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2621
Mechanistic insights into Y-Box binding protein-1 mediated regulation of lipid metabolism and oxidative stress in NAFLD via INHBE/TNF-β pathway
Published 2024-12-01“…Our results demonstrated that YB1 is highly expressed in NAFLD. RNA sequencing revealed 798 DEGs between the shCtrl and shYB1 groups, with 190 genes upregulated and 608 genes downregulated. …”
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2622
The Progression of Mycosis Fungoides During Treatment with Mogamulizumab: A BIO-MUSE Case Study of the Tumor and Immune Response in Peripheral Blood and Tissue
Published 2025-01-01“…<b>Methods:</b> We applied 10× genomics-based single-cell RNA sequencing to CD3+ peripheral T-cells, combined with T-cell receptor sequencing, to samples collected at multiple timepoints during the progression of the disease. …”
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2623
Molecular Identification and Antimicrobial Potential of Streptomyces Species from Nepalese Soil
Published 2020-01-01“…In contrast, some Streptomyces species shared identical DNA sequences in multiple copies of 16S rRNA. The sequencing of numerous copies of 16S rRNA is not necessary, and the molecular sequencing of this region is not sufficient for the identification of bacterial species. …”
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2624
Metagenomics: a new frontier for routine pathology testing of gastrointestinal pathogens
Published 2025-01-01“…With the development of newer sequencing assays, it is now feasible to test for a wide range of target organisms in a sample using a single mNGS test. …”
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2625
The role of the microbiota and metabolites in the treatment of pulmonary fibrosis with UC-MSCs: Integrating fecal metabolomics and 16S rDNA analysis.
Published 2025-01-01“…Fecal samples from six mice in each of the Control group, Model group, and UC-MSCs-M groups were collected randomly for 16S rDNA sequencing to analyze the gut microbiota and nontargeted metabolomics.…”
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2626
The N‐terminal domain of gasdermin D induces liver fibrosis by reprogrammed lipid metabolism
Published 2025-01-01“…We analyzed differentially expressed genes by RNA sequencing and explored their biological functions. …”
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2627
A Transcriptomic Dataset of Liver Tissues from Global and Liver-Specific Bmal1 Knockout Mice
Published 2025-02-01“…To explore the transcriptional changes associated with Bmal1 deletion in liver tissues, we collected liver tissues from global and liver-specific Bmal1 knockout mice, along with their respective control groups, at two circadian time points (CT2 and CT14) and used them for transcriptome sequencing analysis. Genotyping, locomotor activity analysis, and comprehensive quality control analyses, including base quality scores, GC content, and mapping rates, confirmed the high quality of sequencing data. …”
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2628
TET2-mediated 5-hydroxymethylcytosine of TXNIP promotes cell cycle arrest in systemic anaplastic large cell lymphoma
Published 2025-01-01“…The ALK-positive cell line, Su-DHL-1, and the ALK-negative cell line, DL-40, were utilized as in vitro experimental models. RNA-sequencing and hMeDIP-sequencing assays were performed to explore the potential functions of TET2 in cell cycle regulation. …”
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2629
Hepatitis E virus infection among blood donors in Ningbo
Published 2025-01-01“…Furthermore, HEV gene sequencing was performed for genotyping analysis, and donors with reactive nucleic acid testing results were followed up to confirm their infection status. …”
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2630
A Missense Mutation in OPA1 Causes Dominant Optic Atrophy in a Chinese Family
Published 2019-01-01“…Four affected family members and one unaffected family member were selected for whole exome sequencing. Sanger sequencing was used to confirm and screen the identified mutation in 18 members of the family. …”
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2631
Intercropping of Saccharum spp. with Dictyophora indusiata: effects on microbial communities and metabolite profiles during bagasse degradation
Published 2025-01-01“…Metabarcoding sequencing showed that DIBA significantly altered the bacterial and fungal communities, reducing microbial diversity. …”
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2632
Novel Compound Heterozygous BBS2 and Homozygous MKKS Variants Detected in Chinese Families with Bardet–Biedl Syndrome
Published 2021-01-01“…Sanger sequencing was used to verify the variants and to perform a segregation analysis. …”
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2633
Chromosome-level genome assembly and annotation of largemouth bronze gudgeon (Coreius guichenoti)
Published 2025-01-01“…Hi-C sequencing data was utilized for chromosome assembly and 25 chromosome sequences were ultimately yielded, with a total length of 1076.8 Mb. …”
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2634
Polysaccharide extract from Rosa laevigata fruit attenuates inflammatory obesity by targeting redox balance and gut interface in high-fat diet-fed rats
Published 2023-03-01“…Moreover, 16S rRNA sequencing coupled with metagenome sequencing showed that RLPs had significantly reduced the ratio of Firmicutes/Bacteroidetes from 8.01 to 2.37, and significantly increased the relative abundances of Alistipes, Prevotella, and Akkermansia from 0.36 %, 1.10 % and 2.61 % to 0.65 %, 2.37 % and 4.42 %, respectively. …”
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2635
The potential role of differentially expressed tRNA-derived fragments in high glucose-induced podocytes
Published 2024-12-01“…In this study, tRFs were identified, and their roles in podocyte injury induced by high-glucose (HG) treatment were explored. High-throughput sequencing of podocytes treated with HG was performed to identify differentially expressed tRFs. …”
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2636
Case Report: Novel ADA2 variants cause atypical adenosine deaminase 2 deficiency
Published 2025-01-01“…Peripheral blood mRNA reverse transcription-Sanger sequencing confirmed that this variant affected mRNA splicing, resulting in a frameshift with premature stop codon c.1083_1103del p. …”
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2637
The impact of glucocorticoid receptor transactivation on context-dependent cell migration dynamics
Published 2025-02-01“…Cell proliferation increased in TN and decreased in ER + cells upon GR activation, reversed by GR antagonist. RNA sequencing revealed dex’s impact on cell adhesion and extracellular matrix signalling in TN cells and on DNA replication in ER + cells. …”
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2638
Wilson and Walker's Principles and Techniques of Biochemistry and Molecular Biology /
Published 2018Table of Contents: “…Biochemical and molecular biological methods in life sciences studies -- Basic principles -- Cell culture techniques -- Recombinant DNA techniques and molecular cloning -- Preparative protein biochemistry -- Electrophoretic techniques -- Immunochemical techniques -- Flow cytometry -- Radioisotope techniques -- Principles of clinical biochemistry -- Microscopy -- Centrifugation and ultracentrifugation -- Spectroscopic techniques -- Basic techniques probing molecular structure and interactions -- Mass spectrometric techniques -- Fundamentals of bioinformatics -- Fundamentals of chemoinformatics -- The python programming language -- Data analysis -- Fundamentals of genome sequencing and annotation -- Fundamentals of proteomics -- Fundamentals of metabolomics -- Enzymes and receptors -- Drug discovery and development.…”
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2639
Perspectives of International Human Epigenome Consortium
Published 2013-03-01“…Epigenome data will cover from whole genome bisulfite sequencing, histone modification, and chromatin access information to miRNA-seq. …”
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2640
Exploration of developmental toxicity mechanism of emerging environmental contaminants
Published 2024-12-01“…In this column, the developmental toxicity mechanisms of various emerging pollutants were studied by employing model animals, big data analysis, and single-cell sequencing. We hope that this column will encourage further research into the developmental toxicity mechanisms of emerging environmental contaminants and provide a scientific base for policy-making.…”
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