference could be observed for the incidence of relapse.Conclusions The results of this study provide a prospectively validated standard laboratory biomarker index to estimate the transplant-related mortality risk after alloSCT. …”
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Clinical depression prevalence and associated factors among adolescents with sickle cell anemia in dar es salaam, tanzania: a cross-sectional study by Linda Paul Athman, Agnes Jonathan, Fatima Musa, Honesta John Kipasika, Isihaka Mahawi, Florence Urio, Mwashungi Ally, Ritah Mutagonda, Lulu Chirande, Julie Makani, Emmanuel Balandya

“…A P value of less than 0.05 was considered statistically significant. Results Among the 326 adolescents enrolled and screened, 49 adolescents (15%) had clinical depression, encompassing those in the moderate, moderately severe, and severe depression categories. …”
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Efficacy of Antimicrobial Photodynamic Therapy for Treating Moderate to Deep Periodontal Pockets in Individuals with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis by João Victor Soares Rodrigues, Mariella Boaretti Deroide, Wilton Mitsunari Takeshita, Valdir Gouveia Garcia, Rafael Scaf de Molon, Leticia Helena Theodoro

“…Forest plots for PD, BOP, PI, and CAL at baseline, three months, and six months revealed no statistically significant differences between the SI+aPDT group and the SI-only group. …”
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The association between blood selenium and metabolic syndrome in adults: a systematic review and dose–response meta-analysis of epidemiologic studies by Zahra Hajhashemy, Zahra Hajhashemy, Sahar Foshati, Mohammad Bagherniya, Gholamreza Askari

“…Linear dose–response analysis illustrated each 50 μg/L increment in circulating selenium was related to 7% higher risk of MetS (RR: 1.07, 95%CI: 0.99, 1.15) However, this association was not statistically significant. Additionally, non-linear dose–response analysis indicated a U-shaped association between blood selenium and risk of MetS with the lowest risk at 160 ug/L of blood selenium (p < 0.001).ConclusionThere is a U-shaped relationship between blood selenium levels risk of MetS. …”
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Enhancing furcation involvement classification on panoramic radiographs with vision transformers by Xuan Zhang, Enting Guo, Xu Liu, Hong Zhao, Jie Yang, Wen Li, Wenlei Wu, Weibin Sun

“…ViT also recorded the highest area under the curve (AUC) (98%), outperforming the other models with statistically significant differences (p < 0.05), confirming its enhanced classification capability. …”
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Predictive factors of thrombosis during autologous stem cell transplantation in multiple myeloma: Experience from EHU Oran (Algeria) by Mohammed Amine BEKADJA, Brahim BENZINEB, Mansour BELKACEM, Hafida OUDJERIOUAT, Badra ENTASOLTAN, Soufi OSMANI, Kamila AMANI, Samira BOUCHAMA, Leila CHAREF, Mohamed BRAHIMI, Abdessamad ARABI, Rachir Amar BOUHASS, Nabil YAFOUR

“…Thepredictive factors studied are: age, co-morbidities, use of IMiDs, use of Granocyte colony stimualing factor in mobilization, the central venous catheter insertion site, cytapheresis count, CD34+ perfused, and finally deep venous thrombosis prophylaxis by a low molecular weight heparin .The statistical analysis focused on a univariate study, followed by a multivariate analysis using binary logistic regression. …”
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Is ultrasound-guided radiofrequency ablation a reliable treatment option for unifocal T1aN0M0 papillary thyroid carcinoma in the isthmus: a retrospective comparative study based on... by Gongli Zhou, Dong Xu, Beibei Zhang, Ruiqing Su, Ke Xu, Xuefeng Zhang, Feng Li, Wei Zhao, Tingting Cai

“…The efficacy of ultrasound-guided RFA was evaluated by volume reduction rate (VRR), complete disappearance rate (CDR) and disease progression, and the safety was evaluated by incidence of complications.Results The two groups exhibited a consistent trend of change, with the PTCI group performing better in volume, VRR and CDR at all follow-up time points expect 1 month, but the differences were not statistically significant (p > 0.05). The mean initial volume of the PTCI group vs the PTCL group decreased significantly from 65.4 ± 69.79 vs 86.38 ± 87.09 mm³ (range 10.92-427.58 vs 3.05-471.6 mm³) to 0 vs 0 mm³ at a mean follow-up time of 31.12 ± 12.5 months (range 12-60 months); their VRR increased significantly from −618.62 ± 655.61% vs −789.85 ± 1135.07% at 1 month to 100% vs 100% at 48 months. …”
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Questionnaire survey on the clinical application of Hall technique preformed metal crowns in caries of primary molars in China by Junhui Wang, Baize Zhang, Yujiang Chen, Lulu Wang, Yang Du, Xin Ge, Fen Liu, Fen Liu, Jing Gong, Jing Gong, Xiaojing Wang

