Gut dysbiosis-induced vitamin B6 metabolic disorder contributes to chronic stress-related abnormal behaviors in a cortisol-independent manner by Wenxiang Qing, Huimin Chen, Xin Ma, Jie Chen, Yuan Le, Hui Chen, Jianhua Tong, Kaiming Duan, Daqing Ma, Wen Ouyang, Jianbin Tong

“…However, the causal relationship and key factors between gut dysbiosis and brain disorders in chronic stress remain elusive, particularly under non-sterile conditions. Here, using a repeated restraint stress (RRS) rat model, we show that sequential transplantation of the cecal contents of different RRS stages to normal rats reproduced RRS-induced core phenotypes, including abnormal behaviors, increased peripheral blood corticosterone and inflammatory cytokines, and a unique gut microbial phenotype. …”
Get full text

Continuously relapsing (for two years) course of diarrheal variant of IBS (<i>Clinical case</i>) by Ye. A. Poluektova, S. Yu. Kuchumova, A. A. Kurbatova, A. A. Sheptulin, O. S. Shifrin, V. T. Ivashkin

“…Patient had no nausea and vomiting the next day, however the abdominal pain and unstable stool persisted for a long time. The patient was repeatedly examined, but according to carried out investigation no significant changes were revealed. …”
Get full text

Comparison of In Vitro Fertilization Outcomes between Normal and T-Shaped Uteri, Diagnosed by Hysterosalpingography in Women with infertility: A Retrospective Cohort Study by Fattaneh Pahlavan, Shohreh Irani, Mehri Mashayekhi, Samira Vesali, Fatemeh Niknejad, Firoozeh Ahmadi, Narges Bagheri-Lankarani

“…Inclusion criteria were as follow: womenof 20-45 years old, primary infertility, no repeated implantation failure (RIF), embryo quality “grade A” or “grade B”(freeze), and no consumption of smoking or alcohol. …”
Get full text

Angiogenesis Regulated by Electroacupuncture Combined with Rehabilitation Training in Cerebral Ischemia Involved in PI3K/Akt Signaling Pathway by Wenchao YAO, Mengxing LI, Qing LIU, Mingyue TONG, Peng HE, Wei TANG

“…The relative expression levels of vascular endothelial growth factor (VEGF), brain-derived neurotrophic factor (BDNF), PI3K and Akt were detected by Western blot and RT-PCR respectively.Results:(1) The neurons in the ischemic area of the model group were irregular in morphology, vacuolation, reduction of glycosomes and autophagic vesicles in the cytoplasm, swelling of mitochondria and pyknosis of nucleus; Compared with the model group, on day 3, 7 and 14 of treatment, the neuron cell membrane of the combined acupuncture group showed a tendency to repair, and the structure of organelles and the degree of vacuolation were significantly improved.(2) On day 3, 7 and 14 of treatment, the MVD count of cerebral ischemia area was statistically significant in different groups (<italic>F</italic>_Intergroup=141.762, <italic>P</italic>&lt; 0.001), the MVD count of the combined acupuncture group was higher than that of the other two groups, the difference was statistically significant respectively (<italic>P</italic>&lt; 0.01); On day 3, 7 and 14 of treatment, there was significant difference in the change trend of different time points respectively (<italic>F</italic>_Time=81.920, <italic>P</italic>&lt; 0.001), the combined acupuncture group increased significantly on the 14th day of treatment, and the differences were statistically significant (<italic>P</italic>&lt; 0.01); MVD count had group×time obvious interaction (<italic>F</italic>_Interaction=44.960, <italic>P</italic>&lt; 0.001). (3) The variance analysis of repeated measurements of VEGF, BDNF, PI3K, Akt proteins in the brain tissue of the ischemic area showed that the variables were statistically significant among different groups respectively (<italic>F</italic>_Intergroup=398.772, 903.082, 2 312.264, and 1 581.880, <italic>P</italic>&lt; 0.001). …”
Get full text

Features of surgical treatment for gunshot wounds of the heart and great vessels with migration of foreign bodies by I.A. Lurin, E.M. Khoroshun, V.V. Makarov, V.V. Nehoduiko, O.V. Buchnieva, I.V. Veryovkin

