Risk Factors for Fracture in Patients with Coexisting Chronic Kidney Disease and Type 2 Diabetes: An Observational Analysis from the CREDENCE Trial by Tamara K. Young, Nigel D. Toussaint, Gian Luca Di Tanna, Clare Arnott, Carinna Hockham, Amy Kang, Aletta E. Schutte, Vlado Perkovic, Kenneth W. Mahaffey, Rajiv Agarwal, George L. Bakris, David M. Charytan, Hiddo J. L. Heerspink, Adeera Levin, Carol Pollock, David C. Wheeler, Hong Zhang, Meg J. Jardine

“…Independent fracture predictors were older age (hazard ratio [HR] 1.04, confidence interval [CI] 1.01–1.06), female sex (HR 2.49, CI 1.70–3.65), previous fracture (HR 2.30, CI 1.58–3.34), Asian race (HR 1.74, CI 1.09–2.78), vitamin D therapy requirement (HR 2.05, CI 1.31–3.21), HbA1c (HR 1.14, CI 1.00–1.32), prior cardiovascular event (HR 1.60, CI 1.10–2.33), and serum albumin (HR 0.41, CI 0.23–0.74) (lower albumin associated with greater risk). …”
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Increased Mortality After Lower Extremity Amputation in a Danish Nationwide Cohort: The Mediating Role of Postoperative Complications by Brix ATH, Petersen TG, Nymark T, Schmal H, Lindberg-Larsen M, Rubin KH

“…Secondarily, to examine the mediation role of post-amputation complications.Study Design and Setting: With data from the Danish National Patient Registry, 11,695 first-time MLEAs in patients aged ≥ 50 years were identified between January 1, 2010, and December 31, 2021, along with 58,466 unamputated persons matched 1:5 by year of birth, sex, and region of residence. Mediators were identified through diagnosis codes (ICD-10) present in 6 months following MLEA.Results: The increased mortality following MLEA was highest in the month following MLEA, hazard ratio (HR) 38.7 (95% confidence interval (CI) 30.5– 48.9) in women and HR 55.7 (CI 44.3– 70.2) in men compared to a matched unamputated cohort. …”
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Self-assessed depressive symptoms in adolescents comparing two Swedish cohorts born 15 years apart by Carl Wikberg, Pia Augustsson, Marcus Praetorius Björk, Tord Ivarsson, Gudny Sveinsdottir, Eiríkur Örn Arnarson, W. Edward Craighead, Ina Marteinsdottir, Josefine Lilja

“…However, the later cohort exhibited higher scores on three CDI items (''Nothing is fun at all,'' ''I am bad all the time,'' ''I can never be as good as other kids'') and in the sub-domain of self-deprecation. Sex differences were observed, with girls scoring higher than boys in both cohorts. …”
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EPIGENETICS TODAY AND TOMORROW by B. F. Vanyushin

“…It is regulated by hormones and aging-related changes, being one of the mechanisms controlling cellular and sex differentiation. DNA methylation controls all genetic functions: DNA replication, recombination, repair, transcription and others. …”
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Transmantle pressure under the influence of free breathing: non-invasive quantification of the aqueduct pressure gradient in healthy adults by Pan Liu, Kimi Owashi, Heimiri Monnier, Serge Metanbou, Cyrille Capel, Olivier Balédent

“…The relationships between aqueduct resistance and flow rates and ΔP driven by cardiac and breathing activity were analysed, including a sex difference analysis. Results The aqueduct resistance was 78 ± 51 mPa·s/mm³. …”
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Family history of cardiovascular disease and death in patients with out-of-hospital cardiac arrest by Magnus Gylling, Johanna Krøll, Peder Emil Warming, Carolina Malta Hansen, Fredrik Folke, Steen M. Hansen, Lars Køber, Christian Torp-Pedersen, Rodrigue Garcia, Jacob Tfelt-Hansen, Peter E. Weeke

“…Patients with OHCA were matched 1:4 (age, sex, and number of identifiable parents) with individuals from the background population (controls) to compare family histories (events in first-degree relatives before OHCA) of CVD, all-cause death, cardiovascular death, and premature death (death <60 years). …”
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Sessile Serrated Lesions: Searching for the True Prevalence and Risk Factors in China by Bing-Yue Yao, Li Zhang, Chuan-Xia Wu, Liang Zheng, Ben-Song Duan, Qin-Wei Xu, Jing-Jing Lian, Hai-Bin Zhang, Yu Wang, Jia Cao