“…The education background and nature of the workplace had a statistically significant difference in the application of the HT, the number of years of application, the selection of indications, and the choice of treatment methods for children who do not cooperate.ConclusionsThe survey showed that the awareness level and application frequency of the HT were relatively low in China. …”
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Identification of Resistance to Bacterial Blight in Introgression Lines of Yuanjiang Common Wild Rice and Analysis of Its Japonica Indica Properties by Wang KAN, Hesheng YANG, Huanzhi MENG, Jiyun ZHOU, Zaiquan CHENG, Yun ZHANG, Suqin XIAO, Li LIU, Bo WANG, Fuyou YIN, Qiaofang ZHONG, Jinlu LI, Dunyu ZHANG, Ling CHEN

“…The correlation between these two traits was discussed by statistical analysis.【Result】The results of japonica and indica property analysis showed that among 280 introgression lines, indica rice types were dominant, with a total of 218 samples, while japonica rice types had 61 samples, and the japonica and indica properties of another one could not clearly be distinguished. …”
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Optimization of the extraction methods and evaluation of the hypoglycemic effect of Adhatoda Zeylanica extracts on artificially induced diabetic mice by Md Fahim Ahmed, Khalid Hasan Raby, Nishat Tasnim, Md Tariful Islam, Mahbub Chowdhury, Zarin Tasnim Juthi, Md Ashik Mia, Lubna Jahan, A.K.M. Zakir Hossain, Shoeb Ahmed

“…A. zeylanica at 400 mg/kg BW dose and metformin demonstrated statistically similar and significant blood glucose level reduction (p < 0.001). …”
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Novel biomarkers: the RUNX family as prognostic predictors in colorectal cancer by Yingting Liu, Yingting Liu, Yingting Liu, Junjun Chen, Junjun Chen, Junjun Chen, An Li, An Li, An Li, Yue Wu, Yue Wu, Yue Wu, Junwei Ge, Junwei Ge, Junwei Ge, Maoling Yuan, Maoling Yuan, Maoling Yuan, Bin Xu, Bin Xu, Bin Xu, Xiao Zheng, Xiao Zheng, Xiao Zheng, Lujun Chen, Lujun Chen, Lujun Chen, Jingting Jiang, Jingting Jiang, Jingting Jiang

“…Our study of human colorectal cancer tissue microarray (TMA) also revealed positive and statistically significant correlations between the expressions of RUNX1, RUNX2, and RUNX3 in both CD8+T cells and CD103+CD8+T cells. …”
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Profiles of Killer Systems and Volatile Organic Compounds of Rowanberry and Rosehip-Inhabiting Yeasts Substantiate Implications for Biocontrol by Iglė Vepštaitė-Monstavičė, Juliana Lukša-Žebelovič, Violeta Apšegaitė, Raimondas Mozūraitis, Robertas Lisicinas, Ramunė Stanevičienė, Laima Blažytė-Čereškienė, Saulius Serva, Elena Servienė

“…It was revealed that the patterns of emitted volatiles are yeast species-specific. Statistically significant differences between the individual VOCs were observed among killing phenotype-possessing vs. non-killer <i>S. paradoxus</i> yeasts, thus revealing the involvement of killer systems in multi-level biocontrol enablement. …”
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Quasi-weekly oscillation of regional PM_2.5 transport over China driven by the synoptic-scale disturbance of the East Asian winter monsoon circulation by Y. Bai, T. Zhao, K. Meng, Y. Zhou, J. Xiong, X. Sun, L. Shen, Y. Yue, Y. Zhu, W. Hu, J. Yao

“…By constructing the data of daily PM<span class="inline-formula">_2.5</span> transport flux in CEC in the winters of 2015–2019, we utilize the extended empirical orthogonal function (EEOF) decomposition and other statistical methods to extract the moving spatial distribution of regional PM<span class="inline-formula">_2.5</span> transport over CEC, recognizing the QWO in regional PM<span class="inline-formula">_2.5</span> transport with the spatial–temporal variations over CEC. …”
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Assessing the resilience of child immunisation programmes using geospatial modelling and interrupted time series analysis in Ethiopia and Kenya amidst the COVID-19 pandemic: tracki... by McEwen Khundi, Themba Mzembe, Michael Give Chipeta, Chimwemwe Chifungo, Nyovani Janet Madise, Chifuniro Somanje Mankhwala, Tabitha Ngwira, Maame B Peterson

“…Interrupted time series analyses provided counterfactual coverage assessments, assuming no COVID-19 impact.Results At the national level, minor short-term disruptions in coverage were observed following pandemic peaks in Kenya and Ethiopia, which were considered statistically insignificant. In Ethiopia, a subnational assessment reveals that full vaccination coverage remained relatively stable, with significant changes observed in the southeast regions of Somali and Dire Dawa. …”
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