MEK Inhibition Targets Cancer Stem Cells and Impedes Migration of Pancreatic Cancer Cells In Vitro and In Vivo by Karolin Walter, Kanishka Tiwary, Marija Trajkovic-Arsic, Ana Hidalgo-Sastre, Laura Dierichs, Sven T. Liffers, Jiangning Gu, Johann Gout, Lucas-Alexander Schulte, Jan Münch, Thomas Seufferlein, Bruno Sainz, Jens T. Siveke, Eva Rodriguez-Aznar, Patrick C. Hermann

“…Herein, we use a genetically engineered mouse model of pancreatic cancer and primary pancreatic cancer cells were derived from this model to demonstrate that small-molecule MEK inhibitors functionally abrogate cancer stem cell populations as demonstrated by reduced sphere and organoid formation capacity. Furthermore, we demonstrate that MEK inhibition suppresses TGFβ-induced epithelial-to-mesenchymal transition and migration in vitro and ultimately results in a highly significant reduction in circulating tumor cells in mice.…”
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Detecting glacial lake water quality indicators from RGB surveillance images via deep learning by Zijian Lu, Xueyan Zhu, Jinfeng Li, Mingyue Li, Jie Wang, Wenqiang Wang, Yili Zheng, Qianggong Zhang

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Global Research Trends and Focus on the Link Between Heart Failure and NLRP3 Inflammasome: A Bibliometric Analysis From 2010 to 2024 by Lian Y, Zhang H, Xing W, Li S, Lai X, Jia S, Shang J, Liu H

“…INTERNATIONAL IMMUNOPHARMACOLOGY was the periodical with the most numerous publications in this sphere. CIRCULATION, however, received the highest number of citations, indicating its substantial influence on investigations in this field. …”
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THE PLACE OF PROFESSIONAL EDUCATION SYSTEM IN FORMATION OF GRADUATES’ COMPETITIVENESS by G. F. Shafranov-Kutsev, G. Z. Efimova

“…The respondents focused in the labour sphere on competitive strategy more often recognise insufficiency of knowledge and competencies received by them during the learning process in educational institution. …”
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Relationship between the ideal and reality in civil service: retrospective approach towards ethical problems in the interwar Lithuanian Republic by Jolanta Palidauskaitė

“…Critical analyses of certain problems in the Lithuanian public sphere helped lawyers, economists, specialists of management and public figures in constructing the ideal model. …”
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Reflexive Methods of Knowledge in Educational Activities: Phenomenological Hermeneutics by T. N. Korneenko

“…Today, lifelong learning and self-education individual skills are of paramount importance for each representative of the society in relation to the world trends of a post-industrial era: economic domination in the innovative sector, progressive increase of intensity of information flows and rates of distribution of high technologies, rapid development of science and industry of knowledge, quickly changing and becoming tougher requirements to professionalism, qualification and creativity of experts irrespective of the sphere of employment. It is obvious that structural formation and improvement of ways of students’ thinking is one of the most important tasks of the educational system; reflection is of particular importance. …”
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Le réseau hydraulique à Pompéi (Italie) de l’époque des Samnites à Auguste (fin ive-fin ier s. av. J.-C.) by Federico Giletti

“…For their part, wells connected to the nerve centres of the urban road network and to the supply system of thermal buildings would seem to have been in decline, becoming supplementary to the supply provided by the aqueduct pressure system.The collection wells categorically and definitively fell into disuse through the complete obliteration of the reservoir or, if originally in the public sphere, through their assimilation into private property, or even through functional conversion to drains, favoured as it was by the dispersive capacities of the geological subsoil and the considerable depths of the pipe.While this is the information that can be deduced from the analyses conducted on the city of Pompeii’s earliest historical phases, the data that have emerged from the middle and late Samnite periods reveal a change in previous conditions and the adoption of new mechanisms.Between the 3rd and 2nd centuries BC, the introduction of a new urban layout and Pompeii’s entry into Rome’s sphere of influence triggered an urbanistic mutation of the site inspired by the model of the Roman city.Roman-style hydraulic engineering in Pompeii also encouraged the choice of vaulted chamber cisterns, which were often introduced into the city as a complement to the previous storage structures.The chambered cistern type not only reduced the cost of excavating the lava bed, but also made for greater safety in open-air construction and enhanced the static capacity of the walls and cement cover to improve the structural qualities of the cisterns and considerably increase their storage capacity.In particular, the adoption of the sub-type of cistern with multiple, parallel chambers also made it possible, through the principal of the discharge of forces through the vaulted system, to terrace and amplify the spaces available for building.This is what research has shown in the urban construction of Pompeii, which in the course of the 2nd century BC was also focused near the height of the promontory, as attested above all along the southern lava ridge of Regio VIII. …”
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Rab21-Targeted Nano Drug Delivery System-Based FFPG for Efficient Paclitaxel Delivery to Inhibit Lung Cancer Progression by Jing Wang, Xueying Yan, Wenfei Wang, Shu Wang, Hongxiang Jiang, Xinhua Zhu, Zhehui Li, Defu Cai, Yonggang Xia

“…The same conclusion was obtained in 3D tumor spheres. In vivo experiments exhibited that FFPG-lips-PTX showed more significant lung cancer-targeting activity and anti-tumor effects. …”
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Increasing the uptake of long-acting reversible contraception in general practice: the Australian Contraceptive ChOice pRoject (ACCORd) cluster randomised controlled trial longitud... by Danielle Mazza, Angela Taft, Kevin McGeechan, Kathleen Mcnamee, Natalie Amos, Kirsten I Black, Cathy J Watson, Marion Haas, Jeffrey F Peipert, Jayne Lucke

