In vitro antitumor and immunomodulatory activities of 1,2,4-oxadiazole derivatives by Héverton Mendes Araújo, Gabriel Acácio de Moura, Yasmim Mendes Rocha, Cristian Vicson Pinheiro Gomes, Valentina Nascimento e Melo de Oliveira, Ronaldo Nascimento de Oliveira, Larissa Deadame de Figueiredo Nicolete, Emanuel Paula Magalhães, Ramon R.P.P.B. de Menezes, Roberto Nicolete

“…Melanoma is the most aggressive and lethal type of skin cancer, responsible for approximately 60,000 deaths annually. …”
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TCF1-positive and TCF1-negative TRM CD8 T cell subsets and cDC1s orchestrate melanoma protection and immunotherapy response by Saraí G De León-Rodríguez, Cristina Aguilar-Flores, Julián A Gajón, Ángel Juárez-Flores, Alejandra Mantilla, Raquel Gerson-Cwilich, José Fabián Martínez-Herrera, Diana Alejandra Villegas-Osorno, Claudia T Gutiérrez-Quiroz, Sergio Buenaventura-Cisneros, Mario Alberto Sánchez-Prieto, Edmundo Castelán-Maldonado, Samuel Rivera Rivera, Ezequiel M Fuentes-Pananá, Laura C Bonifaz

“…Background Melanoma, the most lethal form of skin cancer, has undergone a transformative treatment shift with the advent of checkpoint blockade immunotherapy (CBI). …”
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Clinical implementation of next-generation sequencing testing and genomically-matched therapy: a real-world data in a tertiary hospital by Jin Won Kim, Hee Young Na, Sejoon Lee, Ji-Won Kim, Koung Jin Suh, Se Hyun Kim, Yu Jung Kim, Keun-Wook Lee, Jong Seok Lee, Jaihwan Kim, Jin-Hyeok Hwang, Kihwan Hwang, Chae-Yong Kim, Yong Beom Kim, Soomin Ahn, Kyu Sang Lee, Hyojin Kim, Hye Seung Lee, So Yeon Park, Gheeyoung Choe, Jee Hyun Kim, Jin-Haeng Chung

“…Of patients with tier I variants, 13.7% received NGS-based therapy as follows: Thyroid cancer (2/7, 28.6%), skin cancer (2/8, 25.0%), gynecologic cancer (7/65, 10.8%), and lung cancer (12/112, 10.7%). …”
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Preclinical pharmaco-toxicological screening of biomimetic melanin-like nanoparticles as a potential therapeutic strategy for cutaneous melanoma by Iasmina Marcovici, Iasmina Marcovici, Raul Chioibas, Raul Chioibas, Istvan Zupko, Iulia Pinzaru, Iulia Pinzaru, Alina Moaca, Alina Moaca, Adriana Ledeti, Adriana Ledeti, Lucian Barbu-Tudoran, Lucian Barbu-Tudoran, Andreea Geamantan, Andreea Geamantan, Iasmina Predescu, Iasmina Predescu, Cristina Adriana Dehelean, Cristina Adriana Dehelean

“…IntroductionDespite its rarity, cutaneous melanoma (CM) represents the deadliest skin cancer with a high mortality rate, an incidence on the rise, and limited therapeutic options at present. …”
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Phase I study of intratumoral administration of CV8102 in patients with advanced melanoma, squamous cell carcinoma of the skin, squamous cell carcinoma of the head and neck, or ade... by Lucie Heinzerling, Michael Fluck, Caroline Robert, Celeste Lebbe, Erika Richtig, Sven D Koch, Ulrike Gnad-Vogt, Tobias Seibel, Thomas Eigentler, Juan Martin-Liberal, Sebastian Ochsenreither, Peter Mohr, Patrick Terheyden, Carsten Weishaupt, Michael Erdmann, Lukas Koch, Ainara Soria, Igor Samoylenko, Jürgen Krauß, Peter Brossart, Franz Georg Bauernfeind, Marina Gonzalez, Peter Wengenmayer, Ioannis Thomas, Artem Poltoratskiy, Marina Sekacheva, Beate Schmitt-Bormann, Gianluca Quintini, Martin Falk, Paula Codó, Arjun Oberoi, Jana Hess, Yulia Semiletova, Casilda Llacer Perez, Oliver Schönborn-Kellenberger

