Prevalence of daily fruit and vegetable intake by socio-economic characteristics, women’s empowerment, and climate zone: an ecological study in Latin American cities by Giovanna Valentino, Amy H. Auchincloss, Binod Acharya, Natalia Tumas, Nancy López-Olmedo, Ana Ortigoza, Mariana Carvalho de Menezes, María Fernanda Kroker-Lobos, Carolina Nazzal

“…Using a mixed-effects model, we estimated age and sex-standardised city prevalences of daily F&V intake. …”
Get full text

Studying the Digital Intervention Engagement–Mediated Relationship Between Intrapersonal Measures and Pre-Exposure Prophylaxis Adherence in Sexual and Gender Minority Youth: Second... by Michael P Williams, Justin Manjourides, Louisa H Smith, Crissi B Rainer, Lisa B Hightow-Weidman, Danielle F Haley

“… BackgroundImproving adherence to pre-exposure prophylaxis (PrEP) via digital health interventions (DHIs) for young sexual and gender minority men who have sex with men (YSGMMSM) is promising for reducing the HIV burden. …”
Get full text

Risk Factors for Gastrointestinal Bleeding in Patients With Acute Myocardial Infarction: Multicenter Retrospective Cohort Study by Yanqi Kou, Shicai Ye, Yuan Tian, Ke Yang, Ling Qin, Zhe Huang, Botao Luo, Yanping Ha, Liping Zhan, Ruyin Ye, Yujie Huang, Qing Zhang, Kun He, Mouji Liang, Jieming Zheng, Haoyuan Huang, Chunyi Wu, Lei Ge, Yuping Yang

“…Stratified analyses by sex, age, occupation, marital status, and other subgroups consistently showed that the association between CHD and GIB remained robust across all subgroups. …”
Get full text

Demographic and Dietary Determinants of the Association between Dietary Fiber Intake and Obesity in Japanese Adults with Type 2 Diabetes: A Cross-Sectional Study (JDDM 78) by Efrem d'Ávila Ferreira, Mariko Hatta, Laymon Khin, Izumi Ikeda, Mizuki Takeuchi, Yasunaga Takeda, Sakiko Yoshizawa Morikawa, Chika Horikawa, Noriko Kato, Hiroshi Maegawa, Kazuya Fujihara, Hirohito Sone

“…Further research is needed to understand sex- and age-specific factors in the fiber-obesity relationship in diverse populations. …”
Get full text

Atrial fibrillation outcomes in patients from Asia and non-Asia countries: insights from GARFIELD-AF by Karen Pieper, Xian-hong Fang, Kai Sun, Ajay K Kakkar, Saverio Virdone, Shinya Goto, Gloria Kayani, Zhi-Cheng Jing, John Camm, Chun-Yan Cheng, Tian-Yu Lian, Xi-Jie Zhu, Xian-Mei Li

“…Average age and prevalence of cardiovascular comorbidities were lower than in non-Asian countries and patients at high risk of stroke (ie, CHA2DS2-VASc≥2 excl. sex) were less frequently anticoagulated (60.1% vs 73.2%). …”
Get full text

Association between Atopic Dermatitis and Dementia: Evidence from Systematic Review, Meta-analysis, and Mendelian Randomization by Yeon-Su Gwak, Seo-Yeon Kim, Chae-Eon Woo, Kihyuk Shin, Eunjeong Son, Jin-Woo Kim, Sung-Jin Kim, Tae-Jin Song, Hae Ryoun Park, Kihun Kim, Dai Sik Ko, Yun Hak Kim

“…The adjustment accounted for various factors, including sex, age, smoking status, and other medical comorbidities, along with several additional variables. …”
Get full text

Mineralocorticoid axis activity and cardiac remodeling in patients with ACTH-dependent Cushing’s syndrome by Peter Wolf, Simon Travers, Oliver Domenig, Stephanie Baron, Anne Blanchard, Khaoula Bouazizi, Nadjia Kachenoura, Sylvie Salenave, Marko Poglitsch, Alban Redheuil, Severine Trabado, Jacques Young, Philippe Chanson, Peter Kamenický

“…Methods: In this ancillary study of our previous study prospectively investigating patients with ACTH-dependent Cushing’s syndrome by cardiac magnetic resonance imaging (NCT02202902), 11 patients without any interfering medication were cross-sectionally compared to 20 control subjects matched for age, sex and body mass index. Angiotensin metabolites and adrenal steroids were measured by liquid chromatography tandem mass spectrometry, and their relation to blood pressure and cardiac structure was evaluated. …”
Get full text

Effect of prehospital physician presence on Out-of-Hospital cardiac arrest (OHCA) patients undergoing extracorporeal cardiopulmonary resuscitation (ECPR): A secondary analysis of t... by Futoshi Nagashima, Satoshi Inoue, Tomohiro Oda, Tomohiro Hamagami, Tomoya Matsuda, Makoto Kobayashi, Akihiko Inoue, Toru Hifumi, Tetsuya Sakamoto, Yasuhiro Kuroda

