Development and interpretation of a pathomics-driven ensemble model for predicting the response to immunotherapy in gastric cancer by Jing Wang, Zhe Li, Wei Wang, Md Tauhidul Islam, Xiaoyan Wang, Zhen Han, Zihan Li, Guoxin Li, Yuming Jiang, Taojun Zhang, Wenjun Xiong, Zepang Sun, Lequan Yu, Zhicheng Zhang, Xianqi Yang, Shengtian Sang, Alyssa A Guo

“…The univariate Cox regression analysis revealed that the prediction signature of pathomics-driven ensemble model was a prognostic factor for progression-free survival in patients with gastric cancer who underwent immunotherapy (p<0.001, HR 0.35 (95% CI 0.24 to 0.50)), and remained an independent predictor after multivariable Cox regression adjusted for clinicopathological variables, (including sex, age, carcinoembryonic antigen, carbohydrate antigen 19-9, therapy regime, line of therapy, differentiation, location and programmed death ligand 1 (PD-L1) expression in all patients (p<0.001, HR 0.34 (95% CI 0.24 to 0.50)). …”
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Geography and age drive racial and ethnic disparities in hospital mortality for paediatric community-acquired pneumonia in the United States: a retrospective population based cohor... by Cody-Aaron L. Gathers, Nadir Yehya, Anireddy Reddy, Paula M. Magee, Vanessa C. Denny, Michelle R. Mayeda, Amanda O’Halloran, Sanjiv D. Mehta, Stephanie Wanamaker, Jessica C. Fowler, Garrett Keim

“…Multivariable logistic regression, clustered by hospital and adjusting for sex, primary insurance payer, median household income quartile, urban identification, and the presence of a complex chronic condition(s), quantified the relationship between the joint exposure and all-cause mortality for paediatric community-acquired pneumonia. …”
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A noncanonical role of roX RNAs in autosomal epigenetic repression by Jianjian Li, Shuyang Xu, Zicong Liu, Liuyi Yang, Zhe Ming, Rui Zhang, Wenjuan Zhao, Huipai Peng, Jeffrey J. Quinn, Manyin Wu, Yushan Geng, Yuying Zhang, Jiazhi He, Minghai Chen, Nan Li, Ning-Yi Shao, Qing Ma

“…While roX RNAs are recognized for their role in sex-chromosome dosage compensation, ensuring balanced expression of X-linked genes in both sexes, their potential influence on autosomal gene regulation remains unexplored. …”
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Heterogeneous clinical phenotypes of sporadic early-onset Alzheimer’s disease: a neuropsychological data-driven approach by Deepti Putcha, Yuta Katsumi, Alexandra Touroutoglou, Ani Eloyan, Alexander Taurone, Maryanne Thangarajah, Paul Aisen, Jeffrey L. Dage, Tatiana Foroud, Clifford R. Jack, Joel H. Kramer, Kelly N. H. Nudelman, Rema Raman, Prashanthi Vemuri, Alireza Atri, Gregory S. Day, Ranjan Duara, Neill R. Graff-Radford, Ian M. Grant, Lawrence S. Honig, Erik C. B. Johnson, David T. Jones, Joseph C. Masdeu, Mario F. Mendez, Erik Musiek, Chiadi U. Onyike, Meghan Riddle, Emily Rogalski, Stephen Salloway, Sharon Sha, R. Scott Turner, Thomas S. Wingo, David A. Wolk, Kyle Womack, Maria C. Carrillo, Gil D. Rabinovici, Bradford C. Dickerson, Liana G. Apostolova, Dustin B. Hammers, the LEADS Consortium

