NF-κB Inhibition after Cecal Ligation and Puncture Reduces Sepsis-Associated Lung Injury without Altering Bacterial Host Defense by Hui Li, Wei Han, Vasilly Polosukhin, Fiona E. Yull, Brahm H. Segal, Can-Mao Xie, Timothy S. Blackwell

“…Since the NF-κB pathway regulates both inflammation and host defense, it is uncertain whether interventions targeting NF-κB would be beneficial in sepsis. Based on the kinetics of the innate immune response, we postulated that selective NF-κB inhibition during a defined time period after the onset of sepsis would reduce acute lung injury without compromising bacterial host defense. …”
Get full text

The Urinary Liver-Type Fatty Acid Binding Protein (L-FABP) in Early Detection and Outcome Prediction of Sepsis-Associated Acute Kidney Injury by Ghi Nguyen Hai, Binh Nguyen Gia, Hoa Do Thanh, Cuong Nguyen Thai, Duc Vu Anh, Anh Duong Duc, Duong Le Xuan Xuan

Subjects: Get full text

Norepinephrine titration in patients with sepsis-induced encephalopathy: cerebral pulsatility index compared to mean arterial pressure guided protocol: randomized controlled trial by Mai Salah Salem, Motaz Amr Abosabaa, Mohamed Samir Abd El Ghafar, Hala Mohey EI-Deen Mohamed EI-Gendy, Salah El-din Ibrahim Alsherif

Subjects: “…Sepsis-induced encephalopathy…”
Get full text

Facilitating high quality acute care in resource-constrained environments: Perspectives of patients recovering from sepsis, their caregivers and healthcare workers in Uganda and Malawi. by Felix Limbani, Olive Kabajaasi, Margaret Basemera, Kate Gooding, Nathan Kenya-Mugisha, Mercy Mkandawire, Davis Rusoke, Shevin T Jacob, Anne Ruhweza Katahoire, Jamie Rylance, African Research Collaboration on Sepsis, Patient Experience Study Group

“…Sepsis is a major global health problem, especially in sub-Saharan Africa. …”
Get full text

Vitamin D supplementation during intensive care unit stay is associated with improved outcomes in critically Ill patients with sepsis: a cohort study by Caifeng Li, Ke Zhao, Qian Ren, Lin Chen, Ying Zhang, Guolin Wang, Keliang Xie

Subjects: Get full text

Early and high-volume administration of sodium bicarbonate in sepsis-associated acute kidney injury in patients with malignancies, during continuous renal replacement therapy by Lamei Ouyang, Yin Pan, Ya-Fei Wu, Qiang Tang, Dao-Feng Wang, Ning Lou

Subjects: “…Sepsis-associated acute kidney injury…”
Get full text

Increased Death of Peripheral Blood Mononuclear Cells after TLR4 Inhibition in Sepsis Is Not via TNF/TNF Receptor-Mediated Apoptotic Pathway by Chien-Ming Chu, Li-Chung Chiu, Chung-Chieh Yu, Li-Pang Chuang, Kuo-Chin Kao, Li-Fu Li, Huang-Pin Wu

“…Apoptosis is one of the causes of immune depression in sepsis. Pyroptosis also occurs in sepsis. The toll-like receptor (TLR) 4 and receptor for advanced glycation end products (RAGE) have been shown to play important roles in apoptosis and pyroptosis. …”
Get full text

Astrocyte-Derived Interleukin 11 Modulates Astrocyte–Microglia Crosstalk via Nuclear Factor-κB Signaling Pathway in Sepsis-Associated Encephalopathy by Dandan Zhu, Peng Wang, Xiyue Chen, Kaituo Wang, Yunsong Wu, Min Zhang, Jianhua Qin

“…Sepsis-associated encephalopathy (SAE) is a severe and frequent septic complication, characterized by neuronal damage as key pathological features. …”
Get full text

Analysis of the correlation between the group-based trajectory modeling of serum osmolality and prognosis in patients with sepsis-associated encephalopathy at 72 h after admission by Wentao Wu, Chen Wang, Yuhua Zhang, Yongpeng Xie, Xiaomin Li