“…Propensity score matching (PSM) was performed using six covariates (age, sex, witness status, presence of bystander CPR, initial heart rhythm, and location of cardiac arrest) to adjust for baseline differences. …”
Get full text

Analysis of the relationships between the degree of migraine with right-to-left shunts and changes in white matter lesions and brain structural volume by Xin Pan, Haoran Ren, Lili Xie, Yu Zou, Furong Li, Xiaowen Sui, Li Cui, Zhengping Cheng, Jiaojiao Wu, Feng Shi, Hongling Zhao, Shubei Ma

“…The brain structural volumes of 102 migraineurs with RLS were calculated from T1-weighted images via artificial intelligence, and the brain structural volumes of healthy controls matched according to age and sex were also calculated. The correlations among WML location, RLS, headache degree, WML severity and brain structural volume changes in migraineurs were analyzed. (1) The WMLs of migraineurs with RLS were concentrated mainly in the white matter of the lateral ventricular margin and deep white matter. …”
Get full text

Distinct response patterns of endothelial markers to the BNT162b2 mRNA COVID-19 booster vaccine are associated with the spike-specific IgG antibody production by Beatriz Castro-Robles, Francisco J. Cimas, Francisco J. Cimas, Lourdes Arias-Salazar, Jesús Ontañón, Julia Lozano, Susana López-López, Fernando Andrés-Pretel, María Ángeles Requena-Calleja, Antonio Mas, Antonio Mas, Antonio Mas, Gemma Serrano-Heras, Tomás Segura, Tomás Segura, Javier Solera

“…Incremental and decremental response groups did not differ in terms of age, sex, cardiovascular risk factors, previous SARS-CoV-2 infection and influenza vaccine co-administration. …”
Get full text

Comparison of Influence of Office and 24‐h Central Aortic Blood Pressure on Target Organ Damage in Hypertension by Yueliang Hu, Hui Yang, Guili Chang, Yaya Bai, Alberto Avolio, Qian Wang, Shenshen Gao, Junli Zuo

“…When accounting for confounding factors (age, sex, BMI, triglycerides, total cholesterol, LDL, glucose, smoking, and heart rate), central systolic (cSBP), diastolic (DBP), and pulse (cPP) pressure obtained with 24‐h monitoring was more strongly correlated with LVMI than office measurements. …”
Get full text

Expression Analysis of Fibronectin Type III Domain-Containing (FNDC) Genes in Inflammatory Bowel Disease and Colorectal Cancer by Tilo Wuensch, Jonas Wizenty, Janina Quint, Wolfgang Spitz, Madeleen Bosma, Olaf Becker, Andreas Adler, Wilfried Veltzke-Schlieker, Martin Stockmann, Sascha Weiss, Matthias Biebl, Johann Pratschke, Felix Aigner

“…The expression of FNDCs and GPR116 was independent of age and sex. Conclusions. FNDC1 and FNDC4 may play a relevant role in the pathobiology of IBD, but none of the investigated FNDCs is regulated in CRC. …”
Get full text

Prevalence of Respiratory Syncytial Virus Infection in Hospitalized COPD Patients in Spain Between 2018–2022 by Rosa María Gómez-García, Javier De-Miguel-Díez, Ana López-de-Andrés, Valentín Hernández-Barrera, Ana Jimenez-Sierra, Natividad Cuadrado-Corrales, José J. Zamorano-León, David Carabantes-Alarcón, Andrés Bodas-Pinedo, Rodrigo Jiménez-García

“…To obtain comparable populations, for each subject with COPD and RSV infection, a subject without an RSV code was selected, with the COPD code in the same diagnostic position (1 to 20), as well as the same year of admission, sex, and age. Results: Among subjects aged ≥40 years, 1,429,288 were identified as having COPD, of whom 5673 also had RSV infection. …”
Get full text

Attitudes toward scale-up of an Intensive Combination Approach to Rollback the Epidemic in Nigerian adolescents (iCARE) intervention for youth in Nigeria: results of a mixed method... by Arthi Kozhumam, Revika Singh, Oche Agbaji, Adedotun Adetunji, Bopo Taiwo, Olayinka Omigbodun, Kehinde Kuti, Agatha David, Sulaimon Akanmu, Folashade Adekambi, Akinsegun Akinbami, Bibilola Oladeji, Babafemi Taiwo, Lisa M. Kuhns, Ogochukwu Okonkwor, Baiba Berzins, Amy K. Johnson, Titilope Badru, Patrick Janulis, Olubusuyi M. Adewumi, Marbella Cervantes, Olutosin Awolude, Robert Garofalo, Aima A. Ahonkhai, Lisa R. Hirschhorn

“…In a 2020–2022 pilot study, iCARE Nigeria, successfully tested a combination intervention incorporating mobile health technology and peer navigation to: 1) improve testing and linkage to HIV care for young men, especially young men who have sex with men (YMSM) and 2) improve medication adherence and treatment outcomes for YLH. …”
Get full text