“…These phenotypes did not differ by age, sex, or years of education. The APOE ɛ4 genotype was enriched in the Amnestic Predominant group, who were also rated as least impaired. …”
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Association of Total Mortality and Cardiovascular Endpoints With the Timing of the First and Second Systolic Peak of the Aortic Pulse Wave by Yi‐Bang Cheng, De‐Wei An, Lucas S. Aparicio, Qi‐Fang Huang, Yu‐Ling Yu, Chang‐Sheng Sheng, Teemu J. Niiranen, Fang‐Fei Wei, José Boggia, Katarzyna Stolarz‐Skrzypek, Natasza Gilis‐Malinowska, Valérie Tikhonoff, Wiktoria Wojciechowska, Edoardo Casiglia, Krzysztof Narkiewicz, Wen‐Yi Yang, Jan Filipovský, Kalina Kawecka‐Jaszcz, Ji‐Guang Wang, Tim S. Nawrot, Yan Li, Jan A. Staessen, the International Database of Central Arterial Properties for Risk Stratification (IDCARS) Investigators

“…Mean TP1 and TP2, standardized for cohort, sex, age, and heart rate, were 103 and 228 ms. Shorter TP1 and TP2 were associated with higher mortality and shorter TP1 with a higher risk of cardiovascular and cardiac endpoints (trend p ≤ 0.004). …”
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Global, regional, and national epidemiology of childhood neuroblastoma (1990–2021): a statistical analysis of incidence, mortality, and DALYsResearch in context by Jusen Nong, Cheng Su, Changhua Li, Congjun Wang, Wei Li, Yong Li, Peng Chen, Yanqiang Li, Zihao Li, Xinjin She, Zuxin Yuan, Sentian Liu, Chao Chen, Qian Liao, Yige Luo, Bo Shi

“…Data from 204 countries and territories were stratified by age, sex, and location. Trends were assessed using Joinpoint regression models to compute the annual percent change (APC) and log-transformed linear regression models to calculate the estimated average annual percentage change (EAPC). …”
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Three in four children age 12–23 months missed opportunities for vaccination in Sub-Saharan African countries: a multilevel mixed effect analysis of demographic health and surveys... by Melak Jejaw, Tesfahun Zemene Tafere, Misganaw Guadie Tiruneh, Asebe Hagos, Getachew Teshale, Mikias Mered Tilahun, Wubshet D. Negash, Kaleb Assegid Demissie

“…Children’s age, maternal age, marital status, education, antenatal care visit, health insurance utilization, sex of household head, religion, place of delivery, residence, media exposure, distance to reach health facility, community wealth status, community educational status, and human development index of the countries were significantly associated with MOV. …”
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scRNA-seq reveals elevated interferon responses and TNF-α signaling via NFkB in monocytes in children with uncomplicated malaria by Collins M. Morang’a, Riley S. Drake, Riley S. Drake, Riley S. Drake, Riley S. Drake, Vincent N. Miao, Vincent N. Miao, Vincent N. Miao, Vincent N. Miao, Nancy K. Nyakoe, Dominic S. Y. Amuzu, Vincent Appiah, Yaw Aniweh, Yaw Bediako, Saikou Y. Bah, Alex K. Shalek, Alex K. Shalek, Alex K. Shalek, Alex K. Shalek, Gordon A. Awandare, Thomas D. Otto, Lucas Amenga-Etego

“…Then, we applied single-cell RNA sequencing to compare the immunological phenotypes of 18,176 peripheral blood mononuclear cells isolated from a subset of the participants (n = 11/224), matched on age, sex, and parasite density. Patients had higher parasite densities compared to the controls, although the levels had a negative correlation with age in both groups, suggesting that they are key indicators of disease pathogenesis. …”
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Association of extreme high temperature weather with non-accidental deaths among residents of Yichang city: a time-stratified case-crossover analysis by Xiaoyan MING, Yang HAN, Zhongcheng YANG, Zaoxia WANG, Shuguang XIE, Chuangang FAN

“…Stratified analysis showed that the effects of extreme high temperature events on non-accidental deaths persisted in different sex and age subgroups. For both male and female subgroups, the effect of P97.5-3 d was strongest at lag day 0, with ORs (95%CI) of 1.36 (1.21 – 1.54) for males and 1.24 (1.08 – 1.43) for females. …”
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The Knee-SCHOOL: a brief patient-centered multidisciplinary educational program for knee osteoarthritis by Denise Vianna Machado Ayres, Sabrina Saemy Tome Uchiyama, Andréa Oliveira Prates, Rosana Aparecida Freitas Lopes, Antenor Bispo Santos Silva, Denise Rodrigues Tsukimoto, Rosimeire Alves Amorim, Taynah Souza Ribeiro, Artur Cesar Aquino Santos, André Tadeu Sugawara, André Tadeu Sugawara, Marcos Montagnini, Linamara Rizzo Battistella, Linamara Rizzo Battistella, Marta Imamura, Marta Imamura

