Resistome phylodynamics of multidrug-resistant Shigella isolated from diarrheal patients by Asaduzzaman Asad, Md. Abu Jaher Nayeem, Md. Golam Mostafa, Ruma Begum, Shah Nayeem Faruque, Suraia Nusrin, Israt Jahan, Shoma Hayat, Zhahirul Islam

“…The MDR plasmids and resistant GIs were phylogenetically relevant to Europe, USA, or China-derived isolates, indicating carry-over of the emerging ARGs from heavily industrialized countries and MSM-burdened (men who have sex with men) populations. The global burden of resistance GIs has increased sharply, especially after 2014. …”
Get full text

Mitochondrial oxygen metabolism as a potential predictor of weight loss after laparoscopic sleeve gastrectomy for class III obesity by Markus Engelmann, Markus Engelmann, Juliane Götze, Juliane Götze, Philipp Baumbach, Philipp Baumbach, Charles Neu, Charles Neu, Utz Settmacher, Michael Ardelt, Hermann Kissler, Sina M. Coldewey, Sina M. Coldewey

“…We compared the values obtained in patients with obesity with those of age- and sex-matched healthy controls and investigated changes up to one year after LSG. 48 patients (46.5 years [35.5-55.3]; 38/48 female (79.2%); BMI 46.7 [42.5-51.0]) completed the study. …”
Get full text

Association of Cardiovascular Risk Factors With Major and Minor Electrocardiographic Abnormalities: A Report From the Cross‐Sectional Phase of Tehran Cohort Study by Pooria Ahmadi, Sajjad Ahmadi‐Renani, Parmida Sadat Pezeshki, Sepehr Nayebirad, Arash Jalali, Akbar Shafiee, Aryan Ayati, Arian Afzalian, Farshid Alaeddini, Soheil Saadat, Farzad Masoudkabir, Ali Vasheghani‐Farahani, Saeed Sadeghian, Mohamamdali Boroumand, Abbasali Karimi, Boshra Pourbashash, Kaveh Hosseini, Frits R. Rosendaal

“…In contrast, intermediate (OR = 0.69; 95% CI: 0.57–0.84) and high physical activity levels (OR = 0.66; 95% CI: 0.51–0.86) were associated with a lower prevalence of major abnormalities. Male sex, older age, hypertension, and current smoking were also associated with an increased prevalence of ECG abnormalities combined (major or minor). …”
Get full text

Effect of retirement on the body mass index in China: a nationwide study based on the regression discontinuity design by Jiarun Mi, Xueyan Han, Hanchao Cheng, Zhaoyang Pan, Jian Guo, Hailu Zhu, Qi Wang, Yicong Wang, Yuanli Liu, Congyi Zheng, Xin Wang, Xue Cao, Zhen Hu, Yixin Tian, Zengwu Wang, Tianjia Guan

“…Additionally, the study examined variations in the effects of retirement among groups stratified by sex and educational attainment. Results The fully adjusted model suggested that retirement did not have a significant impact on the BMI or overweight and obesity rates of the overall population. …”
Get full text

Examining the impact of a community-based exercise intervention on cardiorespiratory fitness, cardiovascular health, strength, flexibility and physical activity among adults living... by Kelly K O'Brien, Aileen M Davis, Soo Chan Carusone, Lisa Avery, Ada Tang, Patricia Solomon, Rachel Aubry, Mehdi Zobeiry, Ivan Ilic, Zoran Pandovski, Ahmed M Bayoumi

“…We used segmented regression (adjusted for baseline age and sex) to assess the change in trend (slope) among phases. …”
Get full text

Seroconversion and dynamics of IgG anti-SARS-CoV-2 antibodies during the pandemic: A two-month observation cohort study on the population of Sleman in Indonesia. by Jajah Fachiroh, Septi Kurnia Lestari, Dewi Kartikawati Paramita, Bagas Suryo Bintoro, Fatwa Sari Tetra Dewi, Lutfan Lazuardi, Cici Permata Rusadi, Erti Nur Sagenah, Eggi Arguni

