An updated review summarizing the anticancer potential of flavonoids via targeting NF-kB pathway by Pratibha Pandey, Sorabh Lakhanpal, Danish Mahmood, Han Na Kang, Byunggyu Kim, Sojin Kang, Jinwon Choi, Min Choi, Shivam Pandey, Mahakshit Bhat, Shilpa Sharma, Fahad Khan, Moon Nyeo Park, Bonglee Kim, Bonglee Kim

Subjects: Get full text

Decreased expression of miR-200a and miR-223-3p in endometriosis during the secretory phase of menstrual cycle: Insights from a case-control study on molecular biomarkers and disea... by Yasaman Nazari Hagh, Mohamadreza Ahmadifard, Sedigheh Esmaelzadeh, Soheila Abbaszadeh, Naser Shokrzadeh

Subjects: “…Endometriosis, miRNA, Implantation, Signaling pathways, Biomarkers, Infertility, Menstrual cycle.…”
Get full text

Targeting Chondrocyte Hypertrophy as Strategies for the Treatment of Osteoarthritis by Da-Long Dong, Guang-Zhen Jin

Subjects: Get full text

Phytochemicals in Breast Cancer Prevention and Treatment: A Comprehensive Review by Adil Farooq Wali, Jayachithra Ramakrishna Pillai, Sirajunisa Talath, Pooja Shivappa, Sathvik Belagodu Sridhar, Mohamed El-Tanani, Imran Rashid Rangraze, Omnia Ibrahim Mohamed, Nowar Nizar Al Ani

Subjects: Get full text

Lactate Ameliorates Kainic Acid-Induced Neuroinflammation and Cognitive Impairment via the Chemokine Signaling Pathway in Mice by Chu X, Ge Y, Geng C, Cao P, Wei P, Fu B, Deng Z, Li Y, Zhao G

“…In mice with acute epilepsy, lactate treatment mitigated neuronal damage, microglial activation, and inflammatory responses in the hippocampus and ameliorated anxiety-like behavior and cognitive impairment.Conclusion: Lactate exerts therapeutic effects on epilepsy through the chemokine signaling pathway. The neuroinflammation is an important contributor to cognitive impairment. …”
Get full text

Escin Chemosensitizes Human Pancreatic Cancer Cells and Inhibits the Nuclear Factor-kappaB Signaling Pathway by A. Rimmon, A. Vexler, L. Berkovich, G. Earon, I. Ron, S. Lev-Ari

“…Escin decreased pancreatic cancer cell survival, induced apoptosis, and downregulated NF-κB signaling pathway. Moreover, Escin sensitized pancreatic cancer cells to chemotherapy. …”
Get full text

Regulatory T Cells Resist Cyclosporine-Induced Cell Death via CD44-Mediated Signaling Pathways by Shannon M. Ruppert, Ben A. Falk, S. Alice Long, Paul L. Bollyky

Get full text

Neuroprotective Role of Transchalcone in Parkinson‘s Disease through AMP-activated Protein Kinase-mediated Signaling Pathway by Yao Cheng, Shaik Althaf Hussain, Turki Mayudh Alrubie, Xiaomin Zhang

“…This study investigates the neuroprotective effects of transchalcone in a rat model of PD, focusing on its impact on the activation levels of AMP-activated protein kinase (AMPK) signaling pathway, sirtuin1 (SIRT1) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) proteins, and mitochondrial-inflammatory responses. …”
Get full text

The Olive Oil Monophenolic Secoiridoid Ligstroside Aglycone Suppresses Melanoma Progression by Targeting the BRAF Signaling Pathway by Md Ashiq Mahmud, Abu Bakar Siddique, Afsana Tajmim, Judy Ann King, Khalid A. El Sayed

“…Daily oral 10 mg/kg LA exhibited potent in vivo antitumor effects against Malme-3M cells xenograft in a nude mouse model by targeting the BRAF signaling pathway. A human Clariom S microarray analysis of the collected Malme- 3M tumors identified 571 dysregulated genes, with the downregulation of pathways critical for melanoma cells growth and survival. …”
Get full text

Suberosin attenuates rheumatoid arthritis by repolarizing macrophages and inhibiting synovitis via the JAK/STAT signaling pathway by Huan Liu, Qianwei Li, Yuehong Chen, Min Dong, Hongjiang Liu, Jiaqian Zhang, Leiyi Yang, Geng Yin, Qibing Xie

“…SBR exhibited anti-arthritic effects via the JAK1/STAT3 and JAK1/STAT6 signaling pathways, inhibiting synovial tissue inflammation and M1 macrophage polarization while promoting M2 macrophage polarization. …”
Get full text

The sphingosine‐1‐phosphate signaling pathway (sphingosine‐1‐phosphate and its receptor, sphingosine kinase) and epilepsy by Lin Wang, Qingxia Kong, Xinyi Leng, Howan Leung, Yang Li