“…Study measures included demographic data (age, sex, and educational level), pain duration (years), pain intensity (visual analogue scale), affected knee (right, left, or both knees), comorbidities (presence of hypertension, diabetes, and hypercholesterolemia), Body Mass Index (BMI), Bristol Stool Scale, Adapted Healthy Eating Index (AHEI), bioelectrical impedance, daytime sleepiness, and the impact of the KOA on pain, symptoms, activities of daily living, recreation, and quality of life. …”
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Six months of hybrid closed-loop therapy improves diabetes-specific positive well-being, and reduces diabetes distress and fear of hypoglycemia: secondary analysis of a randomized... by Anthony C Keech, Vijaya Sundararajan, Bruce R King, Sara Vogrin, Richard J MacIsaac, Leon A Bach, Jane Speight, Alicia J Jenkins, Christel Hendrieckx, David O’Neal, Sybil A McAuley, Geoff R Ambler, Fergus J Cameron, Jan M Fairchild, Elizabeth A Davis, Timothy W Jones, Morton G Burt, Philip M Clarke, Neale D Cohen, Peter G Colman, Joey Kaye, Kavita Kumareswaran, Melissa H Lee, Roland W Mccallum, Barbora Paldus, Stephen N Stranks, Steven Trawley, Glenn M Ward, David N O’Neal, Sienna Russell-Green, Deborah Jane Holmes-Walker, Benjamin Lam, Jennifer A Halliday, Glenn Ward, Catriona M Sims, D Jane Holmes-Walker, Andrzej Januszewski, Hanafi Mohammed Husin, Martin I de Bock, Mary B Abraham

“…Linear mixed models were conducted, using restricted maximum likelihood estimation, unadjusted and adjusted (for covariates: age, sex, diabetes duration, glycated hemoglobin, recent severe hypoglycemia, pre-trial insulin delivery modality, enrollment and mid-study scores).Results 120 participants (mean age 44±12 years) were randomized to intervention (n=61) or standard therapy (n=59). …”
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Long-Term Time in Target Range for Systolic Blood Pressure Since Childhood and Midlife Arterial Stiffness by Yang Wang, MD, PhD, Han Qi, PhD, Hao Jia, MD, Dan Wang, MD, Yue Sun, MD, Bo-Wen Zhang, MPH, Ming-Fei Du, MD, Gui-Lin Hu, MD, Zi-Yue Man, MD, Chao Chu, MD, PhD, Xiao-Jun Yang, MPH, Teng Zhang, MD, Tong-Shuai Guo, MD, Xi Zhang, MD, Yu Yan, MD, Zheng Liu, PhD, Ming-Ke Chang, MD, Hao Li, MD, Fang-Yao Chen, PhD, Yu-Ming Kang, PhD, Jie Ren, MD, Zu-Yi Yuan, MD, PhD, Ling Zhang, PhD, Jian-Jun Mu, MD

“…SBP-TTR was assessed over 36 years, with the target ranges of SBP defined as the 90th to 95th percentile of SBP for age, sex, and height in childhood, and 110 to 130 mm Hg in adulthood. …”
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Relationship between physical activity level, leisure sedentary time, and frailty among residents aged 30 – 79 years in Wuzhong district, Suzhou city: a baseline surveillance data... by Xikang FAN, Jiang HUA, Jian SU, Hao YU, Yan LU, Yujie HUA, Jianrong JIN, Pei PEI, Dianjianyi SUN, Canqing YU, Jun LYU, Jinyi ZHOU, Ran TAO