“…Descriptive analysis showed that sex, marital status, smoking habits, obesity, vaccination status, and preventive measures were different between the IgG anti-RBD-SARS-CoV-2 seropositive and negative individuals (p≤ 0.05). …”
Get full text

Cardiovascular risk associated with glucagon-like peptide-1 receptor agonists versus other conventional glucose-lowering drugs in patients with type-2 diabetes: protocol for a nati... by François Schiele, Mikael Mazighi, Nicolas Danchin, Igor Sibon, Gilles Lemesle, Kamel Mohammedi, Laurent Fauchier, Bruno Detournay, Alexandre Caron, Corinne Emery, Camille Nevoret, Lucile Vigié, Christine Massien

“…Comparative analyses will be conducted versus these control groups, adjusting for cardiovascular event history and a propensity score considering age, sex, area of residence, deprivation index, comorbidities, duration of diabetes, use of lipid-lowering drugs, anticoagulants, antiplatelet therapies and blood pressure-lowering therapies. …”
Get full text

Incidence and contributing factors of dementia among people living with HIV in British Columbia, Canada, from 2002 to 2016: a retrospective cohort study by Rolando Barrios, Julio S G Montaner, Silvia Guillemi, Ni Gusti Ayu Nanditha, Viviane D Lima, Thomas L Patterson, Fidel Vila-Rodriguez, William G Honer, Jason Trigg, Hasan Nathani, Sara Shayegi-Nik, Weijia Yin, Alejandra Fonseca, Bronhilda T Takeh

“…The crude 15-year prevalence of dementia was 2.1%, and the age–sex standardised incidence rate of dementia was 4.3 (95% CI: 4.2 to 4.4) per 1000 person-years. …”
Get full text

Predicted impact of banning nonessential, energy-dense food and beverages in schools in Mexico: A microsimulation study. by Ana Basto-Abreu, Martha Carnalla, Francisco Reyes-Sánchez, Alan Reyes-García, Michelle M Haby, Isabel Junquera-Badilla, Lianca Sartoris-Ayala, Juan A Rivera, Barry M Popkin, Tonatiuh Barrientos-Gutiérrez

“…The TEI after the intervention was estimated under 4 scenarios: (1) using national data to inform the intervention effect; (2) varying law compliance; (3) using meta-analytic data to inform the intervention effect size on calories; and (4) using national data to inform the intervention effect by sex and socioeconomic status (SES). We used Hall's microsimulation model to estimate the potential impact on body weight and obesity prevalence of children and adolescents 1 year after implementing the intervention in Mexican schools. …”
Get full text

Subclinical Plasmodium spp. Infections in a Community Setting in Bangui, Central African Republic by Nzoumbou-Boko R, Denissio Morissi Nalingbo MCI, Yambiyo BM, Detol R, Moussa ERF, Nalinga D, Namsenei-Dankpea LJVDLG, Manirakiza A, Ayong L, Boum II Y

“…Proportions of positive tests for malaria parasites were determined by combining the results of antigen-based malaria rapid diagnostic test (mRDT), thick blood smear microscopy, and polymerase chain reaction (PCR).Results: A total of 638 participants (mean age, 26.44 years (range, [1– 75] years) with a sex ratio (M/F) of 1.22) were tested for malaria using all three detection methods. …”
Get full text

Real-world, feasibility study to investigate the use of a multidisciplinary app (Pulsara) to improve prehospital communication and timelines for acute stroke/STEMI care by Joosup Kim, Dominique A Cadilhac, Karen Smith, Ramesh Sahathevan, Stephen Bernard, Dion Stub, Voltaire Nadurata, Ernesto Oqueli, Thomas Kraemer, Chris F Bladin, Kathleen L Bagot, Michelle Vu, Grant Hocking, Tessa Coupland, Debra Pearce, Diane Badcock, Marc Budge, Wayne Pearce, Howard Hall, Ben Kelly, Angie Spencer, Pauline Chapman, Casey Hair

