NT5E Mediates Cisplatin Resistance in NSCLC Through the PI3K-AKT Signaling Pathway by Liangfeng Zheng, Jian Liu, Feiyue Ji, Chunxiang Li, Ye Qian, Lili Shao, Xiaomin Lu

Get full text

Effect of Electroacupuncture on Chondrocyte Apoptosis in Knee Osteoarthritis Rat Based on PI3K/Akt Signaling Pathway by Yuanyuan ZHANG, Xinyu JIANG, Xihai LI, Mingxia WU

Subjects: Get full text

Signaling pathway mechanisms of circadian clock gene Bmal1 regulating bone and cartilage metabolism: a review by Yiting Ze, Yongyao Wu, Zhen Tan, Rui Li, Rong Li, Wenzhen Gao, Qing Zhao

“…Studies have shown that multiple signaling pathways are involved in the process of Bmal1 regulating bone and cartilage metabolism, but the exact regulatory mechanisms remain unclear. …”
Get full text

Cellular Cholesterol Loss Impairs Synaptic Vesicle Mobility via the CAMK2/Synapsin-1 Signaling Pathway by Atikam Qurban, Mengqi Zhang, Hengbing Zu, Kai Yao

Get full text

Whole-Genome Expression Analysis and Signal Pathway Screening of Synovium-Derived Mesenchymal Stromal Cells in Rheumatoid Arthritis by Jingyi Hou, Yi Ouyang, Haiquan Deng, Zhong Chen, Bin Song, Zhongyu Xie, Peng Wang, Jinteng Li, Weiping Li, Rui Yang

“…Our study found that differentially expressed genes in the MAPK signaling, rheumatoid arthritis, and p53 signaling pathways may help to explain the pathogenic mechanism of RA and lead to therapeutic RA SMSC applications.…”
Get full text

Tegaserod maleate exerts anti-tumor effects on prostate cancer via repressing sonic hedgehog signaling pathway by Maoping Cai, Shengdong Ge, Yaying Hong, Yao Chen, Yang-Zi Ren, Dacai Zhong, Mingkun Chen, Yuan Liu, Zhe-Sheng Chen, Ninghan Feng, Zhanghui Chen, Shan-Chao Zhao

“…Mechanistically, TM exerted anti-tumor effects via downregulating GLI2, and its downtream targets, thus inhibiting the sonic hedgehog (SHH) signaling pathway. In brief, our findings demonstrated that TM effectively inhibited the activities of PCa cells by suppressing the SHH signaling pathway and provided a potential new agent for the treatment of PCa.…”
Get full text

Early Intervention of Didang Decoction on MLCK Signaling Pathways in Vascular Endothelial Cells of Type 2 Diabetic Rats by Shoujiao Ye, Zhenqiang Song, Jing Li, Chunshen Li, Juhong Yang, Bai Chang

“…In conclusion, the early use of DDD improves the permeability of vascular endothelial cells by regulating the MLCK signaling pathway.…”
Get full text

Corrigendum to “Neuroprotective Effects of the Sonic Hedgehog Signaling Pathway in Ischemic Injury through Promotion of Synaptic and Neuronal Health” by Sen Yin, Xuemei Bai, Danqing Xin, Tingting Li, Xili Chu, Hongfei Ke, Min Han, Wenqiang Chen, Xingang Li, Zhen Wang

Get full text

Exploring the Analgesic Effect of Acupuncture on Knee Osteoarthritis Based on MLT/cAMP/PKA/CREB Signaling Pathway by Zhang C, Yu M, Zhang L, Zhou X, Han J, Fu B, Xue H, Zhang C

“…In addition, acupuncture significantly reduced the expression of the inflammatory factor MMP-3 in knee joint fluid and significantly increased the levels of MLT, AANAT, MT1, MT2, cAMP, PKA and CREB.Conclusion: By regulating sympathetic excitability, acupuncture may activate the MLT/cAMP/PKA/CREB signaling pathway, decrease inflammatory factor expression and slow down degradation of articular cartilage, resulting in the relief of knee pain.Keywords: acupuncture, knee osteoarthritis, MLT/cAMP/PKA/CREB pathway, melatonin…”
Get full text

Postoperative Tongqi Formula ameliorates postoperative ileus via p38 MAPK signaling pathway and metabolic disorder by Mengmeng Yang, Yuxuan Lu, Shufan Jin, Wanqiu Liu, Miaoshi Yao, Zhiwei Jiang, Yachun Shu