“…Plain Language Summary This article combines the latest research literature at home and abroad to review the sphingosine 1‐phosphate signaling pathway and epileptogenesis, drug‐resistant epilepsy, epilepsy comorbidities, other diseases that can cause epilepsy, as well as the sphingosine‐1‐phosphate signaling pathway regulators and epilepsy, with the expectation of providing a certain theoretical basis for finding potential epilepsy treatment targets and/or epileptogenic biomarkers in the sphingosine‐1‐phosphate signaling pathway.…”
Get full text

Inhibition of TNF-α and JNK Signaling Pathway Can Reduce Paclitaxel-Induced Apoptosis of Mouse Cardiomyocytes by Shuang Ren, Tianwen Huang, Danyan Ou, Luhuai Feng, Sisi Huang, Chaonan Zhou, Lianying Ge

“…The findings suggested that inhibition of the NK signaling pathway and TNF-α can lessen the effect of PTX on mouse cardiomyocytes.…”
Get full text

CENPN contributes to pancreatic carcinoma progression through the MDM2-mediated p53 signaling pathway by Ming Xu, Jie Tang, Qiong Sun, Jing Meng, Guoyu Chen, Yunli Chang, Yao Yao, Jieru Ji, Hao Luo, Lingling Chen, Minxue Lu, Weiwei Shi

Subjects: Get full text

Resistance Response of the Jasmonic Acid and Salicylic Acid Signaling Pathways in Mango Fruits Infected with Lasodiplodia theobromae by QU Xiangxiang, HU Meijiao, SUN Jinhua, GONG Deqiang, GAO Zhaoyin, CHEN Gengxin, LI Min

“…In order to explore the response patterns of the jasmonic acid (JA) and salicylic acid (SA) signaling pathways in mango fruits to Lasiodiplodia theobromae, we analyzed the synthesis of JA and SA in L. theobromae mycelia infecting the fruit and in the infected fruit as well as the expression of genes involved in the JA and SA signaling pathways and the expression of resistance-related genes. …”
Get full text

Puerarin Promotes the Migration and Differentiation of Myoblasts by Activating the FAK and PI3K/AKT Signaling Pathways by Xiaofeng Fang, Hangjia Xu, Zhaoxin Fan, Hongge Yang, Yan Huang, Lin Xu, Yiwei Rong, Wei Ma, Liubao Pei, Hongsheng Liang

Get full text

Identification of Differentially Expressed Genes and Signaling Pathways in Acute Myocardial Infarction Based on Integrated Bioinformatics Analysis by Da-Qiu Chen, Xiang-Sheng Kong, Xue-Bin Shen, Mao-Zhi Huang, Jian-Ping Zheng, Jing Sun, Shang-Hua Xu

“…These DEGs were mainly enriched in cytokine-cytokine receptor interaction, chemokine signaling pathway, TNF signaling pathway, and so on. The module analysis filtered out 18 key genes, including Cxcl5, Arg1, Cxcl1, Spp1, Selp, Ptx3, Tnfaip6, Mmp8, Serpine1, Ptgs2, Il6, Il1r2, Il1b, Ccl3, Ccr1, Hmox1, Cxcl2, and Ccl2. …”
Get full text

Biological sex, microglial signaling pathways, and radiation exposure shape cortical proteomic profiles and behavior in mice by Alexandra O. Strohm, Sadie Oldfield, Eric Hernady, Carl J. Johnston, Brian Marples, M. Kerry O'Banion, Ania K. Majewska

“…Here, we used a system levels approach to examine how deficiencies in purinergic and fractalkine signaling, two important microglial signaling pathways, impact brain proteomic and behavioral profiles in irradiated and control male and female mice. …”
Get full text

Effect of Cell Growth and Proliferation Factors (EGF/PDGF Signaling Pathway) on the Etiopathogenesis of Intrauterine Growth Restriction by Serhan Can İşcan, Erhan Demirdağ, Melek Yaman, Emin Ümit Bağrıacık, Merih Bayram

“…Objective: It is likely that the subgroups of the epidermal growth factor/platelet-derived growth factor (EGF/PDGF) signaling pathway play a role in the etiopathogenesis of intrauterine growth restriction (IUGR). …”
Get full text

Consensus representation of multiple cell–cell graphs from gene signaling pathways for cell type annotation by Yu-An Huang, Yue-Chao Li, Zhu-Hong You, Lun Hu, Peng-Wei Hu, Lei Wang, Yuzhong Peng, Zhi-An Huang

Get full text

Human Placenta-Derived Mesenchymal Stem Cells Ameliorate Diabetic Neuropathy via Wnt Signaling Pathway by Songsong Pan, Sushant S. Hada, Yang Liu, Chao Hu, Mengdie Zhou, Shaoqiu Zheng, Minjie Xu, Changsheng Shi, Shiwu Yin, Xiaoyun Xie

“…To investigate the effect of placenta-derived mesenchymal stem cells (PMSCs) on diabetic peripheral neuropathy and explore the role of Wnt signaling pathway. Method. Twenty-seven male db/db mice were randomly categorized into the control group, PMSC group, and PMSC treatment with Wnt inhibitor treatment group. …”
Get full text