“…After adjusting for confounding factors such as sex, age, education level, marital status, annual household income, smoking status, alcohol consumption, frequency of fresh vegetable intake, frequency of fresh fruit intake, and frequency of red meat intake, the results of unordered multinomial logistic regression analysis showed that compared with residents with a physical activity level of < 12.73 MET-h/d, the risk of pre-frailty was 0.76 times lower (OR = 0.76, 95%CI = 0.72 – 0.80), 0.67 times lower (OR = 0.67, 95%CI = 0.63 – 0.71), and 0.66 times lower (OR = 0.66, 95%CI = 0.62 – 0.69) for those with physical activity levels of 12.73 – 23.19 MET-h/d, 23.20 – 37.29 MET-h/d, and ≥ 37.30 MET-h/d, respectively. …”
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Evaluation of gestational nonpersistent pesticide exposure with newborn size and gestational length in rural Ghana using a novel time-varying extension of multiple informant models by Wylie BJ, Kaali S, Duttweiler L, Ae-Ngibise KA, Mujtaba M, Tawiah C, Gibson E, Calafat AM, Ospina M, Jack DJ, Agyei O, Lee AG, Roberts DJ, Boamah-Kaali EA, Factor-Litvak P, Modest AM, Hauser R, Coull BA, Asante KP

“…We estimated associations of biomarker concentrations with newborn anthropometrics and gestational length, adjusting for confounders and exploring effect modification by infant sex and placental malaria. Results: 1,211 pregnant women contributed 3,786 gestational urinary samples. …”
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Correlates of mental health of people living with HIV co-infected with SARS-CoV-2: findings from the COVIDHIV study in France by Issifou Yaya, Issifou Yaya, Yvenie Amboise, Yvenie Amboise, Guillaume Roucoux, Guillaume Roucoux, Lisa Yombo-Kokule, Lisa Yombo-Kokule, Fabienne Marcellin, Claudine Duvivier, Claudine Duvivier, Karine Lacombe, Karine Lacombe, James W. Griffith, James W. Griffith, Marie Préau, Antoine Cheret, Antoine Cheret, Martin Duracinsky, Martin Duracinsky, Martin Duracinsky

“…In multivariable regression adjusted for sex, COVID-19 wave and duration between COVID-19 confirmation and enrolment, age (adjusted odds-ratio (aOR): 0.97 [0.95-0.99]), being professionally active (0.43 [0.25-0.75]), and the number of self-reported symptoms (1.17 [1.11-1.24]) were associated with anxiety. …”
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Association of chronic heart failure with mortality in old intensive care patients suffering from Covid‐19 by Raphael Romano Bruno, Bernhard Wernly, Georg Wolff, Jesper Fjølner, Antonio Artigas, Bernardo Bollen Pinto, Joerg C. Schefold, Detlef Kindgen‐Milles, Philipp Heinrich Baldia, Malte Kelm, Michael Beil, Sigal Sviri, Peter Vernon vanHeerden, Wojciech Szczeklik, Arzu Topeli, Muhammed Elhadi, Michael Joannidis, Sandra Oeyen, Eumorfia Kondili, Brian Marsh, Finn H. Andersen, Rui Moreno, Susannah Leaver, Ariane Boumendil, Dylan W. De Lange, Bertrand Guidet, Hans Flaatten, Christian Jung, COVIP study group

“…After multivariate adjustment for confounders (SOFA, age, sex, and frailty), no independent association of CHF with mortality remained [adjusted odds ratio (aOR) 1.2, 95% CI 0.5–1.5; P = 0.137]. …”
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Enhancing clinical and public health interpretation of accelerometer-assessed physical activity with age-referenced values based on UK Biobank data by Alex V. Rowlands, Andrew P. Kingsnorth, Bjørge H. Hansen, Stuart J. Fairclough, Lynne M. Boddy, Benjamin D. Maylor, Henrik R. Eckmann, Borja del Pozo Cruz, Nathan P. Dawkins, Cameron Razieh, Kamlesh Khunti, Francesco Zaccardi, Tom Yates