“…Assessment and treatment times were recorded for 12 months (May 2017–April 2018), with timelines compared between ‘Pulsara initiated’ (Pulsara) and ‘not initiated’ (no Pulsara).Primary outcome measure Door-to-treatment (needle for stroke, balloon for STEMI) Secondary outcome measures: ambulance and hospital processes.Results Stroke (no Pulsara n=215, Pulsara n=389) and STEMI (no Pulsara n=76, Pulsara n=171) groups were of similar age and sex (stroke: 76 vs 75 years; both groups 50% male; STEMI: 66 vs 63 years; 68% and 72% male). …”
Get full text

Utilisation of alcohol-related treatment after a first alcohol use disorder diagnosis in Hamburg, Germany by Jakob Manthey, Kilian Huß, Sven Buth, Ludwig Kraus, Anna Schranz, Carolin Kilian, Jürgen Gallinat, Ingo Schäfer, Bernd Schulte

“…Treatment utilisation was associated with younger age, female sex, unemployment, German nationality, and lower physical comorbidity. …”
Get full text

Delta radiomics modeling based on CTP for predicting hemorrhagic transformation after intravenous thrombolysis in acute cerebral infarction: an 8-year retrospective pilot study by Xiaxia Wu, Xiaxia Wu, Jinfang Yang, Jinfang Yang, Xianqun Ji, Yingjian Ye, Ping Song, Lina Song, Peng An, Peng An

“…These were combined with baseline patient data (e.g., age, sex, NIHSS score, medical history) to establish various models for predicting HT-ACI through multivariable logistic regression analysis. …”
Get full text

Promotion of microfracture-mediated cartilage repair by the intra-articular injection of Mg2+ by Zhian Chen, Tianhua Zhou, Zhengbo Yin, Peiya Duan, Ying Zhang, Yujiao Feng, Rongmao Shi, Yongqing Xu, Rongqing Pang, Hongbo Tan

“…The RT-qPCR results showed that sirtuin 1/bone morphogenetic protein-2/sex-determining region Y box 9 (SIRT1/BMP-2/SOX-9) and hypoxia-inducible factor 1-alpha (HIF-1α) messenger RNA levels were up-regulated after Mg2+ injection. …”
Get full text

Type 2 diabetes mellitus’ impact on heart failure patients’ exercise tolerance: a focus on maximal fat oxidation during exercise by Huiying Zhu, Huiying Zhu, Jianchao Pan, Jianxuan Wen, Jianxuan Wen, Xiaojing Dang, Xiaojing Dang, Xiankun Chen, Xiankun Chen, Yunxiang Fan, Yunxiang Fan, Weihui Lu, Weihui Lu, Wei Jiang, Wei Jiang

“…After adjusting for age, sex, body mass index (BMI), log N-terminal pro-B type natriuretic peptide (log NT-proBNP), left ventricular ejection fraction (LVEF), hemoglobin, renal function, coronary heart disease and hypertension, the peak VO2 was lower in the T2DM group compared to the non-T2DM group with a mean difference (MD) of −2.0 ml/kg/min [95% confidence interval (CI), −3.18 to −0.82, P < 0.01]. …”
Get full text

Blood levels of cytokines highlight the role of inflammation in Alzheimer's disease by Lorenzo Campanelli, Pablo Galeano, Federico A. Prestia, Carolina Cuesta, Maria C. Dalmasso, María Flores-López, Cristian Gona, Nicolás Irureta, Claudia Kairiyama, Julieta Lisso, Antonio Jesús López-Gambero, Ines Mintz, Nancy Medel, Karen S. Campuzano, Carolina Muchnik, Gisela V. Novack, Natividad Olivar, Ivana Quiroga, Nerea Requena-Ocaña, Jose Antonio Reyes-Bueno, Pedro Serrano-Castro, Zulma Sevillano, Patricia Solis, Juan Suárez, Ivana Villella, Nancy Wukitsevits, Eduardo M. Castaño, Fernando Taragano, Silvia Kochen, Daniel G. Politis, Luis I. Brusco, Fernando Rodríguez de Fonseca, Laura Morelli