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A Global Survey of Self-Reported Cancer Screening Practices by Health Professionals for Kidney Transplant Candidates and Recipients by Nida Saleem, Nida Saleem, Nida Saleem, Wai H. Lim, Wai H. Lim, Jacqueline H. Stephens, Jacqueline H. Stephens, Annabelle Wilson, Billie Bonevski, Allison Jaure, Allison Jaure, Armando Teixeira-Pinto, Armando Teixeira-Pinto, Eleonora Dal Grande, Eleonora Dal Grande, Martin Howell, Martin Howell, Farzaneh Boroumand, Farzaneh Boroumand, Anita van Zwieten, Anita van Zwieten, Chandana Guha, Chandana Guha, Nicole Scholes-Robertson, Nicole Scholes-Robertson, Steven J. Chadban, Steven J. Chadban, Carmel M. Hawley, Carmel M. Hawley, Jonathan C. Craig, Jeremy R. Chapman, Danyal Hassan, Greg Knoll, Greg Knoll, Naoka Murakami, Germaine Wong, Germaine Wong, Germaine Wong

“…About 85% recommended lung cancer screening for higher-risk individuals. Skin cancer screening recommendations varied from 69% for transplant candidates and 84% for recipients. …”
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A systematic analysis of the contribution of genetics to multimorbidity and comparisons with primary care dataResearch in context by Olivia Murrin, Ninon Mounier, Bethany Voller, Linus Tata, Carlos Gallego-Moll, Albert Roso-Llorach, Lucía A. Carrasco-Ribelles, Chris Fox, Louise M. Allan, Ruby M. Woodward, Xiaoran Liang, Jose M. Valderas, Sara M. Khalid, Frank Dudbridge, Sally E. Lamb, Mary Mancini, Leon Farmer, Kate Boddy, Jack Bowden, David Melzer, Timothy M. Frayling, Jane A.H. Masoli, Luke C. Pilling, Concepción Violán, João Delgado

“…., iron deficiency anaemia and peripheral arterial disease: genetic correlation Rg = 0.45 [95% Confidence Intervals 0.27:0.64]). 33 pairs displayed negative genetic correlations, such as skin cancer and rheumatoid arthritis (Rg = −0.14 [−0.21:−0.06]), due to potential adverse drug effects. …”
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Basal Cell Carcinoma of the Female Breast Masquerading as Invasive Primary Breast Carcinoma: An Uncommon Presentation Site by Mark B. Ulanja, Mohamed E. Taha, Arshad A. Al-Mashhadani, Marwah Muaad Al-Tekreeti, Christie Elliot, Santhosh Ambika

“…Skin cancer as a single entity is the most common malignancy in North America, accounting for half of all human cancers. …”
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Cutaneous Carcinosarcoma with Metastasis to the Parotid Gland by Tze Ling Loh, Jeanne Tomlinson, Ronald Chin, Guy D. Eslick

“…It is similar to nonmelanoma skin cancers in terms of risk and prognostic factors. …”
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<i>Cordyceps militaris</i>-Derived Bioactive Gels: Therapeutic and Anti-Aging Applications in Dermatology by Trung Quang Nguyen, Thinh Van Pham, Yusuf Andriana, Minh Ngoc Truong

“…In response to the rising incidence of skin cancers and the growing demand for natural bioactive ingredients, <i>C. militaris</i> has emerged as a valuable source of functional compounds, including cordycepin, polysaccharides, and adenosine. …”
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Erythema Ab Igne due to Heating Pad Use: A Case Report and Review of Clinical Presentation, Prevention, and Complications by Marissa Milchak, Joanne Smucker, Catherine G. Chung, Elizabeth V. Seiverling

“…While this dermatosis carries a favorable prognosis, nonmelanoma skin cancers have been reported to arise within lesions of erythema ab igne. …”
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Application of adoptive cell therapy in malignant melanoma by Qianrong Hu, Jiangying Xuan, Lu Wang, Kangjie Shen, Zixu Gao, Yuhong Zhou, Chuanyuan Wei, Jianying Gu