“…In two (18.2 %) cases, repeated surgical interventions were performed for repeated intraoperative migration of a foreign body from one side to another along the system of pulmonary arteries in the scope of thoracotomy, pneumotomy, arteriotomy, removal of a foreign body, and artery suturing. …”
Get full text

A systematic review exploring the factors that contribute to increased primary care physician turnover in socio-economically deprived areas. by Jasmine Lee, Evangelos Kontopantelis

“…<h4>Conclusions</h4>The studies reviewed have consistently highlighted the repeating cycle of persistent staff shortages contributing to an increased turnover rate within disadvantaged areas internationally. …”
Get full text

Effects of information on consumer attitudes towards gene-edited foods: a comparison between livestock and vegetables by Naoko Kato-Nitta, Yusuke Inagaki, Tadahiko Maeda, Masashi Tachikawa

“…Japanese food producers and researchers are optimistic about the application of the clustered regularly interspaced short palindromic repeats (CRISPR) approach to food. Due to the strict regulations regarding genetically modified (GM) food, GM crops are not commercially cultivated in Japan. …”
Get full text

Adult validation of a self-administered tablet audiometer by Mark Bastianelli, Amy E. Mark, Arran McAfee, David Schramm, Renée Lefrançois, Matthew Bromwich

“…The mean difference between repeat assessments was 0 (SD = 2.1) in the left ear, and 0.1 (SD = 1.1) in the right ear. …”
Get full text

Evaluating the effects of time-restricted eating on overweight and obese women with polycystic ovary syndrome: A randomized controlled trial study protocol. by Hui Liu, Fuliang Shangguan, Fen Liu, Yu Guo, Huixi Yu, Hanbing Li, Yinhua Su, Zhongyu Li

“…Statistical analysis will include the Anderson-Darling test for normality, T-test/Wilcoxon test based on distribution, mixed-effects models for assessing time/group effects, Cox model for time-to-event analysis, repeated ANOVA for change analysis, and sensitivity analysis. …”
Get full text

Causal links between obesity, lipids, adipokines, and cognition: a bidirectional Mendelian-randomization analysis by Meng Gong, Haichao Liu, Zhixiang Liu, Yongshen Wang, Shiyi Qi, Hong Guo, Song Jin

“…We employed genetic instruments for adiposity indicators as exposures in one direction, and repeated the analysis in the opposite direction using instruments for cognitive function. …”
Get full text

Percutaneous Vertebroplasty and Facet Blocking for Treating Back Pain Caused by Osteoporotic Vertebral Compression Fracture by Yongquan Cheng, Xiaoliang Wu, Jiawei Shi, Hui Jiang

“…The χ2 test, Student’s t-test, and repeated measures analysis of variance were used to compare the differences between the two groups. …”
Get full text

Analysis of Body Fluid Distribution, Phase Angle and Its Association With Maximal Oxygen Consumption in Facioscapulohumeral Dystrophy: An Observational Study by Oscar Crisafulli, Renato Baptista, Patrik Drid, Luca Grattarola, Giorgio Bottoni, Emanuela Lavaselli, Massimo Negro, Rossella Tupler, Venere Quintiero, Giuseppe D'Antona

“…Bioimpedance analysis (BIA) allows a noninvasive and repeatable estimate of body composition but is based on the use of predictive equations which, if used in cohorts with different characteristics from those for which the equation was originally formulated, could give biased results. …”
Get full text

Clinical laboratory evaluation of the Hologic Panther Aptima BV and CV/TV assays for the diagnosis of vaginitis in Dunedin, Aotearoa New Zealand by Juliet Elvy, Katelyn Carter, Jenna Paterson, Megan Smith, Gayleen Parslow, James E. Ussher

“…Importantly, we found Gram stain for bacterial vaginosis (BV) to be error prone, with 20% of Gram stain results discordant on repeat examination. We show the potential for molecular methods to increase BV diagnoses and improve reproducibility and consistency of reporting which, according to our clinical audit results, would lead to more women being treated for this dysbiosis condition overall.…”
Get full text

Functional Analysis of Patients with Spinal Muscular Atrophy Based on Exploratory Item Response Theory Modeling by FAN Yabei, CHEN Jinjin, GE Panli, CHENG Xi, ZHANG Yichen, LIN Feng