“…Data were sourced through the electronic medical record system and included information such as age, sex, lesion location, number, and pathology. This study predominantly focused on the detection rate and the clinical and endoscopic features of SSL. …”
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High HDL-C and high LDL-C are risk factors of pterygium in a population-based cross-sectional study in Southern China: the Dongguan Eye Study by Liang Zhang, Min Zhang, Ying Cui, Lixin Zhang, Guanrong Zhang, Qingyang Liu, Haike Guo, Qianli Meng, Siwen Zang, Chun-Han Lo, Yanlei Chen, Jin Zeng

“…The prevalence of pterygium was 17.3% after adjusting the sex and age distribution, 22.0% in participants with hypercholesterolaemia (total cholesterol ≥6.22 mmol/L (240 mg/dL)) and 21.8% in those with low-density lipoprotein-cholesterol (LDL-C) ≥4.14 mmol/L (160 mg/dL), respectively. …”
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Differences and analogies in thyroid cancer discovered incidentally or by thyroid-related screening: a multicenter study by Laura Croce, Rosaria Maddalena Ruggeri, Camilla Virili, Carlo Cappelli, Marsida Teliti, Pietro Costa, Spyridon Chytiris, Antonio Nicocia, Francesca Coperchini, Maria Flavia Bagaglini, Flavia Magri, Alfredo Campennì, Mario Rotondi

“…Measurements: Data on pre-surgery reasons leading to TC diagnosis, age, sex, BMI, presence of cardiometabolic comorbidities and non-thyroid cancer were collected. …”
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Machine learning-based plasma metabolomics for improved cirrhosis risk stratification by Jingru Song, Ziwei Gao, Liqun Lai, Jie Zhang, Binbin Liu, Yi Sang, Siqi Chen, Jiachen Qi, Yujun Zhang, Huang Kai, Wei Ye

“…Several metabolites showed an independent association with cirrhosis events (68 out of 168 metabolites after adjustment for age and sex, and 21 out of 168 metabolites after full adjustment). …”
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Effectiveness of lateral femoral cutaneous and femoral nerve block in managing postoperative pain for hemiarthroplasty patients by Kazi Mahzabin Arin, Shofina Sultana, Ayesha Sultana, Abdul Hannan Mohammad, Chandra Shekhar Karmakar, AKM Akhtaruzzaman

“…Adjusted time based on age, sex, body mass index, and Anesthesiologists class for the FIC block group was 6.8 (0.9) hours, while the LFCN plus FN block group recorded 7.5 (0.8) hours (P=0.003). …”
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The clinical impact of conventional therapies for adults and adolescents suffering from eosinophilic esophagitis, a type 2 inflammatory chronic disease, and their economic conseque... by Giorgio Walter Canonica, MD, Gherardo Mazziotti, MD, PhD, Alessandro Repici, MD, Massimiliano Povero, PhD, Luca Castello, MSc, Lorenzo Pradelli, MD, Miryana Dobreva, MSc, Francesca Fanelli, MSc, Jean Pierre Saab, MD, Edoardo Vincenzo Savarino, MD, PhD

“…Treatment outcomes varied by sex and presence of atopic conditions. TCSs discontinuation increased the risk of clinical relapse (0.70 cases per person-year), whereas continuous use was linked to a rise in nonserious adverse events (dilation, infections, upper respiratory tract infections, and skin disorders). …”
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Clinical and Onychoscopy Patterns in Fingernail Onychomycosis—A Study by the International Dermoscopy Society Trichoscopy And Onychoscopy Task Force by Matilde Iorizzo, Bianca Maria Piraccini, Aurora Alessandrini, Francesca Bruni, Laura Vollono, Francesca Pampaloni, Nilton Gioia Di Chiacchio, Nilton Di Chiacchio, Juan Jimenez-Cahue, Chander Grover, Zoe Apalla, Asmahne Souissi, Awatef Kelati, Eirini Kyrmanidou, Elizabeth Lazaridou, Michela Starace