“…Average acceleration and intensity gradient were derived as proxies for PA volume and intensity. We generated sex-specific centile curves using Generalized Additive Models for Location Scale and Shape (GAMLSS) and modeled the effect of adding moderate (walking) or vigorous (running) activity on the combined change in the volume and intensity centiles (change in PA profile). …”
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Gestational exposure to environmental chemical mixtures and cognitive abilities in children: A pooled analysis of two North American birth cohorts by Jagadeesh Puvvula, Wei-Ting Hwang, Lawrence McCandless, Changchun Xie, Joseph M. Braun, Ann M. Vuong, Youssef Oulhote, Enrique F. Schisterman, Russell T. Shinohara, Linda Booij, Maryse F. Bouchard, Kristin Linn, Michael M. Borghese, Jean R. Seguin, Angelika Zidek, Christine Till, William Fraser, Kimberly Yolton, Kim M. Cecil, Jillian Ashley-Martin, Tye E. Arbuckle, Bruce Lanphear, Aimin Chen

“…Although statistical significance was not attained for child sex as an effect modifier, our stratified analysis unveiled a moderate divergence in association trends. …”
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Risk factors associated with in-hospital mortality during yellow fever outbreak in Brazil by Max McClure, Izabela Maurício de Rezende, Leonardo Soares Pereira, Maria Rita Teixeira Dutra, Jordana Rodrigues Barbosa Fradico, Rodrigo Macedo, Marcelle Cardoso Marçal, Lívia Soares Coelho Fonte Boa, Alexandre Maurício Castro Bragato, Flávio Augusto de Almeida Faria, Livia Pamplona, Rodrigo Fabiano do Carmo Said, Carlos Eduardo Calzavara-Silva, Dario Brock Ramalho, Cintia Lopes de Brito Magalhães, Pedro Augusto Alves, Thaysa Drummond Palmeira Gama, Gláucia Fernandes Cota, Thomas P. Monath, Olindo Assis Martins-Filho, Marcelo Antônio Pascoal-Xavier, Andrea Teixeira-Carvalho, Betânia Paiva Drumond, A. Desiree LaBeaud, Yellow Fever Collaborative Group, Argus Leão Araújo, Barbara Lenoir, Bruno Dala Vedova Gomes Beato, Carolina Lins Rodrigues Vieira, Daniel Vitor de Vasconcelos Santos, Flavia Mansur Starling, Gabriela Miana de Mattos Paixão, Indiara Penido, Izabela Aparecida Coelho, Leandro Henrique Malta Cunha, Letícia Menezes, Livia Frota Rabelo, Letícia Lemos Jardim, Lívia Fulgêncio da Cunha Melo, Lívia Zignago Moreira dos Santos, Ludmila de Paula, Luísa Lages de Abre Paladino, Natalia Soares Albuquerque, Simone Lopes Oliveira Lemos, Tayrine Araújo

“…Age was significantly higher in fatal (median 49.5, IQR 41.0, 61.0]) than in non-fatal cases [46 (36, 55)] (p &lt; 0.01). Male sex was associated with an increased risk of death (RR 4.66, 95% CI 1.19, 18.2; p &lt; 0.01). …”
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Associations of sociodemographic and smoking characteristics with intention to quit among Chinese adults aged 20–69 years who smoke: Findings from nationwide China Health Literacy... by Zhen-xiao Huang, Ying-hua Li, Ying Xie, Yi Liu, Zheng Su, Xin Xia, Dan Xiao, Chen Wang

“…ItQ was significantly associated with smoking characteristics, including occasional smoking (OR = 2.08, 95 % CI = 1.88–2.20), fewer pack-years (OR = 0.70, 95 % CI = 0.68–0.73), older smoking initiation age (OR = 1.22, 95 % CI = 1.18–1.27), and ICD-10 Nicotine dependence (OR = 1.12, 95 % CI = 1.06–1.19), as well as age, sex, socioeconomic factors, and health status. Withdrawal symptoms were positively associated with ItQ in individuals who smoke without ICD-10 Nicotine dependence but negatively in those with ICD-10 Nicotine dependence. …”
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