Subjects: “…Sepsis-associated encephalopathy…”
Get full text

Coupling of an Au@AgPt nanozyme array with an micrococcal nuclease-specific responsiveness strategy for colorimetric/SERS sensing of Staphylococcus aureus in patients with sepsis by Xueqin Huang, Yingqi Yang, Hanlin Zhou, Liping Hu, Annan Yang, Hua Jin, Biying Zheng, Jiang Pi, Jun Xu, Pinghua Sun, Huai-Hong Cai, Xujing Liang, Bin Pan, Junxia Zheng, Haibo Zhou

“…Meanwhile, the MNase-mediated strategy characterized by high specificity and sensitivity successfully discriminated between patients with sepsis (n = 7) and healthy participants (n = 3), as well as monitored the prognostic progression of the disease (n = 2). …”
Get full text

Diagnostic Value of Dynamics Serum sCD163, sTREM-1, PCT, and CRP in Differentiating Sepsis, Severity Assessment, and Prognostic Prediction by Longxiang Su, Lin Feng, Qing Song, Hongjun Kang, Xingang Zhang, Zhixin Liang, Yanhong Jia, Dan Feng, Changting Liu, Lixin Xie

“…An SIRS group (30 cases) and a sepsis group (100 cases) were involved in this study. …”
Get full text

Early urea-to-creatinine ratio to predict rapid muscle loss in critically ill patients with sepsis: a single-center retrospective observational study by Jie Jiang, Hui Chen, Shan-shan Meng, Chun Pan, Jian-Feng Xie, Feng-Mei Guo

Subjects: “…Sepsis…”
Get full text

Prevalence of neonatal sepsis and associated factors among neonates admitted in the neonatal intensive care unit at Lira Regional Referral Hospital, Northern Uganda. by Brendah Katugume, JohnBaptist Muzungu, Nelson Okello, Eustes Kigongo, Deborah Andrinar Namutebi

“…<h4>Background</h4>Sepsis is one of the leading causes of mortality and morbidity among neonates. …”
Get full text

Maternal Infections, Antibiotics, Steroid Use, and Diabetes Mellitus Increase Risk of Early-Onset Sepsis in Preterm Neonates: A Nationwide Population-Based Study by Hao-Yuan Lee, Yu-Lung Hsu, Wen-Yuan Lee, Kuang-Hua Huang, Ming-Luen Tsai, Chyi-Liang Chen, Yu-Chia Chang, Hung-Chih Lin

Subjects: “…early-onset sepsis…”
Get full text

Mdivi-1 Protects CD4+ T Cells against Apoptosis via Balancing Mitochondrial Fusion-Fission and Preventing the Induction of Endoplasmic Reticulum Stress in Sepsis by You Wu, Yong-Ming Yao, He-Liang Ke, Lan Ying, Yao Wu, Guang-Ju Zhao, Zhong-Qiu Lu

“…Apoptosis of CD4+ T cells plays a central role in the progression of sepsis because it is associated with subsequent immunosuppression and the lack of specific treatment. …”
Get full text

Parthenolide improves sepsis-induced coagulopathy by inhibiting mitochondrial-mediated apoptosis in vascular endothelial cells through BRD4/BCL-xL pathway by Jun Zhang, Xing Zhu, Yong Li, Yinyu Wu, Yunxia Du, Hai Yang, Zhengchao Liu, Haoyu Pei, Rui Li, Huan Luo, Deyu Zuo, Han She, Qingxiang Mao

Subjects: “…Sepsis-induced coagulopathy…”
Get full text

Albumin corrected anion gap and clinical outcomes in elderly patients with acute kidney injury caused or accompanied by sepsis: a MIMIC-IV retrospective study by Yongbin Wang, Lei Zhong, Jie Min, Jianhong Lu, Jinyu Zhang, Jiajun Su

Subjects: Get full text

Risk factors associated with mortality and pathogen characteristics of bloodstream infection-induced severe sepsis in the pediatric intensive care unit: a retrospective cohort study by Jian Chen, Jian Chen, Haixin Huang, Ruichen Zhang, Yueqiang Fu, Chunmei Jing

Subjects: Get full text

Ursodeoxycholic acid protects against sepsis-induced acute kidney injury by activating Nrf2/HO-1 and inhibiting NF-κB pathway by Yunpeng Lou, Hongguang Shi, Ning Sha, Feifei Li, Xiaofeng Gu, Huiyan Lin

Subjects: Get full text

Association between platelet count and 30-day in-hospital mortality among intensive care unit patients with sepsis: a multicenter retrospective cohort study by Jun Wang, Pan Zhou, Xin Li, Li Zhou, Zhe Deng

Subjects: Get full text