“…Data collected included age, sex, affected hand, affected fingernails, isolated fungal microorganism, clinical, and onychoscopic signs. …”
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Positive Antithyroid Antibodies and Nonsuppressed TSH Are Associated with Thyroid Cancer: A Retrospective Cross-Sectional Study by Jan Krátký, Jana Ježková, Mikuláš Kosák, Hana Vítková, Jana Bartáková, Miloš Mráz, Jindřich Lukáš, Zdenka Límanová, Jan Jiskra

“…Totally, 91 patients with primary TC and 182 sex- and age-matched controls were included. Positive antithyroid peroxidase (anti-TPO) and antithyroglobulin (anti-Tg) antibodies were associated with TC (anti-TPO 44% in TC vs. 27% in controls, P=0.005, anti-TG 35% in TC group vs. 21% in controls, P=0.018), and the TC group had significantly higher TSH (median 1.88 mIU/l vs. 1.21 mIU/l, P<0.001). …”
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Cross-sectional design and protocol for Artificial Intelligence Ready and Equitable Atlas for Diabetes Insights (AI-READI) by Gerald McGwin, Linda M Zangwill, Nicholas Evans, Shannon McWeeney, Cecilia S Lee, Bhavesh Patel, Jeffrey C Edberg, Cynthia Owsley, Aaron Lee, Cecilia Lee, Sally L Baxter, Michael Snyder, Samantha Hurst, Nicole Ehrhardt, Christopher Chute, Dawn S Matthies, Julia P Owen, Amir Bahmani, Sally Baxter, Edward Boyko, Aaron Cohen, Jorge Contreras, Garrison Cottrell, Virginia de Sa, Jeffrey Edberg, Irl Hirsch, Michelle Hribar, T.Y. Alvin Liu, Bonnie Maldenado, Sara Singer, Bradley Voytek, Joseph Yracheta, Linda Zangwill

“…The fundamental rationale for promoting health resilience in T2DM stems from its high prevalence of 10.5% of the world’s adult population and its contribution to many adverse health events.Methods AI-READI is a cross-sectional study whose target enrollment is 4000 people aged 40 and older, triple-balanced by self-reported race/ethnicity (Asian, black, Hispanic, white), T2DM (no diabetes, pre-diabetes and lifestyle-controlled diabetes, diabetes treated with oral medications or non-insulin injections and insulin-controlled diabetes) and biological sex (male, female) (Clinicaltrials.org approval number STUDY00016228). …”
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Global, regional and national sodium intakes in 1990 and 2010: a systematic analysis of 24 h urinary sodium excretion and dietary surveys worldwide by J Lennert Veerman, Sarah Lewis, John Britton, Bruce Neal, Kathryn G Andrews, Goodarz Danaei, Majid Ezzati, Yanping Li, Yu Chen, Farshad Farzadfar, Jean-Michel Gaspoz, Idris Guessous, Lital Keinan-Boker, Paul Elliott, Carukshi Arambepola, Antonia Trichopoulou, Philippos Orfanos, Martin C Gulliford, Renata Micha, Dariush Mozaffarian, Wen-Harn Pan, Shoichiro Tsugane, Habibul Ahsan, Manami Inoue, Luz Maria Sanchez-Romero, Andrew Fogarty, Christos Pitsavos, Edward Giovannucci, Stefaan De Henauw, Stephen S Lim, Cho-il Kim, Inge Huybrechts, Didier Garriguet, Simón Barquera, Katia Castetbon, Neville Calleja, Peilin Shi, Hsing-Yi Chang, Yasuhiro Matsumura, Hubert Barennes, Guansheng Ma, Shahab Khatibzadeh, Saman Fahimi, John Powles, Morteza Abdollahi, Anahita Houshiar-rad, Eda Koksal, Sahar Zaghloul, Sirje Vaask, Ana Baylin, Simon Forsyth, Rosely Sichieri, Christian Haerpfer, Ian Brown, Demosthenes B Panagiotakos, Jacqui Webster, Androniki Naska, Dorothy Gauci, Rebecca E Engell, Tim E Byers, Stephanie Smith-Warner, Ibrahim Elmadfa, Mayuree Rao, Pamela A Abbott, Enrique O Abeyá Gilardon, Suad N Al-Hooti, Wulf Becker, Peter Bjerregaard, Lesley T Bourne, Mario V Capanzana, Melanie J Cowan, Dulitha N Fernando, Regina M Fisberg, Brahmam NV Ginnela, Wilbur Hadden, Daniel J Hoffman, Nahla C Hwalla, Hajah Masni Ibrahim, Maria D Jackson, Lars Johansson, Hae-Jeung Lee, Chan Mei Fen, Gert BM Mensink, Rafael A Monge-Rojas, Balakrishna Nagalla, Marga C Ocke, Maciej Oltarzewski, Marja-Leena Ovaskainen, Gulden Ayla Pekcan, Stefka Petrova, Noppawan Piaseu, Leanne M Riley, Rusidah BT Selamat, Chansimaly Simmala, Laufey Steingrimsdottir, Gillian Swan, Lucjan Szponar, Heli Tapanainen, Robert Templeton, Anastasia Thanopoulou, Holmfridur Thorgeirsdóttir, Inga Thorsdottir, Aida Turrini, Nowak Verena, Anna Waskiewicz, Gábor Zajkás, Shadi Kalantarian, Pattra Wirojratana, Mary Anne Land, Tricia McKeever, Mohannad Abed Alfattah Al Nsour, Medical Science, Heléne Enghardt Barbieri, Aida Filipovic Hadziomeragic, Nur Indrawaty Lipoeto, Stephen T. McGarvey, Abdulrahman Obaid. Musaiger, Luz Gladys. Posada, Elz˙bieta Halina. Sygnowska