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PlaceField2BVec: A bionic geospatial location encoding method for hierarchical temporal memory model by Zugang Chen, Shaohua Wang, Kai Wu, Guoqing Li, Jing Li, Jian Wang

“…In recent years, some methods (such as Place2Vec, Space2Vec, and Sphere2Vec) were proposed to encode geospatial point as a high-dimensional vector. …”
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Intraoperative haemodynamic optimisation using the Hypotension Prediction Index and its impact on tissular perfusion: a protocol for a randomised controlled trial by Javier Ripollés-Melchor, Ane Abad-motos, Juan Victor Lorente, Ignacio Jimenez, Alejandra Becerra, Wilbert Wesselink, Francesca Reguant, Irene Mojarro, Maria de los Angeles Fuentes, Elizabeth Agudelo, Francisco Herrero-Machancoses, Paula Callejo, Joan Bosch, Manuel Ignacio Monge

“…Haemodynamic management of patients in the intervention group will be based on functional haemodynamic parameters provided by the HemoSphere platform (Edwards Lifesciences), including dynamic arterial elastance, dP/dtmax and the HPI. …”
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Automatic Reproduction of Natural Head Position in Orthognathic Surgery Using a Geometric Deep Learning Network by Ji-Yong Yoo, Su Yang, Sang-Heon Lim, Ji Yong Han, Jun-Min Kim, Jo-Eun Kim, Kyung-Hoe Huh, Sam-Sun Lee, Min-Suk Heo, Hoon Joo Yang, Won-Jin Yi

“…Three-dimensional skull meshes were converted into point clouds and normalized to fit within a unit sphere. NHP-Net was trained to predict a 3 × 3 rotation matrix to align the CT-acquired posture with the NHP. …”
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Probing Quantum Telecloning on Superconducting Quantum Processors by Elijah Pelofske, Andreas Bartschi, Stephan Eidenbenz, Bryan Garcia, Boris Kiefer

“…We perform the cloning procedure on many different message states across the Bloch sphere, on seven IBM Quantum processors, optionally using the error suppression technique X–X sequence digital dynamical decoupling. …”
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Rusførebygging i skulen som diskursivt forma pedagogisk-politisk fenomen. Eit teoretisk-empirisk bidrag til omgrepsutvikling by Øyvind Wiik Halvorsen, Liv Eide, Olin Blaalid Oldeide

“…The research question for the article is: How is school-based drug prevention discursively shaped in the media public sphere? Discourses on school-based drug prevention are theoretically conceptualized as activating cultural images of children and youths and as legitimizing prevention technologies. …”
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INSTITUTIONAL GLOBALIZATION AS A SYSTEM OF INTEGRATION THE PHENOMENON OF THE POSTMODERN DEVELOPMENT by V. V. Zinchenko

“…Policy enhancing the role of human rights and the development of the principle of subjectivity means deepening the democratic foundations of the state structure. In the social sphere the subjectivity is expressed in the individualization of the social existence of man and the personification of public relations and it is implemented through the mechanisms of liberal institutions. …”
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Cancer-associated fibroblast-derived COL17A1 promotes gemcitabine resistance and tumorigenesis in pancreatic cancer cells by interacting with ACTN4 by Rongyu Shi, Ning Zhang, Han Li, Hu Zhong, Chengcheng Zhong, Wei Du, Xi Yang

“…Functional analyses were conducted using MTT, 5-ethynyl-2ʹ-deoxyuridine, transwell, and sphere formation assays, respectively. The interaction between COL17A1 and ACTN4 was analyzed by Co-immunoprecipitation and immunofluorescence assays. …”
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Pharmacotherapy for AMD: state-of-the-art by I.A. Koroleva, A.A. Gvetadze, T.B. Romanova

“…<br> ²LLC “Clinic “Sphere”. 10, Starokachalovskaya str., Moscow, 117628, Russian Federation.…”
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Calpain 2 promotes Lenvatinib resistance and cancer stem cell traits via both proteolysis-dependent and independent approach in hepatocellular carcinoma by Xiaolu Ma, Kaixia Zhou, Tianqing Yan, Ling Hu, Suhong Xie, Hui Zheng, Ying Tong, Heng Zhang, Yanchun Wang, Zhiyun Gong, Cuncun Chen, Yanan Tian, Lin Guo, Renquan Lu

“…Interestingly, we observed a close relationship between CAPN2 expression and cancer stem cell (CSC) traits in HCC cells, evidenced by impaired sphere-forming and CSC-related marker expressions after CAPN2 knockdown, and verse vice. …”
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Transprofessional education in the student discourse: Demand, expectations, risks by A. N. Pinchuk, S. G. Karepova, D. A. Tikhomirov

“…As the analysis of empirical materials has shown, the argumentation techniques of the majority of the study participants reflect the guidelines for the multidimensionality of professional competencies in the rapidly changing professional and labour sphere. At the same time, the students spoke most of all about the need for experience in mastering the related branches of specialisation. …”
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MODIFICATION OF STUDENT ASSESSMENT CRITERIA AS A CONDITION OF MOTIVATION INCREASING FOR PHYSICAL EDUCATION LESSONS by E. M. Revenko

“…As a result, some teens dominate the development of the mental sphere, while the others dominate in the motor one. …”
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