Subjects: Get full text

The auxin signaling pathway to its PIN transporters: insights based on a meta-analysis of auxin-induced transcriptomes by V. V. Kovrizhnykh, Z. S. Mustafin, Z. Z. Bagautdinova

“…Regulation of auxin-response genes occurs through the ARF-Aux/IAA signaling pathway. However, it is not known which ARF-Aux/IAA proteins are involved in the regulation of PIN gene expression by auxin. …”
Get full text

Repeated low-intensity noise exposure exacerbates age-related hearing loss via RAGE signaling pathway by Jianbin Sun, Na Sai, Tong Zhang, Chaoying Tang, Shuhang Fan, Qin Wang, Da Liu, Xianhai Zeng, Juanjuan Li, Weiwei Guo, Shiming Yang, Weiju Han

“…Proteomics analysis revealed an upregulation in the receptor for the advanced glycation end-products (RAGE) signaling pathway, which was associated with an activated inflammatory response, vascular injury, and mitochondrial and synaptic dysfunction. …”
Get full text

Rutin attenuates zearalenone-induced ferroptosis of endometrial stromal cells in piglets through the p53 signaling pathway by Chenlong Wang, Chuangjiang Chen, MengYa Wang, Sajid Ur Rahman, Bin Wei, Hongyan Ding, Wanyue Huang, Xichun Wang

Subjects: Get full text

NADPH Oxidase Signaling Pathway Mediates Mesenchymal Stem Cell-Induced Inhibition of Hepatic Stellate Cell Activation by Haowen Qiao, Yu Zhou, Xingping Qin, Jing Cheng, Yun He, Yugang Jiang

“…The effect of hBM-MSCs reduced the signaling pathway of NADPH oxidase in activated HSCs. Besides, the signaling pathway of NADPH oxidase mediated hBM-MSC upregulation of the expression of the peroxisome proliferator-activated receptor γ and downregulation of the expression of α1(I) collagen and alpha-smooth muscle actin (α-SMA) in activated HSCs. …”
Get full text

Schistosoma sex-biased microRNAs regulate ovarian development and egg production by targeting Wnt signaling pathway by Pengfei Du, Tianqi Xia, Xuxin Li, Bikash R. Giri, Chuantao Fang, Shun Li, Shi Yan, Guofeng Cheng

“…Here, we describe that Bantam miRNA and miR-1989 regulate Wnt signaling pathway by targeting Frizzled-5/7/9, which is involved in ovarian development and oviposition. …”
Get full text

The potential of melatonin in sepsis-associated acute kidney injury: Mitochondrial protection and cGAS-STING signaling pathway by Yuchun Cao, Xiaofang He, Zeyuan Liu, Liying Miao, Bin Zhu

“…We intraperitoneally injected H151 and Mel into SA-AKI mouse models to interfere the cGAS-STING signaling pathway. By comparing behavioral, pathological, and molecular biology results, we discovered that Mel could reduce cGAS-STING signaling pathway while greatly relieving kidney damage and function. …”
Get full text

Pien Tze Huang Inhibites Colorectal Cancer Cell via Regulating Hedgehog Signaling Pathway in Vivo and in Vitro by Qunchuan ZHUANG, Minghe LIN, Lihui WEI, Jun PENG, Jiumao LIN

Subjects: Get full text

L-Carnitine Alleviates the Myocardial Infarction and Left Ventricular Remodeling through Bax/Bcl-2 Signal Pathway by Hao-Ran Li, Xiao-Ming Zheng, Yan Liu, Jing-Hui Tian, Jie-Jian Kou, Jun-Zhuo Shi, Xiao-Bin Pang, Xin-Mei Xie, Yu Yan

“…The key proteins in the Bax/Bcl-2 signaling pathway were also examined by Western blot. Results. …”
Get full text

Mechanism of Acupuncture Therapy on RANKL/OPG Signaling Pathway to Regulate Bone Metabolism Balance in Osteoporosis Model Rats by Qin YIN, Hong PAN, Xiaojuan DING, Xiaoguang QIN, Xiaorong GUO

Subjects: Get full text

Beta-Hydroxybutyric Acid Inhibits Renal Tubular Reabsorption via the AKT/DAB2/Megalin Signalling Pathway by Minxia Zuo, Cheng Meng, Qian Song, Zhongai Gao, Xiao Cui, Jingyu Wang, Yongmei Li, Xiaochen Li, Chunyan Shan, Juhong Yang, Baocheng Chang

“…High concentrations of BOHB downregulate megalin expression by inhibiting the AKT/DAB2/megalin signalling pathway and albumin endocytosis in proximal renal tubules.…”
Get full text