Sepsis: the silent killer we should be stopping

“…Discusses global impacts of sepsis, calling for further education in sepsis recognition and treatment. …”
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Review of the Predictive Value of Biomarkers in Sepsis Mortality by Nai Zhang, Yujuan Liu, Chuang Yang, Xinai Li

“…Sepsis is a leading cause of mortality among severely ill individuals, primarily due to its potential to induce fatal organ dysfunction. …”
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Emerging Evidence concerning the Role of Sirtuins in Sepsis by Lulan Li, Zhongqing Chen, Weijun Fu, Shumin Cai, Zhenhua Zeng

“…Sepsis, a dysregulated host response to infection, is a major public health concern. …”
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Poststernotomy Osteomyelitis Presenting with Severe Sepsis and Rhabdomyolysis by Eugene M. Tan, Melissa Lyle, Kelly Cawcutt, Zelalem Temesgen

“…A 39-year-old male, who recently underwent a composite valve graft of the aortic root and ascending aorta for bicuspid aortic valve and aortic root aneurysm, was hospitalized for severe sepsis, rhabdomyolysis (creatine kinase 29000 U/L), and severe liver dysfunction (AST > 7000 U/L, ALT 4228 U/L, and INR > 10). …”
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Hyperuricemia: An Early Marker for Severity of Illness in Sepsis by Sana R. Akbar, Dustin M. Long, Kashif Hussain, Ahmad Alhajhusain, Umair S. Ahmed, Hafiz I. Iqbal, Ailia W. Ali, Rachel Leonard, Cheryl Dalton

“…Since high levels of oxyradicals and lower antioxidant levels in septic patients are believed to result in multiorgan failure, uric acid levels could be used as a marker of oxidative stress and poor prognosis in patients with sepsis. Design. We conducted a prospective cohort study on Medical Intensive Care Unit (MICU) patients and hypothesized that elevated uric acid in patients with sepsis is predictive of greater morbidity. …”
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Retracted: The Parenteral Vitamin C Improves Sepsis and Sepsis-Induced Multiple Organ Dysfunction Syndrome via Preventing Cellular Immunosuppression by Mediators of Inflammation

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The Complete Blood Count Sepsis Index Using Monocyte Distribution Width for Early Detection of Sepsis in Patients Without Obvious Signs by Scott Levin, PhD, Nima Sarani, MD, Jeremiah Hinson, MD, PhD, Melissa Naiman, PhD, Chad Cannon, MD, Aria Smith, MS, Benjamin Steinhart, MS, Arnaud DeBraine, BS, Sarah Kehoe, PhD, Bryan Immhoff, MD, Yasir Taribichi, MD, Alexandra Malinovska, MD, Kemi Badaki-Makun, MD

“…The objective of this study was to develop the CBC Sepsis Index (CBC-SI) that incorporates monocyte distribution width (MDW) to enhance rapid sepsis screening. …”
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FREQUENCY OF NEONATAL SEPSIS AMONG NEONATES PRESENTING WITH SEIZURES by Abid Imran, Sijad-Ur- Rehman, Imran Qadir, Kainaat Sheikh, Romana Bibi, Muhammad Idrees

“…More over the 42% neonates had neonatal sepsis while 58% neonates didn’t had neonatal sepsis.  …”
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Early detection of sepsis using machine learning algorithms by Rasha M. Abd El-Aziz, Alanazi Rayan

Subjects: “…Sepsis…”
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Age influences the circulating immune profile in pediatric sepsis by Grace Fisler, Grace Fisler, Grace Fisler, Mariana R. Brewer, Mariana R. Brewer, Mariana R. Brewer, Omar Yaipen, Clifford S. Deutschman, Clifford S. Deutschman, Clifford S. Deutschman, Matthew D. Taylor, Matthew D. Taylor, Matthew D. Taylor

Subjects: “…sepsis…”
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How BATF silencing protects neonatal lungs in sepsis by Eliza Glodkowska-Mrowka, Marlena Tynecka, Andrzej Eljaszewicz

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Drp1–associated genes implicated in sepsis survival by Marissa D. Pokharel, Marissa D. Pokharel, Anlin Feng, Anlin Feng, Ying Liang, Ying Liang, Wenli Ma, Wenli Ma, Saurabh Aggarwal, Hoshang Unwalla, Stephen M. Black, Stephen M. Black, Stephen M. Black, Ting Wang, Ting Wang, Ting Wang

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Thrombomodulin: A Bifunctional Modulator of Inflammation and Coagulation in Sepsis by Takayuki Okamoto, Hironobu Tanigami, Koji Suzuki, Motomu Shimaoka

“…Deregulated interplay between inflammation and coagulation plays a pivotal role in the pathogenesis of sepsis. Therapeutic approaches that simultaneously target both inflammation and coagulation hold great promise for the treatment of sepsis. …”
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The injury effect of osteopontin in sepsis-associated lung injury by Qian Wang, Zhicai Yu, Zhixin Song, Xue Lu, Zhu Li, Dandan Pi, Jing Li, Feng Xu

Subjects: “…Sepsis…”
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Serum Calprotectin: A Potential Biomarker for Neonatal Sepsis by Lidia Decembrino, Mara De Amici, Margherita Pozzi, Annalisa De Silvestri, Mauro Stronati

“…The correct diagnosis of neonatal sepsis is a relevant problem because sepsis is one of the most important causes of neonatal morbidity, mortality, and prolonged hospital stay. …”
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Sepsis, Failure of Passive Transfer, and Fluid Therapy in Calves. by Amanda M. House, Max Irsik, Jan K. Shearer

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Increased NTPDase Activity in Lymphocytes during Experimental Sepsis by Claudia de Mello Bertoncheli, Carine Eloise Prestes Zimmermann, Jeandre Augusto dos Santos Jaques, Cláudio Alberto Martins Leal, Jader Betsch Ruchel, Bruna Cipolatto Rocha, Kelly de Vargas Pinheiro, Viviane do Carmo Gonçalves Souza, Daniel Roulim Stainki, Sônia Cristina Almeida Luz, Maria Rosa Chitolina Schetinger, Daniela Bitencourt Rosa Leal

“…We investigated in rats induced to sepsis the activity of ectonucleoside triphosphate diphosphohydrolase (NTPDase; CD39; E.C. 3.6.1.5), an enzyme involved in the modulation of immune responses. …”
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MicroRNA-155: Regulation of Immune Cells in Sepsis by Ming Chen, Fuquan Wang, Haifa Xia, Shanglong Yao

“…In addition, by blocking the proinflammatory effects of miR-155, it can effectively improve sepsis-related organ injury, providing novel insights to identify potential biomarkers and therapeutic targets for sepsis. …”
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Unveiling promising sepsis biomarkers: a clinical perspective by Hong Zhang, Junpeng Zhao, Zhiping Wang, Mengxiang Huang, Zhonghua Tan, Feng Jiang, Yuhong Zhou, Linhua Wang, Mingbing Xiao

Subjects: “…sepsis…”
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Biomarker Acute Kidney Injury (AKI) pada Sepsis by Dional Setiawan, Harnavi Harun, Syaiful Azmi, Drajad Priyono

“…Sepsis didefinisikan sebagai infeksi bersama dengan manifestasi sistemik dari infeksi. …”
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