Associations between left atrial indices and cardiorespiratory and muscular fitness among physically active military personnel by Yen-Chen Lin, Yen-Chen Lin, Pang-Yen Liu, Kun-Zhe Tsai, Kun-Zhe Tsai, Kun-Zhe Tsai, Wei-Chun Huang, Wei-Chun Huang, Wen-Chung Yu, Wen-Chung Yu, Xuemei Sui, Carl J. Lavie, Gen-Min Lin, Gen-Min Lin

“…The top 16% of runners were compared sex-specifically, with the remaining 84% as controls to identify LA discriminators for running capacity. …”
Get full text

Exploring the Impact of the Multimodal CAPABLE eHealth Intervention on Health-Related Quality of Life in Patients With Melanoma Undergoing Immune-Checkpoint Inhibition: Prospective... by Itske Fraterman, Lucia Sacchi, Henk Mallo, Valentina Tibollo, Savannah Lucia Catherina Glaser, Stephanie Medlock, Ronald Cornet, Matteo Gabetta, Vitali Hisko, Vadzim Khadakou, Ella Barkan, Laura Del Campo, David Glasspool, Alexandra Kogan, Giordano Lanzola, Roy Leizer, Manuel Ottaviano, Mor Peleg, Konrad Śniatała, Aneta Lisowska, Szymon Wilk, Enea Parimbelli, Silvana Quaglini, Mimma Rizzo, Laura Deborah Locati, Annelies Boekhout, Lonneke V van de Poll-Franse, Sofie Wilgenhof

“…Baseline HRQoL was on average 10 points higher in the intervention group compared with controls, although equally matched on baseline and clinical characteristics. When correcting for sex, age, disease stage, and baseline scores, an adjusted difference in fatigue of −5.09 (95% CI −15.20 to 5.02, P=P ConclusionsThe intervention showed a limited effect on HRQoL, although there was a small improvement in fatigue at 3 months, as well as information satisfaction. …”
Get full text

Identification of Inflammatory Biomarkers for Predicting Peripheral Arterial Disease Prognosis in Patients with Diabetes by Kian Draper, Ben Li, Muzammil Syed, Farah Shaikh, Abdelrahman Zamzam, Batool Jamal Abuhalimeh, Kharram Rasheed, Houssam K. Younes, Rawand Abdin, Mohammad Qadura

“…Results: The cohort of 392 patients was matched for age, sex, and comorbidities. Five proteins were identified (TNFa: tumor necrosis factor alpha, BMP-10: bone morphogenic protein 10, CCL15/MIP1 delta: chemokine (c-c motif) ligand 15/macrophage inflammatory protein 1 delta, MMP-10: matrix metalloprotease 10, and HTRA2/Omi: HTRA2, also known as Omi) as having a significantly higher level of expression in the DM PAD group. …”
Get full text

Tregs levels and phenotype modifications during Amyotrophic Lateral Sclerosis course by Elisabetta Zucchi, Elisabetta Zucchi, Federico Banchelli, Cecilia Simonini, Sara De Biasi, Ilaria Martinelli, Giulia Gianferrari, Giulia Gianferrari, Domenico Lo Tartaro, Andrea Cossarizza, Andrea Cossarizza, Roberto D’Amico, Roberto D’Amico, Jessica Mandrioli, Jessica Mandrioli

“…However, PD1+Tregs decreased and CD39+Tregs increased over time. Male sex and cholesterol levels were associated with increasing Tregs (%) over time, while monocytes positively affected Treg concentrations. …”
Get full text

The effect of immunosuppression on outcomes in elderly patients with community-acquired pneumonia by Lixue Huang, Bingxuan Weng, Yuanqi Wang, Mengyuan Wang, Yin Mei, Wei Chen, Meng Ma, Jingnan Li, Jianzhen Weng, Yang Ju, Xuefeng Zhong, Xunliang Tong, Yanming Li

“…After adjusting for age, sex, and comorbidities, immunosuppression was significantly associated with a higher risk of 30-day mortality (odds ratio 5.004, 95% CI [2.618–9.530]). …”
Get full text

Low-grade systemic inflammation, but not neuroinflammation, is associated with 12-month postoperative outcome after total hip arthroplasty in patients with painful osteoarthritis:... by Morten R. Blichfeldt-Eckhardt, Claus Varnum, Jørgen T. Lauridsen, Lasse E. Rasmussen, Winnie C. P. Mortensen, Hanne I. Jensen, Henrik B. Vaegter, Kate L. Lambertsen

“…Multiple regression models for each clinical outcome were included for biomarkers in blood and CSF, respectively, including age, sex, BMI, and Kellgren-Lawrence score. Results: Change in OHS was associated with blood concentrations of tumour necrosis factor (TNF), interleukin-8 (IL-8), interleukin-6 receptor (IL-6R), glycoprotein 130 (gp130), and IL-1β (R2 = 0.28, p = 0.006), but not with CSF biomarkers. …”
Get full text