“…Dietary estimates were converted to urine equivalents based on 79 pairs of dual measurements.Modelling methods Bayesian hierarchical modelling used survey data and their characteristics to estimate mean sodium intake, by sex, 5 years age group and associated uncertainty for persons aged 20+ in 187 countries in 1990 and 2010. …”
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Models based on dietary nutrients predicting all-cause and cardiovascular mortality in people with diabetes by Fang Wang, Yukang Mao, Jinyu Sun, Jiaming Yang, Li Xiao, Qingxia Huang, Chenchen Wei, Zhongshan Gou, Kerui Zhang

“…The association of key dietary nutrients with all-cause and cardiovascular mortality were visualized by restricted cubic spline (RCS) models both in the whole and subgroups by sex, age, drinking and smoking status. The overall median age of the cohort was 62.0 years (interquartile range (IQR) 52.0–70.0), 2564 (50.67%) being male. …”
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A serosurvey study of hand, foot and mouth disease in healthy children aged 6 to 71 months old in West Bandung and Bandung Region, Indonesia by Rodman Tarigan Girsang, Kusnandi Rusmil, Eddy Fadlyana, Budi Setiabudiawan, Riyadi Adrizain, Rizky Perdana Mulyadi, Arief Budiman, Rona Kania Utami, Behesti Zahra Mardiah, Muhammad Gilang Dwi Putra, Frizka Primadewi Fulendry, Dinda Tiaraningrum Nashsyah, Hadyana Sukandar

“…Results In total, 596 subjects (99.3%) were positive for the seroprevalence of EV71 IgG in rural and urban areas. Child age, sex, nutritional status, height/age, immunisation status, parental income, and father’s and mother’s educations were not statistically related in rural and urban areas (p > 0.05) because the rate of IgG EV71 seropositivity was very high. …”
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Evaluating reproduction traits in a crossbreeding program between indigenous and exotic sheep in semi-arid lands by E. Oyieng, J.M.K. Ojango, M. Gauly, R. Mrode, R. Dooso, A.M. Okeyo, C. Kalinda, S. König

“…LBWT and LWWT were significantly affected by the sex of the lamb, type of birth of the lamb and parity in which the lambs were born in. …”
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Changes in photoperiod during the dry period impact colostrum production in Holstein and Jersey cows by K.J. Alward, A.J. Duncan, A.D. Ealy, G.E. Dahl, C.S. Petersson-Wolfe, R.R. Cockrum

“…Random effects included replicate, lactation number, genetic inbreeding percentage, previous lactation mature equivalent 305-d protein production, and calf sex. For colostrum, Brix score, colostral protein, fat, IgA, and IgM were increased in Jersey cows compared with Holstein cows. …”
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