PTMNavigator: interactive visualization of differentially regulated post-translational modifications in cellular signaling pathways by Julian Müller, Florian P. Bayer, Mathias Wilhelm, Maximilian G. Schuh, Bernhard Kuster, Matthew The

“…This offers a comprehensive view of the intricate relationship between PTMs and signaling pathways. We demonstrate the utility of PTMNavigator by applying it to two phosphoproteomics datasets, showing how it can enhance pathway enrichment analysis, visualize how drug treatments result in a discernable flow of PTM-driven signaling, and aid in proposing extensions to existing pathways. …”
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T cell receptor signaling pathway subgroups and construction of a novel prognostic model in osteosarcoma by Huan Xu, Huimin Tao

“…Background: T cell receptor (TCR) signaling pathway is closely related to tumor progress and immunotherapy. …”
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Wnt/β-catenin and notch signaling pathways in cardiovascular disease: Mechanisms and therapeutics approaches by Manizheh Azhdari, Axel zur Hausen

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The beneficial effects of curcumin on aging and age-related diseases: from oxidative stress to antioxidant mechanisms, brain health and apoptosis by Ying He, Ying He, Yongqing Liu, Min Zhang

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IUPHAR review: Targeted therapies of signaling pathways based on the gut microbiome in autism spectrum disorders: Mechanistic and therapeutic applications by Abdullah Al Mamun, Peiwu Geng, Shuanghu Wang, Chuxiao Shao, Jian Xiao

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Insights Into the Role of Bmi‐1 Deregulation in Promoting Stemness and Therapy Resistance in Glioblastoma: A Narrative Review by Fatima Shaalan, Nissrine Ballout, Wafaa Takash Chamoun

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Editorial: Spatio-temporal molecular mechanisms regulating synapse function and neural circuit dynamics by Tomohisa Hosokawa, Yoshiyuki Kubota, Yoshiyuki Kubota, Yoshiyuki Kubota, Tetsuya Takano, Tetsuya Takano

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cGAS/STING signaling pathway in gynecological malignancies: From molecular mechanisms to therapeutic values by Danyang Zhang, Bingxue Zhang

“…Gynecological cancers, including cervical, ovarian, and endometrial malignancies, remain a significant global health burden, exacerbated by disparities in access to preventive measures such as HPV vaccination and routine screening. The cGAS/STING signaling pathway, a pivotal mechanism in innate immunity, detects cytosolic DNA from pathogens or cellular damage, triggering immune responses via type I interferons and inflammatory cytokines. …”
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Targeting the Wnt/β-catenin signaling pathway for precision therapy in laryngeal squamous cell carcinoma by Shyamaladevi Babu, Madhan Krishnan

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Loss of Kat2b impairs intraflagellar transport and the Hedgehog signaling pathway in primary cilia by Jae Hee Jun, Hwayeon Cha, Je Yeong Ko, Ho-Shik Kim, Kyung Hyun Yoo, Jong Hoon Park

“…Abstract Primary cilia are sensory organelles that regulate various signaling pathways. When microtubules are compared to a highway, motor proteins carry and transport cargo proteins, which are tuned by post-translational modifications, such as acetylation. …”
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Endoplasmic Reticulum Is at the Crossroads of Autophagy, Inflammation, and Apoptosis Signaling Pathways and Participates in the Pathogenesis of Diabetes Mellitus by Jing Su, Lei Zhou, Xiaoxia Kong, Xiaochun Yang, Xiyan Xiang, Yu Zhang, Xiaoning Li, Liankun Sun

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Characterization of Escherichia coli outer membrane vesicles and the impact of pathogenic ones on NLR signaling pathways by Roghayeh Mohammadzadeh, Ava Behrouzi, Farzam Vaziri, Seyed Davar Siadat

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Advancements in Research on Non-AR- Signaling Pathways and Targeted Therapies for Castration-Resistant Prostate Cancer by Haq Dad, Asger Hansen

“…While the androgen receptor (AR) signaling pathway is widely recognized as central to CRPC pathogenesis, emerging research highlights the critical involvement of the non-AR signaling pathway in the disease. …”
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Mechanism of Bone-metastatic LUAD Cells Promoting Angiogenesis 
Through HGF/YAP Signaling Pathway by Yan DENG, Rong QIU, Xingyu LIU, Yingyang SU, Yang XUE, Yuzhen DU

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Itraconazole promotes melanoma cells apoptosis via inhibiting hedgehog signaling pathway-mediated autophagy by Shunqiao Jin, Shunqiao Jin, Xiaojiao Liu, Xiaojiao Liu, Lingqin Cai, Lingqin Cai, Jiayu Yan, Ling Li, Hongjun Dong, Yuxue Gao, Xicong Zhu, Cong Zhang, Xuezhu Xu

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Sex differences in the neuroinflammatory signaling pathway: effect of miRNAs on fatty acid synthesis in microglia by Haolin Zheng, Akiko Mizokami, Sergio Romera-Giner, Jaime Llera-Oyola, Yosuke Yamawaki, Tomomi Sano, Eijiro Jimi, Francisco García-García, Takashi Kanematsu

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Uncovering the Heterogeneity of Signaling Pathways in Skin Cutaneous Melanoma: Insights into Prognostic Values and Immune Interactions by Liu Y, Li C, Deng W

“…Yufang Liu,1,* Chunyan Li,2,* Weiwei Deng2 1Department of Dermatology and Venereology, Fuyang People’s Hospital, Fuyang, Anhui, 236000, People’s Republic of China; 2Department of Dermatology and Venereology, Dermatology Hospital of Southern Medical University, Department of Dermatology, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Weiwei Deng, Email dengww@smu.edu.cnBackground: Signaling pathways play crucial roles in tumor cells. However, functional heterogeneity of signaling pathways in skin cutaneous melanoma (SKCM) has not been established.Methods: Based on a recent computational pipeline, pathway activities between SKCM and normal samples were identified.Results: The results showed that high activities in 12 pathways were associated with poor prognoses, while high activities in 17 pathways were associated with favorable prognoses. …”
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ASPM Promotes the Progression of Anaplastic Thyroid Carcinomas by Regulating the Wnt/β-Catenin Signaling Pathway by Liang Jiang, Shuai Zhang, Ning An, Guoqing Chai, Changhong Ye

“…The involvement of Wnt/β-catenin signaling pathway was also investigated. Results. ASPM was overexpressed in ATC patients and cell lines. …”
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Naringenin induces ferroptosis in osteosarcoma cells through the STAT3-MGST2 signaling pathway by Yingang Li, Xizhuang Bai

“…In summary, our study demonstrates that naringenin induces ferroptosis in osteosarcoma cells through the STAT3-MGST2 signaling pathway, providing a promising strategy for osteosarcoma treatment.…”
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Xanthoxyletin blocks the RANK/RANKL signaling pathway to suppress the growth of human pancreatic cancer cells by Zhang Xin, Li Luming, Wu Yan

“…Collectively, xanthoxyletin targets the RANK/RANKL signaling pathway in pancreatic cancer cells to induce cell apoptosis and may prove to be an important lead molecule.…”
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