“…IRM was constructed using these repeated measurement data based on stack design^［1］. …”
Get full text

Importance of OsRac1 in Signalling of Pigm-1 Mediated Resistance to Rice Blast Disease by Dewei Yang, Niqing He, Fenghuang Huang, Jialin Chen, Minxiang Yu, Yidan Jin, Shaojun Lin, Shengping Li

“…In rice, leucine-rich repeat nucleotide-binding site (NLR) proteins are pivotal immune receptors in combating <i>Magnaporthe oryzae</i>-triggered rice blast. …”
Get full text

Multimodal MRI analysis of microstructural and functional connectivity brain changes following systematic audio-visual training in a virtual environment by Kholoud Alwashmi, Fiona Rowe, Georg Meyer

“…Therefore, behavioural performance change is likely to be the result of microstructural, functional activation, and connectivity changes in extended neural networks.Here we show for the first time that learning-induced microstructural change in WM tracts, quantified with diffusion tensor and kurtosis imaging (DTI, DKI) is linked to functional connectivity changes in brain areas that use these tracts to communicate.Twenty healthy participants engaged in a month of virtual reality (VR) systematic audiovisual (AV) training. DTI analysis using repeated-measures ANOVA unveiled a decrease in mean diffusivity (MD) in the SLF II, alongside a significant increase in fractional anisotropy (FA) in optic radiations post-training, persisting in the follow-up (FU) assessment (post: MD t(76) = 6.13, p < 0.001, FA t(76) = 3.68, p < 0.01, FU: MD t(76) = 4.51, p < 0.001, FA t(76) = 2.989, p < 0.05). …”
Get full text

RNA-Sequence Reveals the Regulatory Mechanism of miR-149 on Osteoblast Skeleton under Mechanical Tension by Yifan Wang, Guanyin Zhu, Fang Pei, Yigan Wang, Jun Liu, Caixia Lu, Zhihe Zhao

“…Real-time quantitative polymerase chain reaction (RT-qPCR) detected the expression of miR-149 and ARFGAP with SH3 domain, Ankyrin repeat, and Ph domain 3 (ASAP3) mRNA. Western blot detected the protein levels of ASAP3, F-actin, osteogenic markers bone morphogenetic protein 2 (BMP2), and runt-related transcription factor 2 (RUNX2). …”
Get full text

Opioid consumption frequency and its associations with potential life problems during opioid agonist treatment in individuals with prescription-type opioid use disorder: explorator... by Anne Bouthillier, Gabriel Bastien, Christina McAnulty, Hamzah Bakouni, Bernard Le Foll, M. Eugenia Socias, Didier Jutras-Aswad

“…The 114 participants who completed both baseline and end-of-study questionnaires were included. A repeated-measures generalized linear mixed model (GLMM) was used to evaluate the influence of OUF on potential life problems. …”
Get full text

Joint trajectories of physical activity, health, and income before and after statutory retirement: A 22-year follow-up. by Tea Lallukka, Petteri Kolmonen, Ossi Rahkonen, Eero Lahelma, Jouni Lahti

“…<h4>Methods</h4>We studied former employees of the City of Helsinki, Finland, who transitioned to full statutory retirement between 2000 and 2022 (n = 5209, 80% women). We examined five repeated questionnaire surveys to identify any joint developmental patterns in the key indicators of healthy aging and well-being-leisure-time physical activity, health measured by general health perceptions, and household income, over a follow-up of 22 years. …”
Get full text

Abnormal sagittal patellar tilt during active knee flexion and extension on 4DCT might be associated with patellofemoral pain by Yurou Chen, Xin Liu, Bo Sheng, Mao Yuan, Furong Lv, Fajin Lv, Fan Yu, Jia Li

“…Patella-patellar tendon angle (P-PTA), patella-lateral tibial plateau angle (P-LTPA), patella-screen horizontal line angle (P-SHLA), articular facet of the patella-lateral tibial plateau angle (PA-LTPA), articular facet of the patella-screen horizontal line angle (PA-SHLA), and upper margin of the patella-quadriceps tendon angle (PU-QTA) were used to evaluate the sagittal patellar tilt. Two-factor repeated-measures ANOVA was used to compare all parameters between the two groups. …”
Get full text