“…Non-parametric MANCOVA showed that sex and diagnosis affected cytokine levels in the blood. …”
Get full text

Could cough hypersensitivity symptom profile differentiate phenotypes of chronic cough? by Mi-Yeong Kim, Ha-Kyeong Won, Ji-Yoon Oh, Ji-Hyang Lee, Eun-Jung Jo, Sung-Yoon Kang, Ji-Ho Lee, Seung-Eun Lee, Noeul Kang, Young-Chan Kim, Hwa Young Lee, Jin An, Youngsang Yoo, Ji-Su Shim, So-Young Park, Han-Ki Park, Min-Hye Kim, Sae-Hoon Kim, Sang-Heon Kim, Yoon-Seok Chang, Sang-Hoon Kim, Byung-Jae Lee, Surinder S. Birring, Woo-Jung Song

“…Baseline CHQ scores were similar between the groups (8.3±3.7 in asthmatic cough versus 8.9±3.9 in RCC; p=0.215, adjusted for age, sex and LCQ score). There were no significant between-group differences in the LCQ and cough severity Visual Analog Scale scores. …”
Get full text

Reduction of intestinal RIPK1 ameliorates HFD-induced metabolic disorders in female mice by Ye Yuan, Xiaomin Hu, Chunguang Guo, Yihua Xu, Shihan Li, Wei Wen, Xinli Hu, Fanxin Zeng, Weiyi Cui, Wenli Chen, Xueting Sun, Ning Hou, Jue Wang, Rui-Ping Xiao, Xiuqin Zhang

“…These findings demonstrate a new, sex-specific intestinal regulatory mechanism and highlight the critical role of intestinal RIPK1 in regulating HFD-induced metabolic disorders in females.…”
Get full text

Incidence and prevalence of traumatic and non-traumatic wounds and burns and access to wound care in Sierra Leone; data from a nationwide household survey (PRESSCO) 2020 by Jonathan H. Vas Nunes, Alex J. van Duinen, Daniel Boateng, Amidu J. Tommy, Osman Sankoh, Martin P. Grobusch, Håkon A. Bolkan

“…Risk factors for developing a wound were male sex (p = 0.004), older age (p = 0.037) and smoking (p = 0.001). …”
Get full text

Investigating heterogeneity across autism, ADHD, and typical development using measures of cortical thickness, surface area, cortical/subcortical volume, and structural covariance by Younes Sadat-Nejad, Younes Sadat-Nejad, Marlee M. Vandewouw, Marlee M. Vandewouw, R. Cardy, J. Lerch, J. Lerch, J. Lerch, M. J. Taylor, M. J. Taylor, A. Iaboni, C. Hammill, B. Syed, J. A. Brian, J. A. Brian, E. Kelley, E. Kelley, E. Kelley, M. Ayub, J. Crosbie, J. Crosbie, R. Schachar, R. Schachar, S. Georgiades, R. Nicolson, E. Anagnostou, E. Anagnostou, A. Kushki, A. Kushki

“…We integrated cortical thickness, surface area, and cortical/subcortical volume, with a measure of single-participant structural covariance using a graph neural network approach.ResultsOur findings suggest two large clusters, which differed in measures of adaptive functioning (χ2 = 7.8, P = 0.004), inattention (χ2 = 11.169, P < 0.001), hyperactivity (χ2 = 18.44, P < 0.001), IQ (χ2 = 9.24, P = 0.002), age (χ2 = 70.87, P < 0.001), and sex (χ2 = 105.6, P < 0.001).DiscussionThese clusters did not align with existing diagnostic labels, suggesting that brain structure is more likely to be associated with differences in adaptive functioning, IQ, and ADHD features.…”
Get full text