“…Abstract Cutaneous melanoma is one of the most aggressive skin cancers originating from skin pigment cells. Patients with advanced melanoma suffer a poor prognosis and generally cannot benefit well from surgical resection and chemo/target therapy due to metastasis and drug resistance. …”
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RAS/RAF/MEK/ERK and PI3K/PTEN/AKT Signaling in Malignant Melanoma Progression and Therapy by Ichiro Yajima, Mayuko Y. Kumasaka, Nguyen Dinh Thang, Yuji Goto, Kozue Takeda, Osamu Yamanoshita, Machiko Iida, Nobutaka Ohgami, Haruka Tamura, Yoshiyuki Kawamoto, Masashi Kato

“…Cutaneous malignant melanoma is one of the most serious skin cancers and is highly invasive and markedly resistant to conventional therapy. …”
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Development and Validation of a Simple and Selective Analytical HPLC Method for the Quantification of Oxaliplatin by Breno Noronha Matos, Paula Martins de Oliveira, Thaiene Avila Reis, Taís Gratieri, Marcílio Cunha-Filho, Guilherme Martins Gelfuso

“…Such method will be essential during the future development of innovative, topical drug formulations for the treatment of mucosal and skin cancers. Validated method demonstrated OXPt separation without interference from the solvents or polymers with the most relevance for developing of bioadhesive pharmaceutical drug carries (chitosan and poloxamer). …”
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Composite submental flaps in facial reconstructive surgery involving the zygoma and orbit by Usman Khan, Sebastian Haupt, Matthew Rigby, S. Mark Taylor, Martin Corsten, Jonathan Trites

“…All were performed following resection of skin cancers with invasion of the upper facial skeleton. …”
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Hedgehog pathway inhibitors (HHI) combined with radiotherapy and immunotherapy for advanced basal cell carcinoma: a case report by Zhuren Ruan, Chen Zhao, Longshan Li, Xianghui Li, Zhijian Yao, Gao Wei

“…Purpose Basal cell carcinoma (BCC) is one of the most common skin cancers. Most BCCs can be treated with surgery excision. …”
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An Evaluation of Skin Lesion Segmentation Using Deep Learning Architectures by Rabia Öztaş Kara, Devrim Akgün, Bekir Murat Aydın, Gökçen Çetinel, Sevda Gül

“…Skin lesion segmentation for recognizing and defining the boundaries of skin lesions in images is proper for automated analysis of skin lesion images, especially for the early diagnosis and detection of skin cancers. Deep learning architectures are an efficient way to implement segmentation once a skin lesion dataset is provided with ground truth images. …”
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IFN-γ licenses normal and pathogenic ALPK1/TIFA pathway in human monocytes by Amandine Martin, Solène Caron, Mélissa Marcotte, Pauline Bronnec, Etienne Garneret, Nora Martel, Georgina Maalouf, Pascal Sève, David Saadoun, Yvan Jamilloux, Thomas Henry

“…Specific mutations in ALPK1 are associated with an autoinflammatory syndrome termed ROSAH and with spiradenoma (skin cancers with sweat gland differentiation). This study investigated ALPK1 responses in human mononuclear cells and demonstrates that human mononuclear cells have distinct abilities to respond to ADP-heptose. …”
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Development of a Reference Method and Materials for Quantitative Measurement of UV-Induced DNA Damage in Mammalian Cells: Comparison of Comet Assay and Cell Viability by Donald H. Atha, Alessandro Tona, Vytas Reipa

“…Application of DNA damage diagnostic tests is rapidly growing, in particular for ovarian, prostate, and skin cancers; environmental monitoring; chronic and degenerative diseases; and male infertility. …”
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miRNAs and Melanoma: How Are They Connected? by Adriana Taveira da Cruz, Miriam Galvonas Jasiulionis

“…Despite being rare, its metastatic form is usually incurable, which makes melanoma the major death cause of all skin cancers. Some molecular pathways are frequently disrupted in melanoma, and miRNAs probably have a decisive role on these alterations. …”
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